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| 1 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 2 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 3 | A Transgenic Study on Affecting Potato Tuber Yield by Expressing the Rice Sucrose Transporter Genes OsSUT5Z and OsSUT2M显示文摘在许多植物,蔗糖 transporters 为从来源和进口的两个蔗糖出口是必要的进水池,显示功能在吸收划分。为了调查蔗糖 transporters 是否能改进淀粉的收益,种,土豆植物(茄属 tuberosum L。cv。 | Aijun Sun Yan Dai Xinsheng Zhang Chunmin Li Kun Meng Honglin Xu Xiaoli Wei Guifang Xiao Pieter B.F, Ouwerkerk Mei Wang Zhen Zhu | 2011 | Journal of Integrative Plant Biology2011，53，7： | 9 |
| 4 | Autoantigen Microarray for High-throughput Autoantibody Profiling in Systemic Lupus Erythematosus显示文摘Systemic lupus erythematosus(SLE) is a complex autoimmune disease characterized by the production of autoantibodies to a broad range of self-antigens. Profiling the autoantibody repertoire using array-based technology has emerged as a powerful tool for the identification of biomarkers in SLE and other autoimmune diseases. Proteomic microarray has the capacity to hold large number of self-antigens on a solid surface and serve as a high-throughput screening method for the determination of autoantibody specificities. The autoantigen arrays carrying a wide variety of self-antigens, such as cell nuclear components(nucleic acids and associated proteins), cytoplasmic proteins, phospholipid proteins, cell matrix proteins, mucosal/secreted proteins, glomeruli, and other tissue-specific proteins, have been used for screening of autoantibody specificities associated with different manifestations of SLE. Arrays containing synthetic peptides and molecular modified proteins are also being utilized for identification of autoantibodies targeting to special antigenic epitopes. Different isotypes of autoantibodies, including Ig G, Ig M, Ig A, and Ig E, as well as other Ig subtypes, can be detected simultaneously with multi-color labeled secondary antibodies. Serum and plasma are the most common biologic materials for autoantibody detection, but other body fluids such as cerebrospinal fluid, synovial fluid, and saliva can also be a source of autoantibody detection.Proteomic microarray as a multiplexed high-throughput screening platform is playing an increasingly-important role in autoantibody diagnostics.In this article,we highlight the use of autoantigen microarrays for autoantibody exploration in SLE. | Honglin Zhu Hui Luo Mei Yan Xiaoxia Zuo Quan-Zhen Li | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 6 |
| 5 | Determination of trace and rare-earth elements in Chinese soil and clay reference materials by ICP-MS显示文摘Inductively coupled plasma mass spectrometry(ICP-MS) has become a powerful tool for providing reliable analytical results in many laboratories around the word. In this study, the mixture of HF and HNO3 acids in high-temperature and high-pressure closed-vessel digestion technique were used to decompose some Chinese reference materials, and thirty seven elements were determined by ICP-MS. Most of the results for Chinese soil reference materials were found to be in reasonable agreement with the reference values, except Cs, Ta, Li, Ge, Zn, Nd, Tb and Ta whose values need to be revised. Their precisions were typically lower than 5% RSD. However, the Precisions of Chinese clay reference materials, especially for GBW03102 and GBW03102a, were significantly different with reference values, probably reflecting the existence of a coarser-grained fraction(>70 μm) in samples, and the formation of fluorides in Al-rich samples during sample decomposition by using the mixture of HF and HNO3 acids. Moreover, thirty-seven trace elements covering the mass range from Li to U in four Chinese clay reference materials were firstly provided with good precision and accuracy in this study. | LIU Ye DIWU Chunrong ZHAO Yan LIU Xiaoming YUAN Honglin WANG Jianqi | 2014 | Chinese Journal Of Geochemistry2014，33，1： | 6 |
| 6 | Characterization of aroma compounds of Pu-erh ripen tea using solvent assisted flavor evaporation coupled with gas chromatography-mass spectrometry and gas chromatography-olfactometry显示文摘Pu-erh ripen tea becomes popular worldwide owing to its unique taste and aroma.In the present study,volatile compounds from Pu-erh ripen tea were extracted using a solvent assisted flavor evaporation(SAFE)and analyzed with a gas chromatography-mass spectrometry(GC-MS)and a gas chromatography olfactometry(GC-O).Results demonstrated that 58 major volatile compounds and 24 aroma active substances of Pu-erh ripen tea were identified by GC-MS and GC-O analysis.Among volatile compounds identified,methoxyphenyl compounds were considered as the dominate compounds in the aroma of Pu-erh ripen tea.Further investigation showed that 6 methoxybenzenes were responsible for the aging aroma in Pu-erh ripen tea;α-ionone,3,4-dimethoxytoluene,1,3-dimethoxybenzene,etc.were responsible for the wood-like aroma.Linalool,α-terpineol,α-ionone,β-ionone,and benzeneacetaldehyde were responsible for the floral odor.Compared the odor detection threshold(ODT)among the 8 methoxyphenyl compounds in water,1,2,3-trimethoxybenzene showed the highest ODT,followed by 3,4-dimethoxyphenol.1,3-dimethoxybenzene(105μg/L)and 1,2,3-trimethoxy-5-methylbenzene(100μg/L)were present at relatively low odor threshold values.The result indicated that methoxyphenyl compounds play a vital role in the unique flavor of Pu-erh ripen tea. | Bei Wang Qing Meng Lin Xiao Ruili Li Chunhai Peng Xueli Liao Jingna Yan Honglin Liu Guanhua Xie Chi-Tang Ho Huarong Tong | 2022 | Food Science and Human Wellness2022，11，3： | 6 |
| 7 | Regulation of REGγ cellular distribution and function by SUMO modification显示文摘新兴的调整 REG 的蛋白质的发现在多重生物过程作为一条重要小径加重了 REG-proteasome,包括细胞生长,细胞周期规定,和 apoptosis。然而,很少对 REG-proteasome 小径的规定被知道。这里,我们证明 REG 能是在 vitro 并且在由 SUMO-1, SUMO-2,和 SUMO-3 的 vivo 的 SUMOylated。激活的 STAT (PIAS ) 的 SUMO-E3 蛋白质禁止者 1 身体上与 REG 联系并且支持 REG 的 SUMOylation。REG 的 SUMOylation 被发现发生在多重地点,包括 K6, K14,和 K12。变化分析显示这些相扑地点同时在房间贡献了 REG 的 SUMOylation 地位。由相扑变化形式的 REG 的 Posttranslational 修正被揭示调停 REG 并且到原因的 cytosolic translocation 增加了这 proteasome 使活跃之物的稳定性。显示的 SUMOylation 缺乏的 REG 稀释了能力降级 p21Waf//Cip1 由于为 p21 的 REG SUMOylation 有缺点的异种的减少的亲密关系。一起拿,我们报导调整 proteasome 使活跃之物 REG 的活动的以前未被认出的机制。这规章的机制可以使 REG 能与一个更宽广的底层系列在蛋白质降级作为一个更多的有势力因素工作。 | Yan Wu Lu Wang Ping Zhou Guangqiang Wang Yu Zeng Ying Wang Jian Liu Bianhong Zhang Shuang Liu Honglin Luo Xiaotao Li | 2011 | Cell Research2011，21，5： | 4 |
| 8 | Human umbilical cord mesenchymal stem cells for psoriasis:a phase 1/2a,single-arm study显示文摘Psoriasis is a common,chronic immune-mediated systemic disease that had no effective and durable treatment.Mesenchymal stem cells(MSCs)have immunomodulatory properties.Therefore,we performed a phase 1/2a,single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs(UMSCs)in the treatment of psoriasis and to preliminarily explore the possible mechanisms.Seventeen patients with psoriasis were enrolled and received UMsC infusions.Adverse events,laboratory parameters,PASl,and PGA were analyzed.We did not observe obvious side effects during the treatment and 6-month follow-up.A total of 47.1%(8/17)of the psoriasis patients had at least 40%improvement in the PASl score,and 17.6%(3/17)had no sign of disease or minimal disease based on the PGA score.And the efficiency was 25%(2/8)for males and 66.7%(6/9)for females.After UMSC transplantation(UMSCT),the frequencies of Tregs and CD4^(+)memory T cells were significantly increased,and the frequencies of T helper(Th)17 and CD4^(+)naive T cells were significantly decreased in peripheral blood(PB)of psoriasis patients.And all responders showed significant increases in Tregs and CD4^(+)memory T cells,and significant decreases in Th17 cells and serum IL-17 level after UMsCT.And baseline level of Tregs in responders were significantly lower than those in nonresponders.In conclusion,allogeneic UMSCT is safe and partially effective in psoriasis patients,and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT.Trial registration Clinical Trials NCT03765957. | Lamei Cheng Siqi Wang Cong Peng Xiao Zou Chao Yang Hua Mei Chuang Li Xian Su Na Xiao Qi Ouyang Mi Zhang Qiaolin Wang Yan Luo Minxue Shen Qun Qin Honglin Wang Wu Zhu Guangxiu Lu Ge Lin Yehong Kuang Xiang Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 9 | Analysis of the degradation mechanism of methylene blue by atmospheric pressure dielectric barrier discharge plasma显示文摘 | Fangmin Huang Li Chen Honglin Wang Zongcheng Yan | 2010 | Chemical Engineering Journal2010，，1： | 2 |
| 10 | Efficient production of transgenic chickens using self-inactive HIV-based lentiviral vectors显示文摘We demonstrated the simple and effective production of transgenic chickens,in which the enhanced green fluorescence protein(EGFP)was expressed by using third-generation self-inactive HIV-based lentiviral vectors.In our experiments,lentiviruses were injected into 204 fertilized eggs,from which 30(15%)chickens were hatched.The exogenous gene was detected in the genomes of 16 out of 30(53%)chickens.The green fluorescence signal was observed directly in various body parts,and was particularly significant in the testes.The transgenes were also found in the offspring of these chickens.The results indicate that HIV-based lentiviral vectors can be used to generate transgenic birds economically and effectively. | Shiyong XU Yan SUN Hongmei DING Meng WANG Yafei CAI Jie CHEN Honglin LIU | 2009 | Current Zoology2009，55，5： | 2 |
| 11 | Effects of cutting parameter on microstructure and corrosion behavior of 304 stainless steel in simulated primary water显示文摘The influence of surface conditions on the corrosion behavior of engineering structures has been paid more attention.However,there is still a lack of systematic research on the effect of cutting parameters on material’s microstructure and performance in service.In this paper,the effect of cutting parameters on microstructure and corrosion behaviors of 304 stainless steel in simulated primary water is well investigated.The results show that different cutting parameters can cause the superficial layer a gradient microstructure with nanocrystalized layer on top and deformation band structures underneath.With the similar surface roughness,the deformation microstructure can be very different due to the different cutting parameters.The effect degree on the depth of deformation zone is feed rate>cutting depth>cutting speed.The larger feed rate,lower cutting depth,lower cutting rate may induce a deeper deformation zone.With the increasing depth away from the machined surface,the localized corrosion rate is decreased,and at the same depth the localized corrosion rate along the deformation bands is higher than that along the grain boundaries(GBs).The nanocrystalized surface has a smallest general corrosion rate due to the quick formation of Cr rich oxide film.However,once the corrosion penetrates through this nanocrystalized layer,subsequent preferential corrosion at deformation bands and GBs will dominate and may lead to the significant increase of corrosion rate of the component in high temperature pressurized water. | Honglin Yan Jianqiu Wang Zhiming Zhang Bright O.Okonkwo | 2022 | Journal of Materials Science & Technology2022，，27： | 2 |
| 12 | Emergy analysis of cassava chips-suitable feed- stock for fuel ethanol in China显示文摘 | Hui Yang Li Chen Zongcheng Yan Honglin Wang | 2010 | Ecological Engineer- ing2010，，36： | 1 |
| 13 | Targeting of DICE1 tumor suppressor by Epstein–Barr virus‐encoded miR‐BART3* microRNA in nasopharyngeal carcinoma显示文摘 | Ting Lei Kit‐San Yuen Rui Xu Sai Wah Tsao Honglin Chen Mengfeng Li Kin‐Hang Kok Dong‐Yan Jin | 2013 | Int J Cancer2013，，1： | 1 |
| 14 | Origin and tectonic significance of a Meso- zoic multi-layer over-thrust system within the Yangtze Block (South China) 显示文摘 | Yan Danping Zhou Meffu Song Honglin Wang Xin- wen Malpas J | 2003 | Tectonophysies2003，361，34： | 1 |
| 15 | Synthesis and photocatalytic activity of three-dimensional ZnS/CdS composites显示文摘 | Shuling Liu Honglin Li Lu Yan | 2013 | Materials Research Bulletin2013，，9： | 1 |
| 16 | Ontogenetic trace element distribution in brachiopod shells:An indicator of original seawater chemistry显示文摘 | Xinqing Lee Ruizhong Hu Uwe Brand Hui Zhou Xiaoming Liu Honglin Yuan Chongling Yan Hongguang Cheng | 2004 | Chemical Geology2004，209，： | 1 |
| 17 | Highly efficient metal-free catalyst from cellulose for hydrogen peroxide photoproduction instructed by machine learning and transient photovoltage technology显示文摘Great attention has been paid to green procedures and technologies for the design of environmental catalytic systems.Biomassderived catalysts represent one of the greener alternatives for green catalysis.Photocatalytic production of hydrogen peroxide(H_(2)O_(2))from O_(2) and H_(2)O is an ideal green way and has attracted widespread attention.Here,we show a metal-free photocatalyst from cellulose,which has a high photocatalytic activity for the photoproduction of H_(2)O_(2) with the reaction rate up to 2,093μmol/(h·g)and the apparent quantum efficiency of 2.33%.Importantly,a machine learning model was constructed to guide the synthesis of this metal-free photocatalyst.With the help of transient photovoltage(TPV)tests,we optimized their fabrication and catalytic activity,and clearly showed that the formation of carbon dots(CDs)facilitates the generation,separation,and transfer of photo-induced charges on the catalyst surface.This work provides a green way for the highly efficient metal-free photocatalyst design and study from biomass materials with the machine learning and TPV technology. | Yan Liu Xiao Wang Yajie Zhao Qingyao Wu Haodong Nie Honglin Si Hui Huang Yang Liu Mingwang Shao Zhenhui Kang | 2022 | Nano Research2022，15，5： | 1 |
| 18 | Analysis of the degradation mechanism of methylene blue by atmospheric pressure dielectric barrier discharge plasma显示文摘 | Fangming Huang Lichen Honglin Wang Zongcheng Yan | | 0，，： | 1 |
| 19 | Optimi- zation of bioethanol production during simultaneous sac-charification and fermentation in very high-gravity cassavamash 显示文摘 | Bao Yingling Yan Zongcheng Wang Honglin | 2011 | Antonie van Leeuwenhoek2011，99，2： | 1 |
| 20 | Development of universal environment for constructing 5-axis virtual machine tool based on modified D-H notation and OpenGL显示文摘 | Rong Shean Lee Yan Honglin | 2010 | Robotics and Computer-Integrated Manufacturing2010，26，3： | 1 |
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