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| 1 | In vitro derivation of functional insulin-producing cells from human embryonic stem cells显示文摘为人的胚胎的茎(ES ) 的自强和区别的能力细胞为对待类型 Idiabetes mellitus 为胰腺的贝它细胞的产生使他们成为潜在的来源。这里,我们报导一最新发展了并且有效方法,在aserum免费的系统执行了,区分进生产胰岛素的 cells.Activin A 的导致的人的 ES 房间它在起始的阶段被使用从人的 EScells 导致权威的内胚叶区别,是由权威的内胚叶标记 Sox17 和 Brachyury.Further 的表示检测了, all-trans retinoic 酸( RA )被用来支持胰腺的区别,由早胰腺的抄写因素 pdx1 和 hlxb9 的表示显示了。在成熟 inDMEM/F12 以后有 bFGF 和菸碱的没有浆液的媒介,区分的房间表示了小岛特定的标记象 C 肽,胰岛素,胰高血糖素和 glut2 那样。百分比 ofC-peptide-positive 房间超过了 15% 。由这些房间的胰岛素和 C 肽的分泌物在葡萄糖层次对应于变化。当移植了进肾的囊时, ofStreptozotocin (STZ ) 对待裸体老鼠,这些区分的人的 ES 房间熬过并且维持贝它房间标记基因的表示包括 C 肽, pdx1, glucokinase, nkx6.1, IAPP, pax6and Tcf1。百分之三十只移植裸体老鼠展出了 stableeuglycemia 的明显的恢复;并且改正的显型被支撑超过六个星期。我们的新方法为学习人的胰开发的机制提供一个有希望的试管内区别模特儿并且说明为类型 Idiabetes mellitus 的处理使用人的 ES 房间的潜力。 | Wei Jiang Yan Shi Dongxin Zhao Song Chen Jun Yong Jing Zhang Tingting Qing Xiaoning Sun Peng Zhang Mingxiao Ding Dongsheng Li Hongkui Deng | 2007 | Cell Research2007，17，4： | 38 |
| 2 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 3 | Fluoride Conversion Coating on Biodegradable AZ31B Magnesium Alloy显示文摘A fluoride conversion coating was successfully prepared on AZ31 B magnesium alloy by chemical reaction in hydrofluoric acid.Morphologies,composition,bonding strength,corrosion properties,in vitro cytotoxicity and antibacterial properties of the coating were investigated,respectively.The scanning electron microscopy observations revealed a dense coating with some irregular pores.The thin-film X-ray diffraction analysis indicated that the coating was mainly composed of MgO and MgF2.The electrochemical impedance spectroscopy results showed that the fluoride conversion coating significantly improved the corrosion resistance of AZ31 B.The hydroxyapatite formed on the surface of the fluoride coated AZ31 B after being immersed in the simulated blood plasma indicated the good bioactivity of the material.The in vitro cytotoxicity test showed that the fluoride coated AZ31 B alloy was not toxic to BMMSCs(human bone marrow-derived mesenchymal stem cells).It was also found that the fluoride coated AZ31 B alloy had antibacterial capability. | Tingting Yan Lili Tan Bingchun Zhang Ke Yang | 2014 | Journal of Materials Science & Technology2014，30，7： | 11 |
| 4 | Association of COVID-19 Vaccination and Clinical Severity of Patients Infected with Delta or Omicron Variants——China,May 21,2021-February 28,2022显示文摘Summary What is already known about this topic?Compared with the international mRNA and adenovirus-vectored coronavirus disease 2019(COVID-19)vaccines,there is less real-world research data about breakthrough cases in people vaccinated with China-made COVID-19 vaccines.Analyses of clinical outcomes of breakthrough cases will be an important supplement to the clinical trial efficacy and observational effectiveness data of China-made COVID-19 vaccines. | Mingshuang Li Qianqian Liu Dan Wu Lin Tang Xiaoqi Wang Tingting Yan Zhijie An Zundong Yin Geroge F.Gao Fuzhen Wang Hui Zheng | 2022 | China CDC weekly2022，4，14： | 10 |
| 5 | The Epitope Study on the SARS-CoV Nucleocapsid Protein显示文摘The nucleocapsid protein (N protein) has been found to be an antigenic protein in a number of coronaviruses. Whether the N protein in severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is antigenic remains to be elucidated. Using Western blot and Enzyme-linked Immunosorbent Assay (ELISA),the recombinant N proteins and the synthesized peptides derived from the N protein were screened in sera from SARS patients. All patient sera in this study displayed strong positive immunoreactivities against the recombinant N proteins,whereas normal sera gave negative immunoresponses to these proteins, indicating that the N protein of SARS-CoV is an antigenic protein. Furthermore, the epitope sites in the N protein were determined by competition experiments, in which the recombinant proteins or the synthesized peptides competed against the SARS-CoV proteins to bind to the antibodies raised in SARS sera. One epitope site located at the C-terminus was confirmed as the most antigenic region in this protein. A detailed screening of peptide with ELISA demonstrated that the amino sequence from Codons 371 to 407 was the epitope site at the C-terminus of the N protein. Understanding of the epitope sites could be very significant for developing an effective diagnostic approach to SARS. | Shuting Li, Liang Lin, Hao Wang, Jianning Yin, Yan Ren, Zhe Zhao, Jie Wen, Cuiqi Zhou, Xumin Zhang, Xiaolei Li, Jingqiang Wang, Zhengfeng Zhou, Jinxiu Liu, Jianmin Shao, Tingting Lei, Jianqiu Fang, Ningzhi Xu, and Siqi LiuBeijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China & Beijing Proteomics Institute, Beijing 101300, China | 2003 | Genomics, Proteomics & Bioinformatics2003，1，3： | 9 |
| 6 | C/EBPα regulates SIRT1 expression during adipogenesis显示文摘SIRT1 在 adipogenesis 起一个重要作用,但是 SIRT1 怎么在 adipogenesis 被调整,大部分是未知的。在这研究,我们证明 SIRT1 蛋白质和 mRNA 层次与 CCAAT/enhancer-binding 蛋白质伪一起被增加(C/EBP 伪) 在 adipocyte 区别期间。C/EBP 伪,然而并非 C/EBP 伪 p 30,在 HeLa 房间和 3T3-L1 的激活的 SIRT1 倡导者 preadipocytes。而且, C/EBP 伪 upregulated SIRT1 mRNA 和蛋白质在 Soas2 房间以一种 p53 独立的方式在 HeLa 铺平房间和增加的 SIRT1 表示。在 preadipocytes, C/EBP 伪 upregulated SIRT1 蛋白质水平的宫外的表示并且导致的 C/EBP 伪击倒 SIRT1 的减少蛋白质水平。而且由倡导者删除分析,胶化移动试金和染色质 immunoprecipitation,我们发现了那 C/EBP,伪在一个一致 C/EBP 伪绑定地点跳了到 SIRT1 倡导者。这些数据证明那 C/EBP 伪在 adipogenesis 期间调整 SIRT1 表示由对 SIRT1 倡导者直接有约束力。 | Qihuang Jin Fang Zhang Tingting Yan Zhen Liu Chunxi Wang Xinjian Ge Qiwei Zhai | 2010 | Cell Research2010，20，4： | 8 |
| 7 | Ultra-sensitive graphene strain sensor for sound signal acquisition and recognition显示文摘为健全信号获得和识别的一个便携、高精确的传感器从编织的特殊设计的 graphene 的薄电影被制作织物(GWF ) 。在被拉长之上,随机的裂缝的高密度出现在网络,它减少当前的小径,从而增加电阻。因此,这部电影能对人的喉咙作为一个紧张传感器起作用以便测量通过肌肉运动,一个声音是否被生产的讲话。超离频敏感允许由提取声波的签名特征的快速、低频率的讲话采样的实现。在这研究, 26 封英语信,典型汉字和音调的代表性的信号,甚至短语和句子被测试,揭示在电阻的明显、典型的变化。而且, graphene 传感器的电阻变化与预告录下的声音完美地反应了。由把人工智能与数字信号处理相结合,我们期望以后,这个 graphene 传感器将能成功地达成复杂声学的系统和听觉的数据的大数量。 | Yan Wang Tingting Yang Junchao Lao Rujing Zhang Yangyang Zhang Miao Zhu Xiao Li Xiaobei Zang Kunlin Wang Wenjian YU Hu Jin Li Wang Hongwei Zhu | 2015 | Nano Research2015，8，5： | 8 |
| 8 | Analyzing and modeling the coverage of vegetation in the Qaidam Basin of China: The role of spatial autocorrelation显示文摘在植被和环境因素之间的关系总是是在生态学的一个主要话题,但是揭示植被也是一个重要方法对的动态反应和气候上的效果改变的反馈。为特殊地理地点和 Qaidam 盆的气候的特征,与支持传统并且遥感数据,在这份报纸,一个植被范围模型被建立。由五个环境因素的植被范围的量的预言开始通过多重逐步的回归(MSR ) 被认识到模型。然而,在这五个环境因素之中有重要 multicollinearity,它减少 MSR 模型的表演。然后通过 Moran 的介绍索引,反映植被分发,仅仅平均年度降雨的二个变量和本地 Moran 索引的空间自相关的指示物在植被范围模型的最后的建立被使用。结果证明在植被的分发有重要空间自相关。在植被范围模型的建立的空间自相关的角色让改进不仅从 0.608 ~ 0.656 的模型试穿 R2,而且在独立人士之中移开 multicollinearity。 | ZHU Wenbin JIA Shaofeng LU Aifeng YAN Tingting | 2012 | Journal of Geographical Sciences2012，22，2： | 8 |
| 9 | Transcriptome analysis of blood stasis syndrome in subjects with hypertension显示文摘OBJECTIVE:To screen for m RNAs associated with blood stasis syndrome and to explore the genetic mechanisms of blood stasis syndrome in hypertension.METHODS:This study involved groups of patients with hypertension and blood stasis,including those with Qi deficiency,Qi stagnation,cold retention and heat retention;as well as hypertensive patients without blood stasis and healthy individuals.Human umbilical vein endothelial cells were co-cultured with the sera of these healthy individuals and patients with blood stasis syndrome.Total RNA was extracted from these cells and assessed by a high-throughput sequencing method(Solexa)and digital gene expression.Differentially expressed genes among these six groups were compared using whole genome sequences,and m RNAs associated with blood stasis syndrome identified.Differences in gene use and gene ontology function were an-alyzed.Genes enriched significantly and their pathways were determined,as were network interactions,and encoded proteins.Gene identities were confirmed by real-time polymerase chain reactions.RESULTS:Compared with cells cultured in sera of the blood stasis groups,those culture in sera of healthy individuals and of the non-blood stasis group showed 11 and 301 differences,respectively in stasis-related genes.Genes identified as differing between the blood stasis and healthy groups included activating transcription factor 4,activating transcription factor 3,DNA-damage inducible transcription factor 3,Tribbles homolog 3,CCAAT/enhancer binding protein-β,and Jun proto-oncogene(JUN).Pathway and protein interaction network analyses showed that these genes were associated with endoplasmic reticulum stress.Cells cultured in sera of patients with blood stasis and Qi deficiency,Qi stagnation,heat retention,and cold retention were compared with cells cultured in sera of patients with the other types blood stasis syndrome.The comparison showed differences in expression of 28,28,34,and 32 specific genes,respectively.CONCLUSION:The pathogenesis of blood stasis syndrome in hypertension is related to endoplasmic reticulum stress and involves the differential expression of the activating transcription factor 4,activating transcription factor 3,DNA-damage inducible transcription factor 3,Tribbles homolog 3,CCAAT/enhancer binding protein-β,and JUN genes. | He Ling Fang Meixia Chen Liguo Zhou Jianhua Yuan Jing Xu Jing Shan Yan Xu Qingyun Xiong Tingting | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 7 |
| 10 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 11 | Systematic characterization of transport and thermoelectric properties of a macroscopic graphene fiber显示文摘Graphene,有非凡的电、热、有弹性的性能的二维的材料,是未来技术的一个潜在的候选人。然而, graphene 的优异性质还没为 graphenederived 被认识到宏观的结构象 graphene 纤维那样。在这研究,我们系统地调查了温度(T) 依赖者运输和 graphene 纤维的热电的性质,包括热传导性() ,电的电导率() ,并且 Seebeck 系数(S) 。从 45.8 ~ 149.7 Wd | Weigang Ma Yingjun Liu Shen Yan Tingting Miao Shaoyi Shi Mincheng Yang Xing Zhang Chao Gao | 2016 | Nano Research2016，9，11： | 6 |
| 12 | Chemically doped macroscopic graphene fibers with significantly enhanced thermoelectric properties显示文摘当与突出的热电的性质结合了时,灵活便携电子学为收获系统的未来精力正在答应候选人。Graphene 和它的宏观的集会(例如,基于 graphene 的纤维和电影) 因为他们的非凡的电、机械的性质,因此是众多的研究的题目。然而,这些集会没由于他们的高内在的热传导性为热电的应用程序被认为合适。在这研究,溴做被表明是为显著地提高 graphene 纤维的热电的性质的一个有效方法。做提高声子由于增加的缺点散布并且因此减少热传导性,当电的传导性和 Seebeck 系数被费密增加时,铺平换至较低排挡。作为结果,优点的最大的数字是 2. | Weigang Ma Yingjun Liu Shen Yan Tingting Miao Shaoyi Shi Zhen Xu Xing Zhang Chao Gao | 2018 | Nano Research2018，11，2： | 6 |
| 13 | Realization of non-equilibrium process for high thermoelectric performance Sb-doped Ge Te显示文摘Pristine GeTe shows inferior thermoelectric performance around unit due to the large carrier concentration induced by the presence of intrinsic high concentration of Ge vacancy. In this study, we report a thermoelectric figure of merit ZT of 1.56 at 700 K, realized in Sb-doped GeTe based thermoelectric(TE)materials via combined effect of suppression of intrinsic Ge vacancy and Sb doping. The nonequilibrium nature during melt spinning process plays very important role. For one thing, it promotes the homogeneity in Ge_(1-x)Sb_xTe samples and refines the grain size of the product. Moreover the persistent Ge precipitated as impurity phase in the traditional synthesis process is found to be dissolved back into the GeTe sublattice, accompanying with a drastic suppression of Ge vacancies concentration which in combination with Sb electron doping significantly reduced the inherent carrier concentration in GeTe.Low carrier concentration, approaching the optimum carrier concentration ~3.74 × 10^(-20) cm^(-3) and a high power factor of 4.01 × 10^(-3) W m^(-1)K^(-2) at 750 K are achieved for Ge_(0.98)Sb_(0.02) Te sample. In addition,the enhanced grain boundary phonon scattering by refining the grain size through melt spinning(MS)process, coupled with the intensified alloying phonon scattering via Sb doping leads to low thermal conductivity of 1.53 W m^(-1) K^(-1) at 700 K for Ge_(0.94) Sb_(0.06) Te sample. All those contribute to a high ZT value,representing over 50% improvement in the ZT value compared to the Sb free samples, which provides an alternative way for ultrafast synthesis of high performance GeTe based thermoelectric material. | Evariste Nshimyimana Xianli Su Hongyao Xie Wei Liu Rigui Deng Tingting Luo Yonggao Yan Xinfeng Tang | 2018 | Science Bulletin2018，63，11： | 6 |
| 14 | Current applications and future prospects of nanotechnology in cancer immunotherapy显示文摘Cancer immunotherapy is an artificial stimulation of the immune system to recognize cancer cells and activate specific immune cells to target and attack cancer cells.In clinical trials, immunotherapy has recently shown impressive results in the treatment of multiple cancers.Thus, cancer immunotherapy has gained a lot of attention for its unique advantages and promising future.With extensive research on cancer immunotherapy, its safety and effectiveness has gradually been revealed.However, it is still a huge challenge to expand and drive this therapy while maintaining low toxicity, high specificity, and long-lasting efficacy.As a unique technology, nanotechnology has been applied in many fields, the advantages of which will promote the development of cancer immunotherapies.Researchers have tried to apply nanomaterials to cancer immunotherapy due to their advantageous properties,such as large specific surface areas, effective drug delivery, and controlled surface chemistry, to improve treatment efficacy.Here,we briefly introduce the current applications of nanomaterials in cancer immunotherapy, including adoptive cell therapy(ACT),therapeutic cancer vaccines, and monoclonal antibodies, and throw light on future directions of nanotechnology-based cancer immunotherapy. | Sen Yan Peng Zhao Tingting Yu Ning Gu | 2019 | Cancer Biology & Medicine2019，16，3： | 6 |
| 15 | Bimetallic nickel molybdate supported Pt catalyst for efficient removal of formaldehyde at low temperature显示文摘Efficient removal of formaldehyde from indoor environments is of significance for human health.In this work,a typical binary transition metal oxide that could provide various oxidation states,β-NiMoO4,was employed as a support to immobilize the active Pt component(Pt/NiMoO4)for catalytic formaldehyde elimination at low ambient temperature(15℃).The results showed that the hydrothermal preparation temperature and time had a noticeable impact on the morphology and catalytic activity of the samples.The catalyst prepared with hydrothermal temperature of 150℃for 4 hr(Pt-150-4)exhibited superior catalytic activity and stability mainly due to its distinctly porous structure,relative abundance of adsorbed surface hydroxyls/water,and high oxidation ability,which resulted from the interaction of Pt with Ni and Mo of the bimetallic NiMoO4 support.Our results might shed light on the rational design of multifunctional catalysts for removal of indoor air pollutants at low ambient temperature. | Gang Huang Zhaoxiong Yan Shuyuan Liu Tingting Luo Liang An Zhihua Xu | 2020 | Journal of Environmental Sciences2020，32，1： | 6 |
| 16 | A novel approach to melt purification of magnesium alloys显示文摘A novel low-cost method for melt purification of magnesium alloys,the melt self-purifying technology(MSPT),has been developed successfully based on a low temperature melt treatment(LTMT)without adding any fluxes.The iron solubility in the molten liquid of magnesium and its alloys,and the settlement velocity of iron particles were calculated.It is shown that the low temperature melt treatment is an effective method to decrease the impurity Fe content in magnesium and its alloys.Without any additions,the Fe content in the AZ31 alloy was reduced to 15 ppm from the initial 65 ppm,and the Fe content in the AZ61 melt was decreased to 20 ppm from the initial 150 ppm after the low temperature melt treatment.The results also showed that the Fe content in AM60 and AM50 dropped to 15 and 18 ppm,respectively,from the initial 150 ppm after the low temperature melt treatment.For ZK 60,the Fe content in the melt down to less than 5 ppm was achieved.After the low temperature melt treatment,the Si content in the above alloys was also decreased obviously. | Fusheng Pan Xianhua Chen Tao Yan Tingting Liu Jianjun Mao Wei Luo Qin Wang Jian Peng Aitao Tang Bin Jiang | 2016 | Journal of Magnesium and Alloys2016，4，1： | 5 |
| 17 | Preferential binding between intracellular organic matters and Al_(13) polymer to enhance coagulation performance显示文摘Coagulation is the best available method for removing intracellular organic matter(IOM),which is released from algae cells and is an important precursor to disinfection by-products in drinking water treatment. To gain insight into the best strategy to optimize IOM removal, the coagulation performance of two Al salts, i.e., aluminum chloride(AlCl_3) and polyaluminum chloride(PACl, containing 81.2% Al_(13)), was investigated to illuminate the effect of Al species distribution on IOM removal. PACl showed better removal efficiency than AlCl_3 with regard to the removal of turbidity and dissolved organic carbon(DOC), owing to the higher charge neutralization effect and greater stability of pre-formed Al_(13) species. High pressure size exclusion chromatography analysis indicated that the superiority of PACl in DOC removal could be ascribed to the higher binding affinity between Al_(13) polymer and the low and medium molecular weight(MW) fractions of IOM. The results of differential log-transformed absorbance at 254 and 350 nm indicated more significant formation of complexes between AlCl_3 and IOM, which benefits the removal of tryptophan-like proteins thereafter. Additionally,PACl showed more significant superiority compared to AlCl_3 in the removal of <5 kD a and hydrophilic fractions, which are widely viewed as the most difficult to remove by coagulation.This study provides insight into the interactions between Al species and IOM, and advances the optimization of coagulation for the removal of IOM in eutrophic water. | Ruiping Liu Tingting Guo Min Ma Mingquan Yan Jing Qi Chengzhi Hu Gang Liu Huijuan Liu Jiuhui Qu Walter van der Meer | 2019 | Journal of Environmental Sciences2019，31，2： | 5 |
| 18 | ZBP1 mediates interferon-induced necroptosis显示文摘Interferons(IFNs)play an important role in immunomodulatory and antiviral functions.IFN-induced necroptosis has been reported in cells deficient in receptor-interacting protein kinase 1(RIPK1),Fas-associated protein with death domain(FADD),or caspase-8,but the mechanism is largely unknown.Here,we report that the DNA-dependent activator of IFN regulatory factors(ZBP1,also known as DAI)is required for both type Ⅰ(β)and type Ⅱ(γ)IFN-induced necroptosis.We show that L929 fibroblast cells became susceptible to IFN-induced necroptosis when RIPK1,FADD,or Caspase-8 was genetically deleted,confirming the antinecroptotic role of these proteins in IFN signaling.We found that the pronecroptotic signal from IFN stimulation depends on new protein synthesis and identified ZBP1,an IFN-stimulated gene(ISG)product,as the de novo synthesized protein that triggers necroptosis in IFN-stimulated cells.The N-terminal domain(ND)of ZBP1 is important for ZBP1–ZBP1 homointeraction,and its RHIM domain in the C-terminal region interacts with RIPK3 to initiate RIPK3-dependent necroptosis.The antinecroptotic function of RIPK1,FADD,and caspase-8 in IFN-treated cells is most likely executed by caspase-8-mediated cleavage of RIPK3,since the inhibitory effect on necroptosis was eliminated when the caspase-8 cleavage site in RIPK3 was mutated.ZBP1-mediated necroptosis in IFN-treated cells is likely physiologically relevant,as ZBP1 KO mice were significantly protected against acute systemic inflammatory response syndrome(SIRS)induced by TNF+IFN-γ. | Daowei Yang Yaoji Liang Shubo Zhao Yan Ding Qiuyu Zhuang Qilin Shi Tingting Ai Su-Qin Wu Jiahuai Han | 2020 | Cellular & Molecular Immunology2020，17，4： | 5 |
| 19 | Effects of soaking process on arsenic and other mineral elements in brown rice显示文摘One of the main food crops in the world,rice can accumulate high levels of arsenic from flooded paddy soils,which seriously threatens human health.Soaking,a common processing method for brown rice products,especially for brown rice noodles,was investigated in this study.Japonica rice(Dao Hua Xiang No.2)and Indica rice(Ye Xiang You No.3)were selected for studying the effects of soaking on arsenic concentrations,species,and distributions.Results revealed that soaking can efficiently remove arsenic in these two rice varieties,and the main part of removal is endosperm with the maximal rate of about 40%.Inorganic arsenic(I-As)(about 85%)is the main species of arsenic reduction.Meanwhile,the variations of four other elements(i.e.,Mg,Ca,Zn,and Fe)were analyzed.Collectively,the findings of this study indicate that soaking can efficiently remove arsenic in brown rice under controlled soaking conditions,which thereby reduces the arsenic intake for brown rice customers. | Fan Zhang Fengying Gu Huili Yan Zhenyan He Bolun Wang Hao Liu Tingting Yang Feng Wang | 2020 | Food Science and Human Wellness2020，9，2： | 5 |
| 20 | Effectiveness and safety of Chinese herbal medicines for hepatitis B virus-related acute-on-chronic liver failure:study protocol for a multicenter randomized controlled trial显示文摘OBJECTIVE:To conduct a multicenter randomized controlled trial of the efficacy of standardized Chinese herbal medicines(CHMs)against acuteon-chronic liver failure(ACLF)and provide reproducible and high-level evidence for clinical practice.METHODS:This is a prospective,multicenter,centrally randomized controlled trial.Patients diagnosed with hepatitis B virus-related ACLF(n=510)will be allocated to the standard medical therapy or CHM group at a 1∶1 ratio.Two CHMs will be used on the basis of the traditional Chinese medicine syndrome:Liangxue Jiedu granules for excess syndromes and Yiqi Jiedu granules for deficiency syndromes.The primary outcome is transplant-free survival at week 12.The secondary outcomes are(a)transplant-free survival at week 24,(b)liver function as assessed using the model for end-stage liver disease score at week 12,(c)liver function as assessed using the Child-Pugh score at week 12,and(d)the incidence of complications at week 12.DISCUSSION:The effectiveness and safety of CHM formulations will be assessed following treatment for ACLF.TRIAL REGISTRATION:The trial was registered at Clinical Trials.gov(NCT03577938)on June 24,2018. | Zhang Ning Zhou Chao Wang Lifu He Tingting Wang Yao Wang Yan Bai Yunfeng Li Jun Xiao Xiaohe Gong Man | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 5 |
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