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| 1 | Efficient genome editing in plants using a CRISPR/Cas system显示文摘 | Zhengyan Feng Botao Zhang Wona Ding Xiaodong Liu Dong-Lei Yang Pengliang Wei Fengqiu Cao Shihua Zhu Feng Zhang Yanfei Mao Jian-Kang Zhu | 2013 | Cell Research2013，23，10： | 211 |
| 2 | Eocene Basins on the SE Tibetan Plateau: Markers of Minor Offset along the Xuelongshan–Diancangshan–Ailaoshan Structural System显示文摘The offset of geological bodies provides robust evidence of displacement along a fault or ductile shear zone. The amount of displacement along the Xuelongshan–Diancangshan–Ailaoshan structural system, southeastern Tibetan Plateau, is uncertain because of the lack of offset geological markers. This NNW–SSE-trending system is developed in three isolated metamorphic complexes and interjacent nonmetamorphosed rocks. They are expected to record similar post-Eocene strain, although their structural patterns should be distinct. Geological mapping in the area between the Xuelongshan and Diancangshan metamorphic complexes has revealed a small Eocene basin, the Madeng Basin, located to the west of the structural system. The sedimentary and volcanic successions of the Madeng Basin are comparable to those of the Jianchuan Basin, which is located to the east of the structural system. Zircon U–Pb geochronological and bulk geochemical data demonstrate that the volcanic rocks of both basins formed during 37–34 Ma and share the same geochemical features. These data suggest that the Madeng and Jianchuan basins previously constituted a single basin, with the distribution of high-K volcanic rocks in the basins defining an ENE–WSW-trending volcanic belt that shows a limited dextral offset of ≤20 km across the Xuelongshan–Diancangshan–Ailaoshan structural system. Therefore, the northern segment of the structural system records no evidence of large-scale lateral movement/displacement. The results suggest that the Indochina block, which is bounded by the Xuelongshan–Diancangshan–Ailaoshan structural system to the east and the Sagaing Fault to the west, has not extruded southward as a whole but rather has been deformed by pervasive crustal shortening. | LIAO Cheng YANG Tiannan XUE Chuandong LIANG Mingjuan XIN Di XIANG Kun JIANG Lili SHI Pengliang ZHU Wenbin WAN Liangchun TANG Jing YU Jing WU Pinglei | 2020 | Acta Geologica Sinica(English Edition)2020，94，4： | 5 |
| 3 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 4 | A review of some methodological developments on full waveform inversion tackled in the SEISCOPE group显示文摘Full waveform inversion(FWI)is a data-fitting inverse problem aiming to delineate high-resolution quantitative images of the Earth.While its basic principle has been proposed in the eighties,the approach has been significantly developed and applied to2Dand 3Dproblems at various scales for the last fifteen years.Despite these successes,FWI is still facing some issues for applications in complex geological setups because of some lack of robustness and automatic workflow,while being computationally intensive.In this paper,after a short review of the basic FWI formulation and analysis of the FWI gradient,three recent methodological developments performed in the frame of the SEISCOPE project are presented.First,an algorithmic development is presented as a low-memory and computationally efficient approach for building the time-domain FWI gradient in 3Dviscous media.Second,a reformulation of FWI is performed to handle reflections in their tomography regime while still using the diving waves,leading to the joint full waveform inversion(JFWI)approach.Finally,an optimal transport approach is proposed as an alternative to the classical difference-based misfit for mitigating the cycle-skipping issue. | Romain BROSSIER Ludovic METIVIER Jean VIRIEUX YANG Pengliang ZHOU Wei | 2017 | 石油物探2017，56，1： | 2 |
| 5 | Biomimetic ultrathin pepsomes for photo-controllable catalysis显示文摘Artificial vesicles for mimicking the unique structures and functions of natural organelles represent a promising scientific object in biomimicry.However,the development of the stimuli-responsive and ultrathin vesicles assembled from sequence-defined biomimetic polymers for controllable applications is still a significant challenge.Herein,we report the self-assembly of azobenzene-based amphiphilic alternating peptoids to generate photo-responsive and ultrathin peptoid vesicle(pepsomes)with an average diameter of∼180 nm.Both cryo-transmission electron microscopy(TEM)and dissipative particle dynamics simulation proved that the vesicular membrane was the ultrathin bilayer structure around∼1.6 nm.The photo-responsive ability of pepsomes was demonstrated by the reversible size changes upon the alternative irradiation with ultraviolet(UV)and visible lights,which was attributable to the photoisomerization virtue of azobenzene moiety.As a proof-of-concept,the photo-controllable catalytic action of gold nanoparticles-decorated pepsomes was evaluated toward the borohydride-mediated reduction from 4-nitrophenol to 4-aminophenol.Photo-controllable reversible and recyclable catalytic activity was effectively modulated using the alternative irradiation with UV and visible lights for five cycles.Our work provides a simple strategy to prepare stimuli-responsive and ultrathin vesicles for potential application on nanocatalysis. | Guiping Peng Haibao Jin Fan Liu Xiaoyan Yang Pengliang Sui Shaoliang Lin | 2022 | Science China Chemistry2022，65，12： | 1 |
| 6 | Experimental Research of Concrete with Steel Slag Powder and Zeolite Powder显示文摘In order to increase use ratio of steel slag solid waste,the concrete containing steel slag powder and zeolite powder as admixtures was prepared by using the orthogonal test method.The effects of water-binder ratio,sand ratio,steel slag powder content and zeolite powder on working properties,mechanical strength and chloride ion permeability of the concrete was studied.It was found that the early strength of the concrete had a decrease with the mixing of steel slag and zeolite powders,but its later strength approached to pure concrete.Moreover,the physical filling and pozzolanic activity of the admixtures increased the density of the concrete,resulting in the improvement of the durability of the concrete by the migration speed of Cl−reducing.The optimum mix ratio of C40 steel slag powder-zeolite powder concrete is obtained,and which had the slump of 220 mm,the 3 d,7 d and 28 d compressive strengths of 27.8 MPa,37.5 MPa and 48.4 MPa,the 6 h electric flux of 950 C and the diffusion coefficient of 1.65×10−12 m2/s. | Yang Ming Ping Chen Yuanhao Wang Ling Li Xuandong Chen Pengliang Sun | 2020 | Journal of Renewable Materials2020，8，12： | 1 |
| 7 | Global and local constitutive behaviors of friction stir welded AA2024 joints显示文摘In this study, the global and local tensile properties of friction stir welded AA2024 joints were measured with the aid of digital image correlation(DIC) method. A novel model was proposed to describe the global and local constitutive behavior of the joints based on DIC data. Different from conventional division of the zones across the joints, a new reasonable division was proposed, i.e. four zones including central low hardness zone(CLHZ), first heat affected zone(HAZ-I) close to TMAZ, second heat affected zone(HAZ-II)close to base metal(BM) and BM in term of the characteristic distribution of hardness. Results reveal that local true stress-true strain curves are different in each zone of interest. Plastic deformation of the joints is concentrated in CLHZ, where the lowest yield stress and the largest strain appear. Therefore, strain localization and necking occur here in a sequence. In addition, the global true stress-true strain curves and yield stresses at various ratios of the width of CLHZ zone to the gauge length are accurately predicted using the proposed constitutive model of the joints. | Pengliang Niu Wenya Li Zhihan Zhang Xiawei Yang | 2017 | Journal of Materials Science & Technology2017，33，9： | 1 |
| 8 | Virion protein 16 induces demethylation of DNA integrated within chromatin in a novel mammalian cell model显示文摘DNA methylation 和 demethylation 在调停起重要作用 epigenetic 规定。到目前为止, DNA demethylation 的机制留下逃犯、争论。这里,我们构造了 plasmid,与 pCBS-luc 说出,那包含了一个人工的 CpG 岛,八个 Gal4 DNA 有约束力的域绑定地点,一个 SV40 倡导者,和萤火虫酶记者基因。线性化的 pCBS-luc plasmid 是在由 DNA methyltransferase,和 transfected 的 vitro 的 methylated 进 HEK293 房间。有 methylated pCBS-luc (me-pCBS-luc ) 的稳定的 HEK293 transfectants 被选择并且获得。选择稳定的房间线的 methylation 地位被定序聚合酶链反应扩大的重亚硫酸盐证实。methylation 地位能甚至在 15 个段落以后被维持。virion 蛋白质(VP16 ) 16 被报导在 Xenopus 受精卵在它倡导者区域的有约束力的地点附近提高 DNA demethylation。用我们的 me-pCBS-luc 模型,我们发现 VP16 也有能力激活 methylated 酶记者基因的表示并且在哺乳动物的房间在染色质 DNA 导致 DNA demethylation。总的来说,我们构造了与 me-pCBS-luc 记者 plasmid 稳定地综合的一个房间模型,并且在这个模型,我们发现 VP16 能导致 DNA demethylation。我们相信这个房间模型将在关于 DNA demethylation 和染色质修正的动态过程的未来研究有许多潜在的应用。 | Lu Yang Huijun Wang Xin Luo Pengliang Mao Weidong Tian Yujiang Shi Guoying Huang Jin Zhang Duan Ma | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 0 |
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