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| 1 | Protolith ages and timing of peak and retrograde metamorphism of the high-pressure granulites in the Shandong Peninsula,eastern North China Craton显示文摘高压(HP ) granulites 广泛地在 tonalite-trondhjemite-granodiorite (TTG ) 以内作为被外国领地包围的土地发生在山东半岛的早前寒武纪的变形地下室的片麻岩,北方中国 Craton (NCC ) 的东南部分。基于阴极射线发光(CL ) ,激光拉曼光谱学并且在原处标明日期的 U-Pb,我们从 HP granulites 描绘锆石并且组织他们进三种主要类型:继承(magmatic ) 锆石, HP 变形锆石并且后退锆石。有清楚或弱定义的 magmatic zoning 的继承锆石包含 29152890 妈和 27632510 妈的磷灰石,和 207Pb/206Pb 年龄的包括,与在太古代地下室的二个 magmatic 事件相关。同类的 HP 变形锆石包括石榴石, clinopyroxene,斜长石,石英,金红石和磷灰石包含高压的变态的索引矿物质,并且产出在 1900 和 1850 妈之间的 207Pb/206Pb 年龄,标记预定山峰 HP granulite 外形变态。retrograde 锆石包含 orthopyroxene,斜长石,石英,磷灰石和闪石的包括,并且在三个组之中产出 18401820 妈的最年轻的 207Pb/206Pb 年龄,我们它相关到媒介到低压的 granulite 外形后退变态。数据在这研究介绍了建议中央的 subduction -- 并且降低他们在 Palaeoproterozoic (19001850 妈) 期间受到 HP granulite 外形变态的外壳深度的 Neoarchean magmatic protoliths。随后, HP granulites 是到上面的外壳层次的 exhumated,并且被媒介套印到低压的 granulite 和角闪岩外形后退在 ca 的事件。1840820 妈。 | Pinghua Liu Fulai Liu Hong Yang Fang Wang Jianhui Liu | 2012 | Geoscience Frontiers2012，3，6： | 19 |
| 2 | TPX2 knockdown suppressed hepatocellular carcinoma cell invasion via inactivating AKT signaling and inhibiting MMP2 and MMP9 expression显示文摘Objective: Targeting protein for Xenopus kinesin-like protein 2(TPX2) is a nuclear proliferation-related protein that plays a critical role in the formation of mitotic spindle. High expression of TPX2 has been observed in several types of tumors. However, the role of TPX2 in hepatocellular carcinoma(HCC) remains unclear. Our study aimed to investigate the effect of TPX2 on HCC cell invasion.Methods: The immortalized normal human liver cell line L02 and six HCC cell lines including SMMC-7721, BEL-7402, Huh-7, HepG2, Hep3 B and SKHep1 were subjected to qRT-PCR and western blot for TPX2 mRNA and protein, respectively. Furthermore, TPX2 small interfering RNA(siRNA) was used to knock down TPX2 expression in SMMC-7721 and HepG2 cells. Cell proliferation and invasion were determined by MTT and transwell assays. Otherwise, expression of p-AKT, MMP2 and MMP9 were evaluated by western blot in SMMC-7721 cells.Results: The expression of TPX2 in HCC cell lines was markedly higher than that in normal human liver cell line. TPX2 knockdown using a specific TPX2-siRNA reduced the number of invaded cells and inhibited cell proliferation in SMMC-7721 and HepG2 cells. Furthermore, TPX2 knockdown resulted in inactivation of AKT signaling and down-regulation of MMP2 and MMP9 expression in SMMC-7721 cells.Conclusions: Our study identified that TPX2 might contribute to tumor cell invasion through activating AKT signaling and subsequently increasing MMP2 and MMP9 in HCC. | Qingquan Liu Pinghua Yang Kangsheng Tu Hongyong Zhang Xin Zheng Yingmin Yao Qingguang Liu | 2014 | Chinese Journal of Cancer Research2014，26，4： | 11 |
| 3 | Prognostic significance of combining high mobility group Box-1 and OV-6 expression in hepatocellular carcinoma显示文摘The inflammatory environment and existence of cancer stem cells are critical for progression and intrahepatic recurrence of hepatocellular carcinoma(HCC) after curative resections. Here, we investigated the prognostic significance of combining high mobility group box 1(HMGB1) expression and hepatic progenitor marker OV6 in hepatocellular carcinoma. Expression of HMGB1 and OV6 was evaluated using immunohistochemistry profiling in tissue microarrays containing samples from 208 HCC patients. Invasive clinical or pathological factors were found in patients with high expression of HMGB1 or OV6. Higher HMGB1 was associated with poorer clinical outcomes, and independently related to elevated 5-year recurrence incidence(85.5% vs. 62.4%, P<0.001). We also found that more OV6 positive staining was correlated with poor prognosis of HCC patients(P<0.001). Notably, expression of HMGB1 was positively correlated with OV6 in density(R2=0.032, P<0.001) and reversely related to HCC outcomes. Abnormal expression of HMGB1 in combination with positive staining of OV6 displayed poorer prognostic performance than single biomarker alone(area under curve(AUC) survival=0.696). Therefore, HMGB1 and OV6 positive staining are promising prognostic parameters for HCC, and we propose that HMGB1 and OV6 may cooperate with each other and predict poor prognosis of HCC. | Jihui Zhu Han Yu Shuzhen Chen Pinghua Yang Zihui Dong Yan Ling Hao Tang Shilei Bai Wen Yang Liang Tang Feng Shen Hongyang Wang Wen Wen | 2018 | Science China(Life Sciences)2018，61，8： | 4 |
| 4 | Corrosion behavior of equal-channel-angular-pressed pure magnesium in NaCl aqueous solution显示文摘 | Dan Song AiBin Ma Jinghua Jiang Pinghua Lin Donghui Yang Junfeng Fan | 2009 | Corrosion Science2009，，2： | 2 |
| 5 | Global Attractivity of the Periodic Lotka–Volterra System显示文摘 | Yang Pinghua Xu Rui | 1999 | Journal of Mathematical Analysis and Applications1999，，1： | 1 |
| 6 | PERSISTENCE AND STABILITY IN A RATIO-DEPENDENT FOOD-CHAIN SYSTEM WITH TIME DELAYS显示文摘A delayed three-species ratio-dependent predator-prey food-chain model without dominating instantaneous negative feedback is investigated. It is shown that the system is permanent under some appropriate conditions,and sufficient conditions are obtained for the local asymptotic stability of a positive equilibrium of the system. | Xu Rui Feng Hanying Yang Pinghua Wang ZhiqiangDept. of Math.,Mechanical Engineering College,Shijiazhuang 050003. | 2002 | Applied Mathematics(A Journal of Chinese Universities)2002，17，1： | 1 |
| 7 | Investigation of magnetic properties of Tb2Fe17-xMnx compounds显示文摘 | Yang Fuming Lin Pinghua | 1998 | J Appl Phys1998，84，11： | 1 |
| 8 | Reference genome sequence of the model plant Setaria显示文摘 | Jeffrey L Bennetzen Jeremy Schmutz Hao Wang RyanPercifield Jennifer Hawkins Ana C Pontaroli Matt Estep Liang Feng Justin N Vaughn Jane Grimwood JerryJenkins Kerrie Barry Erika Lindquist Uffe Hellsten Shweta Deshpande Xuewen Wang Xiaomei Wu ThereseMitros Jimmy Triplett Xiaohan Yang Chu-Yu Ye Margarita Mauro-Her-rera Lin Wang Pinghua Li ManojSharma Rita Sharma Pamela C Ronald Olivier Panaud Elizabeth A Kellogg Thomas P Brutnell Andrew NDoust Gerald A Tuskan Daniel Rokhsar Katrien MDevos | 2012 | Nature Biotechnology2012，，30： | 1 |
| 9 | Global asymptotic stability of periodic solution in N-species competition system with time delays显示文摘 | Yang Pinghua Xu Rui Feng Hanying | 1999 | Nnn of Diff Eqs1999，，14： | 1 |
| 10 | Bifurcation and chaos in a ratio-dependent predator-prey system with time delay显示文摘 | GAN Qintao XU Rui YANG Pinghua | 2009 | Chaos Solitons and Fractals2009，39，： | 1 |
| 11 | Bifurcation and chaos in a ratio-dependent predator-prey system with time delay 显示文摘 | Gan Qintao Xu Rui Yang Pinghua | 2009 | Chaos Solitons Fractals2009，39，4： | 1 |
| 12 | Bifurcation and chaos in a ratio-dependent predator-prey system with time delay显示文摘 | Gan Qintao Xu Rui Yang Pinghua | 2009 | Chaos Solitons&Fractals2009，39，4： | 1 |
| 13 | Global attractivity of the periodic Lokta-Volterra system显示文摘 | Yang Pinghua Xu Rui | 1999 | J Math Anal Appl1999，233，1： | 1 |
| 14 | Liver resection versus liver transplantation for hepatocellular carcinoma within the Milan criteria based on estimated microvascular invasion risks显示文摘Background:Preoperative prediction of microvascular invasion(MVI)in hepatocellular carcinoma(HCC)may optimize individualized treatment decision-making.This study aimed to investigate the prognostic differences between HCC patients undergoing liver resection(LR)and liver transplantation(LT)based on predicted MVI risks.Methods:We analysed 905 patients who underwent LR,including 524 who underwent anatomical resection(AR)and 117 who underwent LT for HCC within the Milan criteria using propensity score matching.A nomogram model was used to predict preoperative MVI risk.Results:The concordance indices of the nomogram for predicting MVI were 0.809 and 0.838 in patients undergoing LR and LT,respectively.Based on an optimal cut-off value of 200 points,the nomogram defined patients as high-or low-risk MVI groups.LT resulted in a lower 5-year recurrence rate and higher 5-year overall survival(OS)rate than LR among the high-risk patients(23.6%vs 73.2%,P<0.001;87.8%vs 48.1%,P<0.001)and low-risk patients(19.0%vs 45.7%,P<0.001;86.5%vs 70.0%,P=0.002).The hazard ratios(HRs)of LT vs LR for recurrence and OS were 0.18(95%confidence interval[CI],0.09–0.37)and 0.12(95%CI,0.04–0.37)among the high-risk patients and 0.37(95%CI,0.21–0.66)and 0.36(95%CI,0.17–0.78)among the low-risk patients.LT also provided a lower 5-year recurrence rate and higher 5-year OS rate than AR among the high-risk patients(24.8%vs 63.5%,P=0.001;86.7%vs 65.7%,P=0.004),with HRs of LT vs AR for recurrence and OS being 0.24(95%CI,0.11–0.53)and 0.17(95%CI,0.06–0.52),respectively.The 5-year recurrence and OS rates between patients undergoing LT and AR were not significantly different in the low-risk patients(19.4%vs 28.3%,P=0.129;85.7%vs 77.8%,P=0.161).Conclusions:LT was superior to LR for patients with HCC within the Milan criteria with a predicted high or low risk of MVI.No significant differences in prognosis were found between LT and AR in patients with a low risk of MVI. | Pinghua Yang Fei Teng Shilei Bai Yong Xia Zhihao Xie Zhangjun Cheng Jun Li Zhengqing Lei Kui Wang Baohua Zhang Tian Yang Xuying Wan Hao Yin Hao Shen Timothy M Pawlik Wan Yee Lau Zhiren Fu Feng Shen | 2023 | Gastroenterology Report2023，11，1： | 1 |
| 15 | Effect of High Temperature Curing on the Frost Resistance of Recycled Aggregate Concrete and the Physical Properties of Second-Generation Recycled Coarse Aggregate under Freeze-Thaw Cycles显示文摘With the emphasis on environmental issues,the recycling of waste concrete,even recycled concrete,has become a hot spot in the field of architecture.But the repeated recycling of waste concrete used in harsh environments is still a complex problem.This paper discusses the durability and recyclability of recycled aggregate concrete(RAC)as a prefabricated material in the harsh environment,the effect of high-temperature curing(60℃,80℃,and 100℃)on the frost resistance of RAC and physical properties of the second generation recycled coarse aggregate(RCA_(2))of RAC after 300 freeze-thaw cycles were studied.The frost resistance of RAC was characterized by compressive strength,relative dynamic elastic modulus,and mass loss.As the physical properties of RCA_(2),the apparent density,water absorption,and crushing value were measured.And the SEM images of RAC after 300 freeze-thaw cycles were shown.The results indicated that the frost resistance of RAC cured at 80℃ for 7 days was comparable to that cured in the standard condition(cured for 28 days at 20℃±2℃ and 95%humidity),and the RAC cured at 100℃ was slightly worse.However,the frost resistance of RAC cured at 60℃ deteriorated seriously.The RAC cured at 80℃ for 7 days is the best.Whether after the freeze-thaw cycle or not,the RCA that curd at 60℃,80℃,and 100℃ for 7 days can also meet the requirements of Grade III RCA and be used as the aggregate of non-bearing part of prefabricated concrete components.RCA_(2) which is cured at 80℃ for 7 days had the best physical properties. | Xintong Chen Pinghua Zhu Xiancui Yan Lei Yang Huayu Wang | 2023 | Journal of Renewable Materials2023，11，6： | 1 |
| 16 | Nano-silver/multi-walled carbon nanotube composite films for hydrogen peroxide electroanalysis显示文摘 | Pinghua Yang Wanzhi Wei Chunyuan Tao Baohua Xie Xiaoyan Chen | 2008 | Microchimica Acta (-)2008，，1： | 1 |
| 17 | Persistence and stability in a Delayed Ratio-Dependent Ecological System with one predator and Two preys显示文摘 | Xu Rui Yang Pinghua Feng Hanying Wang Zhiqiang | 2002 | Journal of Biomathematics2002，17，2： | 1 |
| 18 | Determination of trace thiocyanate with nano - silver coated multi -walled carbon nanotubes modified glassy carbon electrode 显示文摘 | PINGHUA YANG WANZHI WEI CHUNYUAN TAO | 2007 | Analytica Chimica Acta2007，585，2： | 1 |
| 19 | Global asymptotic stability of periodic solution in N-species competition system with time delays显示文摘 | Yang Pinghua Xu Rui Feng Hanying | 1999 | Nnnof Diff Eqs1999，，14： | 1 |
| 20 | Sol–gel synthesis of yttria stabilized zirconia membranes through controlled hydrolysis of zirconium alkoxide显示文摘 | Xia Changrong Cao Huaqiang Wang Hong Yang pinghua Meng Guangyao Peng Dingkun | 1999 | Journal of Membrane Science1999，，1： | 1 |
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