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| 1 | Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma:a potential role for the chemokine CXCL16显示文摘ILC2s are implicated in asthma pathogenesis, but little is known about the mechanisms underlying their accumulation in airways.We investigated the time course of ILC2 accumulation in different tissues in murine models of asthma induced by a serial per-nasalchallenge with ovalbumin (OVA), house dust mice (HDM), IL-25 and IL-33 and explored the potential roles of ILC2-attractingchemokines in this phenomenon. Flow cytometry was used to enumerate ILC2s at various time points. The effects of cytokines andchemokines on ILC2 migration were measured in vitro using a chemotaxis assay and in vivo using small animal imaging. Comparedwith saline and OVA challenge, both IL-25 and IL-33 challenge alone induced significant accumulation of ILC2s in the mediastinallymph nodes, lung tissue and bronchoalveolar lavage fluid of challenged animals, but with a distinct potency and kinetics. In vitro,IL-33 and CXCL16, but not IL-25 or CCL25, directly induced ILC2 migration. Small animal in vivo imaging further confirmed that asingle intranasal provocation with IL-33 or CXCL16 was sufficient to induce the accumulation of ILC2s in the lungs followinginjection via the tail vein. Moreover, IL-33-induced ILC2 migration involved the activation of ERK1/2, p38, Akt, JNK and NF-κB, whileCXCL16-induced ILC2 migration involved the activation of ERK1/2, p38 and Akt. These data support the hypothesis that epitheliumderived IL-25 and IL-33 induce lung accumulation of ILC2s, while IL-33 exerts a direct chemotactic effect in this process. AlthoughILC2s express the chemokine receptors CXCR6 and CCR9, only CXCL16, the ligand of CXCR6, exhibits a direct chemoattractanteffect. | Yan Li Shihao Chen Yafei Chi Yiran Yang Xiwen Chen Huating Wang Zhe Lv Jingjing Wang Linjie Yuan Ping Huang Kewu Huang Chris JCorrigan Wei Wang Sun Ying | 2019 | Cellular & Molecular Immunology2019，16，1： | 13 |
| 2 | Characteristics of Proinflammatory Cytokines and Chemokines in Airways of Asthmatics: Relationships with Disease Severity and Infiltration of Inflammatory Cells显示文摘 | Ting Yang Yan Li Zhe Lyu Kewu Huang Chris J Corrigan Sun Ying Wei Wang Chen Wang | 2017 | Chinese Medical Journal2017，，17： | 12 |
| 3 | Developmentally Regulated Glucosylation of Bitter Triterpenoid in Cucumber by the UDP-Glucosyltransferase UGT73AM3显示文摘 | Yang Zhong Xiaofeng Xue Zhiqiang Liu Yongshuo Ma Kewu Zeng Lida Han Jingjing Qi Dae-Kyun Ro Soren Bak Sanwen Huang Yuan Zhou Yi Shang | 2017 | Molecular Plant2017，10，7： | 7 |
| 4 | High Robust Broadcasting over DTMB-A with Low-rate LDPC Codes显示文摘As the 2nd generation digital terrestrial television broadcasting(DTTB)standard,digital terrestrial/television multimedia broadcasting-advanced(DTMB-A)can provide higher spectrum efficiency and transmission reliability by adopting flexible frame structure and advanced forward error correction coding compared with the 1 st generation DTTB systems.In order to increase the flexibility and robustness of the DTTB network,the frequency reuse scheme of factor one(reuse-1)is proposed,where the same RF channel is used by different stations covering the adjacent service areas.However,it demands a very low carrier-tonoise ratio(C/N)threshold below 0 dB at the DTTB physical layer.In this paper,a robust broadcasting technique is proposed based on DTMB-A with newly designed low-rate low density parity check(LDPC)codes.By adopting quasi-cyclic(QC)Raptor-like structure and progressive lifting method,the high performance low-rate LDPC codes are designed supporting multiple code lengths.Both density-evolution analyses and laboratory measurements demonstrate that DTMB-A with low-rate coding can complete the demodulation reliably with the C/N threshold below0 d B,which is one important necessary condition to support frequency reuse-1 scheme. | Chao Zhang Kewu Peng Zhitong He Yonglin Xue Hui Yang | 2022 | China Communications2022，19，3： | 2 |
| 5 | Hydrolytic dynamics of pesticide N'-(2,4-dimethylphenyl)-N-methylformamidine in aquatic solution显示文摘HydrolyticdynamicsofpesticideN'-(2,4-dimethylphenyl)-N-methylformamidineinaquaticsolution￥MoHanhong;YangKewu;AnFengchun;LiuYe... | Mo Hanhong Yang Kewu An Fengchun Liu Ye (Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China) | 1996 | Journal of Environmental Sciences1996，8，2： | 1 |
| 6 | Labeling optimization for BICM-ID systems 显示文摘 | YANG Zhixing XIE Qiuliang PENG Kewu el al | 2010 | IEEE Comrnunications Letters2010，14，11： | 1 |
| 7 | Labeling Optimization for BICM-ID Systems 显示文摘 | Yang Zhixing Xie Qiuliang Peng Kewu et ol | 2010 | IEEE Communications Letters2010，14，11： | 1 |
| 8 | Speciation analysis of butyltin compounds in Chinese seawater by capillary gas chromatography with flame photometric detection using insitu hydride derivatization followed by headspace solidphase microextraction 显示文摘 | JING Guibin LIU Jiyan YANG Kewu | 2000 | Analytica Chimica Acta2000，421，1： | 1 |
| 9 | Fate of pesticide N’-(2,4-dimethylphenyl)-N-methylformamide hydrochloride in simulated aquatic ecosystem显示文摘FateofpesticideN’(2,4dimethylphenyl)NmethylformamidehydrochlorideinsimulatedaquaticecosystemYangKewu,MoHanhong,AnFengchu... | Yang Kewu, Mo Hanhong, An Fengchun Research Center for Eco Environmental Sciences, Chinese Academy of Science, Beijing 100085, China | 1997 | Journal of Environmental Sciences1997，9，3： | 0 |
| 10 | MAPK介导的YAP激活促进机械力诱导的肺泡再生显示文摘肺泡是肺器官进行血氧交换的基本单位,由两种肺泡上皮细胞组成:进行气体交换的一型肺泡上皮AT1细胞和分泌肺表面活性物质的二型肺泡AT2细胞。 | Zhe Liu Huijuan Wu Kewu Jiang Yanjie Wang Wenjing Zhang Qiqi Chu Juan Li Huanwei Huang Tao Cai Hongbin Ji Chun Yang 汤楠 | 2017 | 科学新闻2017，0，4： | 0 |
| 11 | Non-Uniform APSK Optimization for BICM Systems显示文摘Traditional Amplitude Phase Shift Keying(APSK) consists of rings with points uniformly spaced. By giving up this uniform-spacing feature, we propose an APSK optimization method based on the uniform APSK with Gray labeling(Gray-APSK). The aim of the optimization is to maximize the Generalized Mutual Information(GMI)of Bit-Interleaved Coded Modulation(BICM) for the targeted code rate and channel. We show that our optimized non-uniform APSK could offer further performance gain compared with the conventional uniform Gray-APSK and considerably outperforms the traditional quadrature amplitude modulation at the targeted SNR and channel. | Keqian Yan Kewu Peng Fang Yang Jian Song | 2015 | Tsinghua Science and Technology2015，20，2： | 0 |
| 12 | Anti-psoriasis molecular targets and active components discovery of Optimized Yinxieling Formula via affinity-purified strategy显示文摘Psoriasis,a prevalent inherited skin condition,involves an inflammatory response as a key pathogenic mechanism.The Optimized Yinxieling Formula(OYF),rooted in traditional Chinese medicine,is extensively utilized in clinical settings to treat psoriasis.Although previous studies have demonstrated OYF’s significant anti-inflammatory effects in psoriasis,its potential molecular targets and active components remain unexplored.This study aimed to unveil the anti-psoriasis molecular targets and active components of OYF.Our findings indicated that OYF extract markedly reduced the production of several inflammatory mediators,including IL-23,nitric oxide,TNF-α,and IL-1β,in LPS-induced RAW264.7 cells.We synthesized OYF extract-crosslinked beads to isolate pharmacological targets from RAW264.7 lysates using an affinity purification strategy,known as Target Fishing.The enriched target proteins were subsequently identified via LC-MS/MS,followed by bioinformatics analysis to map the psoriasis-associated pathway-gene network.We identified a total of 76 potential target proteins,which were highly associated with mRNA transcription mechanisms.In particular,pathway-gene network analysis revealed that the IL-23 inflammatory pathway was involved in the anti-psoriasis effect of OYF extract.We further utilized a target protein-based affinity capture strategy,combined with LC-MS and SPR analysis,to globally screen OYF’s active components,focusing on the mRNA transcription regulator,fused in sarcoma(FUS).This process led to the identification of umbelliferone,vanillic acid,protocatechuic acid,gentisic acid,and echinacoside as key compounds targeting FUS to inhibit IL-23 expression.Additionally,we formulated a compound cocktail(CpdC),which significantly reduced psoriasis area and severity index(PASI)scores and the expressions of IL-23 and Ki67 in an imiquimod(IMQ)-induced psoriasis mouse model.Collectively,our study elucidates the primary molecular targets and active components of OYF,offering novel insights for psoriasis treatment. | WANG Wei LIU Lijuan YANG Zhuo LU Chuanjian TU Pengfei ZHAO Ruizhi ZENG Kewu | 2024 | Chinese Journal of Natural Medicines2024，22，2： | 0 |
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