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| 1 | Energy Optimization for Cellular-Connected Multi-UAV Mobile Edge Computing Systems with Multi-Access Schemes显示文摘In this paper,a cellular-connected unmanned aerial vehicle(UAV)mobile edge computing system is studied where several UAVs are associated to a terrestrial base station(TBS)for computation offloading.To compute the large amount of data bits,a part of computation task is migrated to TBS and the other part is locally handled at UAVs.Our goal is to minimize the total energy consumption of all UAVs by jointly adjusting the bit allocation,power allocation,resource partitioning as well as UAV trajectory under TBS’s energy budget.For deeply comprehending the impact of multi-UAV access strategy on the system performance,four access schemes in the uplink transmission is considered,i.e.,time division multiple access,orthogonal frequency division multiple access,one-by-one access and non-orthogonal multiple access.The involved problems under different access schemes are all formulated in non-convex forms,which are difficult to be tackled optimally.To solve this class of problem,the successive convex approximation technique is employed to obtain the suboptimal solutions.The numerical results show that the proposed scheme save significant energy consumption compared with the benchmark schemes. | Meng Hua Yongming Huang Yi Wang Qingqing Wu Haibo Dai Lyuxi Yang | 2018 | Journal of Communications and Information Networks2018，3，4： | 6 |
| 2 | Morphological Engineering of Sensing Materials for Flexible Pressure Sensors and Artificial Intelligence Applications显示文摘As an indispensable branch of wearable electronics,flexible pressure sensors are gaining tremendous attention due to their extensive applications in health monitoring,human-machine interaction,artificial intelligence,the internet of things,and other fields.In recent years,highly flexible and wearable pressure sensors have been developed using various materials/structures and transduction mechanisms.Morphological engineering of sensing materials at the nanometer and micrometer scales is crucial to obtaining superior sensor performance.This review focuses on the rapid development of morphological engineering technologies for flexible pressure sensors.We discuss different architectures and morphological designs of sensing materials to achieve high performance,including high sensitivity,broad working range,stable sensing,low hysteresis,high transparency,and directional or selective sensing.Additionally,the general fabrication techniques are summarized,including self-assembly,patterning,and auxiliary synthesis methods.Furthermore,we present the emerging applications of high-performing microengineered pressure sensors in healthcare,smart homes,digital sports,security monitoring,and machine learning-enabled computational sensing platform.Finally,the potential challenges and prospects for the future developments of pressure sensors are discussed comprehensively. | Zhengya Shi Lingxian Meng Xinlei Shi Hongpeng Li Juzhong Zhang Qingqing Sun Xuying Liu Jinzhou Chen Shuiren Liu | 2022 | Nano-Micro Letters2022，14，9： | 5 |
| 3 | Functions and clinical significance of mechanical tumor microenvironment:cancer cell sensing,mechanobiology and metastasis显示文摘Dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment fuels the occurrence,progression,invasion,and metastasis of solid tumors.In this process,the tumormicroenvironment(TME)fractures cellular and matrix architecture normality through biochemical and mechanical means,abetting tumorigenesis and treatment resistance.Tumor cells sense and respond to the strength,direction,and duration of mechanical cues in the TME by various mechanotransduction pathways.However,far less understood is the comprehensive perspective of the functions and mechanisms of mechanotransduction.Due to the great therapeutic difficulties brought by the mechanical changes in the TME,emerging studies have focused on targeting the adverse mechanical factors in the TME to attenuate disease rather than conventionally targeting tumor cells themselves,which has been proven to be a potential therapeutic approach.In this review,we discussed the origins and roles ofmechanical factors in the TME,cell sensing,mechano-biological coupling and signal transduction,in vitro construction of the tumormechanicalmicroenvironment,applications and clinical significance in the TME. | Hanying Zhou Meng Wang Yixi Zhang Qingqing Su Zhengxin Xie Xiangyan Chen Ran Yan Ping Li Tingting Li Xiang Qin Hong Yang ChunhuiWu Fengming You Shun Li Yiyao Liu | 2022 | Cancer Communications2022，42，5： | 3 |
| 4 | Bioinspired synthesis of CVD graphene flakes and graphene-supported molybdenum sulfide catalysts for hydrogen evolution reaction显示文摘化学蒸汽免职是为在平面底层上种大区域的高质量的 graphene 电影的大多数有希望途径。在侧面的生长以外,合成三维(3D ) graphene 最近也在金属泡沫和绝缘的 nanoparticles 上被表明了为在电气化学的电极探索他们的应用。然而,存在途径也需要丰富的开始预制,或为 graphene 生长构造多孔的框架底层。此处,我们报导一直接,为用化学蒸汽免职(CVD ) 在乌贼骨底层上种大数量的 graphene 薄片的 bioinspired 策略方法。从生长底层的分开的 graphene 薄片是高度水晶的,超过并且层厚度可控制传统化学上,有很少表面的 exfoliated graphene 组织。由于他们继承导出 biomineral 的形态学, 3D graphene 微观结构显示出高度暴露并且弯的表面,它能装载更多的瞬间 x (x 2 ) 催化剂比对高度有效的氢产生的另外的平面支持。简短, bioinspired 途径被期望为 graphene 生产完成在质量和数量之间的合理平衡,因此推进它在精力的宽应用存储和变换设备。 | Ke Chen Cong Li Zhaolong Chen Liurong Shi Sathish Reddy Huan Meng Qingqing Ji Yanfeng Zhang Zhongfan Liu | 2016 | Nano Research2016，9，1： | 2 |
| 5 | NODAL secreted by male germ cells regulates the proliferation and function of human Sertoli cells from obstructive azoospermia and nonobstructive azoospermia patients显示文摘 | Ru-Hui Tian Shi Yang Zi-Jue Zhu Jun-Long Wang Yun Liu Chencheng Yao Meng Ma Ying Guo Qingqing Yuan Yanan Hai Yi-Ran Huang Zuping He Zheng Li | 2015 | Asian Journal of Andrology2015，17，6： | 2 |
| 6 | FXYD3 enhances IL-17A signaling to promote psoriasis by competitively binding TRAF3 in keratinocytes显示文摘Psoriasis is a common chronic inflammatory skin disease characterized by inflammatory cell infiltration and epidermal hyperplasia.However,the regulatory complexity of cytokine and cellular networks still needs to be investigated.Here,we show that the expression of FXYD3,a member of the FXYD domain-containing regulators of Na+/K+ATPases family,is significantly increased in the lesional skin of psoriasis patients and mice with imiquimod(IMQ)-induced psoriasis.IL-17A,a cytokine important for the development of psoriatic lesions,contributes to FXYD3 expression in human primary keratinocytes.FXYD3 deletion in keratinocytes attenuated the psoriasis-like phenotype and inflammation in an IMQ-induced psoriasis model.Importantly,FXYD3 promotes the formation of the IL-17R-ACT1 complex by competing with IL-17R for binding to TRAF3 and then enhances IL-17A signaling in keratinocytes.This promotes the activation of the NF-κB and MAPK signaling pathways and leads to the expression of proinflammatory factors.Our results clarify the mechanism by which FXYD3 serves as a mediator of IL-17A signaling in keratinocytes to form a positive regulatory loop to promote psoriasis exacerbation.Targeting FXYD3 may serve as a potential therapeutic approach in the treatment of psoriasis. | Wenjuan Yang Rukun He Hao Qu Wenwen Lian Yue Xue Tao Wang Wenlong Lin Peishuo Zhu Meng Xia Lihua Lai Qingqing Wang | 2023 | Cellular & Molecular Immunology2023，20，3： | 2 |
| 7 | Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors显示文摘 | Zhitao Qiao Weiwei Wang Lie Wang Donghua Wen Yaxue Zhao Qing Wang Qingqing Meng Guoqiang Chen Yingli Wu Huchen Zhou | 2011 | Bioorganic & Medicinal Chemistry Letters2011，，21： | 1 |
| 8 | Utilization of Smoking Cessation Support Among Adults-18 PLADs,China,2020显示文摘Summary What is already known about this topic?In 2018,unassisted smoking cessation(USC)was the predominant method for quitting smoking among Chinese adult smokers,accounting for 90.1%of cases.The utilization of professional smoking cessation support was comparatively low in this population.What was added by this report?In 2020,the prevalence of USC methods increased to 93.1%.Concurrently,there was a slight increase in the utilization of pharmaceuticals(from 4.6%in 2018 to 5.5%in 2020)and counseling and quit line services(from 3.2%in 2018 to 7.5%in 2020).On the other hand,the use of e-cigarettes as a cessation aid decreased from 14.9%in 2018 to 9.8%in 2020.Smokers aged 15–24 years old were more likely to rely on pharmaceutical interventions(7.9%),and less likely to choose USC methods(79.0%).What are the implications for public health practice?The promotion of professional cessation support is essential for enhancing smoking cessation rates. | Yongfu Yan Bingliang Lin Qingqing Xu Huiyu Xie Xinying Zeng Xinbo Di Zida Meng Lin Xiao Shiwei Liu | 2023 | China CDC weekly2023，5，21： | 1 |
| 9 | A high-speed 2D optoelectronic in-memory computing device with 6-bit storage and pattern recognition capabilities显示文摘The explosively developed era of big-data compels the increasing demand of nonvolatile memory with high efficiency and excellent storage properties.Herein,we fabricated a high-speed photoelectric multilevel memory device for neuromorphic computing.The novel two-dimensional(2D)MoSSe with a unique Janus structure was employed as the channel,and the stack of Al_(2)O_(3)/black phosphorus quantum dots(BPQDs)/Al_(2)O_(3)was adopted as the dielectric.The storage performance of the resulting memory could be verified by the endurance and retention tests,in which the device could remain stable states of programming and erasing even after 1,000 cycles and 1,000 s.The multibit storage could be realized through both different voltage amplitudes and pulse numbers,which could achieve 6 bits(64 distinguishable levels)under pulse width of 50 ns.Furthermore,our memory device also could realize the simulations of synapses in human brain with optical and electric modulations synergistically,such as excitatory post-synaptic current(EPSC),long-term potentiation/depression(LTP/LTD),and spike-timing-dependent plasticity(STDP).Neuromorphic computing was successfully achieved through a high recognition of handwritten digits up to 92.5%after 103 epochs.This research is a promising avenue for the future development of efficient memory and artificial neural network systems. | Jialin Meng Tianyu Wang Zhenyu He Qingxuan Li Hao Zhu Li Ji Lin Chen Qingqing Sun David Wei Zhang | 2022 | Nano Research2022，15，3： | 1 |
| 10 | Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I: C) for enhanced tumoral photodynamic-immunotherapy显示文摘Red blood cell(RBC)-mimicking nanoparticles(NPs) offer a promising platform for drug delivery because of their prolonged circulation time, reduced immunogenicity and specific targeting ability. Herein, we report the design and preparation of RBC membrane-bound NPs(M@AP), for tumoral photodynamic-immunotherapy. The M@AP is formed by self-assembly of the positively charged aggregation-induced emission luminogen(AIEgen)(named P2-PPh3) and the negatively charged polyinosinic : polycytidylic acid(Poly(I : C)), followed by RBC membrane encapsulation. P2-PPh3 is an AIE-active conjugated polyelectrolyte with additional photosensitizing ability for photodynamic therapy(PDT), while Poly(I : C) serves as an immune-stimulant to stimulate both tumor and immune cells to activate immunity, and thus reduces tumor cell viability. When applied in tumor-bearing mice, the M@AP NPs are enriched in both the tumor region as a result of an enhanced permeability and retention(EPR)effect, and the spleen because of the homing effect of the RBC-mimicking shell. Upon light irradiation,P2-PPh3 promotes strong ROS generation in tumor cells, inducing the release of tumor antigens(TA). The anti-tumor immunity is further enhanced by the presence of Poly(I : C) in M@AP. Thus, this strategy combines the PDT properties of the AIE-active polyelectrolyte and immunotherapy properties of Poly(I : C) to achieve synergistic activation of the immune system for anti-tumor activity, providing a novel strategy for tumor treatment. | Jun Dai Meng Wu Quan Wang Siyang Ding Xiaoqi Dong Liru Xue Qingqing Zhu Jian Zhou Fan Xia Shixuan Wang Yuning Hong | 2021 | National Science Review2021，8，6： | 1 |
| 11 | Molecularly imprinted photonic hydrogels for fast screening of atropine in biological samples with high sensitivity显示文摘 | Liang Meng Pinjia Meng Bugang Tang Qingqing Zhang Yanji Wang | 2013 | Forensic Science International (-)2013，，1： | 1 |
| 12 | Leaf Cuticle Microstructure of Machilus maomingensis sp.nov.(Lauraceae) from the Eocene of the Maoming Basin,South China显示文摘Machilus maomingensis Jin et Tang,sp.nov.from the Eocene Youganwo Formation of the Maoming Basin,South China,is studied in detail from the perspective of the leaf architecture and the excellently preserved cuticle.The leaf margin is entire,the primary venation is pinnate;6 to 8secondary veins are present and the major secondary venation is eucamptodromous.Stomata are paracytic and occur on the lower epidermis.Trichome bases are unicellular.Oil cells are present in the upper epidermis.The new fossil species described has features of the Lauraceae,particularly of the extant genus Machilus Rumphius ex Nees,and it is most similar to Machilus chinensis(Bentham)Hemsley,an extant species distributed in southern China and Vietnam.Hence,Machilus maomingensis sp.nov.is inferred to live in a warm and humid climate.The discovery of the present fossil indicates that Machilus has existed in South China from at least the Eocene. | TANG Biao HAN Meng XU Qingqing JIN Jianhua | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 1 |
| 13 | Shigellosis seasonality and transmission characteristics in different areas of China: A modelling study显示文摘Objective:In China,the burden of shigellosis is unevenly distributed,notably across various ages and geographical areas.Shigellosis temporal trends appear to be seasonal.We should clarify seasonal warnings and regional transmission patterns.Method:This study adopted a Logistic model to assess the seasonality and a dynamics model to compare the transmission in different areas.The next-generation matrix was used to calculate the effective reproduction number(Reff)to quantify the transmissibility.Results:In China,the rate of shigellosis fell from 35.12 cases per 100,000 people in 2005 to 7.85 cases per 100,000 people in 2017,peaking in June and August.After simulation by the Logistic model,the‘peak time’is mainly concentrated from mid-June to mid-July.China's‘early warning time’is primarily focused on from April to May.We predict the‘peak time’of shigellosis is the 6.30th month and the‘early warning time’is 3.87th month in 2021.According to the dynamics model results,the water/food transfer pathway has been mostly blocked off.The transmissibility of different regions varies greatly,such as the mean Reff of Longde County(3.76)is higher than Xiamen City(3.15),higher than Chuxiong City(2.52),and higher than Yichang City(1.70).Conclusion:The‘early warning time’for shigellosis in China is from April to May every year,and it may continue to advance in the future,such as the early warning time in 2021 is in mid-March.Furthermore,we should focus on preventing and controlling the personto-person route of shigellosis and stratified deploy prevention and control measures according to the regional transmission. | Zeyu Zhao Meng Yang Jinlong Lv Qingqing Hu Qiuping Chen Zhao Lei Mingzhai Wang Hao Zhang Xiongjie Zhai Benhua Zhao Yanhua Su Yong Chen Xu-Sheng Zhang Jing-An Cui Roger Frutos Tianmu Chen | 2022 | Infectious Disease Modelling2022，7，2： | 1 |
| 14 | Fast screening of ketamine in biological samples based on mo- lecularly imprinted photonic hydrogels 显示文摘 | Meng Liang Meng Pinjia Zhang Qingqing | 2013 | Analytica Chimiea Acta2013，771，： | 1 |
| 15 | Biological evaluation of 2-methylpyrimidine derivatives as active pan Bcr-Abl inhibitors显示文摘We designed a series of 2-methylpyrimidine derivatives as new BCR-ABL inhibitors using scaffold-hopping strategy.These synthetic compounds exhibited significant inhibition against a broad spectrum of Bcr-Abl mutants including the gatekeeper T315I mutant.Compound 7u showed very potent kinase inhibitory activities against Bcr-Abl WT,Bcr-Abl E255K,Bcr-Abl Q252H,Bcr-Abl G250E and Bcr-Abl T315I,with IC50 values of 0.13 nM,0.17 nM,0.24 nM,0.19 nM and 0.65μM,respectively.This compound also displayed anti-proliferation activity against K562 cell line with an IC50 value of 1.1 nM,thus representing a new lead for further optimization. | ZOU DingBiao QIU YaTao TU ZhengChao LIAO ChenZhong LUO JinFeng MENG QingQing YAO RiSheng LI Zheng JIANG Sheng | 2014 | Science China Chemistry2014，57，6： | 0 |
| 16 | Oxygen vacancies effects on phase diagram of epitaxial La1-xSrxMnO3 thin films显示文摘We investigated the effects of oxygen vacancies on the structural,magnetic,and transport properties of La_(1-x)Sr_xMnO_3(x=0.1,0.2,0.33,0.4,and 0.5)grown around a critical point(without/with oxygen vacancies)under low oxygen pressure(10 Pa)and high oxygen pressure(40 Pa).We found that all films exhibit ferromagnetic behavior below the magnetic critical temperature,and that the films grown under low oxygen pressures have degraded magnetic properties with lower Curie temperatures and smaller magnetic moments.These results show that in epitaxial La_(1-x)Sr_xMnO_3 thin films,the magnetic and transport properties are very sensitive to doping concentration and oxygen vacancies.Phase diagrams of the films based on the doping concentration and oxygen vacancies were plotted and discussed. | Qian Wan KuiJuan Jin QingQing Li YaQing Feng Can Wang Chen Ge Meng He HuiBin Lu HaiZhong Guo XiaoLong Li YuPing Yang GuoZhen Yang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 0 |
| 17 | A chromosome-level genome assembly for Erianthus fulvus provides insights into its biofuel potential and facilitates breeding for improvement of sugarcane显示文摘Erianthus produces substantial biomass,exhibits a good Brix value,and shows wide environmental adaptability,making it a potential biofuel plant.In contrast to closely related sorghum and sugarcane,Erianthus can grow in degraded soils,thus releasing pressure on agricultural lands used for biofuel production.However,the lack of genomic resources for Erianthus hinders its genetic improvement,thus limiting its potential for biofuel production.In the present study,we generated a chromosome-scale reference genome for Erianthus fulvus Nees.The genome size estimated by flow cytometry was 937 Mb,and the assembled genome size was 902 Mb,covering 96.26%of the estimated genome size.A total of 35065 proteincoding genes were predicted,and 67.89%of the genome was found to be repetitive.A recent wholegenome duplication occurred approximately 74.10 million years ago in the E.fulvus genome.Phylogenetic analysis showed that E.fulvus is evolutionarily closer to S.spontaneum and diverged after S.bicolor.Three of the 10 chromosomes of E.fulvus formed through rearrangements of ancestral chromosomes.Phylogenetic reconstruction of the Saccharum complex revealed a polyphyletic origin of the complex and a sister relationship of E.fulvus with Saccharum sp.,excluding S.arundinaceum.On the basis of the four amino acid residues that provide substrate specificity,the E.fulvus SWEET proteins were classified as monoand disaccharide sugar transporters.Ortho-QTL genes identified for 10 biofuel-related traits may aid in the rapid screening of E.fulvus populations to enhance breeding programs for improved biofuel production.The results of this study provide valuable insights for breeding programs aimed at improving biofuel production in E.fulvus and enhancing sugarcane introgression programs. | Ling Kui Aasim Majeed Xianhong Wang Zijiang Yang Jian Chen Lilian He Yining Di Xuzhen Li Zhenfeng Qian Yinming Jiao Guoyun Wang Lufeng Liu Rong Xu Shujie Gu Qinghui Yang Shuying Chen Hongbo Lou Yu Meng Linyan Xie Fu Xu Qingqing Shen Amit Singh Karl Gruber Yunbing Pan Tingting Hao Yang Dong Fusheng Li | 2023 | Plant Communications2023，4，4： | 0 |
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