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| 1 | A novel multifunctional nanocomposite C225-conjugated Fe3O4/Ag enhances the sensitivity of nasopharyngeal carcinoma cells to radiotherapy显示文摘放射疗法是为鼻咽的癌的主要处理,上皮的起源的一个恶意的肿瘤。在这个过程,有高敏感的 tracer 为在放射疗法的诊断成像是枢轴的。这里,我们设计了新奇的多功能的磁性的银 nanocomposite, Fe3O4/Ag 结合了受体特定的抗体(C225 ) 到一个表皮的生长因素,它能潜在地经由磁性的回声成像为同步癌症治疗和诊断被使用。Fe3O4/Ag/C225 的特征被传播电子显微镜学决定,精力散 X 光检查光谱学,紫外系列,并且动态轻散布。结果证明 Fe3O4/Ag/C225 nanoparticles 在水里球形、分散很好。C225 的活动被保存 80% 在 Fe3O4/Ag/C225 nanoparticles。Futhermore,我们在 vitro 为人的鼻咽的癌房间线(CNE ) 测试了 nanocomposite 的 cytotoxicity 和放射敏感度。MTT 分析表明 Fe3O4/Ag/C225 能在一个剂量依赖者和时间依赖者举止禁止 CNE 的增长。clonogenic 试金显示与 X 光检查治疗相结合的 Fe3O4/Ag/C225 能增加 CNE 的敏感到照耀。在一篇摘要,新奇多功能的 nanocomposite Fe3O4/Ag/C225 可能是为对待的潜在的 radiosensitizer 诽谤在诊所的肿瘤。 | Di Zhao Xinchen Sun Jinglong Tong Jun Ma Xiaodong Bu Ruizhi Xu Renhua Fan | 2012 | Acta Biochimica et Biophysica Sinica2012，44，8： | 3 |
| 2 | The SmMYB36-SmERF6/SmERF115 module regulates the biosynthesis of tanshinones and phenolic acids in salvia miltiorrhiza hairy roots显示文摘Tanshinone and phenolic acids are the most important active substances of Salvia miltiorrhiza,and the insight into their transcriptional regulatory mechanisms is an essential process to increase their content in vivo.SmMYB36 has been found to have important regulatory functions in the synthesis of tanshinone and phenolic acid;paradoxically,its mechanism of action in S.miltiorrhiza is not clear.Here,we demonstrated that SmMYB36 functions as a promoter of tanshinones accumulation and a suppressor of phenolic acids through the generation of SmMYB36 overexpressed and chimeric SmMYB36-SRDX(EAR repressive domain)repressor hairy roots in combination with transcriptomic-metabolomic analysis.SmMYB36 directly down-regulate the key enzyme gene of primary metabolism,SmGAPC,up-regulate the tanshinones biosynthesis branch genes SmDXS2,SmGGPPS1,SmCPS1 and down-regulate the phenolic acids biosynthesis branch enzyme gene,SmRAS.Meanwhile,SmERF6,a positive regulator of tanshinone synthesis activating SmCPS1,was up-regulated and SmERF115,a positive regulator of phenolic acid biosynthesis activating SmRAS,was down-regulated.Furthermore,the seven acidic amino acids at the C-terminus of SmMYB36 are required for both self-activating domain and activation of target gene expression.As a consequence,this study contributes to reveal the potential relevance of transcription factors synergistically regulating the biosynthesis of tanshinone and phenolic acid. | Qi Li Xin Fang Ying Zhao Ruizhi Cao Juane Dong Pengda Ma | 2023 | Horticulture Research2023，10，1： | 2 |
| 3 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 4 | Exploring the potential of functional polymer-lipid hybrid nanoparticles for enhanced oral delivery of paclitaxel显示文摘Most biopharmaceutics classification system(BCS)class IV drugs,with poor solubility and inferior permeability,are also substrates of P-glycoprotein(P-gp)and cytochrome P450(CYP450),leading to their low oral bioavailability.The objective of this study is to explore the potential of using functional polymer-lipid hybrid nanoparticles(PLHNs)to enhance the oral absorption of BCS IV drugs.In this paper,taking paclitaxel(PTX)as a drug model,PTX-loaded PLHNs were prepared by a self-assembly method.Chitosan was selected to modify the PLHN to enhance its mucoadhesion and stability.Three P-gp inhibitors(D-α-tocopherol polyethylene glycol 1000 succinate,pluronic P123 and Solutol RHS15)were incorporated into selected PLHNs,and a CYP450 inhibitor(the extract of VBRB,BC0)was utilized to jointly promote the drug absorption.Properties of all the PLHNs were characterized systemically,including particle size,zeta potential,encapsulation efficiency,morphology,stability,in vitro drug release,mucoadhesion,in situ intestinal permeability and in vivo systemic exposure.It was found mucoadhesion of the CS-modified PLHNs was the strongest among all the formulations tested,with absolute bioavailability 21.95%.P-gp and CYP450 inhibitors incorporation further improved the oral bioavailability of PTX to 42.60%,8-fold increase compared with that of PTX itself(4.75%).Taken together,our study might shed light on constructing multifunctional PLHNs based on drug delivery barriers for better oral absorption,especially for BCS IV drugs. | Lu Qin Haiyang Wu Enyu Xu Xin Zhang Jian Guan Ruizhi Zhao Shirui Mao | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，3： | 1 |
| 5 | Small-molecule anti-COVID-19 drugs and a focus on China's homegrown mindeudesivir(WV116)显示文摘The coronavirus disease 2019(COVID-19)pandemic has stimulated tremendous efforts to develop therapeutic agents that target severe acute respiratory syndrome coronavirus 2 to control viral infection.So far,a few small-molecule antiviral drugs,including nirmatrelvir-ritonavir(Paxlovid),remdesivir,and molnupiravir have been marketed for the treatment of COVID-19.Nirmatrelvir-ritonavir has been recommended by the World Health Organization as an early treatment for outpatients with mild-to-moderate COVID-19.However,the existing treatment options have limitations,and effective treatment strategies that are cost-effective and convenient for tackling COVID-19 are still needed.To date,four domestically developed oral anti-COVID-19 drugs have been granted conditional market approval in China.These drugs include azvudine,simnotrelvir-ritonavir(Xiannuoxin),leritrelvir,and mindeudesivir(VV11).Preclinical and clinical studies have explored the efficacy and tolerability of mindeudesivir and supported its early use in mild-to-moderate COVID-19 cases at high risk for progression.In this review,we discuss the most recent findings regarding the pharmacological mechanism and therapeutic effects focusing on mindeudesivir and other small-molecule antiviral agents for COVID-19.These findings will expand our understanding and highlight the potential widespread application of China's homegrown anti-COVID-19 drugs. | Qiuyu Cao Yi Ding Yu Xu Mian Li Ruizhi Zheng Zhujun Cao Weiqing Wang Yufang Bi Guang Ning Yiping Xu Ren Zhao | 2023 | Frontiers of Medicine2023，17，6： | 0 |
| 6 | Allocation of maize varieties according to temperature for use in mechanical kernel harvesting in Ningxia, China显示文摘The reasonable assessment of maize varieties in different ecological regions can allow temperature resources to be fully exploited and reach the goal of high yield and efficiency and is thus an important direction of modern maize development in China.In this study,a logistic power nonlinear growth model was used to simulate the accumulated temperature required for kernel dehydration to moisture contents of 25%,20%,and 16%for various maize cultivar,which were divided into six types based on the accumulated temperature required for kernel dehydration to a moisture content of 25%.The relationship between the yield of maize cultivars and the accumulated temperature required for kernel dehydration to a moisture content of 25%was found to follow a unary function model.Changing the planted maize variety was found to increase economic returns by more than 7000 RMB/hm2 in Ningxia,Northwest China.Under the conditions of mechanical grain harvesting,economic benefits can be further increased by means of selecting high yields and fast-dehydrating varieties,selling when the grain dehydration is below 16%.A better way to achieve grain dehydration to a moisture content below 16%is to postpone the harvest date as much as possible rather than drying after the harvest at physiological maturity.The areas of various types of maize varieties can be dehydrated to moisture contents of 25%,20%,and 16%were marked.Based on the distribution of heat resources in different regions of Ningxia from the normal sowing date to October 31 before winter irrigation,the appropriate cultivars for various regions in the province were determined based on production benefits.Therefore,in different areas of Ningxia,selecting suitable maize varieties according to temperature resources can reach a high yield and mechanical kernel harvesting,and ultimately obtain higher economic benefits. | Hongyan Li Yonghong Wang Jun Xue Ruizhi Xie Keru Wang Rulang Zhao Wanmao Liu Bo Ming Peng Hou Zhentao Zhang Wenjie Zhang Shaokun Li | 2021 | International Journal of Agricultural and Biological Engineering2021，14，1： | 0 |
| 7 | New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohort study显示文摘A new definition of metabolic dysfunction-associated fatty liver disease(MAFLD)has recently been proposed.We aim to examine the associations of MAFLD,particularly its discordance from non-alcoholic fatty liver disease(NAFLD),with the progression of elevated brachial-ankle pulse wave velocity(baPWV)and albuminuria in a community-based study sample in Shanghai,China.After 4.3 years of follow-up,778 participants developed elevated baPWV and 499 developed albuminuria.In comparison with the non-MAFLD group,the multivariable adjusted odds ratio(OR)of MAFLD group for new-onset elevated baPWV was 1.25(95%confidence interval(CI)1.01–1.55)and 1.35(95%CI 1.07–1.70)for albuminuria.Participants without NAFLD but diagnosed according to MAFLD definition were associated with higher risk of incident albuminuria(OR 1.77;95%CI 1.07–2.94).Patients with MAFLD with high value of hepamet fibrosis score or poor-controlled diabetes had higher risk of elevated baPWV or albuminuria.In conclusion,MAFLD was associated with new-onset elevated baPWV and albuminuria independently of body mass index,waist circumference,and hip circumference.Individuals without NAFLD but diagnosed as MAFLD had high risk of albuminuria,supporting that MAFLD criteria would be practical for the evaluation of long-term risk of subclinical atherosclerosis among fatty liver patients. | Jialu Wang Shanshan Liu Qiuyu Cao Shujing Wu Jingya Niu Ruizhi Zheng Lizhan Bie Zhuojun Xin Yuanyue Zhu Shuangyuan Wang Hong Lin Tiange Wang Min Xu Jieli Lu Yuhong Chen Yiping Xu Weiqing Wang Guang Ning Yu Xu Mian Li Yufang Bi Zhiyun Zhao | 2022 | Frontiers of Medicine2022，16，5： | 0 |
| 8 | Efficient Synthesis of P-Chirogenic Compounds Enabled by Chiral Selenide-Catalyzed Enantioselective Electrophilic Aromatic Halogenation显示文摘P-chirogenic compounds have been applied in different fields,especially in asymmetric catalysis as ligands and organocatalysts.However,broader applicability has been severely restricted by the lack of efficient synthetic methods.Consequently,developing efficient methods to access these compounds is of high synthetic value.Herein,we report a convenient,efficient,and unprecedented pathway to construct valuable P-chirogenic compounds via chiral selenide-catalyzed enantioselective electrophilic aromatic halogenation.Using a new chiral bifunctional selenide as the catalyst,a variety of bis(2-hydroxyaryl)aryl phosphine oxides were efficiently converted to the corresponding chlorinated and brominated P-chirogenic compounds with good to excellent enantioselectivities.By slightly adjusting the catalyst and solvent,this method is also able to prepare chiral alkyl diaryl phosphine oxides and diaryl phosphinates.Furthermore,control experiments revealed the decomposition pathways of catalysts and the possible reasons why chiral selenide catalyst was more effective than chiral sulfide catalyst.The effect of hydrogen bonding was studied,and the reason why the chlorination took place on the various aromatic rings was elucidated when the substrates were switched from triaryl phosphine oxides to alkyl diaryl phosphine oxides and diaryl phosphinates. | Ruizhi Guo Ziqi Liu Xiaodan Zhao | 2021 | CCS Chemistry2021，3，11： | 0 |
| 9 | Anti-psoriasis molecular targets and active components discovery of Optimized Yinxieling Formula via affinity-purified strategy显示文摘Psoriasis,a prevalent inherited skin condition,involves an inflammatory response as a key pathogenic mechanism.The Optimized Yinxieling Formula(OYF),rooted in traditional Chinese medicine,is extensively utilized in clinical settings to treat psoriasis.Although previous studies have demonstrated OYF’s significant anti-inflammatory effects in psoriasis,its potential molecular targets and active components remain unexplored.This study aimed to unveil the anti-psoriasis molecular targets and active components of OYF.Our findings indicated that OYF extract markedly reduced the production of several inflammatory mediators,including IL-23,nitric oxide,TNF-α,and IL-1β,in LPS-induced RAW264.7 cells.We synthesized OYF extract-crosslinked beads to isolate pharmacological targets from RAW264.7 lysates using an affinity purification strategy,known as Target Fishing.The enriched target proteins were subsequently identified via LC-MS/MS,followed by bioinformatics analysis to map the psoriasis-associated pathway-gene network.We identified a total of 76 potential target proteins,which were highly associated with mRNA transcription mechanisms.In particular,pathway-gene network analysis revealed that the IL-23 inflammatory pathway was involved in the anti-psoriasis effect of OYF extract.We further utilized a target protein-based affinity capture strategy,combined with LC-MS and SPR analysis,to globally screen OYF’s active components,focusing on the mRNA transcription regulator,fused in sarcoma(FUS).This process led to the identification of umbelliferone,vanillic acid,protocatechuic acid,gentisic acid,and echinacoside as key compounds targeting FUS to inhibit IL-23 expression.Additionally,we formulated a compound cocktail(CpdC),which significantly reduced psoriasis area and severity index(PASI)scores and the expressions of IL-23 and Ki67 in an imiquimod(IMQ)-induced psoriasis mouse model.Collectively,our study elucidates the primary molecular targets and active components of OYF,offering novel insights for psoriasis treatment. | WANG Wei LIU Lijuan YANG Zhuo LU Chuanjian TU Pengfei ZHAO Ruizhi ZENG Kewu | 2024 | Chinese Journal of Natural Medicines2024，22，2： | 0 |
| 10 | A 16-bit,±10-V Input Range SAR ADC with a 5-V Supply Voltage and Mixed-Signal Nonlinearity Calibration显示文摘This paper presents a high-precision,successive approximation register(SAR)analog-to-digital converter(ADC)with resistive analog front-end for lowvoltage and wide input range applications.To suppress the serious nonlinearity brought by the voltage coefficients of analog front-end without deteriorating differential nonlinearity performance,a mixed-signal calibration scheme based on piecewise-linear method with calibration digital-to-analog converter is proposed.A compensation current is designed to sink or source from the reference to keep it independent of input signal,which greatly improves the linearity performance.Fabricated in a 0.5-μm CMOS process,the proposed ADC achieves 88-dB signalto-noise-and-distortion ratio and 103-dB spurious free dynamic range with 5-V supply voltage and 2.5-V reference voltage,and the total power consumption is 37.5 mW. | LUO Hongrui ZHAO Xianlong JIAO Zihao ZHANG Jie WANG Xiaofei ZHANG Ruizhi ZHANG Hong | 2022 | Chinese Journal of Electronics2022，31，4： | 0 |
| 11 | A study on the catalytic performance of Pd/γ-Al_(2)O_(3),prepared by microwave calcination,in the direct synthesis of dimethylether显示文摘A series of Pd/γ-Al_(2)O_(3) hybrid catalysts were prepared by impregnation and subsequent calcination under microwave irradiation.The catalysts were used for direct synthesis of dimethylether(DME)from syngas.The results show that calcination under microwave irradiation improved both the activity and selectivity of the catalysts for DME synthesis.The optimum power of the microwave was determined to be 420 W.Under such optimum conditions,CO conversion,DME selectivity and time space yield of DME were 60.1%,67.0%,and 21.5 mmol$mL-1$h^(-1),respectively.Based on various characterizations such as nitrogen physisorption,X-ray diffraction,COtemperature-programmed desorption,and Fourier transform infrared spectral analysis,the promotional effect of the microwave irradiation on the catalytic property was mainly attributed to both the higher dispersion of Pd and the significant increase in the adsorption on the CO-bridge of Pd.Microwave irradiation with very high power led to the increase in CO-bridge adsorption and thereby decreased the catalytic activity,whereas the coverage by metallic Pd of the active sites on acidicγ-Al_(2)O_(3) significantly occurred under microwave irradiation with very low power,resulting in a decrease in the selectivity to DME. | Ruizhi CHU Xianyong WEI Zhimin ZONG Wenjia ZHAO | 2010 | Frontiers of Chemical Science and Engineering2010，4，4： | 0 |
| 12 | PAID study design on the role of PKC activation in immune/inflammation-related depression:a randomised placebo-controlled trial protocol显示文摘Background Inflammation that is mediated by microglia activation plays an important role in the pathogenesis of depression.Microglia activation can lead to an increase in the levels of proinflammatory cytokines,including TNF-α,which leads to neuronal apoptosis in the specific neural circuits of some brain regions,abnormal cognition and treatment-resistant depression(TRD).Protein kinase C(PKC)is a key regulator of the microglia activation process.We assume that the abnormality in PKC might result in abnormal microglia activation,neuronal apoptosis,significant changes in emotional and cognitive neural circuits,and TRD.In the current study,we plan to target at the PKC signal pathway to improve the TRD treatment outcome.Methods and analysis This is a 12-week,ongoing,randomised,placebo-controlled trial.Patients with TRD(N=180)were recruited from Shanghai Mental Health Center,Shanghai Jiao Tong University.Healthy control volunteers(N=60)were recruited by advertisement.Patients with TRD were randomly assigned to‘escitalopram+golimumab(TNF-αinhibitor)’,‘escitalopram+calcium tablet+vitamin D(PKC activator)’or‘escitalopram+placebo’groups.We define the primary outcome as changes in the 17-item Hamilton Depression Rating Scale(HAMD-17).The secondary outcome is defined as changes in anti-inflammatory effects,cognitive function and quality of life.Discussion This study might be the first randomised,placebo-controlled trial to target at the PKC signal pathway in patients with TRD.Our study might help to propose individualised treatment strategies for depression.Trial registration number The trial protocol is registered with ClinicalTrials.gov under protocol ID 81930033 and ClinicalTrials.gov ID NCT04156425. | Xiaoyun Guo Ruizhi Mao Lvchun Cui Fan Wang Rubai Zhou Yun Wang Jia Huang Yuncheng Zhu Yamin Yao Guoqing Zhao Zezhi Li Jun Chen Jinhui Wang Yiru Fang | 2021 | General Psychiatry2021，34，2： | 0 |
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