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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Dendrite-free all-solid-state lithium batteries with lithium phosphorous oxynitride-modified lithium metal anode and composite solid electrolytes显示文摘Dendrite formation on lithium (Li) metal anode is a key issue which hinders the development of rechargeable Li battery seriously. A novel method for suppress!ng Li dendrites via using Li phosphorous oxynitride (UPON) modified Li anode and Li1.5Al0.5Ge1.5(PO4)3-poly(ethylene oxide)(Li bistrifluoromethane-sulfonimide)(LAGP-PEO(LiTFSI)) composite solid electrolyte in all-solid-state Li battery is proposed, and the effect of the thickness of UPON on Li anode performarice is also studied. LiPON film with a thickness of 500 nm exhibits satisfactory interface property between Li metal anode and the LAGP-PEO(LiTFSI) solid electrolyte. The LiPON film provides a uniform Li^+ flux across the interface and effectively inhibits the formation of Li dendrites in all-solid-state Li batteries. The assembled all-solid-state Li cell Li(LiPON)/LAGP-PEO(LiTFSI)/LiFePO4 delivers an initial discharge capacity of 152.4 mAh·g^-1 and exhibits good cycling stability and rate performanee at 50 ℃. | Chunhua Wang Guoliang Bai Yifu Yang Xingjiang Liu Huixia Shao | 2019 | Nano Research2019，12，1： | 8 |
| 3 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 4 | Wet-chemistry synthesis of cobalt carbide nanoparticles as highly active and stable electrocatalyst for hydrogen evolution reaction显示文摘转变金属碳化物(TMC ) nanomaterials 正在答应选择到磅,并且广泛地为电气化学的氢进化反应被用作异构的 electrocatalysts (她的) 。在这个工作,综合的导致溴化物的湿化学的策略公司 2 C nanoparticles (NP ) 被开发。如此的 NP 展出了高 electrocatalytic 活动(= 为 j = 的 181 mV 10 | Siwei Li Ce Yang Zhen Yin Hanjun Yang Yifu Chen Lili Lin Mengzhu Li Weizhen Li Gang HU Ding Ma | 2017 | Nano Research2017，10，4： | 7 |
| 5 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 6 | Adipose tissue macrophage in immune regulation of metabolism显示文摘The prevalence of obesity and type 2 diabetes is escalating to an epidemic proportion worldwide.Obesity is known to be associated with a state of chronic,low-grade inflammation.Emerging lines of evidence have shown that both innate and adaptive immune responses play crucial roles in the control of metabolic homeostasis.Macrophages in adipose tissues are the essential effector cells in orchestrating metabolic inflammation,which is thought to promote the pathogenic progression of obesity and obesity-related disorders.Here we discuss our current understanding of the distinct modes of activation of adipose tissue macrophages,which can sense the metabolic cues and exert profound effects upon adipose homeostasis.Targeting macrophages in adipose tissues may provide new avenues for developing immunomodulation-based therapeutics against obesity and obesity-associated metabolic diseases. | Yifu Qiu Bo Shan Liu Yang Yong Liu | 2016 | Science China(Life Sciences)2016，59，12： | 6 |
| 7 | Refined chronology of prehistoric cultures and its implication for re-evaluating human-environment relations in the Hexi Corridor,northwest China显示文摘The reconstruction of high-resolution chronologies for prehistoric cultures is a prerequisite for understanding the history of human evolution and its relationship with environmental change, and is valuable for exploring the trajectory of transcontinental cultural exchanges in prehistoric time. The Hexi Corridor of northwest China was one of the earliest centers for long-distance culture exchange in the prehistoric world. The timing and sequence of cultural changes in this area remains poorly understood resulting from the lack of radiometric age control. This paper presents a refined radiocarbon(14 C) chronology to resolve the timing of human occupation and cultural evolution in the Hexi Corridor. Radiocarbon dating of crop remains, which have an annual life cycle, has the advantage of eliminating problems such as the carbon stored in ‘old wood’. As a result,14C dates from crop remains are used to test the validity of the14C dates derived from charcoal, bone and plant remains. The resultant database of ages is modelled using the Bayesian approach. The updated chronology presented in this paper shows generally good agreement with the original dates used to constrain cultural evolution in the Hexi Corridor. However, the occupation of the corridor by the Shajing and Shanma Late Bronze Age-Early Iron Age cultures appears to have taken place ~300 years later than previously thought. On the basis of comparing this updated chronology of cultural evolution with palaeoclimatic and historical records, it is proposed that the collapse of the Shajing and Shanma cultures occurred as a result of geopolitical impact rather than climate change. | Yishi YANG Shanjia ZHANG Chris OLDKNOW Menghan QIU Tingting CHEN Haiming LI Yifu CUI Lele REN Guoke CHEN Hui WANG Guanghui DONG | 2019 | Science China Earth Sciences2019，62，10： | 5 |
| 8 | Transition prediction and sensitivity analysis for a natural laminar flow wing glove flight experiment显示文摘Natural laminar flow technology can significantly reduce aircraft aerodynamic drag and has excellent technical appeal for transport aircraft development with high aerodynamic efficiency.Accurately and efficiently predicting the laminar-to-turbulent transition and revealing the maintenance mechanism of laminar flow in a transport aircraft’s flight environment are significant for developing natural laminar flow wings.In this research,we carry out natural laminar flow flight experiments with different Reynolds numbers and angles of attack.The critical N-factor is calibrated as 9.0 using flight experimental data and linear stability theory from a statistical perspective,which makes sure that the relative error of transition location is within 5%.We then implement a simplified e^(N) transition prediction method with a similar accuracy compared with linear stability theory.We compute the sensitivity information for the simplified eN method with an adjointbased method,using the automatic differentiation technique(ADjoint).The impact of Reynolds numbers and pressure distributions on TS waves is analyzed using the sensitivity information.Through the sensitivity analysis,we find that:favorable pressure gradients not only suppress the development of TS waves but also decrease their sensitivity to Reynolds numbers;there exist three special regions which are very sensitive to the pressure distribution,and the sensitivity decreases as the local favorable pressure gradient increases.The proposed sensitivity analysis method enables robust natural laminar flow wings design. | Tihao YANG Hai ZHONG Yifu CHEN Yayun SHI Junqiang BAI Feifei QIN | 2021 | Chinese Journal of Aeronautics2021，34，8： | 5 |
| 9 | Probing primordial gravitational waves: Ali CMB Polarization Telescope显示文摘In this paper, we will give a general introduction to the Ali CMB Polarization Telescope(Ali CPT) project,which is a Sino–US joint project led by the Institute of High Energy Physics and involves many different institutes in China. It is the first ground-based Cosmic Microwave Background(CMB) polarization experiment in China and an integral part of China's Gravitational-wave Program. The main scientific goal of the Ali CPT project is to probe the primordial gravitational waves(PGWs) originating from the very early Universe. The AliCPT project includes two stages. The first stage, referred to as AliCPT-1, is to build a telescope in the Ali region of Tibet at an altitude of 5250 meters. Once completed, it will be the highest ground-based CMB observatory in the world and will open a new window for probing PGWs in the northern hemisphere. The AliCPT-1 telescope is designed to have about 7000 transition-edge sensor detectors at 95 GHz and 150 GHz. The second stage is to have a more sensitive telescope(Ali CPT-2) with more than 20 000 detectors. Our simulations show that AliCPT will improve the current constraint on the tensor-to-scalar ratio r by one order of magnitude with three years' observation. Besides the PGWs, Ali CPT will also enable a precise measurement of the CMB rotation angle and provide a precise test of the CPT symmetry. We show that three years' observation will improve the current limit by two orders of magnitude. | Hong Li Si-Yu Li Yang Liu Yong-Ping Li Yifu Cai Mingzhe Li Gong-Bo Zhao Cong-Zhan Liu Zheng-Wei Li He Xu Di Wu Yong-Jie Zhang Zu-Hui Fan Yong-Qiang Yao Chao-Lin Kuo Fang-Jun Lu Xinmin Zhang | 2019 | National Science Review2019，6，1： | 4 |
| 10 | Single‑Atom Catalysts:Advances and Challenges in Metal‑Support Interactions for Enhanced Electrocatalysis显示文摘Single-atom catalysts(SACs),which contain a single metal atom supported on a well-confined substrate,are among the most promising heterogeneous catalysts owing to their unique advantages,such as high intrinsic activity and selectivity,tunable bonds and coordination,abundant metal-containing active sites,and atomic economy.Since metal-support interactions(MSIs)in SACs exert a substantial influence on the catalytic properties,gaining a profound understanding and recognition of catalytic reactions depends greatly on investigating MSIs both experimentally and computationally.Hence,the engineer-ing and modulation of MSIs are regarded as one of the most efficient methods to rationally design SACs with disruptively enhanced catalytic properties.In this review,we track the recent advances in SACs from an MSI perspective.We then discuss the existing MSIs in SACs and elucidate the significant role of strong MSIs in catalytic properties and mechanisms.The chal-lenges hindering the rational design of supported SACs with strong MSIs,which are currently still far from being completely understood and overcome,are described.In addition,the correlation between strong MSIs and electrocatalytic activities in SACs,including an outlook to increase our understanding of MSIs,is discussed.Finally,the present review provides some perspectives and an in-depth understanding of strong MSIs to advance high-performing SACs. | Yang Mu Tingting Wang Jian Zhang Changgong Meng Yifu Zhang Zongkui Kou | 2022 | Electrochemical Energy Reviews2022，5，1： | 3 |
| 11 | Microvascular endothelial cells derived from spinal cord promote spinal cord injury repair显示文摘Neural regeneration after spinal cord injury (SCI) closely relates to the microvascular endothelial cell (MEC)- mediated neurovascular unit formation. However, the effects of central nerve system-derived MECs on neovascularization and neurogenesis, and potential signaling involved therein, are unclear. Here, we established a primary spinal cord-derived MECs (SCMECs) isolation with high cell yield and purity to describe the differences with brain-derived MECs (BMECs) and their therapeutic effects on SCI. Transcriptomics and proteomics revealed differentially expressed genes and proteins in SCMECs were involved in angiogenesis, immunity, metabolism, and cell adhesion molecular signaling was the only signaling pathway enriched of top 10 in differentially expressed genes and proteins KEGG analysis. SCMECs and BMECs could be induced angiogenesis by different stiffness stimulation of PEG hydrogels with elastic modulus 50-1650 Pa for SCMECs and 50-300 Pa for BMECs, respectively. Moreover, SCMECs and BMECs promoted spinal cord or brain-derived NSC (SNSC/BNSC) proliferation, migration, and differentiation at different levels. At certain dose, SCMECs in combination with the NeuroRegen scaffold, showed higher effectiveness in the promotion of vascular reconstruction. The potential underlying mechanism of this phenomenon may through VEGF/AKT/eNOS- signaling pathway, and consequently accelerated neuronal regeneration and functional recovery of SCI rats compared to BMECs. Our findings suggested a promising role of SCMECs in restoring vascularization and neural regeneration. | Zhifeng You Xu Gao Xinyi Kang Wen Yang Tiandi Xiong Yue Li Feng Wei Yan Zhuang Ting Zhang Yifu Sun He Shen Jianwu Dai | 2023 | Bioactive Materials2023，，11： | 2 |
| 12 | Promoting nitric oxide electroreduction to ammonia over electron-rich Cu modulated by Ru doping显示文摘Electrocatalytic nitric oxide(NO)reduction is a promising strategy to produce ammonia.Developing a facile approach to synthesize efficient catalysts with enhanced NO electroreduction performance is highly desirable.Here,a series of Ru-doped Cu materials are constructed through in situ electroreduction of corresponding metal hydroxides.The optimized Ru_(0.05)Cu_(0.95)exhibits superior electrocatalytic performance for ammonia synthesis by using NO/Ar(1/4,n/n)as the feedstocks(Faradaic efficiency:64.9%,yield rate:17.68μmol cm^(-2)h^(-1)),obviously outperforming Cu counterpart(Faradaic efficiency:33.0%,yield rate:5.73μmol cm^(-2)h^(-1)).Electrochemical in situ Fourier transform infrared(FTIR)spectroscopy and online differential electrochemical mass spectrometry(DEMS)are adopted to detect intermediates and unveil the possible reaction pathway.The downshift of the Cu d-band center induced by Ru doping facilitates the rate-limiting hydrogenation step and decreases the desorption energy of NH_(3),leading to high Faradaic efficiency and yield of ammonia. | Jiangwei Shi Changhong Wang Rong Yang Fanpeng Chen Nannan Meng Yifu Yu Bin Zhang | 2021 | Science China Chemistry2021，64，9： | 2 |
| 13 | Electrochemical reduction of oxygen on small palladium particles supported on carbon in alkaline solution显示文摘 | Yang Yifu Zbou Yunhong Cha C S | 1995 | Electrochimica Acta1995，40，16： | 1 |
| 14 | Particle size effectg for oxygen reduction on dispersed silver + carbon electrodes in alkaline solution显示文摘 | Yang Yifu Zhou Yunhong | 1995 | J Electroanalytical Chemistry1995，397，12： | 1 |
| 15 | Enhanced electrochemical performance of unique morphological LiMn- PO4/C cathode material prepared by solvothermal method 显示文摘 | Wang Yourong Yang Yifu Yang Yanbao | 2010 | Solid State Comm2010，150，81： | 1 |
| 16 | Food Availability,Enti-tlements and the Chinese Famine of 1959-61显示文摘 | | 2000 | The Eco-nomic Journal2000，，： | 1 |
| 17 | Maltiphcity results for some second-order four-point boundary value problems显示文摘 | BAI Zhanbing GE Weigao YANG Yifu | 2005 | Nonlinear Anal2005，60，： | 1 |
| 18 | Journal of Alloys and Compounds显示文摘 | Wang Yourong Yang Yifu Shao Huixia | 2009 | 481:5902009，481，： | 1 |
| 19 | Study on the surface reaction of LaNi5 alloy during discharge process in KOH solution 显示文摘 | Tan Zuxian Yang Yifu Jiang Fengshan | 2006 | Electrochimica Acta2006，52，1： | 1 |
| 20 | Particle size effects for oxygen reduction on dispersed silver + carbon electrodes in alkaline solution显示文摘 | YANG Yifu ZHOU Yunhong | 1995 | Journal of electroanalytical chemistry1995，397，： | 1 |
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