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| 1 | PTEN regulates RPA1 and protects DNA replication forks显示文摘肿瘤 suppressor PTEN 通过多重机制调整细胞的活动和控制染色体稳定性。在这研究,我们报导 PTEN 为对复制应力的 DNA 复制叉的保护是必要的。我们证明 PTEN 的那删除在叉拖延跟随 hydroxyurea 导致的核苷酸弄空之上导致复制叉倒塌和 chromosomal 不稳定性。PTEN 身体上与复制蛋白质 A 被联系 1 (RPA1 ) 经由 RPA1 C 终端领域。暴风雨和 iPOND 表明 PTEN 在复制地点是局部性的并且在复制叉上支持 RPA1 累积。PTEN 成员调停的 deubiquitinase OTUB1 RPA1 deubiquitination。RPA1 删除授与象与复制叉拖延在 PTEN 猛烈房间观察了那一样的显型。PTEN 和 RPA1 的表示在 colorectal 癌症显示出强壮的关联。RPA1 的异质接合的混乱在老鼠支持 tumorigenesis。这些结果证明 PTEN 为 DNA 复制叉保护是必要的。我们建议 RPA1 是在叉保护的 PTEN 功能的一个目标并且 PTEN 通过 DNA 复制的规定维持染色体稳定性。 | Guangxi Wang Yang Li Pan Wang Hui Liang Ming Cui Minglu Zhu Limei Guo Qian Su Yujie Sun Michael A McNut Yuxin Yin | 2015 | Cell Research2015，25，11： | 6 |
| 2 | Randomized phase II study of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan Clinical Cancer Research Organization PC-01 study)显示文摘 | Masato Ozaka Yuji Matsumura Hiroshi Ishii Yasushi Omuro Takao Itoi Hisatsugu Mouri Keiji Hanada Yasutoshi Kimura Iruru Maetani Yoshinobu Okabe Masaji Tani Takaaki Ikeda Susumu Hijioka Ryouhei Watanabe Shinya Ohoka Yuki Hirose Masafumi Suyama Naoto Egawa A | 2012 | Cancer Chemotherapy and Pharmacology2012，，5： | 3 |
| 3 | Pure isolation of nicotine-degrading microbes显示文摘 | Tashiro A Yuji K Yonemura C | 1996 | Kyushu Kyoritsu Daigaku Kenkyu Hokoku1996，20，： | 1 |
| 4 | EX- AFS study of (Lal M)2Zr207 (M=Nd and Ce)显示文摘 | HIROTO Y YUJI A TSUNEO M | 1996 | Materials1996，238，2： | 1 |
| 5 | Real time monitoring of biphasic glutamate release asing dialg sis electrode in rat acute brain is ehemia 显示文摘 | Satoshi A Yuji I Tadashi K | 1996 | Neuroerport1996，30，7： | 1 |
| 6 | Prompt activation of telomerase by chemical carcinogens in rats deteced with a modified TRAPassay显示文摘 | Masayoshi M Yuji K Tetsuya A | 1998 | Biochemical and biophysical research communications1998，246，： | 1 |
| 7 | The effect of tin of clot removal on chronic vasospasm in a primate model 显示文摘 | Yuji Handa Bryce K A Weir M D | 1987 | Neurosurg1987，67，： | 1 |
| 8 | Gasoline desulfurization by cata-lytic alkylation over silica-supported heteropolyacids : fommodel reaction to real feed conversion显示文摘 | Maria A Michel V Yuji Y | 2008 | Catalysis Today2008，130，： | 1 |
| 9 | Synthesis and characterization of novel low-k polyimides from aromatic dianhydrides and aromatic diamine containing phenylene ether and perfluorobiphenyl units 显示文摘 | Yasufumi W Yuji S Shinji A | 2006 | Polymer Journal2006，38，1： | 1 |
| 10 | Astaxanthin improves muscle lipid metabolism in exercise via inhibitory elect of oxidative CPT I modification显示文摘 | Watam A Yuji N Yoshikazu T | 2008 | Biochemical and Biophysical Research Communicadons2008，366，4： | 1 |
| 11 | Robust adaptive beamforming based on interference covariance matrix reconstruction and steering vector estimation显示文摘 | GU Yujie LESHEM A | 2012 | IEEE Trans Signal Processing2012，60，7： | 1 |
| 12 | Influence of Pyrocarbon Matrix Concentration on Thermal Physical and Mechanical Properties of Pitch-based Carbon/carbon Composites显示文摘The effect of pyrocarbon(PyC) concentration on the thermal physical and mechanical properties of quasi 3dimensional carbon fiber fabrics reinforced pitch-based carbon matrix composites was investigated.As the PyC concen-tration increased from 0 to 22.9vol.%,the tensile strength of pitch-based C/C(Carbon/Carbon) composites initially in-creased and then decreased,so was the tensile modulus.The coefficients of thermal expansion(CTE) were in the sequence of 10.2vol.%<0<22.9vol.%in Z direction.Under the same temperature conditions,PyC layer had a positive-going influence on the TC of the C/C composite,the composite with 22.9vol.%PyC concentrations possessed the highest TC value.The thermal shock resistance of the material with 10.2vol.%PyC concentrations showed the highest value.It is logical to conclude that by adding the a suitable PyC concentration into the carbon fabrics,thermo- mechanical properties,the major concerns for the safety design of load-bearing structural parts,can be tailored,which increase the reliability of pitch-based C/C composites as a structure unit. | LI Yan CUI Hong JIE Yujie JI A'lin ZHOU Shaojian ZHENG Rui | 2016 | Journal of the Chinese Ceramic Society2016，，4： | 1 |
| 13 | Pathologic Features of Mucin-producing Bile Duct Tumors: Two Histopathologic Categories as Counterparts of Pancreatic Intraductal Papillary-mucinous Neoplasms显示文摘 | Hiroaki Shibahara Shugo Tamada Masamichi Goto Koji Oda Masato Nagino Tetsuro Nagasaka Surinder K Batra Michael A Hollingsworth Kohzoh Imai Yuji Nimura Suguru Yonezawa | 2004 | The American Journal of Surgical Pathology2004，，3： | 1 |
| 14 | Cyclic Testing of Beam-to- column Connections with Weld Defects and Assessment of Safety of Numerically Modeled Connections from Brittle Fracture显示文摘 | KOJI A YOSHIKI K YUJI M | 2000 | Engineering Structures2000，22，12： | 1 |
| 15 | Adiponectin receptors,with special focus on the role of the third receptor,T-cadherin,in vascular disease显示文摘 | TAMOTSU T YOSHIHIRO A YUJI O | 2007 | Med Mol Morphol2007，40，： | 1 |
| 16 | Cyclic testing of beam-to-column connections with weld defects and as sessment of safety of numerically modeled connections from brittle fracture 显示文摘 | KOJI A YOSHIAKI K YUJI M | 2000 | Engineering Structures2000，22，12： | 1 |
| 17 | Robust Adaptive Beamforming Based on Interference Covariance Matrix Reconstruc- tion and Steering Vector Estimation显示文摘 | YUJIE G LESHEM A | 2012 | IEEE Trans- actions on Signal Processing2012，60，7： | 1 |
| 18 | Pharmacokinetics of tetrodotoxin in puffer fish Takifugu rubripes by a single administration technique显示文摘 | Takuya Matsumoto Yuji Nagashima Hiroyuki Kusuharab et a/ | 2008 | Toxicon2008，51，： | 1 |
| 19 | Pure isolation of nicotine-degradin microbes显示文摘 | Tashiro A Yuji K Yonemura C | 1996 | Kyushu Kyoritsu Daigaku Kenkyu Hokoku Kogakubu1996，20，： | 1 |
| 20 | Effects of tributyltin on the energy metabolism of pen shell(Atrina pectinata japonica)显示文摘 | Suguru I Yuji O Shin-ichiro A | 2007 | Chemosphere2007，66，7： | 1 |
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