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| 1 | Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters显示文摘Since metabolic process differs between humans and mice, studies were performed in hamsters, which are generally considered to be a more appropriate animal model for studies of obesityrelated metabolic disorders. The modulation of gut microbiota, bile acids and the farnesoid X receptor(FXR) axis is correlated with obesity-induced insulin resistance and hepatic steatosis in mice. However,the interactions among the gut microbiota, bile acids and FXR in metabolic disorders remained largely unexplored in hamsters. In the current study, hamsters fed a 60% high-fat diet(HFD) were administeredvehicle or an antibiotic cocktail by gavage twice a week for four weeks. Antibiotic treatment alleviated HFD-induced glucose intolerance, hepatic steatosis and inflammation accompanied with decreased hepatic lipogenesis and elevated thermogenesis in subcutaneous white adipose tissue(sWAT). In the livers of antibiotic-treated hamsters, cytochrome P450 family 7 subfamily B member 1(CYP7 B1) in the alternative bile acid synthesis pathway was upregulated, contributing to a more hydrophilic bile acid profile with increased tauro-β-muricholic acid(TβMCA). The intestinal FXR signaling was suppressed but remained unchanged in the liver. This study is of potential translational significance in determining the role of gut microbiota-mediated bile acid metabolism in modulating diet-induced glucose intolerance and hepatic steatosis in the hamster. | Lulu Sun Yuanyuan Pang Xuemei Wang Qing Wu Huiying Liu Bo Liu George Liu Min Ye Wei Kong Changtao Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 29 |
| 2 | Wet and dry deposition fluxes of heavy metals in Pearl River Delta Region(China):Characteristics,ecological risk assessment,and source apportionment显示文摘The atmospheric deposition of heavy metals poses serious risks to the ecological system and human health. To advance our knowledge of atmospheric dry/wet heavy metal deposition in the PRD region, monthly fluxes were examined based on soluble/insoluble fractions of five heavy metal elements(Cu, Pb, Cd, Cr and Zn) in samples collected from January 2014 to December 2015 at Guangzhou(urban) and Dinghushan(suburban) sites. The ratios of wet/dry deposition fluxes indicated that heavy metal deposition was governed by wet deposition rather than dry deposition in the PRD region. Affected by the shifting of the Asian monsoon, wet deposition fluxes exhibited significant seasonal variation between summer monsoon seasons(April to September) and winter monsoon seasons(October to February) in this region. Cd was classified as an extremely strong potential ecological risk based on solubility and the Hakanson ecological risk index. Source contributions to wet deposition were calculated by PMF, suggesting that dust, biomass burning, industries,vehicles, long-range transport and marine aerosol sources in Guangzhou, and Zn fertilizers,marine aerosol sources, agriculture, incense burning, biomass burning, vehicles and the ceramics industry in Dinghushan, were the potential sources of heavy metals. | Lyumeng Ye Minjuan Huang Buqing Zhong Xuemei Wang Qiulan Tu Haoran Sun Chao Wang Luolin Wu Ming Chang | 2018 | Journal of Environmental Sciences2018，30，8： | 20 |
| 3 | Photochemical indicators of ozone sensitivity: application in the Pearl River Delta, China显示文摘 | Lyumeng Ye Xuemei Wang Shaofeng Fan Weihua Chen Ming Chang Shengzhen Zhou Zhiyong Wu Qi Fan | 2016 | Frontiers of Environmental Science & Engineering2016，10，6： | 5 |
| 4 | An Anomalous Behavior Detection Model in Cloud Computing显示文摘This paper proposes an anomalous behavior detection model based on cloud computing. Virtual Machines(VMs) are one of the key components of cloud Infrastructure as a Service(Iaa S). The security of such VMs is critical to Iaa S security. Many studies have been done on cloud computing security issues, but research into VM security issues, especially regarding VM network traffic anomalous behavior detection, remains inadequate.More and more studies show that communication among internal nodes exhibits complex patterns. Communication among VMs in cloud computing is invisible. Researchers find such issues challenging, and few solutions have been proposed—leaving cloud computing vulnerable to network attacks. This paper proposes a model that uses Software-Defined Networks(SDN) to implement traffic redirection. Our model can capture inter-VM traffic, detect known and unknown anomalous network behaviors, adopt hybrid techniques to analyze VM network behaviors, and control network systems. The experimental results indicate that the effectiveness of our approach is greater than 90%, and prove the feasibility of the model. | Xiaoming Ye Xingshu Chen Haizhou Wang Xuemei Zeng Guolin Shao Xueyuan Yin Chun Xu | 2016 | Tsinghua Science and Technology2016，21，3： | 5 |
| 5 | A multiple-kernel LSSVR method for separable nonlinear system identifcation显示文摘In some nonlinear dynamic systems,the state variables function usually can be separated from the control variables function,which brings much trouble to the identifcation of such systems.To well solve this problem,an improved least squares support vector regression(LSSVR)model with multiple-kernel is proposed and the model is applied to the nonlinear separable system identifcation.This method utilizes the excellent nonlinear mapping ability of Morlet wavelet kernel function and combines the state and control variables information into a kernel matrix.Using the composite wavelet kernel,the LSSVR includes two nonlinear functions,whose variables are the state variables and the control ones respectively,in this way,the regression function can gain better nonlinear mapping ability,and it can simulate almost any curve in quadratic continuous integral space.Then,they are used to identify the two functions in the separable nonlinear dynamic system.Simulation results show that the multiple-kernel LSSVR method can greatly improve the identifcation accuracy than the single kernel method,and the Morlet wavelet kernel is more effcient than the other kernels. | Yanning CAI Hongqiao WANG Xuemei YE Qinggang FAN | 2013 | 控制理论与应用(英文版)2013，11，4： | 5 |
| 6 | Fast-Suppressor Screening for New Components in Protein Trafficking,Organelle Biogenesis and Silencing Pathway in Arabidopsis thaliana Using DEX-Inducible FREE1-RNAi Plants显示文摘Membrane trafficking is essential for plant growth and responses to external signals.The plant unique FYVE domain-containing protein FREE1 is a component of the ESCRT complex(endosomal sorting complex required for transport).FREE1 plays multiple roles in regulating protein trafficking and organelle biogenesis including the formation of intraluminal vesicles of multivesicular body(MVB),vacuolar protein transport and vacuole biogenesis,and autophagic degradation.FREE1 knockout plants show defective MVB formation,abnormal vacuolar transport,fragmented vacuoles,accumulated autophagosomes,and seedling lethality.To further uncover the underlying mechanisms of FREE1 function in plants,we performed a forward genetic screen for mutants that suppressed the seedling lethal phenotype of FREE1-RNAi transgenic plants.The obtained mutants are termed as suppressors of free1(sof).To date,229 putative sof mutants have been identified.Barely detecting of FREE1 protein with M3plants further identified 84 FREE1-related suppressors.Also145 mutants showing no reduction of FREE1 protein were termed as RNAi-related mutants.Through next-generation sequencing(NGS)of bulked DNA from F2mapping population of two RNAi-related sof mutants,FREE1-RNAi T-DNA inserted on chromosome 1 was identified and the causal mutation of putative sof mutant is being identified similarly.These FREE1-and RNAi-related sof mutants will be useful tools and resources for illustrating the underlying mechanisms of FREE1 function in intracellular trafficking and organelle biogenesis,as well as for uncovering the new components involved in the regulation of silencing pathways in plants. | Qiong Zhao Caiji Gao PoShing Lee Lin Liu Shaofang Li Tangjin Hu Jinbo Shen Shuying Pan Hao Ye Yunru Chen Wenhan Cao Yong Cui Peng Zeng Sheng Yu Yangbin Gao Liang Chen Beixin Mo Xin Liu Shi Xiao Yunde Zhao Silin Zhong Xuemei Chen Liwen Jiang | 2015 | Journal of Genetics and Genomics2015，42，6： | 4 |
| 7 | In vivo rapid fluorescence imaging of Alzheimer's disease through accurate target bio-marking of zinc gluconate显示文摘Alzheimer's disease(AD) is a progressive and age-related irreversible neurodegenerative disease. When AD occurs, the relevant amount of zinc ions in brain considerably changes. In this contribution, we have explored the possibility of in vivo rapid fluorescence imaging of AD through accurate targeting biomarker of zinc gluconate. By using the 3- and 6-month-old Alzheimer's model mice(AD-1) as the experimental models, our observations demonstrate that zinc gluconate molecules could pass through the blood–brain barrier and then produce hippocampus region-specific accumulation of fluorescent zinc nanoclusters in vivo, thus allowing kinetically controlled selective imaging of AD by fluorescence bioimaging. | Lanmei Lai Chunqiu Zhao Meina Su Jing Ye Hui Jiang Xuemei Wang | 2015 | Science Bulletin2015，60，16： | 3 |
| 8 | Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease显示文摘The parahippocampal gyrus-orbitofrontal cortex(PHG-OFC)circuit in humans is homologous to the postrhinal cortex(POR)-ventral lateral orbitofrontal cortex(vlOFC)circuit in rodents.Both are associated with visuospatial malfunctions in Alzheimer’s disease(AD).However,the underlying mechanisms remain to be elucidated.In this study,we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice,and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging(MRI)in patients on the AD spectrum.We demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD mice.Moreover,MRI measurements of the PHG-OFC circuit had an accuracy of 77.33%for the classification of amnestic mild cognitive impairment converters versus non-converters.Thus,the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD,thereby providing a potential predictor for AD progression and a promising interventional approach for AD. | Lin Zhu Zan Wang Zhanhong Du Xinyang Qi Hao Shu Duan Liu Fan Su Qing Ye Xuemei Liu Zheng Zhou Yongqiang Tang Ru Song Xiaobin Wang Li Lin Shijiang Li Ying Han Liping Wang Zhijun Zhang | 2020 | Neuroscience Bulletin2020，36，8： | 2 |
| 9 | A spontaneous thermo-sensitive female sterility mutation in rice enables fully mechanized hybrid breeding显示文摘Male sterility enables hybrid crop breeding to increase yields and has been extensively studied. But thermo-sensitive female sterility, which is an ideal property that may enable full mechanization in hybrid rice breeding, has rarely been investigated due to the absence of such germplasm. Here we identify the spontaneous thermo-sensitive female sterility 1 (tfs1) mutation that confers complete sterility under regular/high temperature and partial fertility under low temperature as a point mutation in ARGONAUTE7 (AGO7). AGO7 associates with miR390 to form an RNA-Induced Silencing Complex (RISC), which triggers the biogenesis of small interfering RNAs (siRNAs) from TRANS-ACTING3 (TAS3) loci by recruiting SUPPRESSOR OF GENE SILENCING (SGS3) and RNA-DEPENDENT RNA POLYMERASE6 (RDR6) to TAS3 transcripts. These siRNAs are known as tasiR-ARFs as they act in trans to repress auxin response factor genes. The mutant TFS1 (mTFS1) protein is compromised in its ability to load the miR390/miR390* duplex and eject miR390* during RISC formation. Furthermore, tasiR-ARF levels are reduced in tfs1 due to the deficiency in RDR6 but not SGS3 recruitment by mTFS1 RISC under regular/high temperature, while low temperature partially restores mTFS1 function in RDR6 recruitment and tasiR-ARF biogenesis. A miR390 mutant also exhibits female sterility, suggesting that female fertility is controlled by the miR390-AGO7 module. Notably, the tfs1 allele introduced into various elite rice cultivars endows thermo-sensitive female sterility. Moreover, field trials confirm the utility of tfs1 as a restorer line in fully mechanized hybrid rice breeding. | Haoxuan Li Chenjiang You Manabu Yoshikawa Xiaoyu Yang Haiyong Gu Chuanguo Li Jie Cui Xuemei Chen Nenghui Ye Jianhua Zhang Guanqun Wang | 2022 | Cell Research2022，32，10： | 2 |
| 10 | Preparation and characterization of copolymerized aminopropyl/phenylsilsesquioxane microparticles显示文摘 | Liu Shumei Lang Xuemei Ye Hua | 2005 | Eur Polym J2005，41，5： | 1 |
| 11 | Emission controls and changes in air quality in Guangzhou during the Asian Games显示文摘 | Huan Liu Xuemei Wang Jinpu Zhang Kebin He Ye Wu Jiayu Xu | 2013 | Atmospheric Environment2013，，： | 1 |
| 12 | Position and Coordination of SPDs in Building显示文摘 | TAO Xuemei YE Feiyu | 2004 | Proceed of the International Conference on Lightning Protection (27th ICLP)2004，1，2： | 1 |
| 13 | Study on the Species-related Flavors and the Ways to Improve the Acceptability of Mutton显示文摘 | ZHANG Xuemei YANG Yong LIU Shuliang YE Jingsong | 2009 | 肉类研究2009，23，3： | 1 |
| 14 | Photoluminescence from Ge-SiO_2 thin films and its mechanism显示文摘Ge-SiO2 thin films were deposited on p-type Si substrates using the radio frequency (rf) magnetron sputtering technique with a Ge-SiO2 composite target. Films were annealed in N2 ambience for 30 min at 300℃-1000℃ with an interval of 100℃. Through the X-ray diffraction, the average size of Ge nanocrystals (nc-Ge) was determined. They increased from 3.9 to 6.1 nm with increasing annealing temperature in the range of 600℃-1000℃. Under ultraviolet excitation, all samples emit a strong violet band centered at 396 nm. With the formation of nc-Ge, the samples exhibit another emission of orange band with the peak at 580 nm and its intensity increases with the increasing size of nc-Ge.The peak positions of two bands do not shift obviously. Experimental data indicate that the violet band comes from GeO defect and the orange band originates mainly from the luminescence centers at the interface between the nc-Ge and SiO2 matrix. | DONG Yemin, CHEN Jing, TANG Naiyun, YE Chunnuan, WU Xuemei, ZHUGE Lanjian & YAO Weiguo1. Department of Physics, Suzhou University, Suzhou 215006, China 2. Shanghai Institute of Metallurgy, Chinese Academy of Sciences, Shanghai 200050, China | 2001 | Chinese Science Bulletin2001，46，15： | 1 |
| 15 | Effect of Low-Frequency Power on Etching Characteristics of 6H-SiC in C4F8/Ar Dual-Frequency Capacitively Coupled Plasma显示文摘Dry etching of 6H silicon carbide(6H-SiC)wafers in a C_4Fs/Ar dual-frequency capacitively coupled plasma(DF-CCP)was investigated.Atomic force microscopy(AFM)and X-ray photoelectron spectroscopy(XPS)were used to measure the SiC surface structure and compositions,respectively.Optical emission spectroscopy(OES)was used to measure the relative concentration of F radicals in the plasma.It was found that the roughness of the etched SiC surface and the etching rate are directly related to the power of low-frequency(LF)source.At lower LF power,a smaller surface roughness and a lower etching rate are obtained due to weak bombardment of low energy ions on the SiC wafers.At higher LF power the etching rate can be efficiently increased,but the surface roughness increases too.Compared with other plasma dry etching methods,the DF-CCP can effectively inhibit C_xF_y films'deposition,and reduce surface residues. | XU Yijun | 2013 | Plasma Science and Technology2013，15，10： | 1 |
| 16 | Application of wavelet analysis in detection of fetal EGG 显示文摘 | Ye Datoan Ouyang Xuemei | 1996 | IEEE Engineering in Medicine and Biology Socity1996，，3： | 1 |
| 17 | LncRNA LIMT(LINC01089)contributes to sorafenib chemoresistance via regulation of miR-665 and epithelial to mesenchymal transition in hepatocellular carcinoma cells显示文摘Hepatocellular carcinoma(HCC)is one of the most malignant tumors worldwide and HCC patients often develop drug resisitene.Long non-coding RNAs(LncRNAs)are closely related to cell cycle,growth,development,differentiation,and apoptosis.Abnormally expressed lncRNAs have been proved to mediate drug resistance in tumor cells.However,the effect of LIMT on drug resistance has not been explored in HCC.In this study,we explored the effect of long non-coding RNA LIMT on drug resistance and its underlying mechanism in hepatocellular carcinoma(HCC).Our results showed that LncRNA LINC01089(LIMT)expression is downregulated in 78.57%(44/56)of 56 HCC tumor tissue samples.LIMT expression is also downregulated in HCC cells compared with that in normal liver LO2 cells.Inhibition of LIMT increases the resistance to sorafenib and promotes cell invasion via regulation of epithelial to mesenchymal transition(EMT)in HCC.StarBase V3.0 was used to predict the potential binding site of miR-665 in LIMT.Furthermore,miR-665 participates in sorafenib resistance and also regulates the level of EMT-related proteins in HCC cells.A rescue experiment demonstrated that silencing of LIMT eliminats the inhibitory effect of the miR-665 inhibitor on sorafenib resistance in HCC cells.Taken together,our findings revealed that downregulation of LIMT increases the resistance of HCC to sorafenib via miR-665 and EMT.Therefore,LIMT,which serves as a therapeutically effective target,will provide new hope for the treatment of HCC. | Jing Sun Xiaoxiao Zheng Baoming Wang Ying Cai Li Zheng Liqiang Hu Xuemei Lu Shangzhi Xie Xin Zhang Hao Liu Longyun Ye | 2022 | Acta Biochimica et Biophysica Sinica2022，54，2： | 1 |
| 18 | Advanced glycation end products increase carbohydrate responsive element binding protein expression and promote cancer cell proliferation显示文摘 | Hanbei Chen Lifang Wu Yakui Li Jian Meng Ning Lin Dianqiang Yang Yemin Zhu Xiaoyong Li Minle Li Ye Xu Yuchen Wu Xuemei Tong Qing Su | 2014 | 2014 (1-2)2014，，1： | 1 |
| 19 | Heat Shock Protein 70 Is Induced in Mouse Human Colon Tumor Xenografts After Sublethal Radiofrequency Ablation显示文摘 | Weng-Lang Yang PhD Deepak G. Nair MD Ryouji Makizumi MD George Gallos MD Xuemei Ye BS Rohit R. Sharma MD T. S. Ravikumar MD | 2004 | Annals of Surgical Oncology2004，，4： | 1 |
| 20 | Heat Shock Protein 70 Is Induced in Mouse Human Colon Tumor Xenografts After Sublethal Radiofrequency Ablation显示文摘 | Weng-Lang Yang PhD Deepak G. Nair MD Ryouji Makizumi MD George Gallos MD Xuemei Ye BS Rohit R. Sharma MD T. S. Ravikumar MD | 2004 | Annals of Surgical Oncology2004，，4： | 1 |
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