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| 1 | A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration显示文摘神经指导水管(NGC ) 是为外部神经新生的自体同源的神经的一种潜在的选择。有希望的治疗学的策略是用物理或化学的指导暗示修改神经指导水管 intraluminal 微型环境。在这研究,神经营养的 peptide-functionalized 能在 vitro 支持 PC12 细胞粘附,增长,和 neuronal 区别的自我装配的肽 nanofiber hydrogel 是在一个空 chitosan 试管(hCST ) 的腔的 prefilled 在一只老鼠加速 axonal 新生臀部的神经缺点模型。functionalized 自我装配的肽被介绍神经营养的肽开发(RGI, RGIDKRHWNSQ ) 源于导出大脑的神经营养的因素(BDNF ) 到自我装配的肽 RADA16 的 C 终点 -- 我(交流 --(RADA )4-CONH2) 。词法,组织学, electrophysiological,和功能的分析证明 RGI-functionalized,自我装配,肽 nanofiber hydrogel RAD/RGI 能生产显著地与提高的 re-myelination 和马达改进了 axonal 新生的神经营养的微型环境功能的恢复。 | Jiaju Lu Xun Sun Heyong Yin Xuezhen Shen Shuhui Yang Yu Wang Wenli Jiang Yue Sun Lingyun Zhao Xiaodan Sun Shibi Lu Antonios G. Mikos Jiang Peng Xiumei Wang | 2018 | Nano Research2018，11，9： | 6 |
| 2 | Arthroscopic Patelloplasty and Circumpatellar Denervation for the Treatment of Patellofemoral Osteoarthritis显示文摘 | Gang Zhao Yujie Liu Bangtuo Yuan Xuezhen Shen Feng Qu Jiangtao Wang Wei Qi Juanli Zhu Yang Liu | 2015 | Chinese Medical Journal2015，，1： | 3 |
| 3 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 4 | Alternations in the gut microbiota and metabolome with newly diagnosed unstable angina显示文摘Gut microbiota plays an important role in coronary heart disease, but its compositional and functional changes in unstable angina(UA) remain unexplored. We performed metagenomic sequencing of 133 newly diagnosed UA patients and 133 sex-and age-matched controls, and profiled the fecal and plasma metabolomes in 30 case-control pairs. The alpha diversity of gut microbiota was increased in UA patients:the adjusted odds ratios(ORs) per standard deviation increase in Shannon and Simpson indices were 1.30(95% confidence interval, 1.01-1.70) and 1.36(1.05-1.81), respectively. Two common species(depleted Klebsiella pneumoniae and enriched Streptococcus parasanguinis;P ≤ 0.002) and three rare species(depleted Weissella confusa, enriched Granulicatella adiacens and Erysipelotrichaceae bacterium 6_1_45;P ≤ 0.005) were associated with UA. The UA-associated gut microbiota was depleted in the pathway of Lphenylalanine degradation(P = 0.001), primarily contributed by Klebsiella pneumoniae. Consistently, we found increased circulating phenylalanine in UA patients(OR = 2.76 [1.17-8.16]). Moreover, Streptococcus parasanguinis was negatively correlated with fecal citrulline(Spearman's r_(s)=-0.470, P = 0.009), a metabolite depleted in UA patients(OR = 0.26 [0.08-0.63]). These findings are informative to help understand the metabolic connection between gut microbiota and UA. | Xuezhen Liu Miaoyan Shen Han Yan Pinpin Long Haijing Jiang Yizhi Zhang Lue Zhou Kuai Yu Gaokun Qiu Handong Yang Xiulou Li Xinwen Min Meian He Xiaomin Zhang Hyungwon Choi Chaolong Wang Tangchun Wu | 2022 | Journal of Genetics and Genomics2022，49，3： | 1 |
| 5 | Construction of a universal recombinant expression vector that regulates the expression of human lysozyme in milk显示文摘The mammary gland provides a novel method for producing recombinant proteins in milk of transgenic animals. A key component in the technology is the construction of an efficient milk expression vector. Here,we established a simple method to construct a milk expression vector, by a combination of homologous recombination and digestion-ligation. Our methodology is expected to have the advantages of both plasmid and bacterial artificial chromosome(BAC) vectors. The BAC of mouse whey acidic protein gene(mWAP) was modified twice by homologous recombination to produce a universal expression vector, and the human lysozyme gene(hLZ) was then inserted into the vector by a digestionligation method. The final vector containing the 8.5 kb mWAP 5′ promoter, 4.8 kb h LZ genomic DNA, and 8.0 kb m WAP 3′ genomic DNA was microinjected into pronuclei of fertilized mouse embryos, to successfully generate two transgenic mouse lines that expressed recombinant human lysozyme(rhLZ) in milk. The highest expression level of rhLZ was 0.45 g$L–1, and rhLZ exhibited the same antibacterial activity as native h LZ. Our results have provided a simple approach to construct a universal milk expression vector, and demonstrated that the resulting vector regulates the expression of hLZ in milk. | Shen LIU Shengzhe SHANG Xuezhen YANG Huihua ZHANG Dan LU Ning LI | 2018 | Frontiers of Agricultural Science and Engineering2018，5，3： | 0 |
| 6 | Bivariate genome-wide association study suggests that the DARC gene influences lean body mass and age at menarche显示文摘Lean body mass(LBM) and age at menarche(AAM) are two important complex traits for human health.The aim of this study was to identify pleiotropic genes for both traits using a powerful bivariate genome-wide association study(GWAS).Two studies,a discovery study and a replication study,were performed.In the discovery study,909622 single nucleotide polymorphisms(SNPs) were genotyped in 801 unrelated female Han Chinese subjects using the Affymetrix human genome-wide SNP array 6.0 platform.Then,a bivariate GWAS was performed to identify the SNPs that may be important for LBM and AAM.In the replication study,significant findings from the discovery study were validated in 1692 unrelated Caucasian female subjects.One SNP rs3027009 that was bivariately associated with left arm lean mass and AAM in the discovery samples(P=7.26×10 6) and in the replication samples(P=0.005) was identified.The SNP is located at the upstream of DARC(Duffy antigen receptor for chemokines) gene,suggesting that DARC may play an important role in regulating the metabolisms of both LBM and AAM. | HAI Rong ZHANG Lei PEI YuFang ZHAO LanJuan RAN Shu HAN YingYing ZHU XueZhen SHEN Hui TIAN Qing DENG HongWen | 2012 | Science China(Life Sciences)2012，55，6： | 0 |
| 7 | 利用激光离子源产生质子束显示文摘In 2018,the technology of the proton beam production with a laser ion source was developed.To produce proton beams with the laser ion source,a solidified hydrogen target system had been developed by the end of 2017.The experiment on the production of proton beams with the laser ion source was carried out at the beginning of 2018.The 8 ns laser pulse with the 0.5 J energy was focused with a lens of f=500 mm onto the hydrogen ice deposited on a copper sheet attached at the second stage of a 4.2 K cryocooler.The laser power density on the ice was estimated to 2.5109 Wcm−2.As shown in Fig.1(a)and(b),the condition of the hydrogen ice formation can be observed through the laser window before each laser shot.The waveform of the proton beam,shown in Fig.1(c),was measured with a Faraday Cup located 2.5 m away from the target.As shown in Fig.1(c),the current intensity of the proton beam was much lower than other ion species.And the repeatability of the proton beam pulses was also poor,the main reason of which is that the conditions of the deposited hydrogen ice were quite different from shot to shot. | Zhao Huanyu Zhang Junjie Shen Dingding Wang Guicai Zhang Xuezhen Sun Liangting Zhao Hongwei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 8 | 2018年在线离子源运行报告显示文摘HIRFL accelerator facility has been operated with two ion sources as its pre-injectors,which are LECR3 and SECRAL-II.In 2018,there were 19 kinds of ion beams delivered successfully,and the service time of the two sources are 4594.5 and 2231 h respectively,amounting to 6825.5 h in total,in which SECRAL and LECR3 provided 4 and 1 kinds of metallic ion beams respectively,and the total service time for the metallic ones is 2322 h,accounting for 34%of the total service time.Table 1 summarizes the main information about the ion beams delivered by the two ion sources. | Feng Yucheng Zhang Wenhui Ma Hongyi Fang Xing Guo Junwei Huang Wei Jia Zehua Jin Qianyu Li Jiaqing Li Jibo Li Libin Li Lixuan Lu Yuting Qian Cheng Shen Zhen Wang Guicai Wang Hui Yang Yao Zhai Yuhan Zhang Junjie Zhang Sheng Zhang Xuezhen Sun Liangting | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 9 | Operational Report of On-line Ion Sources in 2019显示文摘In 2019,the service time of the two on-line ion sources,LECR3 and SECRAL,is 3642.5 and 3617 h respectively,amounting to 7259.5 h.There are 19 kinds of ion beams delivered to the accelerator successfully. | Feng Yucheng Zhang Wenhui Ma Hongyi Ma Jindou Fang Xing Guo Junwei Jia Zehua Jin Qianyu Li Jiaqing Li Jibo Li Libin Li Lixuan Lu Yuting Qian Cheng Shen Zhen Wang Guicai Wang Hui Yang Yao Zhai Yuhan Zhang Junjie Zhang Xuezhen Sun Liangting | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 10 | 近代物理研究所激光源研究进展显示文摘In 2017,great efforts were devoted to the understanding of laser produced plasma,and the development of laser ion sources aiming at their practical applications as well.To gain an insight into plasma heating and expansion,a comparative experimental study of multiply charged ion production from laser-irradiated Cu-Ag mix-Z target was performed.The plasma was produced from planar targets of pure Cu,pure Ag and the composition of these two metals with the atom number ratio of 2 to 3,respectively.As shown in Fig.1,the most intense current was obtained from the target of pure Cu,which is consistent with our previous results that the current intensity decreased with the increasing Z of the target[1]. | Zhao Huanyu Zhang Junjie Jin Qianyu Wang Guicai Shen Dingding Zhang Xuezhen Sun Liangting Zhao Hongwei | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 11 | 2017年在线离子源的运行报告显示文摘Considering that all the ion species provided by LAPECR1 can also be supplied by LECR3,the LAPECR1 was removed during the summer maintenance period in 2017.Therefore,HIRFL-CSR has two online ion sources presently,which are LECR3 and SECRAL.In 2017,16 kinds of ion beams have been delivered successfully,and the total service time of the two on-line ion sources is 6622.5 h,3938.5 h and 2684 h for LECR3 and SECRAL,respectively.In this year,the service time of the two ion sources contributed to metal ion beams amounts to 2028 h,corresponding to 30.6%of the total service time. | Feng Yucheng Zhang Wenhui Ma Hongyi Guo Junwei Fang Xing Yang Yao Li libin Li Jibo Qian Cheng Zhang Junjie Jin Qianyu Wang Hui Ma Baohua Shen zhen Shen dingding Wang guicai Zhang Xuezhen Sun Liangting | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 12 | 6-17 Reseach Status of Laser Ion Sources at IMP显示文摘In 2016,the research and development of laser ion sources were mainly contributed to promote the performance of the ion source,such as to prolong the pulse duration of the ion beam,to realize the repetition rate operation mode of the ion source.In addition,the production of highly charged metallic ion beams from an ECR ion source with laser ablation plasma injection was also investigated preliminarily.The confinement of laser produced plasma with a solenoid was studied.For this purpose,a 1.5 m-long solenoid was installed on the expansion stage of the laser ion source. | Zhao Huanyu Zhang Junjie Wang Guicai Jin Qianyu Guo Junwei Huang Wei Shen Zhen Xu Kai Sun Liangting Zhang Xuezhen Zhao Hongwei | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 13 | 6-20 Development of SECRAL II Ion Source at IMP in 2016显示文摘SECRAL II is the second fully superconducting ECR ion source developed at IMP.It’s almost the duplicate of SECRAL,except for the cryogenic system[1].SECRAL II has integrated LHe recondensation system,which has the dynamic cooling capacity of more than 5 W.The main parameters of SECRAL I&II are shown in Table 1.The magnets of SECRAL II has been successfully fabricated and tested in 2015.In 2016,SECRAL II has been commissioned at 18 and 28 GHz with O and Xe ion beams,which has given very promising results. | Guo Junwei Sun Liangting Zhang Wenhui Shen Zhen Feng Yucheng Fang Xing Zhang Xuezhen Ma Hongyi Yang Yao Li Libing Chang Jianjun Wang Pengpeng Zhao Huanyu Zhao Hongwei | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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