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| 1 | Identification and characterization of rice blast resistance gene Pid4 by a combination of transcriptomic profiling and genome analysis显示文摘Map-based cloning of plant disease resistance (R) genes is time-consuming. Here, we reported the isolation of blast R gene Pid4 using comparative transcriptomic profiling and genome-wide sequence analysis. Pid4 encodes a coiled-coil nucleotide-binding site leucine-rich repeat(CC-NBS-LRR) protein and is constitutively expressed at diverse developmental stages in the rice variety Digu. The Pid4 protein is localized in both the nucleus and cytoplasm. Introduction of Pid4 into susceptible rice cultivars confers race-specific resistance to leaf and neck blast. Amino acid sequence comparison and blast resistance spectrum tests showed that Pid4 is a novel R gene, different from the previously reported R genes located in the same gene cluster. A Pid4 Indel marker was developed to facilitate the identification of Pid4 in different rice varieties. We demonstrated that a plant R gene can be quickly isolated using transcriptomic profiling coupled with genome-wide sequence analysis. | Zhixiong Chen Wen Zhao Xiaobo Zhu Chengdong Zou Junjie Yin Mawsheng Chern Xiaogang Zhou Heng Ying Xin Jiang Yongzhen Li Haicheng Liao Mengping Cheng Weitao Li Min He Jing Wang Jichun Wang Bingtian Ma Jirui Wang Shigui Li Lihuang Zhu Xuewei Chen | 2018 | Journal of Genetics and Genomics2018，45，12： | 7 |
| 2 | Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1显示文摘UDP-glucuronosyltransferase 1A1(UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug–drug interactions(DDIs), hyperbilirubinemia and drug-induced liver injury. This study aimed to investigate and compare the inhibitory effects of icotinib and erlotinib against UGT1A1, as well as to evaluate their potential DDI risks via UGT1A1 inhibition. The results demonstrated that both icotinib and erlotinib are UGT1A1 inhibitors, but the inhibitory effect of icotinib on UGT1A1 is weaker than that of erlotinib. The IC_(50) values of icotinib and erlotinib against UGT1A1-mediated NCHN-O-glucuronidation in human liver microsomes(HLMs) were 5.15 and 0.68 μmol/L, respectively. Inhibition kinetic analyses demonstrated that both icotinib and erlotinib were non-competitive inhibitors against UGT1A1-mediated glucuronidation of NCHN in HLMs, with the Kivalues of 8.55 and 1.23 μmol/L, respectively. Furthermore, their potential DDI risks via UGT1A1 inhibition were quantitatively predicted by the ratio of the areas under the concentration–time curve(AUC) of NCHN. These findings are helpful for the medicinal chemists todesign and develop next generation tyrosine kinase inhibitors with improved safety, as well as to guide reasonable applications of icotinib and erlotinib in clinic, especially for avoiding their potential DDI risks via UGT1A1 inhibition. | Xuewei Cheng Xia Lv Hengyan Qu Dandan Li Mengmeng Hu Wenzhi Guo Guangbo Ge Ruihua Dong | 2017 | Acta Pharmaceutica Sinica B2017，7，6： | 7 |
| 3 | CoPt-Co hybrid supported on amino modified SiO2 nanospheres as a high performance catalyst for hydrogen generation from ammonia borane显示文摘CoPt-Co hybrids were successfully supported on amino modified SiO2 nanospheres by a chemical reduction method at a temperature of 278 K.The solid carrier i.e.amino modified SiO2,provides numerous anchoring sites for the metal nanoparticles(NPs)to improve the dispersion while reducing the size of metal NPs.The supported NPs displayed a narrow particle size distribution on the SiO2 surface with an average diameter of 12 nm.The XRD results alongside with the binary alloy phase diagram suggest that the resulted NPs are bimetallic,composed of CoPt and amorphous Co.Among the prepared materials,the solid with the specific composition of SiO2@Pt0.1Co0.9was proved to be effective catalyst for ammonia borane(AB)hydrolysis in aqueous solution.The turnover frequency(TOF)value of the supported nanocatalyst was 25.59molH2min^-1·molM^-1,almost twice as that of unsupported Pt0.1Co0.9NPs while the activation energy was 37.05 kJ mol^-1.Furthermore,the SiO2@Pt0.1Co0.9composite manifested high catalytic activity even after five cycles of reuse. | Hongming Zhang Dandan Ke Lina Cheng Xuelei Feng Xuewei Hou Jin Wang Yuan Li Shumin Han | 2019 | Progress in Natural Science:Materials International2019，29，1： | 2 |
| 4 | Identification of a New Rice Blast Resistance Gene, Pid3, by Genomewide Comparison of Paired Nucleotide-Binding Site-Leucine-Rich Repeat Genes and Their Pseudogene Alleles Between the Two Sequenced Rice Genomes显示文摘 | Shang Junjun Tao Yong Chen Xuewei Zou Yan Lei Cailin Wang Jing Li Xiaobing Zhao Xianfeng Zhang Meijun Lu Zhike Xu Jichen Cheng Zhukuan Wan Jianmin Zhu Lihuang | 2009 | Genetics2009，，4： | 2 |
| 5 | Enhanced catalytic activity of Ru through N modification toward alkaline hydrogen electrocatalysis显示文摘Exploring highly efficient electrocatalysts and understanding the reaction mechanisms for hydrogen electrocatalysis,including hydrogen oxidation reaction (HOR) and hydrogen evolution reaction (HER) in alkaline media are conducive to the conversion of hydrogen energy.Herein,we reported a new strategy to boost the HER/HOR performances of ruthenium (Ru) nanoparticles through nitrogen (N) modification.The obtained N-Ru/C exhibit remarkable catalytic performance,with normalized HOR exchange current density and mass activity of 0.56 m A/cm^(2)and 0.54 m A/μg,respectively,about 4 and 4.5 times higher than those of Ru/C,and even twofold enhancement compared to commercial Pt/C.Moreover,at the overpotential of 50 m V,the normalized HER current density of N-Ru/C is 5.5 times higher than that of Ru/C.Experimental and density functional theory (DFT) results verify the electronic regulation of Ru after N incorporation,resulting in the optimized hydrogen adsorption Gibbs free energy (ΔG_(H*)) and hence enhancing the HOR/HER performance. | Yuanmeng Zhao Xuewei Wang Zhen Li Pingping Zhao Congliang Tao Gongzhen Cheng Wei Luo | 2022 | Chinese Chemical Letters2022，33，2： | 2 |
| 6 | Ecological functions of uncultured microorganisms in the cobaltrich ferromanganese crust of a seamount in the central Pacific are elucidated by fosmid sequencing显示文摘Cobalt-rich ferromanganese is an important seafloor mineral and is abundantly present in the seamount crusts.Such crusts form potential hotspots for biogeochemical activity and microbial diversity, yet our understanding of their microbial communities is lacking. In this study, a cultivation-independent approach was used to recover genomic information and derive ecological functions of the microbes in a sediment sample collected from the cobalt-rich ferromanganese crust of a seamount region in the central Pacific. A total of 78 distinct clones were obtained by fosmid library screening with a 16 SrRNA based PCR method. Proteobacteria and MGI Thaumarchaeota dominated the bacterial and archaeal 16 SrRNA gene sequence results in the microbial community. Nine fosmid clones were sequenced and annotated. Numerous genes encoding proteins involved in metabolic functions and heavy metal resistance were identified, suggesting alternative metabolic pathways and stress responses that are essential for microbial survival in the cobalt-rich ferromanganese crust. In addition, genes that participate in the synthesis of organic acids and exoploymers were discovered. Reconstruction of the metabolic pathways revealed that the nitrogen cycle is an important biogeochemical process in the cobalt-rich ferromanganese crust. In addition, horizontal gene transfer(HGT) events have been observed, and most of them came from bacteria, with some occurring in archaea and plants. Clone W4-93 a, belonging to MGI Thaumarchaeota, contained a region of gene synteny. Comparative analyses suggested that a high frequency of HGT events as well as genomic divergence play important roles in the microbial adaption to the deep-sea environment. | HUO Yingyi CHENG Hong Anton F.Post WANG Chunsheng JIANG Xiawei PAN Jie WU Min XU Xuewei | 2015 | Acta Oceanologica Sinica2015，34，4： | 2 |
| 7 | Engineering flexible and green electromagnetic interference shielding materials with high performance through modulating WS_(2) nanosheets on carbon fibers显示文摘Flexible and wearable electromagnetic interference(EMI)shielding material is one of the current research focuses in the field of EMI shielding.In this work,for the first time,WS_(2)-carbon fiber(WS_(2)-CF)composites are synthesized by implanting WS_(2),which has a multiphase structure and a large number of defects,onto the surface of carbon fiber(CF)by using a simple one-step hydrothermal method,and are applied to protect electronic devices from EMI.It is found that the EMI shielding performance of WS_(2)-CF is significantly improved,especially for those at Se and C-bands.At 2 GHz,the EMI shielding efficiency could reach 36.0 dB at a typical thickness of 3.00 mm of the composite,which is much better than that of pure CF(25.5 dB).Besides paving a novel avenue to optimize the electromagnetic shielding performance of flexible and wearable CF-based EMI shielding materials,which have great potential in the practical application for EMI shielding,this work provides a new paradigm for the design and synthesis of EMI shielding materials which have a broad application prospect. | Huibin Zhang Tingting Liu Zehao Huang Junye Cheng Honghan Wang Deqing Zhang Xuewei Ba Guangping Zheng Ming Yan Maosheng Cao | 2022 | Journal of Materiomics2022，8，2： | 2 |
| 8 | Numerical simulation of dissolved oxygen concentration in water flow over stepped spillways显示文摘 | Cheng Xiangju Chen Xuewei | 2013 | Water Environment Research2013，85，5： | 1 |
| 9 | Gaseous reduction of pellets of laterite ore containing carbon显示文摘 | PAN Cheng BAI Chenguang LO Xuewei | 2011 | Metalurgia International2011，16，1： | 1 |
| 10 | Real-world emission characteristics of carbonyl compounds from agricultural machines based on a portable emission measurement system显示文摘Emissions of carbonyl compounds from agricultural machines cannot be ignored.Carbonyl compounds can cause the formation of ozone(O3)and secondary organic aerosols,which can cause photochemical smog to form.In this study,20 agricultural machines were tested using portable emission measurement system(PEMS)under real-world tillage processes.The exhaust gases were sampled using 2,4-dinitrophenylhydrazine cartridges,and 15 carbonyl compounds were analyzed by high-performance liquid chromatography.Carbonyl compound emission factors for agricultural machines were 51.14–3315.62 mg/(kg-fuel),and were 2.58±2.05,0.86±1.07 and 0.29±0.20 g/(kg-fuel)for China 0,China II and China III emission standards,respectively.Carbonyl compound emission factor for sowing seeds of China 0 agricultural machines was 3.32±1.73 g/(kg-fuel).Formaldehyde,acetaldehyde and acrolein were the dominant carbonyl compounds emitted.Differences in emission standards and tillage processes impact ozone formation potential(OFP).The mean OFP was 20.15±16.15 g O3/(kg-fuel)for the China 0 emission standard.The OFP values decreased by 66.9% from China 0 to China II,and 67.4%from China II to China III.The mean OFP for sowing seeds of China 0 agricultural machines was 25.92±13.84 g O3/(kg-fuel).Between 1.75 and 24.22 times more ozone was found to be formed during sowing seeds than during other processes for China 0 and China II agricultural machines.Total carbonyl compound emissions from agricultural machines in China was 19.23 Gg in 2019.The results improve our understanding of carbonyl compound emissions from agricultural machines in China. | Wenhan Yu Xianbao Shen BoboWu Lei Kong Kaijie Xuan Cheng Zhao Xinyue Cao Xuewei Hao Xin Li Hanyu Zhang Zhiliang Yao | 2023 | Journal of Environmental Sciences2023，，2： | 1 |
| 11 | Identification of a New Rice Blast Resistance Gene, Pid3, by Genomewide Comparison of Paired Nucleotide-Binding Site-Leucine-Rich Repeat Genes and Their Pseudogene Alleles Between the Two Sequenced Rice Genomes显示文摘 | Shang Junjun Tao Yong Chen Xuewei Zou Yan Lei Cailin Wang Jing Li Xiaobing Zhao Xianfeng Zhang Meijun Lu Zhike Xu Jichen Cheng Zhukuan Wan Jianmin Zhu Lihuang | 2009 | Genetics2009，，4： | 1 |
| 12 | Deletion of a Dna K protein gene causes seedling green-revertible albino by retarding chloroplast development in rice显示文摘Green-revertible albino mutants are important sources for studying chloroplast structure, chloroplast development, chlorophyll biosynthesis, and plant photosynthesis. In the present study, we characterized a greenrevertible albino mutant gra(k), which was obtained from the tissue-cultured rice Kitaake. The mutant gra(k) exhibited albino on its first three leaves. The leaf color started to turn green at the four-leaf stage. The chlorophyll contents were deeply reduced at the seedling stage, and the chloroplast development was delayed in gra(k). The greenrevertible albino(gra) phenotype of the mutant gra(k) was temperature dependent. The main agronomic traits,including plant height, tilling number per plant, seed setting rate, and thousand-grain weight, slightly decreased in gra(k) comparing to those in the wild-type Kitaake.Genetic analysis showed that the gra phenotype was controlled by a single recessive nucleic gene. By using 5,168 recessive F2individuals derived from the cross of gra(k) 9 Jodan, the locus of the gene Gra(k) was delimited in a DNA region of 200 kb between the makers B-31 and P11 on chromosome 5. Sequencing analysis indicated thatthe three functionally annotated genes, LOC_Os05g23700,LOC_Os05g23720, and LOC_Os05g23740, were all deleted in the 200 kb region in the mutant gra(k). Transgenic test revealed that the gra(k) plants over-expressing LOC_Os05g23740CDS were restored to normal green as the wild-type Kitaake. Our results proved that the deletion of the Dna K protein gene LOC_Os05g23740(encoding the chaperon protein Os Hsp70CP1) led to the gra phenotype in the mutant gra(k). | Weitao Li Junjie Yin Bangquan Ye Chunfang Peng Qinshu Cheng Jing Wang Can Yuan Heng Yin Zhixiong Chen Min He Yuping Wang Weilan Chen Jichun Wang Bingtian Ma Peng Qin Shigui Li Xuewei Chen | 2015 | Science Bulletin2015，60，23： | 1 |
| 13 | Research on High Precision Autonomous Navigation of Shared Balancing Vehicles Based on EKF-SLAM显示文摘In view of the technical difficulties of autonomous navigation in local areas,this paper proposes a high-precision autonomous navigation shared bal-ancing bike system based on EKF-SLAM.This system uses the EKF-SLAM algorithm in robot localization to achieve simultaneous localization and map con-struction using the extended Kalmanfilter.At the same time,GPS and IMU are also employed for absolute positioning,and point cloud matching is used for rel-ative positioning to achieve multisensor fusion positioning.For the convenience of users,this system uses the RNN-T model for speech recognition destinations.Through experimental verification,the EKF-SLAM-based autonomous naviga-tion technology proposed in this paper can meet the accurate localization service and can realize the function of high precision autonomous navigation and voice recognition of destinations for shared balancing vehicles in a local area. | Xinyu Cheng Yanqing Wang Dingdong Guo Xuewei Li Yiming Gao | 2023 | 国际计算机前沿大会会议论文集2023，，2： | 0 |
| 14 | Human umbilical cord mesenchymal stem cells protect against ferroptosis in acute liver failure through the IGF1-hepcidin-FPN1 axis and inhibiting iron loading显示文摘Acute liver failure(ALF)is a significant global issue with elevated morbidity and mortality rates.There is an urgent and pressing need for secure and effective treatments.Ferroptosis,a novel iron-dependent regulation of cell death,plays a significant role in multiple pathological processes associated with liver diseases,including ALF.Several studies have demonstrated that mesenchymal stem cells(MsCs)have promising therapeutic potential in the treatment of ALF.This study aims to investigate the positive effects of MSCs against ferroptosis in an ALF model and explore the underlying molecular mechanisms of their therapeutic function.Our results show that in-travenously injected MsCs protect against ferroptosis in ALF mouse models.MsCs decrease iron deposition in the liver of ALF mice by downregulating hepcidin level and upregulating FPN1 level.MSCs labelled with Dil are mainly observed in the hepatic sinusoid and exhibit colocalization with the macrophage marker CD11b fluorescence.ELiSA demonstrates a high level of IGF1 in the CCL4+MSC group.Suppressing the IGF1 effect by the PPP blocks the therapeutic effect of MSCs against ferroptosis in ALF mice.Furthermore,disruption of IGF1 function results in iron deposition in the liver tissue due to impaired inhibitory effects of MsCs on hepcidin level.Our findings suggest that MSCs alleviate ferroptosis induced by disorders of iron metabolism in ALF mice by elevating IGF1 level.Moreover,MSCs are identified as a promising cell source for ferroptosis treatment in ALF mice. | Haiqin Cheng Yaqian Shi Xuewei Li Ning Jin Mengyao Zhang Zhizhen Liu Yuxiang Liang Jun Xie | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
| 15 | Response of Freezing/Thawing Indexes to the Wetting Trend under Warming Climate Conditions over the Qinghai–Tibetan Plateau during 1961–2010:A Numerical Simulation显示文摘Since the 1990s,the Qinghai–Tibetan Plateau(QTP)has experienced a strikingly warming and wetter climate that alters the thermal and hydrological properties of frozen ground.A positive correlation between the warming and thermal degradation in permafrost or seasonally frozen ground(SFG)has long been recognized.Still,a predictive relationship between historical wetting under warming climate conditions and frozen ground has not yet been well demonstrated,despite the expectation that it will become even more important because precipitation over the QTP has been projected to increase continuously in the near future.This study investigates the response of the thermal regime to historical wetting in both permafrost and SFG areas and examines their relationships separately using the Community Land Surface Model version 4.5.Results show that wetting before the 1990s across the QTP mainly cooled the permafrost body in the arid and semiarid zones,with significant correlation coefficients of 0.60 and 0.48,respectively.Precipitation increased continually at the rate of 6.16 mm decade–1 in the arid zone after the 1990s but had a contrasting warming effect on permafrost through a significant shortening of the thawing duration within the active layer.However,diminished rainfall in the humid zone after the 1990s also significantly extended the thawing duration of SFG.The relationship between the ground thawing index and precipitation was significantly negatively correlated(−0.75).The dual effects of wetting on the thermal dynamics of the QTP are becoming critical because of the projected increases in future precipitation. | Xuewei FANG Zhi LI Chen CHENG Klaus FRAEDRICH Anqi WANG Yihui CHEN Yige XU Shihua LYU | 2023 | Advances in Atmospheric Sciences2023，40，2： | 0 |
| 16 | 4-methylumbelliferone (4-MU) enhances drought tolerance of apple by regulating rhizosphere microbial diversity and root architecture显示文摘The dwarfing rootstocks-mediated high-density apple orchard is becoming the main practice management.Currently,dwarfing rootstocks are widely used worldwide,but their shallow root system and drought sensitivity necessitate high irrigation requirements.Here,the root transcriptome and metabolome of dwarfing(M9-T337,a drought-sensitive rootstock)and vigorous rootstocks(Malus sieversii,a drought-tolerant species,is commonly used as a rootstock)showed that a coumarin derivative,4-Methylumbelliferon(4-MU),was found to accumulate significantly in the roots of vigorous rootstock under drought condition.When exogenous 4-MU was applied to the roots of dwarfing rootstock under drought treatment,the plants displayed increased root biomass,higher root-to-shoot ratio,greater photosynthesis,and elevated water use efficiency.In addition,diversity and structure analysis of the rhizosphere soil microbial community demonstrated that 4-MU treatment increased the relative abundance of putatively beneficial bacteria and fungi.Of these,Pseudomonas,Bacillus,Streptomyces,and Chryseolinea bacterial strains and Acremonium,Trichoderma,and Phoma fungal strains known for root growth,or systemic resistance against drought stress,were significantly accumulated in the roots of dwarfing rootstock after 4-MU treatment under drought stress condition.Taken together,we identified a promising compound—4-MU,as a useful tool,to strengthen the drought tolerance of apple dwarfing rootstock. | Dehui Zhang Jieqiang He Pengda Cheng Yutian Zhang Abid Khan Shicong Wang Zhongxing Li Shuang Zhao Xiangqiang Zhan Fengwang Ma Xuewei Li Qingmei Guan | 2023 | Horticulture Research2023，10，7： | 0 |
| 17 | Characterization and Fine Mapping of a Novel Vegetative Senescence Lethal Mutant Locus in Rice显示文摘Mutants showing spontaneous cell death in the absence of pathogen attack are called lesion mimic mutants(lmm)(Lorrain et al.,2003).These mutants usually exhibit typical hypersensitive responses(HRs)within or around the lesion spots,which are frequently observed in plants challenged | Junjie Yin Xiaobo Zhu Can Yuan Jing Wang Weitao Li Yuping Wang Min He Qinshu Cheng Bangquan Ye Weilan Chen Qianyan Linghu Jichun Wang Bingtian Ma Peng Qin Shigui Li Xuewei Chen | 2015 | Journal of Genetics and Genomics2015，42，9： | 0 |
| 18 | A Rational Design of Heterojunction Photocatalyst Cd S Interfacing with One Cycle of ALD Oxide显示文摘Photo-corrosion is one of the major obstacles for Cd S application in wet chemical fields, and atomic layer deposition(ALD) has been proposed as an effective way to suppress the corrosion. Here, prior to ALD coating, Cd S, one facilely corrosive photocatalyst, was synthesized via hydrothermal synthesis to access the fundamental corrosion mechanism and the according corrosive sites. X-ray photoelectron spectroscopy(XPS) and X-ray diffraction(XRD) demonstrated that the failure of catalytic decomposition of methylene blue originated from the formation of soluble Cd SO_4 by oxidizing S^(2-) of as-prepared Cd S. High resolution transmission electron microscopy(HRTEM) further identified the active sites in the V-shaped regions of Cd S nanoparticles, confirmed by the simulated electric field distribution. To rationally coat oxides on Cd S, the right candidates and their thicknesses have been considered by our tunneling model with transfer matrix method based on quantum mechanism, upon which the thickness of protective layer should be less than 0.5 nm to maintain a high tunneling probability, and thus one cycle of ALD Ti O_2 or Al_2O_3 was proposed to passivate the Cd S powder to balance the carrier transportation and corrosion suppression. Based on HRTEM results, we found that the active V-shaped region was covered by ALD oxides(TiO_2 or Al_2O_3). For each case, no soluble Cd SO_4 has been found before and after photocatalytic reactions based XPS measurements. Importantly, we noticed that with the passivation of one cycle of ALD, the catalyst's lifetime was elongated up to >14 times higher than that of the as-prepared Cd S. | Mengyin Liu Xinjian Xie Lei Chen Xuewei Wang Yahui Cheng Feng Lu Wei-Hua Wang Jing Yang Xiwen Du Junda Zhu Haitao Liu Hong Dong Weichao Wang Hui Liu | 2016 | Journal of Materials Science & Technology2016，32，6： | 0 |
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