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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Electrochemical synthesis of nitric acid from air and ammonia through waste utilization显示文摘Commercial nitric acid(HNO3) and ammonia(NH3) are mostly produced through the Ostwald process and the Haber-Bosch process, respectively. However, high energy demand and enormous greenhouse gas accompy these processes. The development of economical and green ways to synthesize HNO3 and NH3 is highly desirable for solving the global energy and environmental crisis. Here, we present two energy-efficient and environmentally friendly strategies to synthesize HNO3 and NH3 at distributed sources, including the electrocatalytic oxidation of N2 in air to HNO3 and the electrocatalytic reduction of residual NO3- contamination in water to NH3. The isotope-labeling studies combined with theoretical calculation reveal the reaction path of the two proposed strategies, confirming the origin of the electrochemical products. Importantly, the electrooxidation-generated NO3- ions may also serve as reactants for the electroreduction synthesis of NH3 in the future. Our work may open avenues for energy-efficient and green production of HNO3 and NH3 at distributed sources. | Yuting Wang Yifu Yu Ranran Jia Chao Zhang Bin Zhang | 2019 | National Science Review2019，6，4： | 10 |
| 3 | Dendrite-free all-solid-state lithium batteries with lithium phosphorous oxynitride-modified lithium metal anode and composite solid electrolytes显示文摘Dendrite formation on lithium (Li) metal anode is a key issue which hinders the development of rechargeable Li battery seriously. A novel method for suppress!ng Li dendrites via using Li phosphorous oxynitride (UPON) modified Li anode and Li1.5Al0.5Ge1.5(PO4)3-poly(ethylene oxide)(Li bistrifluoromethane-sulfonimide)(LAGP-PEO(LiTFSI)) composite solid electrolyte in all-solid-state Li battery is proposed, and the effect of the thickness of UPON on Li anode performarice is also studied. LiPON film with a thickness of 500 nm exhibits satisfactory interface property between Li metal anode and the LAGP-PEO(LiTFSI) solid electrolyte. The LiPON film provides a uniform Li^+ flux across the interface and effectively inhibits the formation of Li dendrites in all-solid-state Li batteries. The assembled all-solid-state Li cell Li(LiPON)/LAGP-PEO(LiTFSI)/LiFePO4 delivers an initial discharge capacity of 152.4 mAh·g^-1 and exhibits good cycling stability and rate performanee at 50 ℃. | Chunhua Wang Guoliang Bai Yifu Yang Xingjiang Liu Huixia Shao | 2019 | Nano Research2019，12，1： | 8 |
| 4 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 5 | Seventy Years of Economic Development: A Review from the Angle of New Structural Economics显示文摘This review paper provides a new narrative by combing through the experiences of structural transformation among developing countries and discussing the roles of government and market in different contexts.Country performance has been influenced by the prevailing development thinking:the structuralism in the 1950s-1970s,which stresses an active government's role to overcome market failures for industrialization,and the neoliberalism in the 1980s-present,which advocates for eliminating government failures to build up a well-functioning market.We find that almost all countries failing by following structuralism in their industrialization and neoliberalism in their transition to a market economy,and the few countries successful in catching up have a few characteristics that go against the prevailing structuralism and neoliberalism.The new structural economics,generated from the experiences of successful East Asian economies and proposing active facilitating roles of government in a market economy to remove market failures,will gain traction and take root. | Justin Yifu Lin Yan Wang | 2020 | China & World Economy2020，28，4： | 7 |
| 6 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 7 | Refined chronology of prehistoric cultures and its implication for re-evaluating human-environment relations in the Hexi Corridor,northwest China显示文摘The reconstruction of high-resolution chronologies for prehistoric cultures is a prerequisite for understanding the history of human evolution and its relationship with environmental change, and is valuable for exploring the trajectory of transcontinental cultural exchanges in prehistoric time. The Hexi Corridor of northwest China was one of the earliest centers for long-distance culture exchange in the prehistoric world. The timing and sequence of cultural changes in this area remains poorly understood resulting from the lack of radiometric age control. This paper presents a refined radiocarbon(14 C) chronology to resolve the timing of human occupation and cultural evolution in the Hexi Corridor. Radiocarbon dating of crop remains, which have an annual life cycle, has the advantage of eliminating problems such as the carbon stored in ‘old wood’. As a result,14C dates from crop remains are used to test the validity of the14C dates derived from charcoal, bone and plant remains. The resultant database of ages is modelled using the Bayesian approach. The updated chronology presented in this paper shows generally good agreement with the original dates used to constrain cultural evolution in the Hexi Corridor. However, the occupation of the corridor by the Shajing and Shanma Late Bronze Age-Early Iron Age cultures appears to have taken place ~300 years later than previously thought. On the basis of comparing this updated chronology of cultural evolution with palaeoclimatic and historical records, it is proposed that the collapse of the Shajing and Shanma cultures occurred as a result of geopolitical impact rather than climate change. | Yishi YANG Shanjia ZHANG Chris OLDKNOW Menghan QIU Tingting CHEN Haiming LI Yifu CUI Lele REN Guoke CHEN Hui WANG Guanghui DONG | 2019 | Science China Earth Sciences2019，62，10： | 5 |
| 8 | 细胞学方法治疗缺血性心脏病的新进展显示文摘尽管缺血性心脏病在防治手段,介入治疗方面有了很大的进展,但是缺血性心脏病仍然是世界上导致患者死亡最多的疾病之一.为了使缺血性心脏病患者心肌梗死部位心肌再生,研究人员尝试了多种物理治疗方法[1-3],如移植乳内动脉到坏死部位的心肌组织[4],或是应用药物治疗,如肝素[2],血管内皮生长因子(VEGF),肝素结合生长因子1和碱性成纤维细胞生长因子[7-10]. | Yifu Zhou Suna Wang Bogdan Kindzelski Keith A Horvath 程斌 黄益民 | 2014 | 心肺血管病杂志2014，33，6： | 4 |
| 9 | Diversity Analysis of Chlorophyll, Flavonoid, Anthocyanin, and Nitrogen Balance Index of Tea Based on Dualex显示文摘The chemical compositions of tea(Camellia sinensis)are affected by numerous factors,such as cultivar,climate,leaf position,and cultivation pattern.However,under the same conditions,the chemical compositions are mainly determined by varieties.Therefore,we investigated the genetic diversity of chemical compositions of tea tree resources in China to screen excellent germplasm resources.Three chemical compositions index(including chlorophyll index,flavonoid index,and anthocyanin index)and the nitrogen balance index of tea leaves were measured in 102 tea germplasms planted in Chinese Tea Plants Improved Variety Germplasm Resources Nursery(CTPIVGRN)by Dualex on April 152019.Results showed that the chlorophyll,flavonoid,and anthocyanin contents and the nitrogen balance index significantly differed between the 102 tea germplasms.The genetic diversity index values were 2.005,2.246,1.599,and 1.838,and the average genetic diversity was 1.922.The 102 tea germplasms can be divided into four categories by cluster analysis under the genetic distance threshold of 11.These results suggest that the genetic diversity of tea germplasm resources in China is rich.This study’s results can serve as a basis for the diversified development and utilization of tea plant. | Yifu Liu Jiazhen Wang Yao Xiao Xiongwen Shi Yixia Zeng | 2021 | Phyton-International Journal of Experimental Botany2021，90，5： | 4 |
| 10 | STRUCTURAL TRANSFORMATION AND ITS REVERSIBILITY IN LIQUID Al-13%Si ALLOY AT HIGH TEMPERATURES显示文摘STRUCTURALTRANSFORMATIONANDITSREVERSIBILITYINLIQUIDAl13%SiALLOYATHIGHTEMPERATURES①WangWeimin,BianXiufang,QinJingyuandYeYifuC... | Wang Weimin Bian Xiufang Qin Jingyu Ye Yifu S.I.Sljusarenko | 1998 | 中国有色金属学会会刊:英文版1998，8，2： | 3 |
| 11 | Single‑Atom Catalysts:Advances and Challenges in Metal‑Support Interactions for Enhanced Electrocatalysis显示文摘Single-atom catalysts(SACs),which contain a single metal atom supported on a well-confined substrate,are among the most promising heterogeneous catalysts owing to their unique advantages,such as high intrinsic activity and selectivity,tunable bonds and coordination,abundant metal-containing active sites,and atomic economy.Since metal-support interactions(MSIs)in SACs exert a substantial influence on the catalytic properties,gaining a profound understanding and recognition of catalytic reactions depends greatly on investigating MSIs both experimentally and computationally.Hence,the engineer-ing and modulation of MSIs are regarded as one of the most efficient methods to rationally design SACs with disruptively enhanced catalytic properties.In this review,we track the recent advances in SACs from an MSI perspective.We then discuss the existing MSIs in SACs and elucidate the significant role of strong MSIs in catalytic properties and mechanisms.The chal-lenges hindering the rational design of supported SACs with strong MSIs,which are currently still far from being completely understood and overcome,are described.In addition,the correlation between strong MSIs and electrocatalytic activities in SACs,including an outlook to increase our understanding of MSIs,is discussed.Finally,the present review provides some perspectives and an in-depth understanding of strong MSIs to advance high-performing SACs. | Yang Mu Tingting Wang Jian Zhang Changgong Meng Yifu Zhang Zongkui Kou | 2022 | Electrochemical Energy Reviews2022，5，1： | 3 |
| 12 | Space- and ground-based CO_2 measurements: A review显示文摘The climate warming is mainly due to the increase in concentrations of anthropogenic greenhouse gases, of which CO_2 is the most important one responsible for radiative forcing of the climate. In order to reduce the great estimation uncertainty of atmospheric CO_2 concentrations, several CO_2-related satellites have been successfully launched and many future greenhouse gas monitoring missions are planned. In this paper, we review the development of CO_2 retrieval algorithms, spatial interpolation methods and ground observations. The main findings include: 1) current CO_2 retrieval algorithms only partially account for atmospheric scattering effects; 2) the accurate estimation of the vertical profile of greenhouse gas concentrations is a long-term challenge for remote sensing techniques; 3) ground-based observations are too sparse to accurately infer CO_2 concentrations on regional scales; and 4) accuracy is the primary challenge of satellite estimation of CO_2 concentrations. These findings, taken as a whole, point to the need to develop a high accuracy method for simulation of carbon sources and sinks on the basis of the fundamental theorem of Earth's surface modelling, which is able to efficiently fuse space- and ground-based measurements on the one hand and work with atmospheric transport models on the other hand. | YUE TianXiang ZHANG LiLi ZHAO MingWei WANG YiFu John WILSON | 2016 | Science China Earth Sciences2016，59，11： | 2 |
| 13 | Promoting selective electroreduction of nitrates to ammonia over electron-deficient Co modulated by rectifying Schottky contacts显示文摘Developing efficient electrocatalysts for selective nitrate contamination reduction into value-added ammonia is significant.Here,heterostructured Co/CoO nanosheet arrays(Co/CoO NSAs)exhibited excellent Faradaic efficiency(93.8%)and selectivity(91.2%)for nitrate electroreduction to ammonia,greatly outperforming Co NSAs.15N isotope labeling experiments and 1H nuclear magnetic resonance(NMR)quantitative testing methods confirmed the origin of the produced ammonia.Electrochemical in situ Fourier transform infrared(FTIR)spectroscopy,online differential electrochemical mass spectrometry(DEMS)data and density functional theory(DFT)results revealed that the superior performances arose from the electron deficiency of Co induced by the rectifying Schottky contact in the Co/CoO heterostructures.The electron transfer from Co to CoO at the interface could not only suppress the competitive hydrogen evolution reaction,but also increase energy barriers for by-products,thus leading to high Faradaic efficiency and selectivity of ammonia. | Yu Yu Changhong Wang Yifu Yu Yuting Wang Bin Zhang | 2020 | Science China Chemistry2020，63，10： | 2 |
| 14 | Adsorption desulfurization of model gasoline by metal–organic framework Ni3(BTC)2显示文摘This work presented the synthesis of Ni-based metal-organic framework material with a paddle-wheel structure Ni3(BTC)2 (Ni-BTC) and its application in thiophene (TP) adsorption from gasoline distillate by batch method. Adsorption isotherms of TP, cyclohexene, and toluene in cyclohexane onto Ni-BTC were conducted at 298-308 K to interpret the different effect of cyclohexene and toluene on TP adsorption. The results showed that, compared w让h cyclohexene, toluene addition in model gasoline led to a more evident decline in sulfur capacity of Ni-BTC, which is opposite to isostructural HKUST-1. The adsorption isotherms of TP, cyclohexene and toluene fit Langmuir model, S-type model and Temkin model well, respectively, indicating that the adsorption mechanisms of TP and the two competitors are different from one another The adsorption capacities on Ni-BTC followed the order of cyclohexene < toluene < TP at the same equilibrium concentrations, implying the order of the adsorption affinities, which is in good agreement with the different extent of influence by the two competitors. The enthalpy of TP adsorption on Ni-BTC was estimated to be -80.01 kj/mol, almost twice that on HKUST-1. The poor reusability of Ni-BTC in batch experiment, which is owing to its sensitivity to the air, can be prevented from regenerating used Ni-BTC in fixed-bed reactor by N2 flow. The difference between Ni-BTC and HKUST-1 in maximum adsorption capacity (q0),△H of TP adsorption, and stability demonstrates that the central metal in isostructural MOFs plays a key role in adjusting the desulfurization performance, which may open up a potential avenue for the development of MOF-based adsorbents with superior desulfurization performance. | Fuping Tian Qiaofeng Ru Chenxia Qiao Xin Sun Cuiying Jia Yu Wang Yifu Zhang | 2019 | Journal of Energy Chemistry2019，28，5： | 2 |
| 15 | Promoting nitric oxide electroreduction to ammonia over electron-rich Cu modulated by Ru doping显示文摘Electrocatalytic nitric oxide(NO)reduction is a promising strategy to produce ammonia.Developing a facile approach to synthesize efficient catalysts with enhanced NO electroreduction performance is highly desirable.Here,a series of Ru-doped Cu materials are constructed through in situ electroreduction of corresponding metal hydroxides.The optimized Ru_(0.05)Cu_(0.95)exhibits superior electrocatalytic performance for ammonia synthesis by using NO/Ar(1/4,n/n)as the feedstocks(Faradaic efficiency:64.9%,yield rate:17.68μmol cm^(-2)h^(-1)),obviously outperforming Cu counterpart(Faradaic efficiency:33.0%,yield rate:5.73μmol cm^(-2)h^(-1)).Electrochemical in situ Fourier transform infrared(FTIR)spectroscopy and online differential electrochemical mass spectrometry(DEMS)are adopted to detect intermediates and unveil the possible reaction pathway.The downshift of the Cu d-band center induced by Ru doping facilitates the rate-limiting hydrogenation step and decreases the desorption energy of NH_(3),leading to high Faradaic efficiency and yield of ammonia. | Jiangwei Shi Changhong Wang Rong Yang Fanpeng Chen Nannan Meng Yifu Yu Bin Zhang | 2021 | Science China Chemistry2021，64，9： | 2 |
| 16 | The metabolism of soluble carbohydrates related to chilling injury in peach fruit exposed to cold stress显示文摘 | Ke Wang Xingfeng Shao Yifu Gong Yong Zhu Hongfei Wang Xinglong Zhang Dandan Yu Fang Yu Ziyun Qiu Hao Lu | 2013 | Postharvest Biology and Technology2013，，： | 1 |
| 17 | Minimal wave speed in a diffusive epidemic model with temporal delay显示文摘 | Guosheng Zhang Yifu Wang | 2007 | Applied Mathematics and Computation2007，188，1： | 1 |
| 18 | Industrial Dynamics, Endowment Structure and Economic Growth 显示文摘 | Ju Jiandong Lin Justin Yifu Wang Yong | 2015 | Journal of Money Economics2015，，： | 1 |
| 19 | Association of GSTM1,CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma:A casecontrol study in Chinese population显示文摘 | Jingwen Wang Yifu Deng Li Li | 2003 | Cancer Sci2003，94，5： | 1 |
| 20 | Enhanced electrochemical performance of unique morphological LiMn- PO4/C cathode material prepared by solvothermal method 显示文摘 | Wang Yourong Yang Yifu Yang Yanbao | 2010 | Solid State Comm2010，150，81： | 1 |
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