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| 1 | The association between early-onset cardiac events caused by neoadjuvant or adjuvant chemotherapy in triple-negative breast cancer patients and some novel autophagy-related polymorphisms in their genomic DNA: a real-world study显示文摘Background:An increasing number of cancer patients die of cardiovascular diseases.The cardiotoxicity of chemo-therapy is particularly important in triple-negative breast cancer(TNBC)with limited therapeutic options.Cardiac autophagy is an important mechanism of cardiotoxicity.This research was aimed to investigate the cardiotoxicity of chemotherapy in TNBC,screen the susceptible population,and determine the relationship between cardiotoxicity and autophagy-related polymorphisms.Methods:From a total of 2450 stage I-III TNBC patients,147 met the inclusion criteria and finally recruited.Electro-cardiography(ECG)was performed before most chemotherapy cycles,and echocardiography(UCG)was performed according to clinical needs.All ECG and UCG records were re-interpreted by cardiologists at the National Center for Cardiovascular Disease,Fuwai Hospital.According to the National Center for Biotechnology Information and the Catalog of Somatic Mutations in Cancer database,we selected 25 single nucleotide polymorphisms(SNPs)related to autophagy and genotyped the 147 TNBC patients.Paired-sample T tests,Chi squared tests,and logistic regression models were employed for the analysis.Results:Only 46(31.3%)patients had normal ECG records after every chemotherapy cycle.Among the 16 patients who underwent UCG,2(12.5%)had a reversible decrease of left ventricular ejection fraction.The use of anthracyclines and excessive alcohol consumption were risk factors of ECG abnormalities.With the continuation of chemotherapy,heart rate gradually increased.Anthracyclines were associated with QRS duration abnormalities(P=0.043).After genotyping for 25 autophagy-related SNPs,we found that the G allele of autophagy-related 13(ATG13)rs10838611 was significantly associated with ECG abnormalities(odds ratio=2.258,95%confidence interval=1.318-3.869;P=0.003).Conclusion:ECG abnormalities caused by chemotherapy are common in the real world.Autophagy-related SNPs are associated with chemotherapy-induced cardiotoxicity,thereby providing new evidence for autophagy as a cause of chemotherapy-induced cardiac damage. | Binliang Liu Tao An Meiying Li Zongbi Yi Chunxiao Li Xiaoying Sun Xiuwen Guan Lixi Li Yanfeng Wang Yuhui Zhang Binghe Xu Fei Ma Yixin Zeng | 2018 | Cancer Communications2018，38，1： | 5 |
| 2 | Improvement of Heating Method for Measuring the Wetness of Flowing Wet Steam显示文摘In this paper, an improvement of heating method for measuring wetness of the flowing wet steam is developed, the basic principle of the heating method is presented and the mathematical model has been built for analyzing the thermodynamics problezns during the process of heating. Moreover, an instru-ment for measuring wetness of wet steam flow was designed and made out. This instrument has been used for measuring wetness of the wet steam flow at the outlet of the nozzle rig in Thermal TUrbine Laboratory Xi’an Jiaotong University. By analyzing the relative error of the result, it was found that this instrument has fairly high accuracy it can be used as the prototype of practical instrument and has an important applicable value in engineering. | Li YanFeng Wang XinJun Xu TingXiang(School of Energy and Power Engineering, Xi’an Jiaotong University Xi’an, Shed, 710049, China) | 1998 | Journal of Thermal Science1998，7，3： | 3 |
| 3 | Wind Tunnel Experiments and Numerical Study on Performance Characteristics of an H-type Vertical Axis Wind Turbine in the Spanwise Direction显示文摘The aerodynamic forces and vortex characteristics of an H-type Vertical Axis Wind Turbine(VAWT)become complicated because of dynamic stall,particularly in the three-dimensional impact on the blade spanwise direction.This study focused on the evaluation of the aerodynamic performance and vortex characteristics of an H-type VAWT in the spanwise direction by numerical simulations and wind tunnel experiments.Pressure acting on the blade surface was obtained from multiport pressure measurement devices by wind tunnel.Meanwhile,the vortex field around different blade sections was investigated through numerical simulations.The stall behavior was analysed by comparing the results of numerical simulations and experiments.As a result,the tangential force of single blade was mainly contributed at the chordwise position of x/c≤0.4 c and the power of single blade was mainly contributed at the azimuthal angle range of 60°≤θ≤150°in the blade section position region of 0≤z/(H/2)≤0.7.At the section position of z/(H/2)=0.5,the initial flow separation was found at the suction side and progressed forward to the leading edge.With the increase of the tip speed ratios,the decreasing position of the averaged local power coefficient of each section was closer to the middle section of z/(H/2)=0,and the attenuation speed became faster.The power coefficient reductions at the blade section position of z/(H/2)=0.9 were 38.29%,46.78%and 56.42%when the tip speed ratios were 1.38,2.19 and 2.58,respectively.The results of this study provided a better understanding of the development of the performance characteristics and vortex characteristics of H-type VAWT. | ZHANG Yanfeng LI Qing’an ZHU Xinyu SONG Xiaowen CAI Chang GUO Zhiping | 2021 | Journal of Thermal Science2021，30，3： | 2 |
| 4 | High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells显示文摘在导致的 pluripotent 干细胞(iPSCs ) 积累的反常 epigenetic 修正是否能最终影响 iPSC pluripotency,仍然保持争论。为了探查这个问题,有一样的基因背景的 iPSC 线和 proviral 集成地点,被建立,并且每根 iPSC 线的 pluripotency 状态用 tetraploid (4N ) 被描绘互补试金。随后,基因表示和 “ 的全球 epigenetic 修正; 4N-ON ”并且相应 “ 4N-OFF ”iPSC 线通过深定序 mRNA 表示,小 RNA 侧面, histone 修正(H3K27me3, H3K4me3,和 H3K4me2 ) ,和 DNA methylation 的分析被比较。我们发现了印的基因的那 methylation, Zrsr1,一致地与减少的 pluripotency 在 iPSC 线被破坏。而且,破坏 methylation 不能被改进文化条件或 iPSCs 的 subcloning 救。而且,在 iPSCs 的 Zrsr1 和 pluripotency 状态的 hypomethylation 之间的关系进一步在线从另外的 reprogramming 系统导出的独立 iPSC 被验证。 | Gang Chang Shuai Gao Xinfeng Hou Zijian Xu Yanfeng Liu Lan Kang Yu Tao Wenqiang Liu Bo Huang Xiaochen Kou Jiayu Chen Lei An Kai Miao Keqian Di Zhilong Wang Kun Tan Tao Cheng Tao Cai Shaorong Gao Jianhui Tian | 2014 | Cell Research2014，24，3： | 2 |
| 5 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 6 | Synthesis and characterization of novel magnetic Fe3O4/polyurethane foam composite applied to the carrier of immobilized microorganisms for wastewater treatment显示文摘 | Lincheng Zhou Guiying Li Taicheng An Yanfeng Li | 2010 | Research on Chemical Intermediates2010，，3： | 1 |
| 7 | Synthesis and characterization of novel magnetic Fe30 polyurethane foam composite to the carrier of immobilized microorganisms for wastewater treatment显示文摘 | Zhou Lilin An Taicheng Li Yanfeng | 2010 | Res Chem Intermed2010，36，： | 1 |
| 8 | Latin Lessons显示文摘Integration presents challenges and opportunities for Chinese companies in Latin America On December 3 the Third Summit of Latin American and Caribbean States lowered its curtain in Caracas, capital of Venezuela, officially signing into effect the formation of the Community of Latin A merican and Caribbean States (CELAC) as the new leading regional bloc, which symbolized further integration of the region and a milestone after Latin America’s independence fighters first raised the battle cry for a united Latin America 200 years ago. As the second largest trade partner and the third largest investor of the region, | SUN YANFENG an associate research fellow with the China Institutes of Contemporary International Relations | 2011 | Beijing Review2011，54，51： | 0 |
| 9 | Effect of semi-continuous water washing on the combustion behaviors of agricultural organic solid waste显示文摘Combustion of agricultural organic solid waste(AOSW)was an ideal solution for their resource utilization in view of their massive annual production and great potential for reduction of fossil fuel utilization.However,high alkali and alkaline earth metals(AAEMs)content in the feedstock can arose severe fouling and slagging issues and thus prohibiting its vast utilization.In this study,a semi-continuous water washing method was proposed to preliminarily remove AAEMs from agricultural organic solid waste and its effects on the combustion behaviors of washed solid product were investigated.Results showed that the combustion index S were improved to 2.63×10-6,over 68%of the total ashes were removed from the cotton stalk,and 96.3%,89.0%and 74.7%of K,Na and Mg were effectively removed,respectively.Moreover,the softening temperature of low temperature ash from the washed sample was as high as 1450◦C,538◦C higher than the low temperature ash from the original sample;the base acid ratio and fouling index were improved from high slagging and fouling risk(1.7 and 90.8)of the original organic solid waste to low and medium risk(0.4 and 3.5),respectively.All these results signified the contributing effect of proposed semi-continuous water washing method on the combustion of agricultural organic solid waste.In a word,this study provided a promising method for fouling and slagging inhibition during the agricultural organic solid waste combustion. | Xiangxi Wang Zhenzhong Hu Jinrong Ma Linlin Yi Jian Li Yanfeng Cheng Jianfei Ma Na An Feng Wang Xian Li Junjun Yan Bo Wei Yue Li Guangqian Luo Hong Yao | 2023 | Carbon Resources Conversion2023，6，1： | 0 |
| 10 | Circulating Lipoproteins Mediate the Association Between Cardiovascular Risk Factors and Cognitive Decline:A Community‑Based Cohort Study显示文摘Cardiovascular health metrics are now widely recognized as modifable risk factors for cognitive decline and dementia.Metabolic perturbations might play roles in the linkage of cardiovascular diseases and dementia.Circulating metabolites profling by metabolomics may improve understanding of the potential mechanism by which cardiovascular risk factors contribute to cognitive decline.In a prospective community-based cohort in China(n=725),312 serum metabolic phenotypes were quantifed,and cardiovascular health score was calculated including smoking,exercise,sleep,diet,body mass index,blood pressure,and blood glucose.Cognitive function assessments were conducted in baseline and follow-up visits to identify longitudinal cognitive decline.A better cardiovascular health was signifcantly associated with lower risk of concentration decline and orientation decline(hazard ratio(HR):0.84–0.90;p<0.05).Apolipoprotein-A1,high-density lipoprotein(HDL)cholesterol,cholesterol ester,and phospholipid concentrations were signifcantly associated with a lower risk of longitudinal memory and orientation decline(p<0.05 and adjusted-p<0.20).Mediation analysis suggested that the negative association between health status and the risk of orientation decline was partly mediated by cholesterol ester and total lipids in HDL-2 and-3(proportion of mediation:7.68–8.21%,both p<0.05).Cardiovascular risk factors were associated with greater risks of cognitive decline,which were found to be mediated by circulating lipoproteins,particularly the medium-size HDL components.These fndings underscore the potential of utilizing lipoproteins as targets for early stage dementia screening and intervention. | Jialin Li Qingxia Huang Yingzhe Wang Mei Cui Kelin Xu Chen Suo Zhenqiu Liu Yanpeng An Li Jin Huiru Tang Xingdong Chen Yanfeng Jiang | 2024 | Phenomics2024，4，1： | 0 |
| 11 | 三阴性乳腺癌患者因新辅助或辅助化疗引起的早发性心脏事件与其基因组DNA中某些新的自噬相关单核苷酸多态性的相关性研究:一项真实世界研究显示文摘背景与目的越来越多的癌症患者死于心血管疾病。三阴性乳腺癌(triple-negative breast cancer,TNBC)可选的治疗方法有限,因此化疗引起的心脏毒性对该类患者非常重要。心脏自噬是心脏毒性的重要机制之一。本研究旨在研究化疗对TNBC患者的心脏毒性,筛选易感人群,探讨心脏毒性与自噬相关基因多态性的相关性。方法在2450例I–III期TNBC患者中,有147例纳入了本研究。大多数患者在化疗周期前进行心电图(electrocardiography,ECG)检查,并根据临床需要进行超声心动图(echocardiography,UCG)检查。所有ECG和UCG资料均由阜外医院国家心血管病中心的心血管专家重新评判。根据美国国家生物技术信息中心数据库和癌症体细胞突变目录数据库,我们筛选了25个与自噬相关的单核苷酸多态性(single nucleotide polymorphisms,SNPs),并对147例TNBC患者进行了基因分型。采用配对样本T检验、卡方检验和logistic回归模型进行分析。结果每个化疗周期后,只有46(31.3%)例患者的ECG完全正常。在接受UCG的16例患者中,有2(12.5%)例患者左心室射血分数可逆性下降。使用蒽环类药物和过量饮酒是ECG异常的危险因素。随着化疗的持续,心率逐渐增加。蒽环类药物与QRS期持续异常有关(P=0.043)。我们对25个与自噬有关的SNP进行基因分型后发现,自噬相关基因13(ATG13)rs10838611的G等位基因与ECG异常显著相关(优势比=2.258,95%置信区间:1.318–3.869;P=0.003)。结论化疗引起的ECG异常在真实世界中很常见。自噬相关单核苷酸多态性与化疗引起的心脏毒性相关,本研究为自噬是化疗所致心脏损害的原因提供了新的证据。 | Binliang Liu Tao An Meiying Li Zongbi Yi Chunxiao Li Xiaoying Sun Xiuwen Guan Lixi Li Yanfeng Wang Yuhui Zhang Binghe Xu Fei Ma Yixin Zeng | 2019 | 癌症2019，38，7： | 0 |
| 12 | Calculation of geoid undulations and gravity anomaliesin the Northwest Pacific by using the Topex/Poseidonand Geosat altimeter data显示文摘INTRODUCTIONThegeoidistheiargeopotentials^econfidingmostlywiththemeanseasurfaceandisdenotedastheheightrelativetotheidealelliPSes^eoftheearth.Thegeoidundulationsinglobalaceareupto100m.TheunevenstructureOftheearthgivesrisetotheunevenfeatureofthecitysot... | Pan Jiayi Wang Junqin Wang Yanfeng Zhang XinmeiYuan Yeli (First Institute of Oceanography State Oceanic Adminitration,Qingdao 266003 China)Zheng Quan’an (Center for Remote Sensing College of Marine Studies University of Delaware Newaerk DE 19716 USA | 1999 | Acta Oceanologica Sinica1999，18，4： | 0 |
| 13 | Integration of embryo–endosperm interaction into a holistic and dynamic picture of seed development using a rice mutant with notched-belly kernels显示文摘Interaction between the embryo and endosperm affects seed development,an essential process in yield formation in crops such as rice.Signals that mediate communication between embryo and endosperm are largely unknown.We used the notched-belly(NB)mutant with impaired communication between embryo and endosperm to investigate the effect of the embryo on developmental staging of the endosperm and signaling pathways in the embryo that regulate endosperm development.Hierachical clustering of m RNA datasets from embryo and endosperm samples collected during development in NB and a wild type showed a delaying effect of the embryo on the developmental transition of the endosperm by extension of the middle stage.K-means clustering further identified coexpression modules of gene sets specific to embryo and endosperm development.Combined gene expression and biochemical analysis showed that T6 P–Sn RK1,gibberellin and auxin signaling by the embryo regulate endosperm developmental transition.We propose a new seed developmental staging system for rice and identify the most detailed signature of rice grain formation to date.These will direct genetic strategies for rice yield improvement. | Yang Tao Lu An Feng Xiao Ganghua Li Yanfeng Ding Matthew JPaul Zhenghui Liu | 2022 | The Crop Journal2022，10，3： | 0 |
| 14 | Halogen-doped phosphorescent carbon dots for grayscale patterning显示文摘Flexible organic materials that exhibit dynamic ultralong room temperature phosphorescence(DURTP)via photoactivation have attracted increasing research interest for their fascinating functions of reversibly writing-reading-erasing graphic information in the form of a long afterglow.However,due to the existence of a nonnegligible activation threshold for the initial exposure dose,the display mode of these materials has thus far been limited to binary patterns.By resorting to halogen element doping of carbon dots(CDs)to enhance intersystem crossing and reduce the activation threshold,we were able to produce,for the first time,a transparent,flexible,and fully programmable DURTP composite film with a reliable grayscale display capacity.Examples of promising applications in UV photography and highly confidential steganography were constructed,partially demonstrating the broad future applications of this material as a programmable platform with a high optical information density. | Yanfeng Liu Mahmoud Al-salihi Yong Guo Roman Ziniuk Songtao Cai Luwei Wang Yuan Li Zhigang Yang Dengfeng Peng Kai Xi Zhongfu An Xudong Jia Liwei Liu Wei Yan Junle Qu | 2022 | Light(Science & Applications)2022，11，7： | 0 |
| 15 | 青藏高原东缘汶川地震断层陡坎类型与级联破裂模型(英文)显示文摘The post-earthquake field investigations reveal that the MW7.9 Wenchuan earthquake of 12th May 2008 ruptured three NE-striking imbricate reverse faults and another NW-trending reverse fault, along the middle Longmenshan fold-and-thrust belt at the eastern margin of the Tibetan plateau. The fault-scarp features can be categorized into eight groups: simple thrust scarp, hanging-wall collapse scarp, simple pressure ridge, dextral pressure ridge, fault-related fold scarp, back-thrust pressure ridge, local normal fault scarp and crocodile-mouth-like scarp. The local normal scarp is first discovered in the reverse-faulting earthquakes as ever reported in the world. Field observation indicates that the Wenchuan earthquake surface rupture is dominated by reverse faulting with a minus right-lateral component, but the relative ratio varies from site to site. Also, the surface ruptures can be divided, for the first order, into two segments, the Yingxiu and Beichuan segments, corresponding to MW7.8 and MW7.57 events, respectively. The two segments further can be divided, for the second order, into four sub-segments in total, which are equivalent to four sub-events of MW7.46, MW7.69, MW6.99 and MW7.52, respectively. The fault segmentation, for different orders, shows a cascade-rupturing pattern and can explain why the quake time of the Wenchuan earthquake was so long as up to 100 second. Aftershock focal mechanisms are also used to constrain the fault geometry for the sub-segments, indicating that the seismogenic faults are listric at depth and in general, the fault plane becomes steeper northward, which enables the fault to accommodate larger strike-slip motion. This earthquake also confirms that the crustal shortening across the Longmenshan fold-and-thrust belt should be responsible for the growth of high topographic relief along the eastern margin of the Tibetan Plateau. | Guihua Yu 徐锡伟 Yann Klinger Guilin Diao Guihua Chen Xiangdong Feng Chenxia Li , Ailan Zhu Renmao Yuan Tingting Guo Xinze Sun Xibin Tan Yanfeng An | 2010 | 国际地震动态2010，，6： | 0 |
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