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| 1 | The initial attempt to reveal the emission processes of both mechanoluminescence and room temperature phosphorescence with the aid of circular dichroism in solid state显示文摘A phenothiazine derivative PtzChol containing non-conjugated chiral cholesterol group was designed and synthesized. By analyzing the single crystal structure of PtzChol carefully, coupled with the circular dichroism(CD) signals before and after grinding, it was found that the introduction of cholesterol produced a positive effect on the production of chiral space group, on mechanoluminescence(ML) and room temperature phosphorescence(RTP), and throughout the entire light-emitting process, the CD signal could well reflect the changes of molecular arrangement. | Yu Tian Xuekang Yang Yanbin Gong Yunsheng Wang Manman Fang Jie Yang Zhiyong Tang Zhen Li | 2021 | Science China Chemistry2021，64，3： | 2 |
| 2 | New perylene diimide derivatives: stable red emission, adjustable property from ACQ to AIE, and good device performance with an EQE value of 4.93%显示文摘Perylene diimide(PDI) derivatives, due to their special opto-electronic property, have been successfully utilized in organic field-effect transistor(OFET), solar cells, and as non-fullerene acceptor and others,while few cases in organic light-emitting diodes(OLEDs). In this work, six perylene bisimide-based red emitters, N,N''-bis(2-decyltetradecyl)-1-([1,1':3',1''-terphenyl]-5'-yl)perylene-3,4,9,10-diimide(STPH),N,N'-bis(2-decyltetradecyl)-1,7-bis([1,1':3',1''-terphenyl]-5'-yl)perylene-3,4,9,10-diimide(DTPH), N,N''-bis(2-decyltetradecyl)-1-(5'-phenyl-[1,1':3',1''-terphenyl]-4-yl)perylene-3,4,9,10-diimide(STRPH), N,N0-bis(2-decyltetradecyl)-1,7-bis(5'-phenyl-[1,1':3',1''-terphenyl]-4-yl)perylene-3,4,9,10-diimide(DTRPH),N,N0-bis(2-decyltetradecyl)-1-(4-(2,2-diphenylvinyl)phenyl)perylene-3,4,9,10-diimide(STTPE) and N,N'-bis(2-decyltetradecyl)-1,7-bis(4-(2,2-diphenylvinyl)phenyl)perylene-3,4,9,10-diimide(DTTPE), with the excellent chemical, thermal and photo-chemical stability, are synthesized through the convenient Suzuki coupling reaction, in which, the fluorescent properties can be modified easily from ACQ to AIE by just simply changing the bulky volume of the introduced aromatic substituents. After being fabricated into organic light-emitting diodes, STRPH exhibits the best performance with the maximum luminescence, power efficiency, current efficiency and external quantum efficiency of 1,948 cd m^(-2), 2.04 lm W^(-1), 5.85 cd A^(-1), 4.93% at Commission Internationale de L'Eclairage(CIE) coordinates of(0.56, 0.34),as the result of the high efficient energy transfer and good energy match achieved in the device. | Luyi Zong Yanbin Gong Yun Yu Yujun Xie Guohua Xie Qian Peng Qianqian Li Zhen Li | 2018 | Science Bulletin2018，63，2： | 2 |
| 3 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 4 | Progress of pyrene-based organic semiconductor in organic field effect transistors显示文摘Thanks to the pure blue emitting, high planarity, electron rich and ease of chemical modification, pyrene has been thoroughly investigated for applications in organic electronics such as organic light emitting diodes(OLEDs), organic field effect transistors(OFETs), and organic solar cells(OSCs). Especially, great progresses have been made of pyrene-based organic semiconductors for OFETs in past decades. Due to the difference of molecular structure, pyrene-based organic semiconductors are divided into three categories, pyrene as terminal group, pyrene as center core and fused pyrene derivatives. This minireview gives a brief introduction of the structure-property relationship and application in OFETs about most of pyrene-based semiconducting materials since 2006,illustrating that pyrene is a good building block to construct semiconductors with superior transport property for OFETs. Finally, we provide a summary concerning the methodology to improve the transport property of the pyrene-based semiconducting materials as well as an outlook. | Yanbin Gong Xuejun Zhan Qianqian Li Zhen Li | 2016 | Science China Chemistry2016，59，12： | 1 |
| 5 | Utilizing Electroplex Emission to Achieve External Quantum Efficiency up to 18.1% in Nondoped Blue OLED显示文摘For the first time,electroplex emission is utilized to enhance the performance of nondoped blue organic light-emitting diodes(OLEDs).By decorating the twisted blue-emitting platform and adjusting the electronic structure,three molecules of 3Cz-Ph-CN,3Cz-mPh-CN,and 3Ph-Cz-CN with a donor-acceptor structure are synthesized and investigated.When external voltage is applied,electroplex emission,which contributes to the emission performance of OLED,can be realized at the interface between the emitting layer and the electron-transporting layer.Accordingly,high external quantum efficiency of 18.1%can be achieved,while the emission wavelength of the device can be controlled in the blue region.Our results provide the possibility to enhance the performance of OLED through electroplex emission,in addition to the generally investigated thermally activated delayed fluorescence(TADF).Excitedly,when 3Ph-Cz-CN is used as host material in orange-emitting phosphorous OLEDs(PO-01 as the dopant),unprecedented high external quantum efficiency of 27.4%can also be achieved. | Xuejun Zhan Zhongbin Wu Yanbin Gong Jin Tu Yujun Xie Qian Peng Dongge Ma Qianqian Li Zhen Li | 2020 | Research2020，，1： | 1 |
| 6 | Effects of trace calcium and strontium on microstructure and properties of Cu-Cr alloys显示文摘Cu-0.57Cr-0.01Ca and Cu-0.58Cr-0.01Sr(wt.%)alloys were fabricated and processed by thermo-mechanical treatment.Their mechanical and electrical properties and microstructure were investigated in detail and compared with those of a Cu-0.57Cr(wt.%)alloy.The results showed that the softening resistance of the Cu-Cr alloy was significantly improved by the additions of Ca and Sr elements.Compared with the Cu-Cr alloy,the deformation microstructure of the Cu-Cr-Ca and Cu-Cr-Sr alloys was more difficult to recrystallize at elevated temperatures,and the Cr precipitates in the Cu-Cr-Ca and Cu-Cr-Sr alloys were smaller in size and had an FCC structure at any given aging state.The high strengths of the Cu-Cr-Ca and Cu-Cr-Sr alloys were mainly attributed to the dislocation strengthening provided by high-density dislocations and the precipitate strengthening provided by fine Cr precipitates.First-principles calculation showed that the segregations of Ca and Sr atoms at interface between Cr precipitates and copper matrix were favorable in energetics.This segregation effectively hindered the growth of Cr precipitates and significantly enhanced the pinning effect on the motion of dislocations and subgrain boundaries,eventually leading to the improvement in the softening resistance of the Cu-Cr alloy. | Muzhi Ma Zhu Xiao Xiangpeng Meng Zhou Li Shen Gong Jie Dai Hongyun Jiang Yanbin Jiang Qian Lei Haigen Wei | 2022 | Journal of Materials Science & Technology2022，，17： | 1 |
| 7 | Improved thermal conductivity of styrene acrylic resin with carbon nanotubes, graphene and boron nitride hybrid fillers显示文摘In the process of printing and copying,the volatilization of toner produces tiny particles and harmful gases that are detrimental to the human body.Low-temperature printing and copying can reduce harmful gas emissions.Styrene acrylic resin is the main component of toner and the thermal conductivity of toner can be improved by increasing the thermal conductivity of styrene acrylic resin.In this paper,hexagonal boron nitride(h-BN),carboxyl modified multi-walled carbon nanotubes(MWCNTs-COOH)and graphene hybrid fillers were added into styrene acrylic resin to improve the thermal conductivity of resin composite by forming a connected thermal conductivity network in resin.The experimental result shows that the thermal conductivity of the h-BN/styrene acrylic resin composite increases with the increase in h-BN filler content(0-20wt%).When 20.0 wt%h-BN is added into styrene acrylic resin,the thermal conductivity is increased by 83.63%.Hybrid fillers(MWCNTs-COOH/graphene and 3.0 wt%h-BN)were added in styrene acrylic resin and the thermal conductivity of the composite is almost the same or higher than that of 20.0 wt%h-BN/styrene acrylic resin composite.The thermal conductivity of styrene acrylic resin composites improved by 69.57%and 87.14%via adding 1.5wt%CNTs-3 wt%h-BN and 1.0wt%graphene-3 wt%h-BN.MWCNTs-COOH or graphene can bridge isolated h-BN aggregates to form a thermally conductive network in styrene acrylic resin,while the addition of graphene improves the thermal conductivity of resin composite higher than that of MWCNTs-COOH. | Fuhua Jia Emmanuel Oluwaseyi Fagbohun Qianyu Wang Duoyin Zhu Jianling Zhang Bin Gong Yanbin Cui | 2021 | Carbon Resources Conversion2021，4，1： | 0 |
| 8 | Imaging cellular distribution of fluorescent supramolecular nanofibers显示文摘In this study, we used the 4-nitro-2,1,3-benzoxadiazole(NBD) as an aromatic capping group for a peptide to construct the supramolecular nanofibers. Taking the advantage of the fluorescence property of NBD, we could directly observe the cellular distribution of the self-assembled nanofibers. We found that the distributions of the nanofibers of NBD-FFETIGGY are different in four mammalian cells and two plant cells. The nanofibers are mainly located at the surface of two mammalian cells and one plant cell, while in the intracellular space of other cells. Different distributions of nanofibers lead to different protein binding patterns of the nanofibers in two different cell lines. We believe that a useful and versatile platform has been offered to the image cellular distribution of nanofibers, which can provide useful information to the biological functions of the self-assembled nanostructures. | Jingyu Wang Jing Zheng Yanbin Cai Jinxin Zheng Jie Gao Qingqiu Gong Zhimou Yang | 2016 | Science China Chemistry2016，59，6： | 0 |
| 9 | Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1显示文摘Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative stress.Functionalized SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application value.Herein,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse liver.Further elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also performed.The results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting study.PTR-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 expression.Besides,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial morphology.Furthermore,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective efficacy.Being a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications. | Si Zou Yetao Gong Xiujie Li Yanbin Wu Jinzhong Wu Jianguo Wu Ka-Hing Wong | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
| 10 | Clogging of slurry-shield tunnel-boring machine drives in sedimentary soft rock:A case study显示文摘This paper presents a case study of the clogging of a slurry-shield tunnel-boring machine(TBM)experienced during tunnel operations in clay-rich argillaceous siltstones under the Ganjiang River,China.The clogging experienced during tunneling was due to special geological conditions,which had a considerably negative impact on the slurry-shield TBM tunneling performance.In this case study,the effect of clogging on the slurry-shield TBM tunneling performance(e.g.,advance speed,thrust,torque,and penetration per revolution)was fully investigated.The potential for clogging during tunnel operations in argillaceous siltstone was estimated using an existing empirical classification chart.Many improvement measures have been proposed to mitigate the clogging potential of two slurry-shield TBMs during tunneling,such as the use of an optimum cutting wheel,a replacement cutting tool,improvements to the circulation flushing system and slurry properties,mixed support integrating slurry,and compressed air to support the excavation face.The mechanisms and potential causes of clogging are explained in detail,and the contributions of these mitigation measures to tunneling performance are discussed.By investigating the actual operational parameters of the slurry-shield TBMs,these mitigation measures were proven to be effective in mitigating the clogging potential of slurry-shield TBMs.This case study provides valuable information for slurry-shield TBMs involving tunneling in clay-rich sedimentary rocks. | Chengyong CAO Xiangsheng CHEN Chenghua SHI Yanbin FU Chenjie GONG Zuxian WANG | 2023 | Frontiers of Structural and Civil Engineering2023，17，10： | 0 |
| 11 | Precise Regulation of Distance between Associated Pyrene Units and Control of Emission Energy and Kinetics in Solid State显示文摘Many approaches have been explored to tune emission behaviors of organic luminogens.However,precise regulation of distances in dimers is seldom reported.Here,four pyrene derivatives are presented,and we precisely regulate the distance between pyrene units of X2P.Its crystal manifests unusual deep-blue excimer emission at 424 nm,while the crystal of X1P with only one pyrene unit for each molecule gives sky-blue emission with a maximum emission peak at 475 nm. | Jiaqiang Wang Qianxi Dang Yanbin Gong Qiuyan Liao Guochang Song Qianqian Li Zhen Li | 2021 | CCS Chemistry2021，3，12： | 0 |
| 12 | Optimizing water-saving irrigation schemes for rice(Oryza sativa L.)using DSSAT-CERES-Rice model显示文摘Rice is one of the major crops in China,and enhancing the rice yield and water use efficiency is critical to ensuring food security in China.Determining how to optimize a scientific and efficient irrigation and drainage scheme by combining existing technology is currently a hot topic.Crop growth models can be used to assess actual or proposed water management regimes intended to increase water use efficiency and mitigate water shortages.In this study,a CERES-Rice model was calibrated and validated using a two-year field experiment.Four irrigation and drainage treatments were designed for the experiment:alternate wetting and drying(AWD),controlled drainage(CD),controlled irrigation and drainage for a low water level(CID1),and controlled irrigation and drainage for a high water level(CID2).According to the indicators normalized root mean square error(NRMSE)and index of agreement(d),the calibrated CERES-Rice model accurately predicted grain yield(NRMSE=6.67%,d=0.77),,shoot biomass(NRMSE=3.37%,d=0.77),actual evapotranspiration(ETa)(NRMSE=3.83%,d=0.74),irrigation volume(NRMSE=15.56%,d=0.94),and leaf area index(NRMSE=9.69%,d=0.98)over 2 a.The calibrated model was subsequently used to evaluate rice production in response to the four treatments(AWD,CD,CID1,and CID2)under 60 meteorological scenarios which were divided into wet years(22 a),normal years(16 a),and dry years(22 a).Results showed that the yield of AWD was the largest among four treatments in different hydrological years.Relative to that of AWD,the yield of CD,CID1,and CID2 were respectively reduced by 5.7%,2.6%,8.7%in wet years,9.2%,2.3%,8.6% in normal years,and 9.2%,3.8%,3.9% in dry years.However,rainwater use efficiency and irrigation water use efficiency were the greatest for CID2 in different hydrological years.The entropy-weighting TOPSIS model was used to optimize the four water-saving irrigation schemes in terms of water-saving,labor-saving and high-yield,based on the simulation results of the CERES-Rice model in the past 60 a.These results showed that CID1 and AWD were optimal in the wet years,CID1 and CID2 were optimal in the normal and dry years.These results may provide a strong scientific basis for the optimization of water-saving irrigation technology for rice. | Shikai Gao Qiongqiong Gu Xuewen Gong Yanbin Li Shaofeng Yan Yuanyuan Li | 2023 | International Journal of Agricultural and Biological Engineering2023，16，2： | 0 |
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