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| 1 | FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation显示文摘F 盒子和 WD 重复包含域 7 (FBW7 ) , E3 ubiquitin ligase SCF FBW7 (SKP1, cullin-1 和 FBW7 的建筑群) ,在各种各样的生理、病理学的过程起重要作用。尽管 FBW7 为脉管的开发被要求,它在内皮细胞层的函数尚待被调查。在这研究,我们证明 FBW7 是 endothelial 功能的一个重要管理者,包括 angiogenesis,白血球粘附和 endothelial 障碍正直。用 RNA 干扰,我们发现 FBW7 的弄空显著地在 vitro 并且在 vivo 损害 angiogenesis。我们识别了锌手指抄写因素 Krü象 ppel 一样因素 2 (KLF2 ) 作为在 endothelial 房间的 FBW7 的一个生理的目标。FBW7 击倒表示在 endothelial 房间导致了内长的 KLF2 蛋白质的累积。调停 FBW7 的 KLF2 破坏被显示在二保存 phosphodegrons 经由肝糖 synthase kinase-3 (GSK3 ) 取决于 KLF2 的 phosphorylation。变异这些 phosphodegron 主题废除了 KLF2 的调停 FBW7 的降级和 ubiquitination。调停 siRNA 显示出的 FBW7 击倒 KLF2 是在 endothelial 的规定的 FBW7 的一个必要目标,这工作。而且,调停 FBW7 的 KLF2 降级被显示为在 teratomas 并且在 zebrafish 开发的 angiogenesis 批评。一起拿,我们的学习在 endothelial 房间移植, angiogenesis,发炎和障碍完整的进程为 FBW7 建议一个角色,并且在 vivo 提供新奇卓见进 KLF2 稳定性的规定。 | Rui Wang Yah Wang Ning Liu Chunguang Ren Cong Jiang Kai Zhang Su Yu Yunfei Chen Hui Tang Qi Deng Cong Fu Yingcong Wang Rong Li Mingyao Liu Weijun Pan Ping Wang | 2013 | Cell Research2013，23，6： | 7 |
| 2 | One Kind of Complete Lie Algebra over a Commutative Ring显示文摘In this paper,we obtain a new kind of complete Lie algebra over a commutative ring,which is the Lie algebra consisting of all n×n anti-symmetric matrices over a 2-torsionfree commutative ring with identity. | ZHAO Yah Xia YAO Rui Ping WANG Deng Yin | 2009 | Journal of Mathematical Research and Exposition2009，29，1： | 2 |
| 3 | Synthesis, characterization and ring-opening polymerization of a novel six-membered cyclic carbonate bearing pendent allyl ether group显示文摘 | He Feng Wang Yah Ping Zhuo Ren Xi | 2008 | Polymer2008，49，5： | 1 |
| 4 | Trichosanthin suppresses Hela cell proliferation through inhibition of the PKC/MAPK signaling pathway显示文摘 | Ping Wang Li - Li Chen Hui Yah | 2008 | Cell Biol Toxicol2008，28，： | 1 |
| 5 | Wind energy environments and dunefield activity in the Chinese deserts显示文摘 | Wang Xunming Dong Zhibao Yah Ping | 2005 | Geomorphology2005，65，： | 1 |
| 6 | Design of a 3 m long electromagnetic launeher显示文摘 | Sun Yaohong Yah Ping Yuan Weiqun | 2009 | IEEE Trans on Magn2009，45，1： | 1 |
| 7 | Cell-Based Biosensors Based on Light-Addressable Potentiometric Sensors for Single Cell Monitoring显示文摘 | Xu Gaixia Ye Xuesong Qing Lifeng Xu Ying Li Yah Li Rong Wang Ping | 2005 | Biosensors and Bioelectronics2005，20，： | 1 |
| 8 | Modeling of electrode system for three-phase electric arc furnace 显示文摘 | WANG Yah MAO Zhi-zhong TIAN Hui-xin LI Yan YUAN Ping | 2010 | Journal of Central South University of Technology2010，17，56： | 1 |
| 9 | Inhibition of the α-mannosidase Man2c1 gene expression enhances adhesion of Jurkat cells显示文摘Protein N-glycosylation plays very important roles in immunity and α-mannosidase is one of the key enzymes in N-glycosylation.This paper reports that inhibition of α-mannosidase Man2cl gene expression enhances adhesion of JurkatT cells.In comparison to the controls with normal expression of the enzyme,Jurkat cells with the inhibition of Man2clgene expression(AS cell)formed larger aggregates in culture,indicating an enhancement of adhesion between the cells.mRNA differential display analysis discovered up-regulation of several adhesion molecule genes in the AS cell.Becauseof the pivotal role played by CD54-LFA-1 interaction in immune cell interaction,this study focused on the contributionof enhanced expression of CD54 and LFA-1 to the enhanced adhesion of AS Jurkat cells.These facts,including increasedbinding of AS cells to ICAM-1-Fc,Mg^(2+)activation of the binding of AS cells to ICAM-1-Fc and enhanced aggregationof AS cells,together with the inhibiting effect of a blocking CD 11a mAb on the binding to ICAM-1-Fc and aggregationof the cells demonstrate an important contribution of enhanced CD54-LFA-1 interaction to increased adhesion betweenAS cells.The enhanced CD54-LFA-1 interaction also resulted in increased adhesion between AS Jurkat T cells and RajiB cells.In addition,AS cells showed cytoskeletal rearrangement.The data imply a biological significance of MAN2C1in T-cell functioning. | Li Qu Ji Yu Ju Shuang Ling Chen Yah Shi Zhi Guang Xiang Yi Qun Zhou Yun Tian Yin Liu Li Ping Zhu | 2006 | Cell Research2006，16，7： | 1 |
| 10 | Lunar topo- graphic model CLTM-s01 from Chang%-1 laser altimeter显示文摘 | Ping Jingsong Huang Qian Yah Jianguo | 2009 | Seience in China Series G Physics Mechanics and Astrono- my2009，52，7： | 1 |
| 11 | 显示文摘 | Bao - Lian Wang Jin - Ping Hu Wei Tan Li Sheng Hui Chen Yah Li | 2008 | Journal of Chromatography B2008，02，： | 1 |
| 12 | Synthesis,phase behaviors,and mechancial properties of biphenyl-type epoxy resins and composites显示文摘 | Shao Ping Ren Li Yah Liang Yan Xun Lan | 2007 | Journal of Applied Polymer Science2007，，106： | 1 |
| 13 | CO2 ab- sorption by using a low-cost solvent: blogas slurry pro- duced by anaerobic digestion of biomass显示文摘 | Yah Shuiping Zhang Liqiang AI Ping | 2013 | Energy Pro- cedia2013，，37： | 1 |
| 14 | Clinical research on treatment of dysphagia with neck acupuncture显示文摘 | Wang Feng yah Sun Ping | 2007 | World J Acu-moxi2007，17，2： | 1 |
| 15 | Discussion on the relationship between normal erythrocyte sedimentation rate of Chi nese young people and geographical factors显示文摘 | Ge Miao Yah Yah Guo Cailing Ma Jinfu and Huang Ping | 1999 | Clinical Hemorheology and Microcirculation1999，20，3： | 1 |
| 16 | Low com- plexity of multi view video plus depth coding显示文摘 | ZHANG Qiu-wen AN Ping ZHANG Yah | 2011 | IEEE Transactions on Consumer Electronics2011，5，4： | 1 |
| 17 | Raising the Cycling Stability of Aqueous Lithium-Ion Batteries by Eliminating O2 in the Electrolyte显示文摘 | Jia Yah Luo Wang Jun Cui Ping He | | 0，，： | 1 |
| 18 | A pulsed magnetohydrodynamic generator for electric launcher显示文摘 | Wang Ying Yah Ping Xue Haizhong | 2005 | IEEE Transactions on Magnetics2005，41，1： | 1 |
| 19 | Dielectric barrier discharge excitated by repetitive nanosecond pulses in air at at- mospheric pressure 显示文摘 | Shao Tao Yah Ping Long Kaihua | 2008 | IEEE Transactions on Plasma Sci- ence2008，36，4： | 1 |
| 20 | Synthesis and characterization of rare earth luminescent material based on PEN 显示文摘 | Yah Changhao Dai Honglib Guo Chunfang Lu Ping Wang Wenxuan Zhang Ming Qiu Guanming | 2007 | Journal of Rare Earths2007，25，1： | 1 |
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