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| 1 | Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus显示文摘分泌蛋白质的刺猬(Hh ) 家庭为在脊椎动物和无脊椎动物的开发是必要的。作为主要 morphogens 之一在后生动物的开发期间,分级的 Hh 信号通过它的细胞质的尾巴的微分 phosphorylation 是越过由 Smoothened (Smo ) 的血浆膜的 transduced,导致小径激活和目标基因的微分表达式。然而,怎么 Smo transduces 经由建筑群糟糕仍然是的 Costal2 (Cos2 )/Fused (Fu ) 的分级的 Hh 信号理解。这里我们在场对由翻译 Smo phosphorylation 信息到 Fu dimerization 和肘脉 interruptus (Ci ) 的一个 Hh 坡度的房间反应的一个模型原子本地化信息。我们的调查结果建议 Smo 的 phosphorylated C 终点招募 Cos2/Fu 建筑群到通过在 Smo 和 Cos2 之间的相互作用的膜,它进一步导致 Fu dimerization。使聚合成二聚物的 Fu 是 phosphorylated 和 transduces 由 phosphorylating Cos2 和 Fu (苏(fu )) 的 Suppressor 的 Hh 信号。我们进一步证明这个过程支持全身的 Ci (Ci155 ) 和 Cos2 或苏(fu ) 的分离,并且导致 Ci155 的 translocation 进原子核,激活目标基因的表示。 | Yanyan Zhang Feifei Mao Yi Lu Wenqing Wu Lei Zhang Yun Zhao | 2011 | Cell Research2011，21，10： | 12 |
| 2 | Review of Remotely Sensed Imagery Classification Patterns Based on Object-oriented Image Analysis显示文摘With the wide use of high-resolution remotely sensed imagery, the object-oriented remotely sensed informa- tion classification pattern has been intensively studied. Starting with the definition of object-oriented remotely sensed information classification pattern and a literature review of related research progress, this paper sums up 4 developing phases of object-oriented classification pattern during the past 20 years. Then, we discuss the three aspects of method- ology in detail, namely remotely sensed imagery segmentation, feature analysis and feature selection, and classification rule generation, through comparing them with remotely sensed information classification method based on per-pixel. At last, this paper presents several points that need to be paid attention to in the future studies on object-oriented RS in- formation classification pattern: 1) developing robust and highly effective image segmentation algorithm for multi-spectral RS imagery; 2) improving the feature-set including edge, spatial-adjacent and temporal characteristics; 3) discussing the classification rule generation classifier based on the decision tree; 4) presenting evaluation methods for classification result by object-oriented classification pattern. | LIU Yongxue LI Manchun MAO Liang XU Feifei HUANG Shuo | 2006 | Chinese Geographical Science2006，16，3： | 9 |
| 3 | Effects of uranium on hydrocarbon generation of hydrocarbon source rocks with type-Ⅲ kerogen显示文摘Organic-inorganic interaction exists universally and is important in the process of mineral resources formation.It is the essential reason why organic oil,gas,coal and inorganic uranium coexist,accumulate,and mineralize in the same sedimentary basins.Hydrocarbon-generating simulation experiment was conducted using low-mature hydrocarbon source rock containing kerogen type III with uranium(UO2CO3 solution)added to study the effects of uranium on the hydrocarbon generation of hydrocarbon source rocks.Experiment results show that uranium can enhance the yield of gas hydrocarbon,promote the total gas output,and increase the total hydrocarbon production(mass or volume).Uranium may lower the hydrocarbon generation threshold temperature and lead to the generation of liquid hydrocarbon in the relative low temperature of hydrocarbon source rock.Uranium can enhance the yield of saturated hydrocarbon,promote the low molecular weight hydrocarbons generating,and in turn increase the content of CH4 and the content of dry gas of the generated hydrocarbons.Uranium is one of the potential inorganic accelerating factors of the immature hydrocarbons. | MAO GuangZhou LIU ChiYang ZHANG DongDong QIU XinWei WANG JianQiang LIU BaoQuan LIU JingJiang QU ShaoDong DENG Yu WANG FeiFei ZHANG Can | 2014 | Science China Earth Sciences2014，57，6： | 5 |
| 4 | A novel battery scheme:Coupling nanostructured phosphorus anodes with lithium sulfide cathodes显示文摘Lithium-ion batteries are approaching their theoretical limit and can no longer keep up with the increasing demands of human society.Lithium-sulfur batteries,with a high theoretical specific energy,are promising candidates for next generation energy storage.However,the use of Li metal in Li-S batteries compromises both safety and performance,enabling dendrite formation and causing fast capacity degradation.Previous studies have probed alternative battery systems to replace the metallic Li in Li-S system,such as a Si/Li2S couple,with limited success in performance.Recently,there is a focus on red P as a favorable anode material to host Li.Here,we establish a novel battery scheme by utilizing a P/C nanocomposite anode and pairing it with a Li2S coated carbon nanofiber cathode.We find that red P anode can be compatible in ether-based electrolyte systems and can be successfully coupled to a Li2S cathode.Our proof of concept full-cell displays remarkable specific capacity,rate and cycling performances.We expect our work will provide a useful alternative system and valuable insight in the quest for next generation energy storage devices. | David Sichen Wu Guangmin Zhou Eryang Mao Yongming Sun Bofei Liu Li Wang Jiangyan Wang Feifei Shi Yi Cui | 2020 | Nano Research2020，13，5： | 4 |
| 5 | Pose-robust feature learning for facial expression recognition显示文摘 | Feifei ZHANG Yongbin YU Qirong MAO Jianping GOU Yongzhao ZHAN | 2016 | Frontiers of Computer Science2016，10，5： | 3 |
| 6 | A novel chemotherapy strategy for advanced hepatocellular carcinoma: a multicenter retrospective study显示文摘Background:Chemotherapy is a common treatment for advanced hepatocellular carcinoma,but the effect is not satisfactory.The study aimed to retrospectively evaluate the effects of adding all-trans-retinoic acid(ATRA)to infusional fluorouracil,leucovorin,and oxaliplatin(FOLFOX4)for advanced hepatocellular carcinoma(HCC).Methods:We extracted the data of patients with advanced HCC who underwent systemic chemotherapy using FOLFOX4 or ATRA plus FOLFOX4 at the Eastern Hepatobiliary Surgery Hospital,First Hospital of Jilin University,and Zhejiang Sian International Hospital and retrospectively compared for overall survival.The Cox proportional hazards model was used to calculate the hazard ratios for overall survival and disease progression after controlling for age,sex,and disease stage.Results:From July 2013 to July 2018,111 patients with HCC were included in this study.The median survival duration was 14.8 months in the ATRA plus FOLFOX4 group and 8.2 months in the FOLFOX4 only group(P<0.001).The ATRA plus FOLFOX4 group had a significantly longer median time to progression compared with the FOLFOX4 group(3.6 monthsvs.1.8 months,P<0.001).Hazard ratios for overall survival and disease progression were 0.465(95%confidence interval:0.298–0.726;P=0.001)and 0.474(0.314–0.717;P<0.001)after adjusting for potential confounders,respectively.Conclusion:ATRA plus FOLFOX4 significantly improves the overall survival and time to disease progression in patients with advanced HCC. | Juxian Sun Chang Liu Jie Shi Nanya Wang Dafeng Jiang Feifei Mao Jingwen Gu Liping Zhou Li Shen Wan Yee Lau Shuqun Cheng | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 7 | Effects of initial particle gradation and rock content on crushing behaviors of weathered phyllite fills——A case of eastern Ankang section of Shiyan—Tianshui highway,China显示文摘The objective of this paper is to investigate the effects of initial particle gradation and rock content on the crushing behavior(i.e.grain size before and after crushing) of weathered phyllite fills.Compaction tests were conducted on weathered phyllite fills with rock contents of 35%,45%,55%,65% and 75%(by weight).First,the particle size distributions(PSDs) were observed before and after compaction,and then the particle breakage of weathered phyllite fills was analyzed by fractal dimension.Relative fractal dimension was proposed to evaluate the effects of initial rock content and initial gradation on the particle breakage.It was found that the fractal dimension method can well characterize the crushing behaviors of the weathered phyllite fills.The finer the fills were,the more they were compacted.That is,after the first compaction,the relative fractal dimension of the weathered phyllite fills increased as the rock content increased,reaching the values of 0.013,0.016,0.024,0.037 and 0.08,respectively.After the second compaction,these relative fractal dimension values,dominated by the initial particle gradation,became 0.059,0.072,0.052,0.095 and 0.118,respectively.In conclusion,the weathered phyllite fills with 55% rock content exhibited the least breakage and were most suitable for filling the subgrade.Findings in this paper will provide significant guidance for the construction of weathered phyllite filling subgrade in future projects. | Feifei Liu Xuesong Mao Yushuo Fan Linping Wu Wei Victor Liu | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，2： | 2 |
| 8 | DNA Barcoding Assessment of Green Macroalgae in Coastal Zone Around Qingdao, China显示文摘An assessment with assistance of DNA barcoding was conducted on green macroalgae in coastal zone around Qingdao, China, during the period of April- December, 2011. Three markers were applied in molecular discrimination, including the plastid elongation factor tufA gene, the internal transcribed spacer(ITS) region of the ribosomal cistron and rubisco large subunit gene 3' regions(rbcL-3P). DNA barcoding discriminated 8 species, excluding species of genus Cladophora and Bryopsis due to failures in amplification. We ascertained and corrected 4 species identified by morphological methods for effectively assisting the classification. The gene tufA presented more advantages as an appropriate DNA marker with the strongest amplification success rate and species discrimination power than the other two genes. The poorest sequencing success largely handicapped the application of ITS. Samples identified by tufA and rbcL as Ulva flexuosa were clustered into the clade of U. prolifera by ITS in the neighbor-joining tree. Confusion with discrimination of the complex of U. linza, U. procera and U. prolifera(as the LPP complex) still existed for the three DNA markers. Based on our results, rbcL is recommended as a preferred marker for assisting tufA to discriminate green macroalgae. In distinguishing green-tide-forming Ulva species, the free-floating sample collected from the green tide in 2011 was proved to be identical with U. prolifera in Yellow Sea for ITS and rbcL genes. This study presents a preliminary survey of green macroalgae distributed in the coastal area around Qingdao, and proves that DNA barcoding is a powerful tool for taxonomy of green macroalgae. | DU Guoying WU Feifei MAO Yunxiang GUO Shenghua XUE Hongfan BI Guiqi | 2014 | Journal of Ocean University of China2014，13，1： | 1 |
| 9 | Determination of fenticonazole in human plasma by HPLC–MS/MS and its application to pharmacokinetic studies显示文摘Two simple and sensitive high performance liquid chromatography–tandem mass spectrometry(HPLC–MS/MS) methods were developed and validated for the determination of fenticonazole in human plasma after percutaneous and intravaginal administration. Mifepristone was used as an internal standard(IS), and simple protein precipitation by acetonitrile containing 2% acetic acid was utilized for extracting the analytes from the plasma samples. Chromatographic separation was performed on a Kinetex XB-C_(18) column. The quantitation was performed by a mass spectrometer equipped with an electrospray ionization source in multiple reactions monitoring(MRM) positive ion mode using precursor-to-product ion transitions of m/z 455.2–199.1 for fenticonazole and m/z 430.2–372.3 for mifepristone. The validated linear ranges of fenticonazole were 5–1000 pg/m L and 0.1–20 ng/m L in plasma for the methods A and B, respectively. For the two methods, the accuracy data ranged from 85% to 115%, the intra- and inter-batch precision data were less than 15%, the recovery data were more than 90%, and no matrix interference was observed. The methods A and B were successfully validated and applied to the pharmacokinetic studies of fenticonazole gel in Chinese healthy volunteers after percutaneous and intravaginal administration, respectively. | Weixing Mao Yiya Wang Wenhui Hu Feifei Jiao Hongwei Fan Li Ding | 2017 | Journal of Pharmaceutical Analysis2017，7，1： | 0 |
| 10 | Combined FOLFOX4 with all-trans retinoic acid versus FOLFOX4 with placebo in treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a randomized, double-blind comparative study显示文摘The majority of hepatocellular carcinoma(HCC)cases are diagnosed at an advanced stage.Currently,there are only a few therapeutic methods available for patients with advanced HCC and extrahepatic metastasis(EHM).Systemic chemotherapy,such as FOLFOX4(infusions of fluorouracil,leucovorin,and oxaliplatin),has been reported for treating advanced HCC with EHM,but its effectiveness is very poor. | Juxian Sun Feifei Mao Chang Liu Fan Zhang Dafeng Jiang Weixing Guo Lei Huo Liping Zhou Wan Yee Lau Jie Shi Shuqun Cheng | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 11 | Clinical relevance of distolingual roots and periodontal status in mandibular first molars: a cross-sectional study employing CBCT analysis显示文摘Objectives:Distolingual root of the permanent mandibular first molar(PMFM-DLR)has been frequently reported,which may complicate the treatment of periodontitis.This study aimed to assess the morphological features of PMFM-DLR and investigate the correlation between the morphological features of PMFM-DLR and periodontal status in patients with Eastern Chinese ethnic background.Materials and methods:A total of 836 cone beam computed tomography(CBCT)images with 1497 mandibular first molars were analyzed to observe the prevalence of PMFM-DLR at the patients and tooth levels in Eastern China.Among them,complete periodontal charts were available for 69 Chinese patients with 103 teeth.Correlation and regression analyses were used to evaluate the correlation between the morphological features of DLR,bone loss,and periodontal clinical parameters,including clinical attachment loss(CAL),probing pocket depth(PPD),gingival recession(GR),and furcation involvement(FI).Results:The patient-level prevalence and tooth-level prevalence of DLR in mandibular first molars were 29.4%and 26.3%,respectively.Multiple linear regression analysis suggested that bone loss at the lingual site and CAL were negatively affected by the angle of separation between distolingual and mesial roots in the transverse section,while they were significantly influenced by age and the angle of separation between distobuccal and mesial roots in the coronal section.Conclusions:The prevalence of PMFM-DLR in Eastern China was relatively high in our cohort.The morphological features of DLR were correlated with the periodontal status of mandibular first molars.This study provides critical information on the morphological features of DLR for improved diagnosis and treatment options of mandibular molars with DLR. | Feifei MAO Meng WANG Shuai ZHOU Yan ZHAO Jiaping HUANG Fengying YIN Haiping YANG Pei-hui DING | 2024 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2024，25，3： | 0 |
| 12 | Recognition for avian influenza virus proteins based on support vector machine and linear discriminant analysis显示文摘Total 200 properties related to structural characteristics were employed to represent structures of 400 HA coded proteins of influenza virus as training samples. Some recognition models for HA proteins of avian influenza virus (AIV) were developed using support vector machine (SVM) and linear discriminant analysis (LDA). The results obtained from LDA are as follows: the identification accuracy (Ria) for training samples is 99.8% and Ria by leave one out cross validation is 99.5%. Both Ria of 99.8% for training samples and Ria of 99.3% by leave one out cross validation are obtained using SVM model, respectively. External 200 HA proteins of influenza virus were used to validate the external predictive power of the resulting model. The external Ria for them is 95.5% by LDA and 96.5% by SVM, respectively, which shows that HA proteins of AIVs are preferably recognized by SVM and LDA, and the performances by SVM are superior to those by LDA. | LIANG GuiZhao CHEN ZeCong YANG ShanBin MEI Hu ZHOU Yuan YANG Li ZHOU Peng YANG ShengXi SHU Mao LIAO ChunYang WU ShiRong LI GenRong HE Liu GAO JianKun Gan MengYu LI DeJing CHEN GuoPing WANG GuiXue LONG Sha JING JuHua ZHENG XiaoLin ZENG Hui ZHANG QiaoXia ZHANG MengJun YANG Qi TIAN FeiFei TONG JianBo WANG JiaoNa LIU YongHong LI Bo QIU LiangJia CAI ShaoXi ZHAO Na YANG Yan SU XiaLi SONG Jian CHEN MeiXia ZHANG XueJiao SUN JiaYing LI JingWei CHEN GuoHua CHEN Gang DENG Jie PENG ChuanYou ZHU WanPing XU LuoNan WU YuQuan LIAO LiMin LI Zhi LI Jun LU DaJun SU QinLiang HUANG ZhengHu ZHOU Ping LI ZhiLiang | 2008 | Science China Chemistry2008，51，2： | 0 |
| 13 | Novel isostructural iron‐series‐MOF calcined derivatives as positive and negative electrodes: A new strategy to obtain matched electrodes in a supercapacitor device显示文摘The performance of asymmetric supercapacitors(ASCs)is strongly restricted by the capacity gap between the positive and negative electrodes.To address this issue,two new electrode materials deriving from Co‐and Fe‐based metal–organic frameworks(MOFs,Co‐TAMBA‐d,and Fe‐TAMBA‐d)through a single‐step sintering method have been developed by considering the superiorities of the derivatives of MOFs including large surface areas,sufficient metal‐atom‐doping content,and extreme surface wettability to the bath solution.The as‐prepared Co‐TAMBA‐d as a positive electrode delivers typical pseudocapacitive behavior with the improvement of capacity,which is better than those of pristine MOF materials,while Fe‐TAMBA‐d as negative electrodes displays better electrochemical behavior than those of activated carbon.ASCs based on these two electrodes exhibits excellent energy density and power density of 47Wh/kg and 1658 W/kg,respectively,where this device can maintain prominent cycling stability with capacity retention after 5000 cycles being about 75%.Furthermore,the capacity can feed a series of red light‐emitting diodes,which gives solid evidence of the potential utilization.These results can afford the feasibility of isostructural MOF derivatives as promising electrodes in novel ASCs. | Yawen Dong Jiadi Liu Hui Zhang Qingqing Li Feifei Mao Aimin Lu Hua Wu Kuaibing Wang Cheng Zhang Qichun Zhang | 2023 | SmartMat2023，4，3： | 0 |
| 14 | Screening the Optimal Patterned Surfaces Consisting of Cell Morphology Mimicking Micro-pillars and Nanotube Arrays for the Design of Titanium Implants#br#显示文摘Micron/nano scale topographic modification has been a significant focus of interest in current titanium(Ti)surface design.However,the influence of micron/nano structured surface on cell or bacterium behavior on the Ti implant has rarely been systematically evaluated.Moreover,except for popular microgrooves,little work has been carried out on the reaction of cells to the bionic structure.In this study,several micro-pillars mimicking cell morphology were prepared on Ti surfaces by lithography and contact printing(ICP)method,and they were further decorated with nanotube arrays by anodization technology.These surface modifications remarkablly increased the surface roughness of pristine Ti surface from 91.17 nm±5.57 nm to be more than 1000 nm,and reduced their water contact angles from 68.3°±0.7°to be 16.9°±2.4°.Then,the effects of these hierarchical micron/nano scale patterns on the behaviors of MG63 osteoblasts,L929 fibroblasts,SCC epithelial cells and P.gingivalis were studied,aiming to evaluate their performance in osseointegration,gingival epithelial sealing and antibacterial ability.Through an innovative scoring strategy,our findings showed that square micro-pillars with 6μm width and 2μm height combined with 85 nm diameter nanotubes was suitable for implant neck design,while square micro-pillars with 3μm width and 3.6μm height combined with 55 nm diameter nanotubes was the best for implant body design.Our study reveals the synergistic effect of the hierarchical micron/nano scale patterns on MG63 osteoblasts,L929 fibroblasts,SCC epithelial cells and P.gingivalis functions.It provides insight into the design of biomedical implant surfaces. | Ping Zhou Hongjiao Li Feifei Mao Hongxin Huang Siqi Long Fei He Jing Chen Shicheng Wei | 2021 | Journal of Bionic Engineering2021，18，2： | 0 |
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