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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | To inhibit coffee ring effect in inkjet printing of light-emitting polymer films by decreasing capillary force显示文摘Polymer thin film with uniform thickness and flat surface profile is the key point for polymer light emitting diodes(PLEDs) by inkjet printing. However, the coffee ring effect is usually observed due to the mismatch between the evaporation of the solvent and the decrease of solution volume, which promotes the formation of radial flow from the interior of the drop to the edge. In this paper, coffee ring effects of inkjet printed poly(spirobifluorene) films were proposed to be restrained by decreasing capillary force by adding co-solvent with high boiling point and high viscosity to the main solvent. The low evaporation rate of the co-solvent can reduce the driving force of the radial flow; meanwhile the high viscosity of the co-solvent can increase the resistance of the radial flow. Thus, polymer films with improve uniformity can be obtained due to the suppression of the radial flow. The device performance was greatly improved under the condition of proper film thickness and film uniformity and the maximum luminous efficiency of devices with inkjet printed poly(spirobifluorene) can reach 80% of the spin-coated devices. | Xinhong Yu Rubo Xing Zhongxiang Peng Yangming Lin Zhonghui Du Junqiao Ding Lixiang Wang Yanchun Han | 2019 | Chinese Chemical Letters2019，30，1： | 4 |
| 3 | Inkjet printing of viscoelastic polymer inks显示文摘Inkjet printing is a new fabricating method that can realize the precise film deposition. For polymer inks,the coil-stretch transition of polymer chains always impacts the ink droplet formation and a beads-on-a string structure filament is formed, thus generating unwanted satellite droplets. This review provides a short introduction of the dynamic process of the droplet formation. Then fluid rheological requirements for a printable polymer ink are summarized. Finally the strain hardening phenomenon of polymer chains in the filament formation and its impact on polymer ink-jetting are discussed. The research of viscoelastic polymer inks shows that rheological parameters and viscoelasticity are two key factors that determine the printability of polymer inks. | Zhonghui Du Xinhong Yu Yanchun Han | 2018 | Chinese Chemical Letters2018，29，3： | 4 |
| 4 | Magnetic Detection Method for Seabed Cable in Marine Engineering Surveying显示文摘海床电报的察觉和鉴定在海洋的工程正在成为一项重要任务。地磁异常的 Thefeatures 能被用来检测海床电报的存在。磁场模型被介绍,并且在模型和观察数据的模拟之间的地磁异常分发的一致性被验证。比较证明海床电报能有效地与合理方法被检测并且识别。 | YU Bo LIU Yanchun ZHAI Guojun BIAN Gang XIAO Fumin | 2007 | Geo-Spatial Information Science2007，10，3： | 3 |
| 5 | Artificial neural network approach to predict the flow stress in the isothermal compression of as-cast TC21 titanium alloy显示文摘 | Yanchun Zhu Weidong Zeng Yu Sun Fei Feng Yigang Zhou | 2011 | Computational Materials Science2011，，5： | 2 |
| 6 | Quantitative Determination of Urine Glucose: Combination of Laminar Flow in Microfluidic Chip with SERS Probe Technique显示文摘 | SUN Dan LIU Xiangyuan XU Shuping TIAN Yu XU Weiqing TAO Yanchun | 2018 | Chemical Research in Chinese Universities2018，34，6： | 2 |
| 7 | Discovery of ABO_(4)scheelites with the extra low thermal conductivity through high-throughput calculations显示文摘Searching for new materials with extra low thermal conductivities is significant in numerous fields like thermal barrier coatings and thermoelectric devices.Traditional multiple-component design has successfully reduced the thermal conductivity,but it also dramatically increases the complexity of manufactural technologies and the risk of material failures.In this work,a specific category known as ABO_(4) scheelites that with both simple crystal structure and the structural signature of the low lattice thermal conductivity is explored.High-throughput calculations are employed to screen for the materials with the targeted performance by multi-dimensional mechanical/thermal property criteria and a database of 46 stable scheelites is constructed.Seven scheelites with both ultra-low thermal conductivities(<1.2 W/(m∙K))and quasi-ductility are predicted to be novel thermal insulation materials.Low thermal conductivities prefer the scheelites with large valence disparity between“A”and“B”cations and/or small ionic radius ratio.The adopted strategy starting from the structural fingerprint and the data-driven material selection is expected to be a reference of future structural and functional ceramics design. | Yuchen Liu Dechang Jia Yu Zhou Yanchun Zhou Juanli Zhao Qian Li Bin Liu | 2020 | Journal of Materiomics2020，6，4： | 2 |
| 8 | High pressure effects on the crystal structure andelectric conductivity of perovskite like (Ca/Sr)_2CuO_2Cl_2 compounds显示文摘The crystal structure stability as well as electric conductance of (Sr/Ca)_2CuO_2Cl_2 compound with K_2NiF_4 structure was investigated up to 31 GPa using diamond anvil technique. It seems that (Sr/Ca)_2CuO_2Cl_2 is quite stable under pressure but with obvious anisotropic compressibility. The equation of state (EOS) obtained shows relative large bulk modulus. | LIU QingQing WANG FuRen LI FengYing CHEN LiangChen YU RiCheng JIN ChangQing LI YanChun LIU Jing | 2008 | Chinese Science Bulletin2008，53，18： | 2 |
| 9 | Formyl tetrahydrofolate deformylase affects hydrogen peroxide accumulation and leaf senescence by regulating the folate status and redox homeostasis in rice显示文摘It is well established that an abnormal tetrahydrofolate(THF)cycle causes the accumulation of hydrogen peroxide(H_(2)O_(2))and leaf senescence,however,the molecular mechanism underlying this relationship remains largely unknown.Here,we reported a novel rice tetrahydrofolate cycle mutant,which exhibited H_(2)O_(2)accumulation and early leaf senescence phenotypes.Map-based cloning revealed that HPA1 encodes a tetrahydrofolate deformylase,and its deficiency led to the accumulation of tetrahydrofolate,5-formyl tetrahydrofolate and 10-formyl tetrahydrofolate,in contrast,a decrease in 5,10-methenyl-tetrahydrofolate.The expression of tetrahydrofolate cycle-associated genes encoding serine hydroxymethyl transferase,glycine decarboxylase and 5-formyl tetrahydrofolate cycloligase was significantly down-regulated.In addition,the accumulation of H_(2)O_(2)in hpa1 was not caused by elevated glycolate oxidation.Proteomics and enzyme activity analyses further revealed that mitochondria oxidative phosphorylation complex I and complex V were differentially expressed in hpa1,which was consistent with the H_(2)O_(2)accumulation in hpa1.In a further feeding assay with exogenous glutathione(GSH),a non-enzymatic antioxidant that consumes H_(2)O_(2),the H_(2)O_(2)accumulation and leaf senescence phenotypes of hpa1 were obviously compensated.Taken together,our findings suggest that the accumulation of H_(2)O_(2)in hpa1 may be mediated by an altered folate status and redox homeostasis,subsequently triggering leaf senescence. | Erhui Xiong Guojun Dong Fei Chen Chen Zhang Shan Li Yanli Zhang Jahidul Islam Shohag Xiaoe Yang Yihua Zhou Qian Qian Limin Wu Yanchun Yu | 2021 | Science China(Life Sciences)2021，64，5： | 1 |
| 10 | Population structure and linkage disequilibrium of a mini core set of maize inbred lines in China显示文摘 | Ronghuan Wang Yongtao Yu Jiuran Zhao Yunsu Shi Yanchun Song Tianyu Wang Yu Li | 2008 | Theoretical and Applied Genetics2008，，7： | 1 |
| 11 | Population structure and linkage disequilibrium of a mini core set of maize inbred lines in China显示文摘 | Ronghuan Wang Yongtao Yu Jiuran Zhao Yunsu Shi Yanchun Song Tianyu Wang Yu Li | 2008 | Theoretical and Applied Genetics2008，，7： | 1 |
| 12 | Recommendations for the diagnosis and treatment of paroxysmal kinesigemc dyskinesia: an expert consensus in China显示文摘Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes.Paroxysmal kinesigenic dyskinesia(PKD)is the most common type of paroxysmal dyskinesia and can be divided into primary and secondary types based on the etiology.Clinically,PKD is characterized by recurrent and transient attacks of involuntary movements precipitated by a sudden voluntary action.The major cause of primary PKD is genetic abnormalities,and the inheritance pattern of PKD is mainly autosomal-dominant with incomplete penetrance.The proline-rich transmembrane protein 2(PRRT2)was the first identified causative gene of PKD,accounting for the majority of PKD cases worldwide.An increasing number of studies has revealed the clinical and genetic characteristics,as well as the underlying mechanisms of PKD.By seeking the views of domestic experts,we propose an expert consensus regarding the diagnosis and treatment of PKD to help establish standardized clinical evaluation and therapies for PKD.In this consensus,we review the clinical manifestations,etiology,clinical diagnostic criteria and therapeutic recommendations for PKD,and results of genetic analyses in PKD patients performed in domestic hospitals. | Li Cao Xiaojun Huang Ning Wang Zhiying Wu Cheng Zhang Weihong Gu Shuyan Cong Jianhua Ma Ling Wei Yanchun Deng Qi Fang Qi Niu Jin Wang Zhaoxia Wang You Yin Jinyong Tian Shufen Tian Hongyan Bi Hong Jiang Xiaorong Liu Yang Lu Meizhen Sun Jianjun Wu Erhe Xu Tao Chen Tao Chen Xu Chen Wei Li Shujian Li Qinghua Li Xiaonan Song Ying Tang Ping Yang Yun Yang Min Zhang Xiong Zhang Yuhu Zhang Ruxu Zhang Yi Ouyang Jintai Yu Quanzhong Hu Qing Ke Yuanrong Yao Zhe Zhao Xiuhe Zhao Guohua Zhao Furu Liang Nan Cheng Jianhong Han Rong Peng Shengdi Chen Beisha Tang | 2021 | Translational Neurodegeneration2021，10，1： | 1 |
| 13 | Development and genetic mapping of SSR markers in foxtail millet [Setaria italica (L.) P. Beauv.]显示文摘 | Xiaoping Jia Zhongbao Zhang Yinghui Liu Chengwei Zhang Yunsu Shi Yanchun Song Tianyu Wang Yu Li | 2009 | Theoretical and Applied Genetics2009，，4： | 1 |
| 14 | Performance of FRP bonding systems under fatigue loading显示文摘 | Yanchun Yun Yu -Fei Wu Wai Ching Tang | 2008 | Engineering Structures2008，30，11： | 1 |
| 15 | The effects of coil-stretch transition behavior of polyfluorene inks on single droplet formation during inkjet printing显示文摘For drop-on-demand(DOD)inkjet printing,stable and single ink droplet fo rmation without satellite dots is the key to improve the print quality.The formation of stable and single droplet is influenced by filament break up and the polymer chain’s coil-stretch transition behavior.In this paper,the droplet formation behaviors of polyfluorene(PFO)ink at various driving voltages(V),polymer chain’s coil-stretch transition mechanism and its effects on single ink droplet formation are investigated.It indicates that when 5863 V,Wi>0.5,the PFO molecular chain is stretched because of the high hydrodynamic forces,resulting unwanted satellite droplets.When 55 | Zhonghui Du Hang Zhou Weiran Cao Xinhong Yu Yanchun Han | 2020 | Chinese Chemical Letters2020，31，12： | 0 |
| 16 | Influence of Tide Models on the Use of Altimetry Data to Research Sea Level Anomaly显示文摘A tide model (named DN1.0), which contains 12 principal constituents over China seas and the Northwest Pacific is estimated by along-track harmonic analysis with TOPEX/Poseidon altimetry data taken from 1993 to 2002. CSR3.0, FES95.2 and DN1.0 are used respectively to detide the data for the time series of sea level anomaly (SLA) in the Yellow Sea, East China Sea, South China Sea and Northwest Pacific. The SLA curves and the power spectral density show that the major components that exist in SLA in China seas arise from the error of the tide models. | XU Jun BAO Jingyang LIU Yanchun YU Caixia | 2007 | Geo-Spatial Information Science2007，10，2： | 0 |
| 17 | Design optimized intermixed phase by tuning polymer-fullerene intercalation for free charge generation显示文摘The inte rmixed phase is important in effective charge separation due to the formation of cascaded energy landscape between intermixed phase and pure phases in polymer/fullerene solar cells.However,the quantitative relationship between the charge separation and the content of intermixed phase has not been investigated clearly so far.Here,we proposed to tune the content of the polymer/PC71BM intermixed phase by cha nging the polymer solution conformatio n.Poly[2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene](PBTTT)and PC71 BM was selected as a model system.The organization of the PBTTT in solution promotes the formation of ordered aggregates as aging time increases,the interdigitation of side-chains restricts the intercalation of PC71 BM.Therefore,the intermixed phase formed by intercalation PC71 BM to PBTTT side chain can be controlled.When the aging time increasing from 0 to 80 min,the extent of inte rcalation gradually from almost complete intercalated phase to almost non-intercalated.As the content of intercalated phase is about 11%,the charge dissociation is most efficie nt and short circuit current(Jsc)increased from 1.60 mA/cm2 to 4.94 mA/cm2,leading to optimized device performance. | Qiang Zhang Jiangang Liu Xinhong Yu Yanchun Han | 2019 | Chinese Chemical Letters2019，30，7： | 0 |
| 18 | A Scheme for Verifying the Integrity of Outsourced Data显示文摘Unauthorized tampering with outsourced data can result in significant losses for both data owner and users.Data integrity therefore becomes an important factor in outsourced data systems.In this paper,we address this problem and propose a scheme for verifying the integrity of outsourced data.We first propose a new authenticated data structure for authenticating membership queries in sets based on accumulators,and then show how to apply it to the problem of verifying the integrity of outsourced data.We also prove that our scheme is secure under the q-strong DiffieHellman assumption.More importantly,our scheme has the constant cost communication,meanwhile keeping other complexity measures constant.Compared to previous schemes based on accumulators,our scheme reduces update cost and so improves previous schemes based on accumulators.In addition,the experimental comparison shows that our scheme outperforms the previous schemes. | WANG Xiaoming YU Fang LIN Yanchun GAN Qingqing WU Daini | 2015 | China Communications2015，12，11： | 0 |
| 19 | Supramolecular complex glycoconjugate vaccine generates self-enhancement effects for carbohydrate antigen delivery显示文摘Targeting delivery of tumor-associated carbohydrate antigen(TACA)-based vaccine to antigen-presenting cells(APCs)mediated by endogenous antibodies can improve the immunogenicity of TACA.However,an essential requirement of this approach is to generate high titers of endogenous antibodies in vivo through pre-immunization,which complicates the immunization procedure and may cause side effects.Herein,we report a new generation of APC-targeting TACA-based supramolecular complex vaccine,assembled by sialyl Thomsen-nouveau-bovine serum albumin-adamantine(sTn-BSA-Ada)and heptavalent rhamnose(Rha)-modifiedβ-cyclodextrin(β-CD)via host-guest interaction.The complex vaccine retained anti-Rha antibodies recruiting capability and facilitated the APCs uptake of the vaccine via the interaction of the Fc-domain with the Fc receptors on APCs.We demonstrate that direct immunization of complex vaccine elicited anti-Rha and anti-sTn specific immune response synchronously,generating a novel self-enhancement effect that can improve the antigen delivery to APCs in high efficacy.The structure-activity relationship(SAR)study proved that complex vaccine 4 with polyethylene glycol 6(PEG 6)linker in host molecule provoked a robust and specific sTn immune response comparable to the pre-immunization approach.The antisera induced by complex vaccine,either through direct immunization or pre-immunization,exhibited equal potency of cytotoxicity against the sTn expression cancer cells.This study provides a general platform for TACA-based vaccines with self-enhancement effects without the need for pre-immunization. | Han Lin Yanchun Li Kun Zhou Dan Li Hangyan Yu Jie Zhao Haofei Hong Zhifang Zhou Zhimeng Wu | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 20 | An Unstructured Finite Volume Method for Impact Dynamics of a Thin Plate显示文摘为结构的动力学的一个未组织的有限体积方法的考试为系统的影响动力学的模拟被估计。柔韧的显示双时间的走方法被利用获得时间精确答案。影响动力学的学习是应该认为力量模型和州的方程描述材料的机械行为的一个复杂问题。当前的方法有几个特征。1 ) 未组织的有限体积方法的分离方程自然地跟随能量守恒定律。2 ) 显示双时间的走方法对影响的分析合适时间的动态问题精确解决方案。3 ) 当大变丑出现了时,方法没生产格子失真。方法被一个有弹性的盘子的影响动力学的问题与起始的条件和材料性质验证。结果验证有限元素数字数据。 | Weidong Chen Yanchun Yu | 2012 | Journal of Marine Science and Application2012，11，4： | 0 |
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