|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes显示文摘 | Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui | 2016 | Cell Research2016，26，2： | 31 |
| 2 | Objective assessment of bradykinesia in Parkinson’s disease using evolutionary algorithms:clinical validation显示文摘Background:There is an urgent need for developing objective,effective and convenient measurements to help clinicians accurately identify bradykinesia.The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping(FT)that uses evolutionary algorithms(EAs)and explore whether it can be used to identify early stage Parkinson’s disease(PD).Methods:One hundred and seven PD,41 essential tremor(ET)patients and 49 normal controls(NC)were recruited.Participants performed a standard FT task with two electromagnetic tracking sensors attached to the thumb and index finger.Readings from the sensors were transmitted to a tablet computer and subsequently analyzed by using EAs.The output from the device(referred to as'PD-Monitor')scaled from−1 to+1(where higher scores indicate greater severity of bradykinesia).Meanwhile,the bradykinesia was rated clinically using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale(MDS-UPDRS)FT item.Results:With an increasing MDS-UPDRS FT score,the PD-Monitor score from the same hand side increased correspondingly.PD-Monitor score correlated well with MDS-UPDRS FT score(right side:r=0.819,P=0.000;left side:r=0.783,P=0.000).Moreover,PD-Monitor scores in 97 PD patients with MDS-UPDRS FT bradykinesia and each PD subgroup(FT bradykinesia scored from 1 to 3)were all higher than that in NC.Receiver operating characteristic(ROC)curves revealed that PD-Monitor FT scores could detect different severity of bradykinesia with high accuracy(≥89.7%)in the right dominant hand.Furthermore,PD-Monitor scores could discriminate early stage PD from NC,with area under the ROC curve greater than or equal to 0.899.Additionally,ET without bradykinesia could be differentiated from PD by PD-Monitor scores.A positive correlation of PD-Monitor scores with modified Hoehn and Yahr stage was found in the left hand sides.Conclusions:Our study demonstrated that a simple to use device employing classifiers derived from EAs could not only be used to accurately measure different severity of bradykinesia in PD,but also had the potential to differentiate early stage PD from normality. | Chao Gao Stephen Smith Michael Lones Stuart Jamieson Jane Alty Jeremy Cosgrove Pingchen Zhang Jin Liu Yimeng Chen Juanjuan Du Shishuang Cui Haiyan Zhou Shengdi Chen | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 3 | Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening显示文摘由系特定的抄写因素的表示的系变换是改变那的 epigenetic 的进程有低效率。一个房间由抵抗系变换的机制大部分是未知的。使用肝特定的抄写因素 Foxa3, Hnf1 和 Gata4 (3TF ) 在老鼠成纤维细胞导致肝的变换,我们证明 3TF 导致了 ATM-p53 小径的强壮的激活,它导致了增长拘捕和房间死亡,和它进一步阻止了肝的变换。尤其是, ATM 激活,独立于 DNA 损坏,对染色质在肝的变换期间开作出回应。由在肝的变换期间描绘早分子的事件,我们发现了那 Baf60b,改变建筑群的 SWI/SNF 染色质的一个成员,连接染色质洞到由便于 ATM 招募到肝的基因 loci 的一块面板的开的染色质区域的 ATM 激活。这些调查结果由在察觉到揭示 ATM-p53 小径的功能使细胞的回答清楚些到系变换染色质洞。 | Shuyi Ji Linying Zhu Yimeng Gao Xiaoran Zhang Yupeng Yan Jin Cen Rongxia Li Rong Zeng Lujian Liao Chunhui Hou Yawei Gao Shaorong Gao Gang Wei Lijian Hui | 2017 | Cell Research2017，27，5： | 2 |
| 4 | The origin of ultrasensitive SERS sensing beyond plasmonics显示文摘Plasmon-free surface-enhanced Raman scattering(SERS)substrates have attracted tremendous attention for their abundant sources,excellent chemical stability,superior biocompatibility,good signal uniformity,and unique selectivity to target molecules.Recently,researchers have made great progress in fabricating novel plasmon-free SERS substrates and exploring new enhancement strategies to improve their sensitivity.This review summarizes the recent developments of plasmon-free SERS substrates and specially focuses on the enhancement mechanisms and strategies.Furthermore,the promising applications of plasmon-free SERS substrates in biomedical diagnosis,metal ions and organic pollutants sensing,chemical and biochemical reactions monitoring,and photoelectric characterization are introduced.Finally,current challenges and future research opportunities in plasmon-free SERS substrates are briefly discussed. | Leilei Lan Yimeng Gao Xingce Fan Mingze Li Qi Hao Teng Qiu | 2021 | Frontiers of physics2021，16，4： | 1 |
| 5 | Ultrastretchable and wearable conductive multifilament enabled by buckled polypyrrole structure in parallel显示文摘Stretchable conductive fibers have attracted much attention due to their potential use in wearable electronics.However,the ultrahigh strain insensitive conductivity is hindered by mechanical mismatch in Young’s modulus and failure of stretchable structures under large deformation.This challenge is addressed with a conductive and elastic multifilament made of the polyurethane monofilaments that are surface-coated with buckled polypyrrole(PPy)of which flexibility is improved by sodium sulfosalicylate.Such parallel conductive monofilaments with PPy buckling on surface reduce the influence of cracks in the conductive coating on the overall conductivity,displaying an ultra-high strain insensitive behavior(quality factor Q=10.9).Remarkably,various complex forms of wearable electronic textiles made by this conductive multifilament maintain the strain-insensitive behavior of the original multifilament,even upon the large deformation of human joint.This multifilament with wrinkled PPy has attractive advantages in the application of super-stretched wearable electronic devices. | Yimeng Li Yaya Gao Lizhen Lan Qian Zhang Leqian Wei Mengqi Shan Lamei Guo Fujun Wang Jifu Mao Ze Zhang Lu Wang | 2022 | npj Flexible Electronics2022，6，1： | 1 |
| 6 | Inhibitory Effects of Propolis Water Extract on the Proliferation of Cervical Cancer Cells显示文摘[Objectives]To investigate the effects of propolis extract on HeLa cells to provide theoretical guidance for facilitating clinical treatment.[Methods]The effects of propolis on inflammation,and proliferation were analyzed based on the levels of DNA transcriptional regulation and mRNA and protein expression levels.[Results]Propolis water extract(PWE)could inhibit the cell proliferation and production of DNA damage in a dosedependent manner.Moreover,the propolis water extract could significantly downregulate the expression of iNOS-Luc,PTGS-2-Luc,and IL-8-Luc,and that it was related to the expression of the NF-κB family protein.After the induction of HeLa cells by propolis,the expression of the cell cycle inhibitor gene p21 was increased,while that of the cell proliferation gene Ki67 was decreased.[Conclusions]Propolis water extract could significantly inhibit the cell proliferation and production of DNA damage,suggesting propolis as a potential candidate for the development of adjunctive therapy against cervical cancer. | Wenbin XU Yimeng GAO Nailong LIANG Ling ZHANG Shuang XING Wensong HAO Shaocong LI | 2023 | Medicinal Plant2023，14，2： | 0 |
| 7 | Micropascal-sensitivity ultrasound sensors based on optical microcavities显示文摘Whispering gallery mode(WGM)microcavities have been widely used for high-sensitivity ultrasound detection,owing to their optical and mechanical dual-resonance enhanced sensitivity.The ultrasound sensitivity of the cavity optomechanical system is fundamentally limited by thermal noise.In this work,we theoretically and experimentally investigate the thermal-noise-limited sensitivity of a WGM microdisk ultrasound sensor and optimize the sensitivity by varying the radius and a thickness of the microdisk,as well as using a trench structure around the disk.Utilizing a microdisk with a radius of 300μm and thickness of 2μm,we achieve a peak sensitivity of 1.18μPa Hz^(-1/2)at 82.6 k Hz.To the best of our knowledge,this represents the record sensitivity among cavity optomechanical ultrasound sensors.Such high sensitivity has the potential to improve the detection range of air-coupled ultrasound sensing technology. | HAO YANG XUENING CAO ZHI-GANG HU YIMENG GAO YUECHEN LEI MIN WANG ZHANCHUN ZUO XIULAI XU BEI-BEI LI | 2023 | Photonics Research2023，11，7： | 0 |
| 8 | Size,shape,charge and“stealthy”surface:Carrier properties affect the drug circulation time in vivo显示文摘The present review sets out to discuss recent developments of the effects and mechanisms of carrier properties on their circulation time.For most drugs,sufficient in vivo circulation time is the basis of high bioavailability.Drug carrier plays an irreplaceable role in helping drug avoid being quickly recognized and cleared by mononuclear phagocyte system,to give drug enough time to arrive at targeted organ and tissue to play its therapeutic effect.The physical and chemical properties of drug carriers,such as size,shape,surface charge and surface modification,would affect their in vivo circulation time,metabolic behavior and biodistribution.The final circulation time of carriers is determined by the balance between macrophage recognitions,blood vessel penetration and urine excretion.Therefore,when designing the drug delivery system,we should pay much attention to the properties of drug carriers to get enough in vivo circulation time to arrive at target site eventually.This article mainly reviews the effect of carrier size,size,surface charge and surface properties on its circulation time in vivo,and discusses the mechanism of these properties affecting circulation time.This review has reference significance for the research of long-circulation drug delivery system. | Jinwei Di Xiang Gao Yimeng Du Hui Zhang Jing Gao Aiping Zheng | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，4： | 0 |
| 9 | Continuous morphing trailing-edge wing concept based on multi-stable nanomaterial显示文摘Morphing technology is one of the most effective methods to improve the flight efficiency of aircraft.Traditional control surfaces based morphing method is mature and widely used on current civil and military aircraft,but insufficiently effective for the entire flight envelope.Recent research on morphing wing still faces the challenge that the skin material for morphing should be both deformable and stiff.In this study,a continuous morphing trailing-edge wing with a new multi-stable nano skin material fabricated using surface mechanical attrition treatment technology was proposed and designed.Computational fluid dynamics simulation was used to study the aerodynamic performance of the continuous morphing trailing-edge wing.Results show that the lift coefficient increases with the increase of deflection angle and so does the lift-drag ratio at a small angle of attack.More importantly,compared with the wing using flaps,the continuous morphing trailing-edge wing can reduce drag during the morphing process and its overall aerodynamic performance is improved at a large angle of attack range.Flow field analysis reveals that the continuous morphing method can delay flow separation in some situations. | Fengqian HAO Tao TANG Yuan GAO Yimeng LI Shenghui YI Jian LU | 2021 | Chinese Journal of Aeronautics2021，34，7： | 0 |
| 10 | Prospective and Practical Significance of Virtual Autopsy Laboratory显示文摘The virtual anatomy laboratory was jointly established by the Jilin Province Department of Public Security,Public Security Bureau of Changchun,Jilin University and Neusoft Medical Systems Co.,Ltd.on December 30,2019.Details of the laboratory construction,virtual autopsy process,case analysis,research and development,establishment of standards,application in teaching,and other aspects of the center are summarized in this paper.In addition,we expound the prospective and practical significance of the virtual anatomy laboratory.Based on computed tomography and magnetic resonance detection methods,the prospective applications of virtual anatomy in forensic identification are explored through the analyses of two real-life cases.Using information from traditional anatomy as the gold standard,this study expanded on and explored the application technology and scenarios of virtual anatomy in imaging,clinical diagnosis,and equipment manufacturing,among other fields.The four cooperating units have their strengths and will yield valuable scientific research results and social benefits. | Yimeng Wang Zhiming Chen Gang Liu Wanan Zhu Wenxin Wang Dandan Zhou Weilong Chen Yanbin Gao Jun Yang Feng Huang Huimao Zhang Guangchi Yu Lijun Wang | 2021 | Journal of Forensic Science and Medicine2021，7，1： | 0 |
| 11 | TEP1 is a risk gene for sporadic cerebral palsy显示文摘Cerebral palsy (CP) is a nonprogressive dyskinesia syndrome caused by early brain injury,with an incidence of approximately2.0—3.5/1000 live births worldwide (Li et al.,2021;Moreno-DeLuca et al.,2021).Currently,there are more than 300,000 children aged 0—6 years diagnosed with CP in China (Liu et al.,1999;Yang et al.,2021),thus making it one of the most common debilitating diseases affecting children. | Yangong Wang Yiran Xu Hongwei Li Tianxiang Tang Yimeng Qiao Ye Cheng Lingling Zhang Juan Song Yu Su Xiaoli Zhang Jun Wang Qing Shang Lili Song Chao Gao Dengna Zhu Xiaoyang Wang Changlian Zhu Qinghe Xing | 2021 | Journal of Genetics and Genomics2021，48，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员