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| 1 | Research Progress on the Development and Application of New Natural Tobacco Humectants显示文摘The research progress on the development and application of new natural tobacco humectants was reviewed in the paper.Plants,animals and microbes contain special moisturizing substances,showing distinctive advantages and outstanding effects in respect of the tobacco moisture content maintaining and cigarette suction comfort promoting.The development necessity,major types,functional mechanism and influence on cigarette quality of new natural tobacco humectants development were compared and elaborated.Additionally,the prospect of new natural tobacco humectants development and application was forecasted. | Xiaojing MA Xinge LIU Zhiqiang XU Yingbo XU Huai WANG Risheng YAO | 2016 | Agricultural Science & Technology2016，17，5： | 2 |
| 2 | Preparation of monodisperse HPMC/PAA hybrid nanogels via surfactant- free seed polymerization显示文摘 | Zhang Weibo Yao Risheng Tao Wei | 2014 | Colloid and Polymer Science2014，292，2： | 1 |
| 3 | Diversity evolution and jump of Polo-like kinase 1 inhibitors显示文摘Polo-like kinase 1(Plk1),a member of a family of serine/threonine kinases,is an attractive target for the development of anticancer drugs because it is involved in the regulation of cell-cycle progression and cytokinesis.This kinase provides two pockets for developing Plk1 inhibitors:the N-terminal catalytic domain(NCD)and the polo-box domain(PBD).For both of the two pockets,some natural products were identified as Plk1 inhibitors and some synthetic Plk1 inhibitors were developed by mimicking ATP and phosphopeptides,natural products binding to NCD and PBD respectively.This article not only reviews the progression of Plk1 inhibitors binding to these two pockets,but also discusses diversity evolution and jump in the process of drug development using Plk1 inhibitors as examples and how they impact on drug design and pharmacophore modeling. | LIAO Chenzhong YAO RiSheng | 2013 | Science China Chemistry2013，56，10： | 1 |
| 4 | p53 transgenic mare highly susceptible to 4-nitroquinoline-l-oxide-induced oral cancer显示文摘 | Zhongqiu Zhang Yian Wang Risheng Yao | 2006 | Mol Cancer Res2006，4，6： | 1 |
| 5 | Degradation of 4-aminophenol by hydrogen peroxide oxidation using enzyme from Serratia marcescens as catalyst显示文摘This paper reports on the degradation of 4-aminophenol using hydrogen peroxide as oxidizer and the enzyme from Serratia marcescens AB 90027 as catalyst.The effecting factors during degradation and the degrading mechanism were studied.Also,the location of the enzyme in the cell,which could catalyze the degradation of 4-aminophenol,was analyzed.The results showed that to degrade 50 mL of 4-aminophenol whose concentration was 500 mg/L,the optimal conditions were:volume of H_(2)O_(2)=3 mL,temperature=40-60°C and pH=9-10.In the degra-dation process,4-aminophenol was first converted to benzo-quinone and NH3,then organic acids including maleic acid,fumaleic acid,and oxalic acid were formed,and then finally CO_(2) and H2O were generated as final products.The enzyme that could catalyze the degradation of 4-aminophenol was mainly extracellular enzyme. | SUN Min YAO Risheng YOU Yahua DENG Shengsong GAO Wenxia | 2007 | Frontiers of Environmental Science & Engineering2007，1，1： | 1 |
| 6 | Biological evaluation of 2-methylpyrimidine derivatives as active pan Bcr-Abl inhibitors显示文摘We designed a series of 2-methylpyrimidine derivatives as new BCR-ABL inhibitors using scaffold-hopping strategy.These synthetic compounds exhibited significant inhibition against a broad spectrum of Bcr-Abl mutants including the gatekeeper T315I mutant.Compound 7u showed very potent kinase inhibitory activities against Bcr-Abl WT,Bcr-Abl E255K,Bcr-Abl Q252H,Bcr-Abl G250E and Bcr-Abl T315I,with IC50 values of 0.13 nM,0.17 nM,0.24 nM,0.19 nM and 0.65μM,respectively.This compound also displayed anti-proliferation activity against K562 cell line with an IC50 value of 1.1 nM,thus representing a new lead for further optimization. | ZOU DingBiao QIU YaTao TU ZhengChao LIAO ChenZhong LUO JinFeng MENG QingQing YAO RiSheng LI Zheng JIANG Sheng | 2014 | Science China Chemistry2014，57，6： | 0 |
| 7 | Facility Cultivation Techniques of ‘Kaorino’ Strawberry显示文摘Strawberry‘Kaorino’is one of the perfect early-maturing strawberry varieties with high quality and high yield due to its anthracnose resistance,early maturity and good quality.The variety has become more and more popular with the promotion over the last few years,but there are great differences from other varieties in cultivation.Based on its varietal characteristics and cultivation performance in production over the last few years,we summarized the seedling cultivation techniques,planting management techniques,main disease control techniques and harvesting and storage techniques,aiming to provide reference for better promotion and application of‘Kaorino’. | Risheng YANG Peng WANG Jingxing YANG Shuwei YAO Defu LI Muxiang JI | 2023 | Agricultural Biotechnology2023，12，5： | 0 |
| 8 | Simultaneous enhancement of phosphorescence and chirality by host–guest recognition of molecular tweezers显示文摘A novel type of host-guest recognition systems have been developed on the basis of a Au(Ⅲ) molecular tweezer receptor and chiral Pt(Ⅱ) guests. The complementary host-guest motifs display high non-covalent binding affinity (Ka: ∼10^(4) L/mol) due to the participation of two-fold intermolecular π-π stacking interactions. Both phosphorescence and chirality signals of the Pt(Ⅱ) guests strengthen in the resulting host-guest complexes, because of the cooperative rigidifying and shielding effects rendered by the tweezer receptor. Their intensities can be reversibly switched toward pH changes, by taking advantage of the electronic repulsion effect between the protonated form of tweezer receptor and the positive-charged guests in acidic environments. Overall, the current study demonstrates the feasibility to enhance and modulate phosphorescence and chirality signals simultaneously via molecular tweezer-based host-guest recognition. | Diankun Jia Hua Zhong Sixun Jiang Risheng Yao Feng Wang | 2022 | Chinese Chemical Letters2022，33，11： | 0 |
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