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| 1 | Synthesis and Evaluation of Novel Chitosan Derivatives for Gene Delivery显示文摘A series of novel water soluble chitosan derivatives as gene vectors was synthesized. The delivery systems were tested for their ability to form complexes with plasmid DNA by utilizing agarose gel electrophoresis, particle size analysis, zeta potential measurement and scanning electron microscopy. Furthermore, cytotoxicity of chitosan derivatives and transfection efficiency of polyplexes were evaluated in vitro. The experimental results showed that the novel chitosan derivatives had lower cytotoxicity, good DNA condensation, and higher transfection efficiencies compared to chitosan in both 293 T and He La cell lines. It was indicated that these chitosan derivatives were promising candidates for non-viral gene vectors. | 付芳 LIU Xiong 吕波 QU Guoyi ZHENG Hua HUANG Zhijun XU Peihu XU Haixing YIN Yihua LIU Xia ZHANG Xueqiong | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，4： | 1 |
| 2 | Discovery of a mammalian FASN inhibitor against xenografts of non-small cell lung cancer and melanoma显示文摘Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(FASN).1,2 The bidirectional relationships of oncogenic signaling and de novo lipogenesis(DNL)suggest that FASN is a druggable target in many cancers. | Danfeng Cao Jie Yang Youchao Deng Meng Su Yeji Wang Xueqiong Feng Yi Xiong Enhe Bai Yanwen Duan Yong Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 3 | An engineered xCas12i with high activity,high specificity,and broad PAM range显示文摘Dear Editor,The clustered regularly interspaced short palindromic repeats-Cas(CRISPR-Cas)systems,including type II Cas9 and type V Cas12 systems,which serve in the adaptive immunity of prokaryotes against viruses,have been developed into genome-editing tools(Anzalone et al.,2020;Doudna,2020).Compared with type II systems,the type V systems including V-A to V-K showed more functional diversity(Yan et al.,2019).Amongst them,Cas12i has a relatively smaller size(1,033-1,093 aa),compared to SpCas9 and Cas12a,and has a 5'-TTN protospacer adjacent motif(PAM)preference(Yan et al.,2019). | Hainan Zhang Xiangfeng Kong Mingxing Xue Jing Hu Zikang Wang Yinghui Wei Haoqiang Wang Jingxing Zhou Weihong Zhang Mengqiu Xu Xiaowen Shen Fengcai Yin Zhiyuan Ai Guangyan Huang Junhui Xia Xueqiong Song Hengbin Li Yuan Yuan Jinhui Li Na Zhong Meiling Zhang Yingsi Zhou Hui Yang | 2023 | Protein & Cell2023，14，7： | 0 |
| 4 | Synthesis of novel magnetic sulfur-doped Fe_3O_4 nanoparticles for efficient removal of Pb(Ⅱ)显示文摘In this work, we report the synthesis of magnetic sulfur-doped Fe_3O_4 nanoparticles (Fe_3O_4:S NPs) with a novel simple strategy,which includes low temperature multicomponent mixing and high temperature sintering. The prepared Fe_3O_4:S NPs exhibit a much better adsorption performance towards Pb(Ⅱ) than bare Fe_3O_4 nanoparticles. FTIR, XPS, and XRD analyses suggested that the removal mechanisms of Pb(Ⅱ) by Fe_3O_4:S NPs were associated with the process of precipitation (formation of PbS), hydrolysis,and surface adsorption. The kinetic studies showed that the adsorption data were described well by a pseudo second-order kinetic model, and the adsorption isotherms could be presented by Freundlich isotherm model. Moreover, the adsorption was not significantly affected by the coexisting ions, and the adsorbent could be easily separated from water by an external magnetic field after Pb(Ⅱ) adsorption. Thus, Fe_3O_4:S NPs are supposed to be a good adsorbents for Pb(Ⅱ) ions in environmental remediation. | Xueqiong Huang Long Kong Shouqiang Huang Min Liu Liang Li | 2018 | Science China Chemistry2018，61，2： | 0 |
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