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| 1 | Effectiveness of Jinying capsule on pelvic inflammatory disease in patients with symptom pattern of damp and heat accumulation: a double-blinded, multicenter, randomized, placebo-controlled clinical trial显示文摘OBJECTIVE: To evaluate the therapeutic effectiveness and safety of Jinying capsule on pelvic inflammatory disease(PID) in patients with symptoms identified as the pattern of damp and heat accumulation in terms of Traditional Chinese Medicine(TCM).METHODS: We conducted a double-blinded, multicenter, randomized, placebo-controlled clinical trial which included 155 patients diagnosed with PID and identified as symptom pattern of damp and heat accumulation. They were randomly divided into experimental group(n = 78) and control group(n = 77) according to a random number table. The treatment lasted for a period of 28 d. The experimental group was given Jinying capsules and oral levofloxacin plus oral metronidazole for first 7 d.They continued with Jinying capsules and levofloxacin placebo and metronidazole placebo for another 7 d. For the remaining 14 d, they continued with Jinying capsules only. Whereas, the control group was treated with oral levofloxacin and metronidazole and Jinying capsule placebo for the first 14 d in the same way as the experimental group and then continued with Jinying capsule placebo only for the remaining 14 d. The clinical efficacy was assessed using McCormack scale, TCM symptom pattern scores, physicochemical indexes including white blood cell and erythrocyte sedimentation rate, C-reaction protein, smear of vaginal discharge,and pelvic ultrasound.RESULTS: Comparing McCormack scale between both groups after treatment, the difference in curative effect between both groups was significant (P = 0.0269). The cure rate of the experimental group and control group is 76.32% and 59.46% respectively at week 4. Comparing TCM symptom pattern scores between both groups before and after treatment, the differences in total effective rate were both significant(P < 0.05). The curative effect rate of experimental group is 2.63% and 13.70% of the control group at week 1(P = 0.0131), and73.33% of the experimental group and 56.94% of the control group at week 4(P = 0.0369). No significant differences were found between the two groups on the Physicochemical indexes(all P >0.05). No adverse events or reactions occurred in the experimental groups.CONCLUSION: Jinying capsule can reduce the dosage of antibiotics needed for PID treatment, and improve the symptoms in PID patients. | Yang Yan Lu Yao Zhou Deping Pei Fenglan Li Qin Chen Shuqiong Wang Qiufeng Wang Yanting Jin Zhe Liu Yanxia | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 10 |
| 2 | Integration of QTL detection and marker assisted selection for improving resistance to Fusarium head blight and important agronomic traits in wheat显示文摘Fusarium head blight(FHB), caused by Fusarium graminearum, is one of the most destructive wheat(Triticum aestivum L.) diseases worldwide. Identification of quantitative trait loci(QTL) conferring FHB resistance followed by marker assisted selection(MAS) is an efficient approach to breed FHB-resistant varieties. In this study, 38 additive QTL and 18 pairs of epistatic QTL for FHB resistance were detected in four environments using a population of recombinant inbred lines(RILs) derived from varieties Neixiang 188 and Yanzhan 1. Six QTL clusters were located on chromosomes 2D, 4B, 4D, 5A, 5D and 7B, suggesting possible polytrophic functions. Six elite lines with good FHB resistance and agronomic traits were selected from the same population using the associated markers. Our results suggest that MAS of multiple QTL will be effective and efficient in wheat breeding. | Chao Lv Yanxia Song Lifeng Gao Qin Yao Ronghua Zhou Rugen Xu Jizeng Jia | 2014 | The Crop Journal2014，2，1： | 2 |
| 3 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 4 | Dye-templating nonsurfactant synthesis of mesoporous silica显示文摘 | Xu Yao Cui Yanxia Yang Dongjiang | 2008 | Microporous and Mesoporous Materials2008，109，： | 1 |
| 5 | Wise Use of Wetlands: Current State of Protection and Utilization of Chinese Wetlands and Recommendations for Improvement显示文摘 | Yanxia Wang Yong Yao Meiting Ju | 2008 | Environmental Management2008，，6： | 1 |
| 6 | Core pluripotency factors promote glycolysis of human embryonic stem cells by activating GLUT1 enhancer显示文摘Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulation of glucose transporter 1 (GLUT1, SLC2A1), a key glycolytic gene to maintain pluripotency. By combining the genome-wide data of bin ding sites of the core pluripotency factors (SOX2, OCT4, NANOG, denoted SON), chromosomal interaction and histone modification in hESCs, we identified a potential enhancer of the GLUT1 gene in hESCs, de noted GLUT1 enhancer (GE) element GE interacts with the promoter of GLUT1, and the deletion of GE significantly reduces the expression of GLUT1, glucose uptake and glycolysis of hESCs, confirming that GE is an enhancer of GLUT1 in hESCs. In addition, the mutation of SON binding motifs within GE reduced the expression of GLUT1 as well as the interaction between GE and GLUT1 promoter, indicating that the binding of SON to GE is important for its activity. Therefore, SON promotes glucose uptake and glycolysis in hESCs by inducing GLUT1 expression through directly activating the enhancer of GLUT1. | Lili Yu Kai-yuan Ji Jian Zhang Yanxia Xu Yue Ying Taoyi Mai Shuxiang Xu Qian-bing Zhang Kai-tai Yao Yang Xu | 2019 | Protein & Cell2019，10，9： | 1 |
| 7 | Invasive Insect Fall Webworm Control in China显示文摘Fall webworm is an alien invasive insect pest in China. The control strategies and methods to it for the last two decades in China were briefly reviewed. Because the fall webworm has already adapted to the new habitat in China, some considerable control strategies should be developed. Based on the study of fall webworm in three typical ecological conditions and its special biological characteristic, relative different control strategies and methods were proposed for this invasive pest. | WEI Jianrong YAO Yanxia | 2005 | Chinese Forestry Science and Technology2005，4，4： | 1 |
| 8 | Synthesis and characterization of HCl doped polyaniline grafted multi-walled carbon nanotubes core-shell nano-composite显示文摘 | Xu Jun Yao Pei Wang Yanxia | | 0，，： | 1 |
| 9 | Studies of dielectric properties of rare earth( Dy, Tb, Eu) doped barium titan- ate sintered in pure nitrogen 显示文摘 | Li Yanxia Yao Xi Wang Xusheng | 2012 | Ceramics International2012，38，： | 1 |
| 10 | Synthesis and characterization of HC1 doped polyaniline grafted multi-walled carbon nanotubes core-shell nano-composite显示文摘 | Xu Jun Yao Pei Wang Yanxia | 2009 | Journal of materials science: materials in electronic2009，20，6： | 1 |
| 11 | Comparison of sizing effect of T700 grade carbon fiber on interfacial properties of fiber/BMI and fiber/epoxy显示文摘 | Lirui Yao Min Li Qing Wu Zhishuang Dai Yizhuo Gu Yanxia Li Zuoguang Zhang | 2012 | Applied Surface Science2012，，： | 1 |
| 12 | Photoluminescence and thermal stability of yellow-emitting Pr^(3+) doped CaAl_(2)O_(4) phosphors显示文摘Pr^(3+)-doped CaAl_(2)O_(4) phosphors with broad yellow emission were synthesized by conventional solid-state reaction in air and their structural and luminescent properties were investigated.A pure monoclinic structure can be obtained when the sintering temperature is 1400℃ or above.With photoluminescence(PL)measurement,the excitation was observed at 450–500 nm,which covered the emission of the blue light-emitting diode(LED)chips.Emission of the phosphors showed a green band and a red band.So these phosphors showed great potential in application of warm white LEDs without reabsorption.Additionally,the optimal emission intensity was obtained when Pr doping level was at 0.2 mol%.Furthermore,the Pr-doped CaAl_(2)O_(4) phosphors have the higher quenching temperature.With an increase in temperature,the emission bands of Pr-doped CaAl_(2)O_(4) showed an abnormal blue-shift. | Hua Zou Dengfeng Peng Zhenming Chu Xusheng Wang Yanxia Li Jun-Wei Hou Xi Yao | 2013 | Journal of Advanced Dielectrics2013，3，3： | 1 |
| 13 | Intensive up-conversion photoluminescence of Er^(3+)-doped Bi_(7)Ti_(4)NbO_(21)ferroelectric ceramics and its temperature sensing显示文摘The intensive up-conversion(UC)photoluminescence and temperature sensing behavior of Er3t-doped Bi_(7)Ti_(4)NbO_(21)(BTN)ferroelectric ceramics prepared by a conventional solid-state reaction technique have been investigated.The X-ray diffraction and field emission scanning electron microscope analyses demonstrated that the Er3t-doped BTN ceramics are single phase and uniform flake-like structure.With the Er3t ions doping,the intensive UC emission was observed without obviously changing the properties of ferroelectric.The optimal emission intensity was obtained when Er doping level was 15 mol.%.The temperature sensing behavior was studied by fluorescence intensity ratio(FIR)technique of two green UC emission bands,and the experimental data fitted very well with the function of temperature in a range of 133–573 K.It suggested that the Er3t-doped BTN ferroelectric ceramics are very good candidates for applications such as optical thermometry,electro-optical devices and bio-imaging ceramics. | Hua Zou Jun Li Qiufeng Cao Xusheng Wang Xinwei Hui Yanxia Li Yao Yu Xi Yao | 2014 | Journal of Advanced Dielectrics2014，4，4： | 1 |
| 14 | Trap modification and mechanoluminescence improvement by Si substitution for Sn in Sr_(2)SnO_(4):Sm^(3+) ceramics显示文摘A series of Sr_(1.96)Sn_(1-x)Si_(x)O_(4):0.04Sm^(3+)(x=0,0.1,0.15,_(0.2),0.3,0.4)were synthesized from solid-state reaction.The mechanoluminescence(ML)performance of Sr_(1.96)SnO_(4):0.04Sm^(3+)was greatly enhanced by partial Si^(4+)substitution for Sn^(4+),and the sample of Sr_(1.96)Sn_(0.8)Si_(0.2)O_(4):0.04Sm^(3+)showed weaker afterglow and twice stronger ML intensity than that in Sr_(1.96) SnO_(4):0.04Sm^(3+).The stress response of Sr_(1.96)Sn_(0.8)Si_(0.2)O_(4):0.04Sm^(3+)ranged from 250 to 1200 N,and its linearity was greatly restored.Particularly,it was very sensitive in the minimal stress response range.These properties of no load threshold for stress sensing and weak afterglow make Sr_(1.96)Sn_(0.8)Si_(0.2)O_(4):0.04Sm^(3+)superior to other excellent ML materials.The introduction of Si^(4+)caused lattice distortion and promoted defect formation in the system.The trap level energy greatly increased and the trap depth changed,which enhanced the trap ability and therefore improved effectively the ML properties. | Hua Fang Gaojian Qiu Xusheng Wang Yanxia Li Xi Yao | 2018 | Journal of Advanced Dielectrics2018，8，3： | 0 |
| 15 | Continuous cropping of alfalfa (Medicago sativa L.) reduces bacterial diversity and simplifies cooccurrence networks in aeolian sandy soil显示文摘Alfalfa is a perennial herbaceous forage legume that is remarkably and negatively affected by monocropping.However,the contribution of the changes in bacterial communities to soil sickness in alfalfa have not been elucidated.Therefore,we investigated bacterial community structures in response to monocropped alfalfa along the chronosequence.Continuous cropping remarkably reduced bacterial alpha diversity and altered community structures,and soil pH,total P and available P were strongly associated with the changes of bacterial diversity and community structures.Intriguingly,10 years of monocropped alfalfa might be a demarcation point separating soil bacterial community structures into two obvious groups that containing soil samples collected in less and more than 10 years.The relative abundances of copiotrophic bacteria of Actinobacteria and Gammaproteobacteria significantly increased with the extension of continuous cropping years,while the oligotrophic bacteria of Armatimonadetes,Chloroflexi,Firmicutes and Gemmatimonadetes showed the opposite changing patterns.Among those altered phyla,Actinobacteria,Chloroflexi,Alphaproteobacteria and Acidobacteria were the most important bacteria which contributed 50.86%of the community variations. Additionally, the relative abundances of nitrogen fixation bacteria ofBradyrhizobium and Mesorhizobium obviously increased with continuous cropping years, while theabundances of Arthrobacter, Bacillus, Burkholderiaceae and Microbacterium with potential functionsof solubilizing phosphorus and potassium remarkably decreased after long-term continuouscropping. Furthermore, bacterial cooccurrence patterns were significantly influenced by continuouscropping years, with long-term monocropped alfalfa simplifying the complexity of the cooccurrencenetworks. These findings enhanced our understandings and provided references for forecasting howsoil bacterial communities responds to monocropped alfalfa. | Yanxia Xu Junjie Liu Xuefeng Liu Hong Li Zhao Yang Hongbao Wang Xinyu Huang Lan Lan Yutong An Lujun Li Qin Yao Guanghua Wang | 2022 | Soil Ecology Letters2022，4，2： | 0 |
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