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| 1 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 2 | Arthroscopic Patelloplasty and Circumpatellar Denervation for the Treatment of Patellofemoral Osteoarthritis显示文摘 | Gang Zhao Yujie Liu Bangtuo Yuan Xuezhen Shen Feng Qu Jiangtao Wang Wei Qi Juanli Zhu Yang Liu | 2015 | Chinese Medical Journal2015，，1： | 3 |
| 3 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 4 | Evaluation of multidecadal and longer-term temperature changes since 850 CE based on Northern Hemisphere proxy-based reconstructions and model simulations显示文摘The temperature variability over multidecadal and longer timescales(e.g., the cold epochs in the late 15 th, 17 th, and early 19 th centuries) is significant and dominant in the millennium-long, large-scale reconstructions and model simulations;however, their temporal patterns in the reconstructed and simulated temperature series are not well understood and require a detailed assessment and comparison. Here, we compare the reconstructed and simulated temperature series for the Northern Hemisphere(NH) at multidecadal and longer-term timescales(>30 years) by evaluating their covariance, climate sensitivity and amplitude of temperature changes. We found that covariances between different reconstructions or between reconstructions and simulations are generally high for the whole period of 850–1999 CE, due to their similar long-term temporal patterns. However,covariances between different reconstructions or between reconstructions and simulations steadily decline as time series extends further back in time, becoming particularly small during Medieval times. This is related to the large uncetainties in the reconstructions caused by the decreased number of proxy records and sample duplication during the pre-instrumental periods.Reconstructions based solely on tree-ring data show higher skill than multiproxy reconstructions in capturing the amplitude of volcanic cooling simulated by models. Meanwhile, climate models have a shorter recovery(i.e., lag) in response to the cooling caused by volcanic eruptions and solar activity minima, implying the lack of some important feedback mechanisms between external forcing and internal climate processes in climate models. Amplitudes of temperature variations in the latest published tree-ring reconstructions are comparable to those of the multiproxy reconstructions. We found that the temperature difference between the Medieval Climate Anomaly(950–1250 CE) and the Little Ice Age(1450–1850 CE) is generally larger in proxybased reconstructions than in model simulations, but the reason is unclear. | Jianglin WANG Bao YANG Jingyun ZHENG Xuezhen ZHANG Zhiyuan WANG Miao FANG Feng SHI Jingjing LIU | 2020 | Science China Earth Sciences2020，63，8： | 3 |
| 5 | Fabricating Cationic Lignin Hydrogels for Dye Adsorption显示文摘Due to the low content of adsorption-active groups in lignin,its application in the field of adsorption is limited.Herein,we first prepared cationic kraft lignin acrylate,from which a cationic lignin(CKLA)hydrogel was further prepared by cationic kraft lignin acrylate,acrylamide,and N,N’-methylenebisacrylamide.The morphology,compression properties and swelling properties of CKLA hydrogels were investigated.The prepared CKLA hydrogel was applied as an adsorbent for Congo red.The effect of CKLA hydrogel dosages,initial concentration of Congo red,and pH on adsorption efficiency was investigated.The maximum Congo red removal efficiency was obtained at the initial concentration of Congo red of 50 mg/L,pH 7,and 5 mg dosage of CKLA hydrogel with 20%cationic lignin content.After five cycles of adsorption,the adsorption efficiency of the hydrogel for Congo red still reached more than 80%.The CKLA hydrogel showed pseudo-second-order adsorption kinetics for Congo red adsorption.These results demonstrate the potential of the CKLA hydrogel as an adsorbent for water treatment. | Chao Wang Xuezhen Feng Wanbing Li Shibin Shang Haibo Zhang | 2023 | Journal of Renewable Materials2023，11，4： | 1 |
| 6 | Operation of LECR3显示文摘 | Feng Yueheng Ma Baohua Wang Hui Li Jinyu Cao Yun Shang Yong Lu Wang Sha Shan Ma Hongyi Zhang Wenhui Lin Shuhao Li Xixia Zhao Huanyu Miao Tingting Guo Xiaohong Zhang Xuezhen Sun Liangting | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 1 |
| 7 | A genome wide association study between copy number variation (CNV) and human height in Chinese population显示文摘Copy number variation (CNV) is a type of genetic variation which may have important roles in phenotypic variability and disease susceptibility. To hunt for genetic variants underlying human height variation, we performed a genome wide CNV association study for human height in 618 Chinese unrelated subjects using Affymetrix 500K array set. After adjusting for age and sex, we found that four CNVs at 6p21.3, 8p23.3-23.2, 9p23 and 16p12.1 were associated with human height (with borderline significant p value: 0.013, 0.011, 0.024, 0.049; respectively). However, after multiple tests correction, none of them was associated with human height. We observed that the gain of copy number (more than 2 copies) at 8p23.3-23.2 was associated with lower height (normal copy number vs. gain of copy number: 161.2 cm vs. 153.7 cm, p = 0.011), which accounted for 0.9% of height variation. Loss of copy number (less than 2 copies) at 6p21.3 was associated with 0.8% lower height (loss of copy number vs. normal copy number: 154.5 cm vs. 161.1 cm, p = 0.013). Since no important genes influencing height located in CNVs at loci of 8p23.3-23.2 and 6p21.3, the two CNVs may cause the structural rear- rangements of neighbored important candidate genes, thus regulates the variation of height. Our results expand our knowledge of the genetic factors underlying height variation and the biological regulation of human height. | Xi Li Lijun Tan Xiaogang Liu Shufeng Lei Tielin Yang Xiangding Chen Fang Zhang Yue Fang Yan Guo Liang Zhang Han Yan Feng Pan Zhixin Zhang Yumei Peng Qi Zhou Lina He Xuezhen Zhu Jing Cheng Lishu Zhang Yaozhong Liu Qing Tian Hongwen Deng | 2010 | Journal of Genetics and Genomics2010，37，12： | 1 |
| 8 | Bandgap engineering of tetragonal phase CuFeS_(2)quantum dots via mixed-valence single-atomic Ag decoration for synergistic Cr(VI)reduction and RhB degradation显示文摘Bandgap engineering through single-atom site binding on semiconducting photocatalyst can boost the intrinsic activity,selectivity,carrier separation,and electron transport.Here,we report a mixed-valence Ag(0)and Ag(I)single atoms co-decorated semiconducting chalcopyrite quantum dots(Ag/CuFeS_(2)QDs)photocatalyst.It demonstrates efficient photocatalytic performances for specific organic dye(rhodamine B,denoted as RhB)as well as inorganic dye(Cr(VI))removal in water under natural sunlight irradiation.The RhB degradation and Cr(VI)removal efficiencies by Ag/CuFeS_(2)QDs were 3.55 and 6.75 times higher than those of the naked CuFeS_(2)QDs at their optimal pH conditions,respectively.Besides,in a mixture of RhB and Cr(VI)solution under neutral condition,the removal ratio has been elevated from 30.2%to 79.4%for Cr(VI),and from 95.2%to 97.3%for RhB degradation by using Ag/CuFeS_(2)QDs after 2 h sunlight illumination.The intrinsic mechanism for the photocatalytic performance improvement is attributed to the narrow bandgap of the single-atomic Ag(I)anchored CuFeS_(2)QDs,which engineers the electronic structure as well as expands the optical light response range.Significantly,the highly active Ag(0)/CuFeS_(2)and Ag(I)/CuFeS_(2)effectively improve the separation efficiency of the carriers,thus enhancing the photocatalytic performances.This work presents a highly efficient single atom/QDs photocatalyst,constructed through bandgap engineering via mixed-valence single noble metal atoms binding on semiconducting QDs.It paves the way for developing high-efficiency single-atom photocatalysts for complex pollutions removal in dyeing wastewater environment. | Yangzi Shangguan Yuanhao Zhou Renji Zheng Xuezhen Feng Qiuyue Ge Ranhao Wang Dazhong Yang Wenfei Wei Xiaoyong Wu Jia Lin Hong Chen | 2021 | Chinese Chemical Letters2021，32，11： | 1 |
| 9 | 6-13 Summary of Ion Source Group in 2015显示文摘Ion source as one very unique and critical part of ion accelerator needs consistent research and development work to improve the performance and to meet the future accelerator needs as well. The ion source group at IMP is taking the responsibility of high performance intense beam ion source development, operation and exploration. | Sun Liangting Feng Yucheng Lu Wang Qian Cheng Zhang Wenhui Wu Qi Yang Yao Guo Junwei Zhao Huanyu Cao Yun Zhang Xuezhen Zhao Hongwei | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 10 | 6-15 Status Report of On-line Ion Sources in 2015显示文摘In 2015, the service time of the two on-line ion sources of HIRFL-CSR accelerator facility, SECRAL and LECR3, is 3 335.5 and 3 168.5 h, respectively, amouting to 6 504 h. Except 26Mg7+, which was required by the accelerator but failed to be produced due the oxidation of the material, 20 kinds of ion beams have been delivered successfull.The failure time is 49 h this year, mainly attributed to the breakdown of the cryostat system. | Feng Yucheng Lu Wang Zhang Wenhui Ma Hongyi Yang Yao Fang Xing Guo Junwei Ma Baohua Wang Hui Qian Cheng Zhang Junjie Li Jibo Jin Qianyu sheng Sifan Liu Pengyan Li Xixia Zhao Huanyu Zhang Xuezhen Sun Liangting | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 11 | Improvement in Liquid Helium System of SECRAL显示文摘 | Guo Xiaohong Zhao Hongwei Zhang Xuezhen Sun Liangting Lu Wang Li Jinyu Feng Yucheng Li Xixia Xie Zuqi Gong Linghui Xu Xiangdong Xu Dong Li wei Chen Lingyu | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 0 |
| 12 | Preliminary Results of SECRAL at 18 GHz显示文摘 | Sun Liangting Zhao Hongwei Zhang Xuezhen Guo Xiaohong He Wei Zhang Zimin Li Jinyu Feng Yucheng Cao Yun Wang Hui Ma Baohua Li Xixia Zhao Huanyu Shang Yong Lu Wang Li Jie Yuan Pin Song Mingtao Zhan Wenlong Wei Baowen D. Z. Xie | 2006 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2006，，1： | 0 |
| 13 | Latest Development on IMP Emittance Scanner System显示文摘 | Cao Yun Lu Wang Sun Liangting Wang Hui Ma Baohua Feng Yucheng Li Jinyu Zhang Xuezhen Zhao Hongwei Martin Stocki | 2006 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2006，，1： | 0 |
| 14 | An ESS System for ECRIS Emittance Research显示文摘There are many characteristics to describe the performance of an ion source, such as beam current, emittance, energy spread of the extracted beam and so on. Among them, the beam emittance is always the one that make us suspicious. So it is especially important to measure and study the emittance of ion beams. Now, there are two kinds of methods to measure ion beam emittance. One is destructive method. With this method, | Cao Yun, Sun Liangting, Ma Baohua, Zhang Ziming, Wang Hui, He Wei, Li Xixia Feng Yucheng, Li Jingyu, Guo Xiaohong, Zhang Xuezhen and Zhao Huanyu | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 0 |
| 15 | Peroxymonosulfate activation based on Co_(9)S_(8)@N-C:A new strategy for highly efficient hydrogen production and synchronous formaldehyde removal in wastewater显示文摘Formaldehyde(FA),as an important chemical raw material,has been widely used in many fields.However,the discharge of a large amount of FA-containing wastewater poses a serious threat to the environment and human health.Recently,the in-situ hydrogen energy release technology of hydrogen-containing stable liquid has been extensively explored due to its safe storage.Exploring a robust method to achieve FA removal and synchronous in-situ hydrogen release from FA containing wastewater is of great significant for environmental protection and energy crisis alleviation.Here,we have innovatively introduced peroxymonosulfate(PMS)activation technology into FA removal and hydrogen production simultaneously.The composite of nitrogen doped carbon coating Co_(9)S_(8)nanotubes(Co_(9)S_(8)@N-C)is employed as a proof of concept for FA decomposition and simultaneously hydrogen production based on PMS activation system.As expected,the Co_(9)S_(8)@N-C/PMS system presents much superior hydrogen production efficiency and satisfactory FA removal rate towards FA wastewater than those of common catalysis,photocatalysis and Fenton reaction in the basic condition in a wide range of FA concentration.The hydrogen yield reaches a value as high as 471μmol within 60 min,corresponding to a FA degradation rate of 30%with an initial FA concentration of 0.722 mol L^(-1).Characterizations and density functional theory(DFT)calculations suggest that the free radical process dominated by superoxide radical(O_(2)·^(-))and nonradical process dominated by singlet oxygen(^(1)O_(2)),which are induced by Co_(9)S_(8)@N-C/PMS system,are responsible for highly efficient hydrogen production via FA degradation.These generated O_(2)·^(-)and ^(1)O_(2)can extract·H from FA to form·OOH intermediate,which can further combine with the·H from water to produce hydrogen.This study provides an applicable technique for environmental purification and new energy development based on FA containing wastewater. | Caiyan Gao Xuezhen Feng Lian Yi Xiaoyong Wu Renji Zheng Gaoke Zhang Yubiao Li | 2022 | Journal of Materials Science & Technology2022，，32： | 0 |
| 16 | Lentivector-mediated RNAi efficiently downregulatesexpression of murine cdk4 gene in vitro显示文摘In order to explore the role of cyclin-dependent kinase 4(cdk4)in neurodegenerative diseases,lentiviral-delivered RNA interference(RNAi)was used to silence the expression of the murine cdk4 gene in vitro.Three cdk4-shRNAs of mouse and a negative sequence were designed.After synthesis and annealing,double strand oligonucleo-tides were cloned into a linearized pSIH1-H1-copGFP shRNA vector.It was confirmed by polymerase chain reaction(PCR)and sequencing that three pairs of cdk4-shRNAs and a negative shRNA were correctly inserted into the pSIH1-H1-copGFP vector.The above recombi-nants were transfected by lipofectamine into BV-2 cells.The gene silencing efficacy rates of the 3 targets were compared by Western blotting.The cdk4-siRNA2 was the most effective in silencing cdk4.The optimized pSIH1-cdk4-siRNA2 and pSIH-negative-siRNA were co-transfected into 293T cells with the lentiviral packaging plasmids respectively.The culture supernatant was har-vested and condensed at the 24th and 48th h after transfection.Interference efficiency of the lentivirus expressing cdk4-siRNA was determined by reverse transcriptase-PCR(RT-PCR)and Western blotting in BV-2 cells.Lentivector-mediated RNAi could efficiently down-regulate the expression of the murine cdk4 gene in vitro,which provides a potential tool for studying and treating cdk4-related diseases. | Feng JIANG Xuezhen WANG Zheng XUE Suming ZHANG Siyu FANG Min ZHANG | 2009 | Frontiers of Medicine2009，3，3： | 0 |
| 17 | 6-42 Status Report of On-line Ion Sources in 2014显示文摘In 2014, the service time of the two on-line ion sources of HIRFL-CSR accelerator facility, SECRAL and LECR3is 3 594 and 3 457.2 h, respectively, amouting to 7051.2 h. 17 kinds of ion beams have been delivered successfull.The failure time is shrinked down to 8 h in this year, which is the lowest among these years. Table 1 summarizesthe main information about the ion beams delievered by the two ion sources. Fig. 1 shows the comparison of theion beam delivering time for HIRFL-CSR accelerator facitily from the three ion sources, LECR3, SECRAL andLAPECR1 since 2007. | Feng Yucheng Lu Wang Zhang Wenhui Ma Hongyi Yang Yao Fang Xing Guo Junwei Ma Baohua Wang Hui Qian Cheng Zhang Junjie Lin Shuhao Li Jibo Li Xixia Zhang Hengjuan Zhang Xuezhen Sun Liangting | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 18 | Updated ECR Ion Source LECR2M显示文摘LECR2 (Lanzhou ECR ion source No. 2) had been run for HIRFL accelerator on-line service for more than 6 years. This source had delivered very high charge state ion beams like Xe27+ , Ar14+,etc. to HIRFL accelerators for many times and greatly enhanced the performances of HIRFL accelerator complex, and had also produced many kinds of intense metallic ion beams to make the acceleration of metallic ion beams pos- | Sun Liangting, Zhang Zimin, Zhang Xuezhen, Li Jinyu, Feng Yucheng, Cao Yun, Wang Hui Ma Baohua, Li Xixia, Zhao Hongwei, Guo Xiaohong, Zhao Huangyu and He Wei | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 19 | Report of Training and Commissioning Results of SECRAL显示文摘SECRAL (Superconducting ECR Ion Source with Advanced design in Lanzhou) is a next generation ECR ion source, and aims at developing a very compact superconducting ECR ion source with an innovative magnet design, which realizes a minimum-B trap by means of six sextupole coils external to the three axial solenoidal coils, i. e. contrary to what is usually done in any ECR ion sources. In this way, the | Sun Liangting Zhao Hongwei Zhang Xuezhen Zhang Zimin Guo Xiaohong He Wei Li Jinyu Feng Yucheng Cao Yun Wang Hui Ma Baohua Li Xixia Zhao Huanyu Shang Yong Lu Wang Li Jie Yuan Pin Song Mingtao Zhan Wenlong Wei Baowen D. Z. Xie | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 20 | First Plasma and Commissioning Results of LAPECR2显示文摘The all permanent ECR (Electron Cyclotron Resonance) ion source LAPECR2 was successfully mounted on the 320 kV HV platform at the beginning of 2005. In March, the plasma chamber, the injection vacuum pumping tubes and the extraction diagnostic chamber were successfully installed on the source and LAEECR2 was then connected to the successive ion beam test bench. The picture of LAPECR2 on the HV platform is given in Fig. 1. | Sun Liangting, Li Jinyu, Ma Baohua, Wang Hui, Zhang Xuezhen, Feng Yucheng Zhang Zimin, Li Xixia, Shang Yong, Zhang Zimin, Zhao Hongwei Ma Xinwen, Song Mingtao and Zhan Wenlong | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
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