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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 3 | Life cycle resource consumption of automotive power seats显示文摘 | Yisong Chen Yanping Yang Xiang Li | 2014 | International Journal of Environmental Studies2014，71，4： | 1 |
| 4 | Invasive and non-invasive plants differ in response to soil heavy metal lead 显示文摘 | Yang Ruyi Tang Jianjun Yang Yisong | 2007 | Botanical Studies2007，48，4： | 1 |
| 5 | Existence of Energy Minimizers as Stable Knotted Solitons in the Faddeev Model显示文摘 | Fanghua Lin Yisong Yang | 2004 | Communications in Mathematical Physics2004，，2： | 1 |
| 6 | Fourth-order two-point boundary value problems显示文摘 | YANG Yisong | 1988 | Pro Amer Math Soci1988，104，： | 1 |
| 7 | A matrix trace inequality显示文摘 | Yang Yisong | 1988 | J Math Anal Appl1988，133，： | 1 |
| 8 | Life cy- cle resource consumption of automotive power seats显示文摘 | Chen Yisong Yang Yanping Li Xiang | 2014 | International Journal of Environmental Studies2014，71，4： | 1 |
| 9 | Fourth-order two-point boundary value problems显示文摘 | Yisong Yang | 1988 | Proc Amer Math Soc1988，104，： | 1 |
| 10 | Fourth-order two-point boundary value problems 显示文摘 | | 1988 | Proc Amer Math Soc1988，，104： | 1 |
| 11 | Fourth-order two-point boundary value problems显示文摘 | YANG Yisong | 1988 | Proe Amer Math Soe1988，104，： | 1 |
| 12 | Design and experiment of nail tooth picking up device for strip type residual film recycling and baling machine显示文摘In order to solve the problem of residual film pollution caused by large area of cotton mulched planting in Xinjiang,a strip type residual film recycling and baling machine was designed,which can complete mulching film picking up,impurities separation,baling and other operations.The picking up device,as the key part of residual film recycling machine,was designed and analyzed.The kinematics of the pick-up nail tooth was analyzed,and its motion equation,motion trajectory and the conditions for completing the film pick-up were determined.And the key parameters were determined by analyzing the conditions of no missing picking and the stress of the residual film.According to the Box-Benhnken test design principle,field experiments were carried out with the forward speed of machine,the pickup speed ratio and the number of auxiliary film removing mechanisms as the key experimental factors,and the residual film pickup rate,the cotton stalk content and the residual film winding rate as the operation performance indexes of the picking up device.The mathematical models between the experimental factors and indexes were established,and the effect of each factor was analyzed.Through multi-objective parameter optimization and field experiment,the optimal combination of operation parameters was obtained as follows:the forward speed of machine of 1.67 m/s,the pickup speed ratio of 1.13,and the number of auxiliary film removing mechanisms of 6.Under this parameter combination,the pickup rate of residual film was 88.9%,the cotton stalk content in recycled residual film of 3.9%,and the residual film winding rate of 1.5%.The absolute error with the theoretical value was less than 0.6%.The research results show that the picking up device has stable operation performance and good residual film recycling effect,which meets the design and practical operation requirements. | Deli Jiang Limin Yan Xuegeng Chen Yisong Mo Jiacheng Yang | 2023 | International Journal of Agricultural and Biological Engineering2023，16，6： | 0 |
| 13 | Satellite remote sensing of atmospheric particulate matter mass concentration:Advances,challenges,and perspectives显示文摘Mapping the mass concentration of near-surface atmospheric particulate matter(PM)using satellite observations has become a popular research niche,leading to the development of a variety of instruments,algorithms,and datasets over the past two decades.In this study,we conducted a holistic review of the major advances and challenges in quantifying PM,with a specific focus on instruments,algorithms,datasets,and modeling methods that have been developed over the past 20 years.The aim of this study is to provide a general guide for future satellite-based PM concentration mapping practices and to better support air quality monitoring and management of environmental health.Specifically,we review the evolution of satellite platforms,sensors,inversion algorithms,and datasets that can be used for monitoring aerosol properties.We then compare various practical methods and techniques that have been used to estimate PM mass concentrations and group them into four primary categories:(1)univariate regression,(2)chemical transport models(CTM),(3)multivariate regression,and(4)empirical physical approaches.Considering the main challenges encountered in PM mapping practices,for example,data gaps and discontinuity,a hybrid method is proposed with the aim of generating PM concentration maps that are both spatially continuous and have high precision. | Ying Zhang Zhengqiang Li Kaixu Bai Yuanyuan Wei Yisong Xie Yuanxun Zhang Yang Ou Jason Cohen Yuhuan Zhang Zongren Peng Xingying Zhang Cheng Chen Jin Hong Hua Xu Jie Guang Yang Lv Kaitao Li Donghui Li | 2021 | Fundamental Research2021，1，3： | 0 |
| 14 | A multi-omics approach identifies bHLH71-like as a positive regulator of yellowing leaf pepper mutants exposed to high-intensity light显示文摘Light quality and intensity can have a significant impact on plant health and crop productivity.Chlorophylls and carotenoids are classes of plant pigments that are responsible for harvesting light energy and protecting plants from the damaging effects of intense light.Our understanding of the role played by plant pigments in light sensitivity has been aided by light-sensitive mutants that change colors upon exposure to light of variable intensity.In this study,we conducted transcriptomic,metabolomic,and hormone analyses on a novel yellowing mutant of pepper(yl1)to shed light on the molecular mechanism that regulates the transition from green to yellow leaves in this mutant upon exposure to high-intensity light.Our results revealed greater accumulation of the carotenoid precursor phytoene and the carotenoids phytofluene,antheraxanthin,and zeaxanthin in yl1 compared with wild-type plants under high light intensity.A transcriptomic analysis confirmed that enzymes involved in zeaxanthin and antheraxanthin biosynthesis were upregulated in yl1 upon exposure to high-intensity light.We also identified a single basic helix–loop–helix(bHLH)transcription factor,bHLH71-like,that was differentially expressed and positively correlated with light intensity in yl1.Silencing of bHLH71-like in pepper plants suppressed the yellowing phenotype and led to reduced accumulation of zeaxanthin and antheraxanthin.We propose that the yellow phenotype of yl1 induced by high light intensity could be caused by an increase in yellow carotenoid pigments,concurrent with a decrease in chlorophyll accumulation.Our results also suggest that bHLH71-like functions as a positive regulator of carotenoid biosynthesis in pepper. | Zhoubin Liu Lianzhen Mao Bozhi Yang Qingzhi Cui Yunhua Dai Xueqiao Li Yisong Chen Xiongze Dai Xuexiao Zou Lijun Ou Sha Yang | 2023 | Horticulture Research2023，10，7： | 0 |
| 15 | Machine learning for the prediction of acute kidney injury in patients with acute pancreatitis admitted to the intensive care unit显示文摘To the Editor:Acute kidney injury(AKI)is a well-known and critical complication of acute pancreatitis in intensive care units(ICUs).Patients with acute pancreatitis who developed AKI had a significantly higher mortality than those without AKI.[1]Currently,the diagnosis of AKI in acute pancreatitis patients includes a sudden decrease in glomerular filtration rate manifested by an increase in serum creatinine or oliguria within 48 h to 7 days.[2]However,kidney damage occurs unstoppably when creatinineincreases or urine output decreases.This study aimed to establish prediction models based on the machine learning algorithm and traditional logistic regression method only with commonly collected variables when admitted to the ICU,and we also compared their performance for predicting the occurrence of AKI in patients with acute pancreatitis. | Yisong Cheng Jie Yang Qin Wu Lili Cao Bo Wang Xiaodong Jin Yan Kang Zhongwei Zhang Min He | 2022 | Chinese Medical Journal2022，135，23： | 0 |
| 16 | Research on Ecological Assessment and Dynamic Optimization of Energy-saving and New Energy Vehicle Business Model Based on Full Life Cycle Theory显示文摘The rapid development of China’s automobile industry has brought ever-increasing impact on resources,energy and environment,the energy-saving and new energy vehicles come into being accordingly.This article firstly systematically introduces the technical route of energy-saving and new energy vehicles of China,focusing on the key bottleneck problems arising from the construction process of current assessment system of the technical route for energy-saving and new energy vehicles,establishes the energy-saving and new energy vehicle business model assessment index system afterward based on the comparative analysis on energy-saving and new energy vehicle business assessment model and the full life cycle theory,and finally makes prospects and forecasts on vital problems of system boundary,dynamic optimization,simulation system of full life cycle assessment of energy-saving and new energy vehicle. | Peipei Chao Yisong Chen Yanping Yang | 2019 | Journal of Mechanical Engineering Research2019，2，2： | 0 |
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