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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma显示文摘Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy. Here, we report the therapeutic efficacy of celastrol as a promising candidate compound for treatment of pancreatic carcinoma via na?ve neutrophil membrane-coated poly(ethylene glycol) methyl ether-block-poly(lactic-co-glycolic acid)(PEG-PLGA) nanoparticles. Neutrophil membranecoated nanoparticles(NNPs) are well demonstrated to overcome the blood pancreas barrier to achieve pancreas-specific drug delivery in vivo. Using tumor-bearing mice xenograft model, NNPs showed selective accumulations at the tumor site following systemic administration as compared to nanoparticles without neutrophil membrane coating. In both orthotopic and ectopic tumor models,celastrol-loaded NNPs demonstrated greatly enhanced tumor inhibition which significantly prolonged the survival of tumor bearing mice and minimizing liver metastases. Overall, these results suggest that celastrol-loaded NNPs represent a viable and effective treatment option for pancreatic carcinoma. | Xi Cao Ying Hu Shi Luo Yuejing Wang Tao Gong Xun Sun Yao Fun Zhirong Zhang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 9 |
| 3 | MAV/UAV task coalition phased-formation method显示文摘The formation of the manned aerial vehicle/unmanned aerial vehicle(MAV/UAV) task coalition is considered. To reduce the scale of the problem, the formation progress is divided into three phases. For the task clustering phase, the geographical position of tasks is taken into consideration and a cluster method is proposed. For the UAV allocation phase, the UAV requirement for both constrained and unconstrained resources is introduced, and a multi-objective optimal algorithm is proposed to solve the allocation problem. For the MAV allocation phase, the optimal model is firstly constructed and it is decomposed according to the ideal of greed to reduce the time complexity of the algorithm. Based on the above phases, the MAV/UAV task coalition formation method is proposed and the effectiveness and practicability are demonstrated by simulation examples. | JIAO Zhiqiang YAO Peiyang ZHANG Jieyong ZHONG Yun WANG Xun | 2019 | Journal of Systems Engineering and Electronics2019，30，2： | 8 |
| 4 | Quality of life and emotional change for middle -aged and elderly patients with diabetic retinopathy显示文摘AIM:To evaluate the SF-36, Diabetes Specificity Quality of Life Scale (DSQL) and anxiety and depression symptoms and investigate its changes in proliferative diabetic retinopathy (PDR) by vitrectomy interventions. METHODS:The present study included 108 diabetic retinopathy (DR) patients:54 with PDR and 54 with non-proliferative diabetic retinopathy (NPDR). Each healthy control group (n =54) sociodemographically matched to DR groups was established respectively. The quality of life, anxiety and depression symptoms were evaluated and analyzed on preoperative and postoperative month 1 using SF-36, DSQL and Hospital Anxiety and Depression Scale (HADS). · RESULTS:DR patients described impaired HRQL (Health Related Quality of life, SF -36) in 6 out of 8 subscales, including ‘Body Health’, ‘Body RoleFunction’,‘General Health’,‘Society Function’,‘Emotion Role Function’and‘Mental Health’. Compared with controls, DR patients (NPDR and PDR) suffered from statistically significantly impaired HRQL (SF-36 Summary score) (P< 0.05). By surgical intervention, the anxiety and depression score were significantly reduced, while the health and quality of life (SF-36 Summary scores and DSQL scores) was improved in patients with PDR (P <0.05). CONCLUSION:DR patients were affected in mentation and quality of life. Surgery interventions can improve SF-36, DSQL, anxiety and depression in PDR patients. | Yao Yu Lie Feng Yi Shao Ping Tu He-Ping Wu Xun Ding Wei-Hua Xiao | 2013 | International Journal of Ophthalmology(English edition)2013，6，1： | 6 |
| 5 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 6 | Prognostic significance of computed tomography-detected extramural vascular invasion in colon cancer显示文摘AIM: To compare disease-free survival(DFS) between extramural vascular invasion(EMVI)-positive and-negative colon cancer patients evaluated by computed tomography(CT).METHODS: Colon cancer patients(n = 194) undergoing curative surgery between January 2009 and December 2013 were included. Each patient's demographics, cancer characteristics, EMVI status, pathological status and survival outcomes were recorded. All included patients had been routinely monitored until December 2015. EMVI was defined as tumor tissue within adjacent vessels beyond the colon wall as seen on enhanced CT. Disease recurrence was defined as metachronous metastases, local recurrence, or death due to colon cancer. Kaplan-Meier analyses were used to compare DFS between the EMVI-positive and-negative groups. Cox's proportional hazards models were used to measure the impact of confounding variables on survival rates.RESULTS: EMVI was observed on CT(ct EMVI) in 60 patients(30.9%, 60/194). One year after surgery, there was no statistically significant difference regarding the rates of progressive events between EMVI-positive and-negative patients [11.7%(7/60) and 6.7%(9/134), respectively; P = 0.266]. At the study endpoint, the EMVI-positive patients had significantly more progressive events than the EMVI-negative patients [43.3%(26/60) and 14.9%(20/134), respectively; oddsratio = 4.4, P < 0.001]. Based on the Kaplan-Meier method, the cumulative 1-year DFS rates were 86.7%(95%CI: 82.3-91.1) and 92.4%(95%CI: 90.1-94.7) for EMVI-positive and EMVI-negative patients, respectively. The cumulative 3-year DFS rates were 49.5%(95%CI: 42.1-56.9) and 85.8%(95%CI: 82.6-89.0), respectively. Cox proportional hazards regression analysis revealed that ctE MVI was an independent predictor of DFS with a hazard ratio of 2.15(95%CI: 1.12-4.14, P = 0.023). CONCLUSION: ctE MVI may be helpful when evaluating disease progression in colon cancer patients. | Xun Yao Su-Xing Yang Xing-He Song Yan-Cheng Cui Ying-Jiang Ye Yi Wang | 2016 | World Journal of Gastroenterology2016，22，31： | 6 |
| 7 | Seasonal changes of organic matter origins and anammox activity in the Changjiang Estuary deduced from multi-biomarkers in suspended particulates显示文摘Human activity-induced eutrophication and harmful algal blooms are main causes of the expansion of the hypoxic zone in the Changjiang Estuary. Among the many changes in biogeochemical processes, anaerobic ammonium oxidation(anammox) is proposed to play an important role in the nitrogen cycle in hypoxic areas. Ladderane lipids have been used as biomarkers to indicate anammox activity in ecosystems, but the origins of anammox bacteria and ladderanes in suspended particulates are still unclear. In this study, we report the results of a suite of biomarker analyses of suspended particulates across a salinity gradient of the Changjiang Estuary in both the spring and summer to evaluate the origins of the ladderanes and their potential as proxies for anammox activity and hypoxia. The spatio-temporal variations in terrestrial biomarkers(n-alkanes and n-alkanols), marine biomarkers(brassicasterol and dinosterol), and the Terrestrial and Marine Biomarker Ratio and Branched and Isoprenoid Tetraether indices reveal that marine organic matter was dominant in the particulates in both the spring(55%) and summer(86%) seasons. Correlations with both marine and terrestrial biomarkers suggest that ladderanes were mainly produced in the water column, and therefore that ladderane concentrations in suspended particulates in the Changjiang Estuary mainly reflect anammox activity in the water column, although changes in anammox bacterial assemblages may also have played a role in ladderane concentrations. Overall, ladderane results suggest that anammox activity was widespread in the Changjiang Estuary; but higher ladderane concentrations in the summer(especially in the upwelling zone) were correlated with lower dissolved oxygen concentrations, which suggest that they are useful proxies for hypoxia. | HU Jing Wen ZHANG Hai Long LI Li WANG Yao Yao ZHAO Mei Xun | 2016 | Science China Earth Sciences2016，59，7： | 5 |
| 8 | Rupture process of the 2015 Pishan earthquake from joint inversion of InSAR, teleseismic data and GPS显示文摘An earthquake of Mw6.4 occurred in Pishan County in Xinjiang Province, northwestern Tibetan Plateau, on July 3,2015. The epicenter was located on an active blind thrust system located at the northern margin of the Western Kunlun Mountain Orogenic Belt southwest of the Tarim Basin. We constructed a shovel-shaped fault model based on the layered-crust model with reference to the seismic reflection profile, and obtained the rupture process of the earthquake from the joint inversion of Interferometric Synthetic Aperture Radar(InSAR) measurements, far-field waveform data, and Global Positioning System(GPS) data. The results show that the seismic fault dips southward with a strike of 109°, and the rupture direction was essentially northward. The fault plane rupture distribution is concentrated, with a maximum recorded slip of 73 cm. The main features of the fault are as follows: low inclination angle(25°–10°), thrust slip at a depth of 9–13 km, rupture propagation time of about 12 s, no significant slip in soft or hard sedimentary layers at 0–4 km depth and propagation from the initial rupture point to the surrounding area with no obvious directionality. The InSAR time-series analysis method is used to determine the deformation rate in the source region within 2 years after the earthquake, and the maximum value is ~17 mm yr-1 in the radar line-of-sight direction. Obvious post-earthquake deformation is evident in the hanging wall, with a similar trend to the coseismic displacement field. These results suggest that the Pishan earthquake has not completely released the accumulated energy of the region, given that the multilayer fold structure above the blind fault is still in a process of slow uplift since the earthquake. Post-earthquake adjustment models and aftershock risk analysis require further study using more independent data. | Xun WANG Weimin WANG Junmeng ZHAO Zhenxing YAO | 2018 | Science China Earth Sciences2018，61，10： | 4 |
| 9 | Biocompatibility of nano-hydroxyapatite/Mg-Zn-Ca alloy composite scaffolds to human umbilical cord mesenchymal stem cells from Wharton's jelly in vitro显示文摘Seeding cells and scaffolds play pivotal roles in bone tissue engineering and regenerative medicine.Wharton’s jelly-derived mesenchymal stem cells(WJCs)from human umbilical cord represent attractive and promising seeding cells in tissue regeneration and engineering for treatment applications.This study was carried out to explore the biocompatibility of scaffolds to seeding cells in vitro.Rod-like nano-hydroxyapatite(RN-HA)and flake-like micro-hydroxyapatite(FM-HA)coatings were prepared on Mg-Zn-Ca alloy substrates using micro-arc oxidation and electrochemical deposition.WJCs were utilized to investigate the cellular biocompatibility of Mg-Zn-Ca alloys after different surface modifications by observing the cell adhesion,morphology,proliferation,and osteoblastic differentiation.The in vitro results indicated that the RN-HA coating group was more suitable for cell proliferation and cell osteoblastic differentiation than the FM-HA group,demonstrating better biocompatibility.Our results suggested that the RN-HA coating on Mg-Zn-Ca alloy substrates might be of great potential in bone tissue engineering. | GUAN FangXia MA ShanShan SHI XinYi MA Xun CHI LianKai LIANG Shuo CUI YuanBo WANG ZhiBin YAO Ning GUAN ShaoKang YANG Bo | 2014 | Science China(Life Sciences)2014，57，2： | 4 |
| 10 | The genome of Magnolia biondii Pamp. provides insights into the evolution of Magnoliales and biosynthesis of terpenoids显示文摘Magnolia biondii Pamp.(Magnoliaceae,magnoliids)is a phylogenetically,economically,and medicinally important ornamental tree species widely grown and cultivated in the north-temperate regions of China.Determining the genome sequence of M.biondii would help resolve the phylogenetic uncertainty of magnoliids and improve the understanding of individual trait evolution within the Magnolia genus.We assembled a chromosome-level reference genome of M.biondii using~67,~175,and~154Gb of raw DNA sequences generated via Pacific Biosciences single-molecule real-time sequencing,10X Genomics Chromium,and Hi-C scaffolding strategies,respectively.The final genome assembly was~2.22Gb,with a contig N50 value of 269.11 kb and a BUSCO complete gene percentage of 91.90%.Approximately 89.17%of the genome was organized into 19 chromosomes,resulting in a scaffold N50 of 92.86Mb.The genome contained 47,547 protein-coding genes,accounting for 23.47%of the genome length,whereas 66.48%of the genome length consisted of repetitive elements.We confirmed a WGD event that occurred very close to the time of the split between the Magnoliales and Laurales.Functional enrichment of the Magnolia-specific and expanded gene families highlighted genes involved in the biosynthesis of secondary metabolites,plant–pathogen interactions,and responses to stimuli,which may improve the ecological fitness and biological adaptability of the lineage.Phylogenomic analyses revealed a sister relationship of magnoliids and Chloranthaceae,which are sister to a clade comprising monocots and eudicots.The genome sequence of M.biondii could lead to trait improvement,germplasm conservation,and evolutionary studies on the rapid radiation of early angiosperms. | Shanshan Dong Min Liu Yang Liu Fei Chen Ting Yang Lu Chen Xingtan Zhang Xing Guo Dongming Fang Linzhou Li Tian Deng Zhangxiu Yao Xiaoan Lang Yiqing Gong Ernest Wu Yaling Wang Yamei Shen Xun Gong Huan Liu Shouzhou Zhang | 2021 | Horticulture Research2021，8，1： | 4 |
| 11 | 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone Induces Circulating MicroRNA Deregulation in Early Lung Carcinogenesis显示文摘Objective To study the alteration of circulating microRNAs in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone(NNK)-induced early stage lung carcinogenesis. Methods A lung cancer model of male F344 rats was induced with systemic NNK and levels of 8 lung cancer-associated miRNAs in whole blood and serum of rats were measured by quantitative RT-PCR of each at weeks 1,5,10,and 20 following NNK treatment. Results No lung cancer was detected in control group and NNK treatment group at week 20 following NNK treatment. The levels of some circulating miRNAs were significantly higher in NNK treatment group than in control group. The miR-210 was down-regulated and the miR-206 was up-regulated in NNK treatment group. The expression level of circulating miRNAs changed from week 1 to week 20 following NNK treatment. Conclusion The expression level of circulating miRNAs is related to NNK-induced early stage lung carcinogenesis in rats and can therefore serve as its potential indicator. | WU Jian Jun YANG Ti LI Xun XIA Yuan ZHAO Yao ZOU Fei JIANG Yi Guo | 2014 | Biomedical and Environmental Sciences2014，27，1： | 3 |
| 12 | Remote,selective,and in situ manipulation of liquid droplets on a femtosecond laser-structured superhydrophobic shape-memory polymer by near-infrared light显示文摘Droplet manipulation plays a significant role in the fields of biomedical detection,microfluidics,and chemical engineering.However,it still remains a great challenge to simultaneously achieve remote,selective,and in situ droplet manipulation on the same surface.Here,Fe_(3)O_(4)nanoparticles were doped in a shape-memory polymer(SMP)to prepare a photothermal-responsive Fe_(3)O_(4)-SMP composite which showed remarkable near-infrared(NIR)light-triggered shape-memory property.Superhydrophobic micropillar array was constructed on such Fe_(3)O_(4)-SMP composite through femtosecond laser microfabrication and fluoroalkylsilane modification.The surface wettability of the as-prepared surface can transform from a low-adhesive sliding state to a high-adhesive pinning state as the micropillars are deformed by pressing.Interestingly,the deformed micropillars can stand up and restore to their original morphology under remote NIR light irradiation,resulting in the reversible and repeatable recovery of the ultralow-adhesive superhydrophobicity.With such light-triggered wettability switching,the droplets pinning on the sample surface can be remotely,selectively,and in situ released.Furthermore,the superhydrophobic Fe_(3)O_(4)-SMP surface is successfully applied in lossless liquid transfer,selective droplet release,and droplet-based microreactor.The as-fabricated superhydrophobic surfaces with NIR light-controlled reversible wettability will hold great promise in the fields of liquid manipulation,lab-on-a-chip,and microfluidics. | Xue Bai Jiale Yong Chao Shan Yao Fang Xun Hou Feng Chen | 2021 | Science China Chemistry2021，64，5： | 3 |
| 13 | The baroreflex afferent pathway plays a critical role in H_(2)S-mediated autonomic control of blood pressure regulation under physiological and hypertensive conditions显示文摘Hydrogen sulfide(H_(2)S),which is closely related to various cardiovascular disorders,lowers blood pressure(BP),but whether this action is mediated via the modification of baroreflex afferent function has not been elucidated.Therefore,the current study aimed to investigate the role of the baroreflex afferent pathway in H_(2)S-mediated autonomic control of BP regulation.The results showed that baroreflex sensitivity(BRS)was increased by acute intravenous NaHS(a H_(2)S donor)administration to renovascular hypertensive(RVH)and control rats.Molecular expression data also showed that the expression levels of critical enzymes related to H_(2)S were aberrantly downregulated in the nodose ganglion(NG)and nucleus tractus solitarius(NTS)in RVH rats.A clear reduction in BP by the microinjection of NaHS or L-cysteine into the NG was confirmed in both RVH and control rats,and a less dramatic effect was observed in model rats.Furthermore,the beneficial effects of NaHS administered by chronic intraperitoneal infusion on dysregulated systolic blood pressure(SBP),cardiac parameters,and BRS were verified in RVH rats.Moreover,the increase in BRS was attributed to activation and upregulation of the ATP-sensitive potassium(KATP)channels Kir6.2 and SUR1,which are functionally expressed in the NG and NTS.In summary,H_(2)S plays a crucial role in the autonomic control of BP regulation by improving baroreflex afferent function due at least in part to increased KATP channel expression in the baroreflex afferent pathway under physiological and hypertensive conditions. | Ying Li Yan Feng Li Liu Xue Li Xin-yu Li Xun Sun Ke-xin Li Rong-rong Zha Hong-dan Wang Meng-di Zhang Xiong-xiong Fan Di Wu Yao Fan Hao-cheng Zhang Guo-fen Qiao Bai-yan Li | 2021 | Acta Pharmacologica Sinica2021，42，6： | 3 |
| 14 | Soluplus micelles for improving the oral bioavailability of scopoletin and their hypouricemic effect in vivo显示文摘Scopoletin 是拥有许多药理学活动的活跃香豆素,包括 anti-hyperuricemic 效果,但是与差的溶解度。改进它的口头的 bioavailability,我们试图包含 scopoletin 进 Soluplus 微粒(基于 Soluplus 的 scopoletin 微粒, Sco 女士) 并且评估了 Sco-Ms.Sco 女士的 hypouricemic 行动用一个薄电影的水和方法被准备。Sco 女士与 59.4 灭敬整祬戠潬正摥 ? 噓木椭摮 ' 讚?的一种平均尺寸显示了近球形的形状 ?? 桰獯桰牯汹瑡潩 ? 猠杵敧瑳湩 ? 桴瑡 ??? ‵捡楴杮甠獰牴慥? 景 ?? 愠摮瀠??偁欠湩獡 | Ying-chun ZENG Sha LI Chang LIU Tao GONG Xun SUN Yao FU Zhi-rong ZHANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 3 |
| 15 | Generation of trans-arachidonic acid under nitrative stress is associated with upregulation of thromponsdin-1 in diabetic rats显示文摘背景 Trans-arachidonic 酸(TAA ) , nitrative 应力的最新发现的标记和氮二氧化物(NO2 ) 的主要产品调停了 arachidonic 酸(AA ) 的异构化,代表导致 NO2 的毒性的新机制。TAA 在导致氧的 microvascular 退化模型被产生, TAA 也在糖尿病的 retinopathy (医生) 被产生,这被报导了模型。在这研究,我们检验了高导致葡萄糖的 nitrative 压力损坏和 TAA 层次并且为反应的氮种类引起的医生探索了可能的机制。方法糖尿病的老鼠被 streptozotocin (STZ ) 的 intraperitoneal 注射在 60 mg/kg 导致。牛的网膜的毛状的 endothelial 房间(BREC ) 与正常或高葡萄糖有选择地有教养、孵化。在糖尿病的老鼠的浆液 TAA 和 AA 被煤气的层析和集体 spectrometry (GC/MS ) 测量方法。到有 79 的选择离子的 AA 的 TAA 的山峰区域的比率被一个组估计(测试。在老鼠视网膜和 BREC 摘录的 Thrombospondin-1 (TSP-1 ) 被西方的弄污检验。细胞外的调整信号的 kinase 1/2 ( ERK1/2 )的 phosphorylation 蛋白质被在与高 glucose.Results 孵化的 BREC 的西方的弄污检验到 AA 比率( TAAs/AA )的 TAA 显著地在 STZ 注射以后在 8 , 12 和 16 个星期在浆液被增加( P < 0.05 ),在 2 或 4 个星期没有显著变化发现( P > 0.05 )。在糖尿病的老鼠的视网膜的 TSP-1 的表示日益增多地根据糖尿病的持续时间被提高。TSP-1 表示在在 48 个小时与高葡萄糖孵化的 BREC 被增加。而且,高葡萄糖也增加了 ERK1/2 表示,它在 30 分钟达到顶点然后在下列 48 hours.Conclusion 减少了 TAAs/AA 的举起与高导致葡萄糖的 nitrative 应力被联系,它可能通过激活 ERK1/2 包含 TSP-1 的 upregulation。 | XU Lin LIU Yu-min YAO Zhu-jun XUN Guo-liang YU Wen-juan LIU Kun SUN Xiao-dong QIU Yun-ping WU Hai-xiang XU Xun | 2011 | Chinese Medical Journal2011，，12： | 3 |
| 16 | Macular choroidal thickness in Chinese preschool children: decrease with axial length but no evident change with age显示文摘AIM: To explore the distribution pattern of macular choroidal thickness(ChT) and its association with age as well as refractive status in Chinese preschoolers.METHODS: School-based, cross-sectional study. A total of 550 healthy preschool children aged 3 to 6 years old from 6 kindergartens were enrolled. Comprehensive ocular examinations, including measurement of visual acuity, axial length, intraocular pressure and slit-lamp examination before cycloplegia, as well as refraction measurement and sweptsource optical coherence tomography(SS-OCT) examination after cycloplegia, were performed. The macular ChT in each sector of the ETDRS grid was measured by the builtin software of SS-OCT.RESULTS: The mean central ChT of the participants was 312±59 μm. The mean axial length and spherical equivalent refraction were 22.36±0.72 mm and 1.51±0.83 D, respectively. Axial length increased with age(P<0.001), while the spherical equivalent refraction was similar among different age groups. Similarly, no significant difference was observed in ChT in all sectors among different age groups(all P>0.05). The central ChT of 3-4, 5 and 6 years old children was 314±59 μm, 312±60 μm and 312±59 μm, respectively(P=0.920). No difference was observed in ChT in most of the sectors between genders. No statistical significant difference was observed among different refractive groups(all P>0.05), though the ChT of each sector seemed to be smaller in myopic children. Axial length and weight were the independent factors of central Ch T. Children with longer axial length(β=-21.184, P<0.001) and smaller weight(β=1.502, P=0.041) tended to have thinner choroid.CONCLUSION: In preschool children, the ChT remains relatively stable with age, while a negative association between ChT and axial length existed. This will be helpful to elucidate the characteristics of ChT during the early refractive development. | Xian-Gui He Jun-Jie Deng Yao Yin Bo Zhang Shu-Yu Xiong Jian-Feng Zhu Hai-Dong Zou Xun Xu Ling Wang | 2019 | International Journal of Ophthalmology(English edition)2019，12，9： | 2 |
| 17 | Four new eremophilendiolides from Ligularia atroviolacea显示文摘从 Ligularia atroviolacea ,四新 eremophilendiolides , 8 β- hydroxy-eremophil-3,7 ( 11 ) -dien-12,8α(14,6α)-diolide ( 1 ), 8 β- methoxy-eremophil-3,7 ( 11 ) -dien-12,8α(14,6α)-diolide ( 2 ), 8 α- hydroxy-eremophil-3,7 ( 11 ) -dien-12,8β(14,6α)-diolide ( 3 )和 eremophil-3,7 ( 11 ), 8-trien-12,8 ( 14,6 α) -diolide ( 4 ),象已知的 diolide ( 5 )一样被孤立。他们的结构象 ESIMS 一样根据 1D 和 2D NMR 被阐明光谱数据。 | Shu Yun Shi Di Yao Wu Xun Gong Hua Peng Rong Ping Zhang Chang Xin Zhou Xiao Jiang Hao Zhong Jian Jia Joachim Stockigt Yu Zhao | 2007 | Chinese Chemical Letters2007，18，1： | 2 |
| 18 | Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms显示文摘瞄准:分别地,(+)-Catechin 和 puerarin 在绿茶和食品是多酚和 flavonoid。他们展出有势力抗氧化剂活动并且广泛地被使用治疗 cardiocerebrovascular 疾病。这个工作的目的是调查在在 Caco-2 房间 monolayers.Methods 在老鼠,和他们的吸收机制跟随并发的口头的管理的(+)-catechin 和 puerarin 之间的潜在的相互作用:Pharmacokinetic 研究在雄的老鼠被进行收到的(+)-catechin (140 mg/kg, po ) 或 puerarin (200 mg/kg, po ) 。在 Caco-2 房间单层和二混合物的相互作用的房间举起和运输行为是 analyzed.Results:当(+)-catechin 和 puerarin 并发地被管理时, AUC 0-12 h 和 C 分别地, puerarin 的最大 价值是 2.48 褶层和 3.91 褶层 puerarin 象那些一样大独自一个;AUC 0-12 h 和 C 分别地,(+)-catechin 的最大 价值独自(+)-catechin 与那些相比被减少到 57.62% 和 77.55% 。在 Caco-2 房间单层,(+)-catechin (300 和 600 μ mol/L ) 显著地增加了房间举起和 puerarin 的运输,而 puerarin (300 和 600 μ mol/L ) 显著地减少了(+)-catechin 的细胞的举起和运输。而且, cyclosporine A (P-glycoprotein 禁止者) 和 MK-571 (MRP-2 禁止者) 显著地增加了(+)-catechin 和 puerarin.Conclusion 的细胞的举起和运输:(+)-catechin 和 puerarin 的并发的口头的管理显著地增加了 puerarin 的绝对口头的 bioavailability,但是减少(+)-catechin 的。由 P-glycoprotein 和 MRP-2 的(+)-catechin 和 puerarin 的竞争流出可能在小肠在他们的吸收过程期间导致这个相互作用。 | Hui-fang SU Qing LIN Xin-yi WANG Yao FU Tao GONG Xun SUN Zhi-rong ZHANG | 2016 | Acta Pharmacologica Sinica2016，37，4： | 2 |
| 19 | Distributed tasks-platforms scheduling method to holonic-C2 organization显示文摘To solve the problem of distributed tasks-platforms scheduling in holonic command and control(C2) organization,the basic elements of the organization are analyzed firstly and the formal description of organizational elements and structure is provided. Based on the improvement of task execution quality,a single task resource scheduling model is established and the solving method based on the m-best algorithm is proposed. For the problem of tactical decision-holon cannot handle tasks with low priority effectively, a distributed resource scheduling collaboration mechanism based on platform pricing and a platform exchange mechanism based on resource capacities are designed. Finally,a series of experiments are designed to prove the effectiveness of these methods. The results show that the proposed distributed scheduling methods can realize the effective balance of platform resources. | WANG Xun YAO Peiyang ZHANG Jieyong WAN Lujun JIA Fangchao | 2019 | Journal of Systems Engineering and Electronics2019，30，1： | 2 |
| 20 | High-power linear-polarization burst-mode all-fibre laser and generation of frequency-adjustable microwave signal显示文摘Narrowband microwave generation with tuneable frequency is demonstrated by illuminating a photoconductive semiconductor switch(PCSS)with a burst-mode fibre laser.The whole system is composed of a high-power linearly polarized burst-mode pulsed fibre laser and a linear-state PCSS.To obtain a high-performance microwave signal,a desired envelope of burst is necessary and a pulse pre-compensation technique is adopted to avoid envelope distortion induced by the gain-saturation effect.Resulting from the technique,homogenous peak power distribution in each burst is ensured.The maximum energy of the laser burst pulse reaches 200μJ with a burst duration of 100 ns at the average power of 10 W,corresponding to a peak power of 4 kW.When the PCSS is illuminated by the burst-mode fibre laser,narrowband microwave generation with tuneable frequency(0.80-1.12 GHz)is obtained with a power up to 300 W.To the best of the authors’knowledge,it is the first demonstration of frequency-tuneable narrowband microwave generation based on a fibre laser.The high-power burst-mode fibre laser reported here has great potential for generating high-power arbitrary microwave signals for a great deal of applicable demands such as smart adaptive radar and intelligent high-power microwave systems. | Xuan He Bin Zhang Shuailin Liu Jinmei Yao Qilin Wu Yuxin Zhao Tao Xun Linyong Yang Jing Hou | 2021 | High Power Laser Science and Engineering2021，9，2： | 2 |
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