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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 3 | Stenting of iliac vein obstruction following catheter-directed thrombolysis in lower extremity deep vein thrombosis显示文摘 | MENG Qing-YOU LI Xiao-qiang JIANG Kun QIAN Ai-min SANG Hong-fei RONG Jian-jie DUAN Peng-fei ZHU Li-wei | 2013 | Chinese Medical Journal2013，，18： | 22 |
| 4 | Temporal and spatial changes in nutrients and chlorophyll-a in a shallow lake,Lake Chaohu, China: An 11-year investigation显示文摘Temporal and spatial changes of total nitrogen(TN),total phosphorus(TP) and chlorophyll-a(Chl-a) in a shallow lake,Lake Chaohu,China,were investigated using monthly monitoring data from 2001 through 2011.The results showed that the annual mean concentration ranges of TN,TP,and Chl-a were 0.08-14.60 mg/L,0.02-1.08 mg/L,and 0.10-465.90 μg/L,respectively.Our data showed that Lake Chaohu was highly eutrophic and that water quality showed no substantial improvement during 2001 through 2011.The mean concentrations of TP,TN and Chl-a in the western lake were significantly higher than in the eastern lake,which indicates a spatial distribution of the three water parameters.The annual mean ratio of TN:TP by weight ranged from 10 to 20,indicating that phosphorus was the limiting nutrient in this lake.A similar seasonality variation for TP and Chl-a was observed.Riverine TP and NH4+ loading from eight major tributaries were in the range of 1.56 × 104-5.47 × 104 and 0.19 × 104-0.51 × 104 tons/yr over 2002-2011,respectively,and exceeded the water environmental capability of the two nutrients in the lake by a factor of 3-6.Thus reduction of nutrient loading in the sub-watershed and tributaries would be essential for the restoration of Lake Chaohu. | Libiao Yang Kun Lei Wei Meng Guo Fu Weijin Yan | 2013 | Journal of Environmental Sciences2013，25，6： | 19 |
| 5 | Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger显示文摘Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. | YIN Zhi Na WU Wen Jia SUN Chong Zhen LIU Hui Fan CHEN Wen Bo ZHAN Qi Ping LEI Zhuo Gui XIN Xuan MA Juan Juan YAO Kun MIN Tian ZHANG Meng Meng WU Hui | 2019 | Biomedical and Environmental Sciences2019，32，1： | 14 |
| 6 | Establishment and preliminery use of hepatitis Bvirus preS1/2 antigen assay显示文摘 | CHEN Kun, HAN Bao Guang, MA Xian Kai, ZHANG He Qiu, MENG Li, WANG Guo Hua, XIA Fang, SONG Xiao Guo and LING Shi Gan | 1999 | World Journal of Gastroenterology1999，5，6： | 14 |
| 7 | Transplantation of VEGF165-gene-transfected endothelial progenitor cells in the treatment of chronic venous thrombosis in rats显示文摘背景血栓症的组织和开运河是一个动态、复杂的过程。研究是在我们构造了的长期的静脉的 thrombosis.Methods 上学习干细胞移植和基因 transfection 的 cotherapeutic 效果的这的目的带脉管的 endothelial 生长因素的 recombinant adenoviral 向量 165 (VEGF165 ) 由使用 pAdEasy 系统的基因,它是随后识别了并且放大。同时, endothelial 祖先房间(EPC ) 用 Ficoll 从老鼠骨头髓被孤立,在 EBM-2MV 媒介有教养,并且识别。然后,房间是有 recombinant Ad-VEGF165 的 transfected。EPC 在移植前用 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine (Dil ) 被标记。长期的静脉血栓的一个老鼠模型被劣等的静脉 cava 的部分结扎开发。老鼠随机被划分成 4 个组(n=25,每) :一, Ad-VEGF165/EPC-transplantation 组收到了 1 ml (10 ~ 6 ) Ad-VEGF165/EPCs;B, EPC-transpiantation 组收到了 1 ml (10 ~ 6 ) EPC;C, Ad/EPC-transplantation 组收到了 1 ml (10 ~ 6 ) Ad/EPCs;D,控制组收到了移植媒介的 1 ml。血栓症和邻近的 ceval 墙被收获在移植以后的 28 天;即时量的聚合酶链反应被用来检测脉管的 endothelial 生长的表示水平因素(VEGF ) Mrna;并且西方的弄污被用来在染色的 VEGF 蛋白质 expression.Hematoxylin 曙红测量变化,染色的 immunohistochemical 被执行检测开运河。Neovascularization 被为 von Willebrand 因素(Vwf ) 用抗体染色的 immunohistochemical 检测,它是份量上由在高力量的 microscope.Results 下面数 capillaries 决定了的毛状的密度是的 endothelial cells.The 的一个部件 Ad-VEGF165 被构造,并且 bone-marrow-derived EPC 被栽培并且成功地识别了。我们决定了支持了 EPC 的生长的最佳 transfection 比率。在 transfection 以后, EPC 分泌了 VEGF 蛋白质。在移植以后,在里面进 endothelial 房间的 EPC 和他们的区别的 vivo 幸存被检测与 Dil 污点联系的荧光决定。VEGF Mrna 在组 A 在移植,和 VEGF Mrna 水平以后在组 A, B, C 和 D 被表示比在组 B, C 和 D 的那些显著地高(P < 0.05 ) ;在组 B 和 C 的 VEGF Mrna 层次比在组 D 的那些显著地高(P < 0.05 ) ,并且在在组 B 和 C 的 VEGF Mrna 层次之间没有统计意义。开运河在组 A 的毛状的密度比在组 B 的那些显著地高, C (P < 0.05 ) 并且 D (P < 0.01 ) ;开运河在组 B 和 C 的毛状的密度在组 D 比那显著地高(P < 0.05 ) 。而且,为 EPC 是的组 B 和 C.Conclusions 的价值之间没有统计重要差别成功地由 Ad-VEGF165 的 transfected。合适的 transfection 比率能在移植以后改进 EPC 和 angiogenesis 的提升的可能性的效率。Transfected EPC 引起了静脉血栓症的加速的组织和开运河。 | MENG Qing-you LI Xiao-qiang YU Xiao-bin LEI Feng-rui JIANG Kun LI Chuan-yong | 2010 | Chinese Medical Journal2010，，4： | 14 |
| 8 | The SLC transporter in nutrient and metabolic sensing, regulation, and drug development显示文摘The prevalence of metabolic diseases is growing worldwide. Accumulating evidence suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic diseases. Consistent with metabolic characteristics, the top five organs in which SLC transporters are highly expressed are the kidney, brain, liver, gut, and heart. We aim to understand the molecular mechanisms of important SLC transporter-mediated physiological processes and their potentials as drug targets. SLC transporters serve as Metabolic gate’ of cells and mediate the transport of a wide range of essential nutrients and metabolites such as glucose, amino acids, vitamins, neurotransmitters, and inorganic/metal ions. Gene-modified animal models have demonstrated that SLC transporters participate in many important physiological functions including nutrient supply, metabolic transformation, energy homeostasis, tissue development, oxidative stress, host defense, and neurological regulation. Furthermore, the human genomic studies have identified that SLC transporters are susceptible or causative genes in various diseases like cancer, metabolic disease, cardiovascular disease, immunological disorders, and neurological dysfunction? Importantly, a number of SLC transporters have been successfully targeted for drug developments。 This review will focus on the current understanding of SLCs in regulating physiology, nutrient sensing and uptake, and risk of diseases. | Yong Zhang Yuping Zhang Kun Sun Ziyi Meng Ligong Chen | 2019 | Journal of Molecular Cell Biology2019，11，1： | 11 |
| 9 | Overexpression of Sweet Pepper Glycerol-3-Phosphate Acyltransferase Gene Enhanced Thermotolerance of Photosynthetic Apparatus in Transgenic Tobacco显示文摘In order to investigate the relationship between the lipid composition in thylakoid membrane and thermostability of pho-tosynthetic apparatus,tobacco transformed with sweet pepper sense glycerol-3-phosphate acyltransferase (GPAT) gene were used to analyze the lipid composition in thylakoid membrane,the net photosynthetic rate and chlorophyll fluorescence parameters under high temperature stress. The results showed that the saturated extent of monogalactosyldiacylglycerol (MGDG),sulfoquinovosyldiacylglycerol,digalactosyldiacylglycerol and phosphatidylglycerol in thylakoid membrane of transgenic tobacco T1 lines increased generally. Particularly,the saturated extent in MGDG increased obviously by 16.2% and 12.0% in T1-2 and T1-1,respectively. With stress temperature elevating,the maximum efficiency of photosystem II (PSII) photochemistry (Fv/Fm),actual photochemical efficiency of PSII in the light ( PSII) and net photosynthetic rate (Pn) of the two lines and wild type tobacco plants decreased gradually,but those parameters decreased much less in transgenic plants. Even though the recovery process appeared differently in the donor and acceptor side of PSII in transgenic tobacco compared with wild-type plants,the entire capability of PSII recovered faster in transgenic tobacco,which was shown in the parameters of PI,Fv/Fm and PSII,as a result,the recovery of Pn was accelerated. Conclusively,we proposed that the increase in saturated extent of thylakoid membrane lipids in transgenic plants enhanced the stability of photosynthetic apparatus under high temperature stress. | Kun Yan Na Chen Yan-Yan Qu Xin-Chun Dong Qing-Wei Meng Shi-Jie Zhao | 2008 | Journal of Integrative Plant Biology2008，50，5： | 11 |
| 10 | Regulation of Rice Tillering by RNA-Directed DNA Methylation at Miniature Inverted-Repeat Transposable Elements显示文摘Tillering is a major determinant of rice plant architecture and grain yield.Here,we report that depletion of rice OsNRPD1a and OsNRPD1b,two orthologs of the largest subunit of RNA polymerase IV,leads to a high-tillering phenotype,in addition to dwarfism and smaller panicles.OsNRPD1a and OsNRPD1b are required for the production of 24-nt small interfering RNAs that direct DNA methylation at transposable elements(TEs)including miniature inverted-repeat TEs(MITEs).Interestingly,many genes are regulated either positively or negatively by TE methylation.Among them,OsMIR156d and OsMIR156j,which promote rice tillering,are repressed by CHH methylation at two MITEs in the promoters.By contrast,D14,which suppresses rice tillering,is activated by CHH methylation at an MITE in its downstream.Our findings reveal regulation of rice tillering by RNA-directed DNA methylation at MITEs and provide potential targets for agronomic trait enhancement through epigenome editing. | Le Xu Kun Yuan Meng Yuan Xiangbing Meng Min Chen Jianguo Wu Jiayang Li Yijun Qi | 2020 | Molecular Plant2020，13，6： | 9 |
| 11 | A Transgenic Study on Affecting Potato Tuber Yield by Expressing the Rice Sucrose Transporter Genes OsSUT5Z and OsSUT2M显示文摘在许多植物,蔗糖 transporters 为从来源和进口的两个蔗糖出口是必要的进水池,显示功能在吸收划分。为了调查蔗糖 transporters 是否能改进淀粉的收益,种,土豆植物(茄属 tuberosum L。cv。 | Aijun Sun Yan Dai Xinsheng Zhang Chunmin Li Kun Meng Honglin Xu Xiaoli Wei Guifang Xiao Pieter B.F, Ouwerkerk Mei Wang Zhen Zhu | 2011 | Journal of Integrative Plant Biology2011，53，7： | 9 |
| 12 | Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex显示文摘To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD patients.Neuronavigated rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five days.Clinical outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four weeks.MRI was measured at days 0 and5.The individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good tolerance.Changes in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized group.Treatment reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized group.We demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement. | Zhijun Zhang Hongxing Zhang Chun-Ming Xie Meng Zhang Yachen Shi Ruize Song Xiang Lu Haisan Zhang Kun Li Bi Wang Yongfeng Yang Xianrui Li Jianli Zhu Yang Zhao Ti-Fei Yuan Georg Northoff | 2021 | Science China(Life Sciences)2021，64，1： | 8 |
| 13 | Circulating tumor cells:biology and clinical significance显示文摘Circulating tumor cells(CTCs)are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood.Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against cancer metastasis.Detecting these very rare CTCs among the massive blood cells is challenging.However,emerging technologies for CTCs detection have profoundly contributed to deepening investigation into the biology of CTCs and have facilitated their clinical application.Current technologies for the detection of CTCs are summarized herein,together with their advantages and disadvantages.The detection of CTCs is usually dependent on molecular markers,with the epithelial cell adhesion molecule being the most widely used,although molecular markers vary between different types of cancer.Properties associated with epithelial-tomesenchymal transition and stemness have been identified in CTCs,indicating their increased metastatic capacity.Only a small proportion of CTCs can survive and eventually initiate metastases,suggesting that an interaction and modulation between CTCs and the hostile blood microenvironment is essential for CTC metastasis.Single-cell sequencing of CTCs has been extensively investigated,and has enabled researchers to reveal the genome and transcriptome of CTCs.Herein,we also review the clinical applications of CTCs,especially for monitoring response to cancer treatment and in evaluating prognosis.Hence,CTCs have and will continue to contribute to providing significant insights into metastatic processes and will open new avenues for useful clinical applications. | Danfeng Lin Lesang Shen Meng Luo Kun Zhang Jinfan Li Qi Yang Fangfang Zhu Dan Zhou Shu Zheng Yiding Chen Jiaojiao Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 8 |
| 14 | Enhancement of the imbibition recovery by surfactants in tight oil reservoirs显示文摘Hydraulic fracturing technology can significantly increase oil production from tight oil formations, but performance data show that production declines rapidly. In the long term, it is necessary to increase the development efficiency of block matrix, surfactant-aided imbibition is a potential way. The current work aimed to explain comprehensively how surfactants can enhance the imbibition rate. Laboratory experiments were performed to investigate the effects of wettability, interfacial tension(IFT), and relative permeability as the key parameters underlying surfactant solution imbibition. Two different types of surfactants, sodium dodecyl sulfate and polyethylene glycol octylphenol ether, at varied concentrations were tested on reservoir rocks. Experimental results showed that the oil recovery rate increased with increased wettability alteration and IFT and decreased residual oil saturation. A mechanistic simulator developed in previous studies was used to perform parametric analysis after successful laboratory-scale validation. Results were proven by parametric studies. This study,which examined the mechanism and factors influencing surfactant solution imbibition, can improve understanding of surfactant-aided imbibition and surfactant screening. | Zhan Meng Sheng-Lai Yang Yan Cui Zi-Yao Zhong Cheng-Gang Liang Lu Wang Kun Qian Quan-Zheng Ma Jun-Ru Wang | 2018 | Petroleum Science2018，15，4： | 7 |
| 15 | Review of Chinese atmospheric science research over the past 70 years: Synoptic meteorology显示文摘Synoptic meteorology is a branch of meteorology that uses synoptic weather observations and charts for the diagnosis,study,and forecasting of weather.Weather refers to the specific state of the atmosphere near the Earth’s surface during a short period of time.The spatial distribution of meteorological elements in the atmosphere can be represented by a variety of transient weather phenomena,which are caused by weather systems of different spatial and temporal scales.Weather is closely related to people’s life,and its development and evolution have always been the focus of atmospheric scientific research and operation.The development of synoptic meteorology is closely related to the development of observation systems,dynamical theories and numerical models.In China,observation networks have been built since the early 1950 s.Up to now,a comprehensive meteorological observation systembased on ground,air and space has been established.In particular,the development of a new generation of dense radar networks,the development of the Fengyun satellite series and the implementation of a series of large field experiments have brought our understanding of weather from large-scale environment to thermal dynamics,cloud microphysical structure and evolution characteristics of meso and micro-scale weather systems.The development of observation has also promoted the development of theory,numerical model and simulation.In the early days,China mainly used foreign numerical models.Lately,China has developed numerical model systems with independent intellectual property rights.Based on the results of high-resolution numerical simulations,in-depth understanding of the initiation and evolution mechanism and predictability of weather at different scales has been obtained.Synoptic meteorology has gradually changed from an initially independent development to a multidisciplinary approach,and the interaction between weather and the change of climate and environment has become a hot and frontier topic in atmospheric science.This paper reviews the important scientific and technological achievements made in China over the past 70 years in the fields of synoptic meteorology based on the literatures in China and abroad,from six aspects respectively including atmospheric dynamics,synoptic-scale weather,typhoon and tropical weather,severe convective weather,numerical weather prediction and data assimilation,weather and climate,atmospheric physics and atmospheric environment. | Zhiyong MENG Fuqing ZHANG Dehai LUO Zhemin TAN Juan FANG Jianhua SUN Xueshun SHEN Yunji ZHANG Shuguang WANG Wei HAN Kun ZHAO Lei ZHU Yongyun HU Huiwen XUE Yaping MA Lijuan ZHANG Ji NIE Ruilin ZHOU Sa LI Hongjun LIU Yuning ZHU | 2019 | Science China Earth Sciences2019，62，12： | 7 |
| 16 | Common Injuries and Repair Mechanisms in the Endothelial Lining显示文摘 | Ling-Bing Meng Kun Chen Yuan-Meng Zhang Tao Gong | 2018 | Chinese Medical Journal2018，，19： | 7 |
| 17 | Hyaluronic acid facilitates bone repair effects of calcium phosphate cement by accelerating osteogenic expression显示文摘Calcium phosphate cements(CPC)are widely anticipated to be an optimum bone repair substitute due to its satisfied biocompatibility and degradability,suitable to be used in minimally invasive treatment of bone defects.However the clinical application of CPC is still not satisfied by its poor cohesiveness and mechanical properties,in particular its osteoinductivity.Hyaluronic acid reinforced calcium phosphate cements(HA/CPC)showed extroadinary potential not only enhancing the compressive strength of the cements but also significantly increasing its osteoinductivity.In our study,the compressive strength of HA/CPC increased significantly when the cement was added 1%hyaluronic acid(denoted as 1-HA/CPC).In the meantime,hyaluronic acid obviously promoted ALP activity,osteogenic related protein and mRNA expression of hBMSCs(human bone marrow mesenchymal stem cells)in vitro,cement group of HA/CPC with 4%hyaluronic acid adding(denoted as 4-HA/CPC)showed optimal enhancement in hBMSCs differentiation.After being implanted in rat tibial defects,4-HA/CPC group exhibited better bone repair ability and bone growth promoting factors,comparing to pure CPC and 1-HA/CPC groups.The underlying biological mechanism of this stimulation for HA/CPC may be on account of higher osteogenic promoting factors secretion and osteogenic genes expression with hyaluronic acid incorporation.These results indicate that hyaluronic acid is a highly anticipated additive to improve physicochemical properties and osteoinductivity performance of CPCs for minimally invasive healing of bone defects. | Xu Cui Chengcheng Huang Zhizhen Chen Meng Zhang Chunyu Liu Kun Su Jianyun Wang Li Li Renxian Wang Bing Li Dafu Chen Changshun Ruan Deping Wang William W.Lu Haobo Pan | 2021 | Bioactive Materials2021，6，11： | 6 |
| 18 | Cloning and Expression Analysis of Rice Sucrose Transporter Genes OsSUT2M and OsSUT5Z显示文摘Two sucrose transporter(SUT) cDNAs,OsSUT2M and OsSUT5Z,were isolated from rice(Oryza sativa L.) by reverse transcription polymerase chain reaction(RT-PCR). Sequencing results indicate they are 1 531 bp and 1 635 bp in length including complete open reading frame 1 506 bp and 1 608 bp,which encode 502 amino acids and 536 amino acids,respectively. The TopPred program suggested that both sucrose transporter proteins,OsSUT2M and OsSUT5Z,consist of potentially 12 transmembrane domains. Semi-quantitative RT-PCR was carried out to investigate the gene expression patterns of OsSUT2M and OsSUT5Z. In vegetative organs,transcripts of OsSUT2M were higher in source leaf blades than in other organs at the same development stage,whereas transcripts of OsSUT5Z were less traceable in all organs investigated. In reproductive organs,both transcripts of these two genes were high in panicles from the booting stage to 7 days after flowering(DAF) and then sharply declined. The potential physiology functions of these two sucrose transporters are discussed. | Ai-Jun Sun Hong-Lin Xu Wan-Kui Gong Hong-Li Zhai Kun Meng Yong-Qin Wang Xiao-Li Wei Gui-Fang Xiao Zhen Zhu | 2008 | Journal of Integrative Plant Biology2008，50，1： | 5 |
| 19 | Molecular characterization of three Hsp90 from Pieris and expression patterns in response to cold and thermal stress in summer and winter diapause of Pieris melete显示文摘热吃惊蛋白质(Hsps ) 在昆虫被连接了到压力和冬季 diapause,但是他们是否是夏天 diapause 的部件,仍然是未知的。分别地,在这研究,从 Pieris melete 的 Hsp90 的互补 DNA, Pieris rapae 和 Pieris canidia,命名 PmHsp90, PrHsp90 和 PcHsp90 被克隆并且定序。推出的氨基酸顺序分别地与 82.6, 82.6 和 82.7 kDa 的一个通常认为的分子的团由 718 氨基酸残余组成了。氨基酸序列在 Hsp90 家庭和合拢活动区域的 bHLH 蛋白质五个保存签名主题包含了所有。响应夏天 diapause 和冬季 diapause 的 PmHsp90 的微分表示模式,与热 / 寒冷应力有关,被调查。冷应力在夏天和冬季 diapause 蛹,然而并非在 nondiapause 个人导致了 Hsp90 upregulation。热吃惊 upregulated PmHsp90 逐渐地随在夏天 diapause,和 PmHsp90 的温度的增加是很快在冬季 diapause 的 upregulated。在 39 点在 30 min 热以后震惊牥捡慥???????? ???? ???? 吗?? | Wu, Yue‐Kun Zou, Chao Fu, Dao‐Meng Zhang, Wan‐Na Xiao, Hai‐Jun | 2018 | Insect Science2018，25，2： | 5 |
| 20 | Large-area high quality PtSe2 thin film with versatile polarity显示文摘Two-dimensional(2D)materials have attracted increasing attention for their outstanding structural and electrical properties.However,for mass-production of field effect transistors(FETs)and potential applications in integrated circuits,large-area and uniform 2D thin films with high mobility,large on-off ratio,and desired polarity are needed to synthesize firstly.Here,a transfer-free growth method for platinum diselenide(PtSe2)films has been developed.The PtSe2 films have been synthesized with various thicknesses in centimeter-sized scale.Typical FET made from a few layer PtSe2 show p-type unipolar,with a high field-effect hole mobility of 6.2 cm^(2) V^(−1) s^(−1) and an on-off ratio of 5×10^(3).The versatile semimetal-unipolar-ambipolar transition in synthesized PtSe2 films is also firstly observed as the thickness thinning.This work realizes the large-scale preparation of PtSe2 with prominent electrical properties and provides a new strategy for polarity's modulation. | Wei Jiang Xudong Wang Yan Chen Guangjian Wu Kun Ba Ningning Xuan Yangye Sun Peng Gong Jingxian Bao Hong Shen Tie Lin Xiangjian Meng Jianlu Wang Zhengzong Sun | 2019 | InfoMat2019，1，2： | 5 |
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