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| 1 | 激光剥蚀信号在线平滑和去汞装置:原位微区铅同位素准确分析利器显示文摘激光原位微区分析可在微观尺度上完成样品的元素定量分析或同位素组成测定,为研究成岩、成矿物质来源和追踪地壳与地幔演化历史提供了独特的观察视野。但是,激光剥蚀等离子体质谱的一些缺陷阻碍了地质样品的高精度、高空间分辨率分析,比如:剥蚀池的位置效应、低剥蚀速率下信号波动影响、激光剥蚀脉动式信号导致的光谱螺纹效应、高频激光剥蚀造成的元素分馏效应等。为此,一些学者设计了不同规格和样式的激光剥蚀信号平滑装置来克服这些问题。但是,这些信号平滑装置普遍还存在气体吹扫时间过长和降低激光剥蚀信号灵敏度等问题。因此,研制新型的信号平滑装置对改善LA—ICP—MS的数据质量具有重要的意义。 | Hu Z Zhang W Liu Y Gao S Li M Zong K Chen H Hu S 刘勇胜 | 2015 | 矿物岩石地球化学通报2015，34，4： | 114 |
| 2 | 患者肠道微生物群失调与肠上皮屏障功能障碍显示文摘最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。 | Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 45 |
| 3 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 4 | Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis显示文摘The 'a disintegrin and metalloprotease' (ADAM) family contributes to regulation of the cell-cell and cell-matrix interactions that are critical determinants of malignancy. To determine the relationship between metastasis and ADAM proteins, we compared the mRNA levels of ADAM9,-10,-12,-15, and-17 in sublines of an EBC-1 lung cancer cell line that were highly metastatic to either brain or bone. ADAM9 mRNA levels were significantly higher in highly brain-metastatic sublines than in the parent or highly bonemetastalic sublines. To elucidate the role ofADAM9 in brain metastasis, we stably transfected A549 and EBC-1 cells with a fulllength ADAM9 expression vector. Compared with mock-transfectants, ADAM9 overexpression resulted in increased invasive capacity | Shintani Y Higashiyama S Ohta M Hirabayashi H Yamamoto S Yoshimasu T Matsuda H Matsuura N | 2004 | 中国神经肿瘤杂志2004，2，2： | 36 |
| 5 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 6 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 7 | Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats显示文摘AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in rats.METHODS:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were dissected.Colonic mucus content was estimated using Alcian blue dye binding technique.In colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were evaluated.The activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were measured.Concentrations of nucleic acids(DNA and RNA)and total protein were also estimated in colon tissues.Colonic levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were estimated.In cross section of colitis tissue the histopathological changes were observed.RESULTS:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls respectively.Naringenin supplementation,significantly and dose dependently increased the colonic mucus content.The elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0.05;26.74±3.17 nmol/L,P<0.01 nmol/L and 17.74±2.69 nmol/L,P<0.01)compared to AA(59.90±16.34 nmol/L)group while the decreased levels of T-GSH and NP-SH and activities of CAT and SOD found increased by NG treatments in dose dependent manner.The decreased values of nucleic acids and total protein in AA group were also significantly(P<0.01)increased in all three NG supplemented groupsrespectively.NG pretreatment inhibited the TNF-levels(123.76±3.76 pg/mg,122.62±3.41 pg/mg and121.51±2.61 pg/mg vs 134.24±4.78 pg/mg,P<0.05)compared to AA group,respectively.Interleukins,IL-1 and IL-6 levels were also decreased in NG50+AA(314.37±16.31 pg/mg and 292.58±23.68 pg/mg,P<0.05)and NG100+AA(416.72±49.62 pg/mg and 407.96±43.87 pg/mg,P<0.05)when compared to AA(352.46±8.58 pg/mg and 638.58±115.98pg/mg)group.Similar decrease(P<0.05)was seen in PGE2and NO values when compared to AA group.The group pretreated with MES,as a reference drug,showed significant(P<0.01)protection against the changes induced in colon tissue by AA administration respectively.CONCLUSION:In present study,NG produced antioxidant and anti-inflammatory effects demonstrating protective effect in inflammatory bowel disease. | Salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M Ahmed | 2013 | World Journal of Gastroenterology2013，19，34： | 20 |
| 8 | Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulation mechanisms: an efficacy study based on findings on neuroimages显示文摘 | Miyatake S Kawabata S Kafimoto Y Aoki A Yokoyama K Yamada M Kuroiwa T Tsuji M Imahori Y Kirihata M Sakurai Y Masunaga S Nagata K Maruhashi A Ono K | 2005 | 中国神经肿瘤杂志2005，3，4： | 14 |
| 9 | Proteome analysis of hepatocellular carcinoma by laser capture microdissection显示文摘 | Ai J Tan Y Ying W Hong Y Liu S Wu M Qian X Wang H | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 10 | 标准和扩大淋巴结切除在胰头导管腺癌根治性胰十二指肠切除中的对比研究:一项日本多中心长期随机对照研究的长期结果显示文摘背景众多回顾性研究以及3个随机对照试验(randomized controlled trials,RCT)均对扩大淋巴结切除的胰十二指肠切除术(pancreatoduodenectomy,PD)治疗胰腺癌的价值进行了评估,但是这3个RCT所使用的指南及所获得的结果却各有不同。因而,一项多中心的RCT研究在1998年提出并施行,旨在评估经标准或扩大淋巴结切除的根治性PD术治疗胰腺癌患者的长期生存情况、发病率、死亡率以及生活质量。方法从2000年3月至2003年5月间,共入选112例有可能治愈的胰头癌患者,手术期间随机分成标准淋巴结切除组和扩大淋巴结切除组,所有手术患者均未行其他任何辅助治疗。结果 101例有效病例可用于分析研究,两组的人口构成以及组织病理学特征均相似。扩大组的平均手术时间、术中失血以及切除淋巴结数量均大于标准组,但是其他手术参数两组并无明显差异。结论尽管该项多中心RCT研究是在严格的条件控制下施行的,但是扩大淋巴结切除的根治性PD术对于本身可切除的胰头癌患者而言并不能改善此类患者的长期预后情况,其发病率、死亡率以及生存质量与行标准淋巴结切除的根治性PD术相比并无明显差别。 | 杨学伟 汪谦 Nimura Y Nagino M Takao S | 2012 | 中华普通外科学文献(电子版)2012，6，3： | 11 |
| 11 | 利用常间回文重复序列丛集介导的基因编辑评估Tet2和甲基转移酶3a在克隆性造血和心血管病中的作用显示文摘克隆性血细胞生成与死亡率、心血管病发生率增加有关。这种情况可能是由于造血干/祖细胞(hematopoietic stem/progenitor cells,HSPC)内的前白血病驱动基因的体细胞突变引起的。大约有40个候选驱动基因已被确定出来,但有研究证明在这些基因中,仅一个基因[10-11易位-2(TET2)]的突变在大鼠模型中可导致心血管病。 | Sano S Ohshima K Wang Y Katanasaka Y Sano M Walsh K 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，7： | 11 |
| 12 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 13 | Synthesis of bis(amine anhydride)s for novel high Tgs and organosoluble poly(amine imide) s by palladium-catalyzed amination of 4-chlorophthalide anhydride 显示文摘 | Li W M Li S H Zhang Q Y | 2007 | Macromolecules2007，40，： | 10 |
| 14 | Effect of human skin-derived stem cells on vessel architecture, tumor growth, and tumor invasion in brain tumor animal models显示文摘 | Pisati F Belicchi M Acerbi F Marchesi C Giussani C Gavina M Javerzat S Hagedorn M Carrabba G Lucini V Gaini SM Bresolin N Bello L Bikfalvi A Torrente Y | 2007 | 中国神经肿瘤杂志2007，5，2： | 10 |
| 15 | 根据血压等级确定脑卒中和冠状动脉粥样硬化性心脏病死亡的终生风险:日本EPOCH(观察队列的心血管预防证据)研究显示文摘在亚洲人群中.很少研究关注根据血压分类确定脑卒中和冠状动脉粥样硬化性心脏病(coronary heartdisease,CHD)的终生风险。该研究旨在用一个包含个体参与者数据的荟萃分析大数据库来评估它。该荟萃分析纳入来源于13个队列的107 737名日本人(男性占42.4%,平均年龄55.1岁)。在平均(15.2±5.3)年(1 559 136人年)的随访期.1922人死于脑卒中,913人死于CHDO研究者在调整其他死亡危险因素后估计风险。 | 陈嘉睿(译) 练桂丽(审校) Satoh M Ohkubo T Asayama K Murakami Y Sugiyama D Yamada M Saitoh S Sakata K Irie F Sairenchi T Ishikawa S Kiyama M Ohnishi H Miura K Imai Y Ueshima H Okamura T EPOCH-JAPAN research group | 2019 | 中华高血压杂志2019，27，4： | 9 |
| 16 | A20 is dynamically regulated in the heart and inhibits the hypertrophic response显示文摘 | Cook S A Novikov M S Ahn Y | 2003 | Circulation2003，108，6： | 8 |
| 17 | Direct-fed microbes: A tool for improving the utilization of low quality roughages in ruminants显示文摘For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial(DFM) can be the most suitable solutions. Microorganisms that are commonly used in DFM for ruminants may be classified mainly as lactic acid producing bacteria(LAB), lactic acid utilizing bacteria(LUB), or other microorganism's species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, Megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFM has not been established; although a variety of mechanisms have been suggested. Bacterial DFM potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFM may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFM may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFM administration. However, the response to DFM is not constant; depending on dosages, feeding times and frequencies, and strains of DFM. Nonetheless, recent studies have supported the positive effects of DFM on ruminant performance. | Mona M Y Elghandour Abdelfattah Z M Salem Jose S Martínez Castaeda Luis M Camacho Ahmed E Kholif Juan C Vázquez Chagoyán | 2015 | Journal of Integrative Agriculture2015，14，3： | 7 |
| 18 | 美白牙膏去除牙外源性色斑的八周效果观察显示文摘目的 :评价含有 1%焦磷酸钠、7%三聚硫酸钠、0 .2 4 3 %氟化钠及 10 %高清洁二氧化硅的牙膏减少外源性牙色斑的效果。方法 :采用双盲、分层、二单位平行观察的临床研究方法。根据改良 L obene色斑指数 (L obene stain in-dex m ethod)均数、性别、吸烟习惯将 91名年龄为 18~ 5 5岁的研究对象平衡地分为两组 ,随机地分配使用试验或对照牙膏。于基线、第 4周及第 8周固定由一名检查者完成研究对象的色斑指数测定。结果 :86人完成了该研究。8周临床研究表明 ,使用美白牙膏的研究对象较对照组的牙齿色斑指数均数降低了 3 7.1% (P=0 .0 0 0 1)。结论 :与对照组牙膏相比 ,使用含有 1%焦磷酸钠、7%三聚硫酸钠、0 .2 4 3 %氟化钠及 10 %高清洁二氧化硅的牙膏可以有效地减少牙外源性色斑。 | 胡德渝 庞若愚 佘晓晴 雷德伦 Volpe A R DeVizio W Petrone M E Zhang Y P Chaknis P Miller S Miller J | 1999 | 华西口腔医学杂志1999，17，3： | 7 |
| 19 | Lancet Gastroenterol Hepatol:新研究称全球有近3亿乙肝病毒携带者,仍无根治药显示文摘英国《柳叶刀·胃肠病与肝脏病学》杂志日前发表的一项新研究显示,2016年全球有近3亿乙肝病毒携带者。美国等国研究人员根据此前多项研究数据和多名各国专家意见,通过建模研究发现,2016年全球约2.92亿人是乙肝病毒携带者,约占全球人口总数的近4%。其中,东亚和撒哈拉以南地区乙肝病毒携带者最为常见。 | Shimakawa Y Seck A Nayagam S Toure-Kane C Lemoine M | 2018 | 疾病监测2018，33，2： | 6 |
| 20 | 血流介导的血管舒张,硝酸甘油诱导的血管舒张,基线肱动脉直径,充血剪切应力与心血管病危险因素之间的相关性显示文摘血流介导的血管舒张功能(flow-mediated vasodilation,FMD)已被用于评估内皮功能。充血性剪切应力(hyperemic shear stress,HSS,一种FMD的刺激因素)、硝酸甘油诱导的血管舒张(nitroglycerine-induced vasodilation,NID,非内皮依赖性血管舒张指数)以及基线肱动脉直径(brachial artery diameter,BAD)也参与血管舒张反应。 | 刘青 叶鹏 Maruhashi T Iwamoto Y Kajikawa M Oda N Kishimoto S Matsui S Hashimoto H Aibara Y Yusoff FM Hidaka T Kihara Y Chayama K Noma K Nakashima A Goto C Hida E Higashi Y | 2018 | 中华高血压杂志2018，26，1： | 5 |
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