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| 1 | Rapid improvement of grain weight via highly efficient CRISPR/Cas9-mediated multiplex genome editing in rice显示文摘Most of the important agronomic traits in crop plants,such as yield,quality and stress response,are quantitative and jointly controlled by many genomic loci or major genes.Improving these complex traits depends on the combination of beneficial alleles at the quantitative trait loci(QTLs).However,the conventional cross breeding method is extremely time-consuming and laborious for pyramiding multiple QTLs.In certain cases,this approach | Rongfang Xu Yachun Yang Ruiying Qin Hao Li Chunhong Qiu Li Li Pengcheng Wei Jianbo Yang | 2016 | Journal of Genetics and Genomics2016，43，8： | 47 |
| 2 | A Recombinant Rabies Virus Expressing Fms-like Tyrosine Kinase 3 Ligand(Flt3L) Induces Enhanced Immunogenicity in Mice显示文摘Rabies is a zoonotic disease that still causes 59,000 human deaths each year,and rabies vaccine is the most effective way to control the disease.Our previous studies suggested that the maturation of DC plays an important role in enhancing the immunogenicity of rabies vaccine.Flt3L has been reported to own the ability to accelerate the DC maturation,therefore,in this study,a recombinant rabies virus expressing mouse Flt3L,designated as LBNSE-Flt3L,was constructed,and its immunogenicity was characterized.It was found that LBNSE-FU3L could enhance the maturation of DC both in vitro and in vivo,and significantly more TFH cells and Germinal Center B(GC B)cells were generated in mice immunized with LBNSE-FU3L than those immunized with the parent virus LBNSE.Consequently,expressing of Flt3L could elevate the level of virus-neutralizing antibodies(VNA)in immunized mice which provides a better protection from a lethal rabies virus challenge.Taken together,our study extends the potential of Flt3L as a good adjuvant to develop novel rabies vaccine by enhancing the VNA production through activating the DC—Tfh^GC B axis in immunized mice. | Yachun Zhang Jie Yang Mingming Li Min Cui Zhen FFu Ling Zhao Ming Zhou | 2019 | Virologica Sinica2019，34，6： | 3 |
| 3 | Structural Networks Constraints on Alteration and Mineralization Processes in the Jiaojia Gold Deposit, Jiaodong Peninsula, China显示文摘Structural network studies could give appropriate opportunities to understanding structural/hydrothermal events,transportation of ore-forming fluids and water/rock interaction process.Four structural deformation/hydrothermal events have been identified in the Jiaojia fault zone according to microtexture and deformation of quartz and feldspars.Plagioclase experienced ductile deformation period with bended polysynthetic twin stripes(>450℃)in the early stage,followed by K-feldspar alteration period with ductile-brittle deformation and subgrain rotation recrystallization of quartz(380-450℃).Then,sericitization period occurred extensive ductile-brittle deformation(350-420℃)and extensive subgrain rotation recrystallization with a little bulging recrystallization in quartz.In the last,gold precipitation-related pyrite-sericite-quartz alteration was dominated by brittle deformation(300-380℃)and total bulging recrystallization of quartz.From the K-feldspar alteration zone and sericitization zone to pyrite-sericitequartz alteration zone,fractal dimension values of dynamically recrystallized quartz grains increase from 1.07 and 1.24 to 1.32,the calculated paleo strain rate values of dynamically recrystallized quartz range from 10^-10^.7(380℃)-10^-9.6(450℃)and 10^-9.3(350℃)-10^-8.2(420℃)to 10^-9.5(300℃)-10^-8.0(380℃),and the paleo differential stress values increase from 36.9 and 39.3,to 121.3 MPa.The increase of fractal dimension values and decrease of grain size from pyrite-sericite-quartz alteration zone and sericitization zone to K-feldspar alteration zone decreased average water/rock ratio values,which could lead to different acidity and redox conditions of ore-forming fluids and mineralization differences.Two kinds of orecontrolling fractures have been distinguished which include the gentle dip types(18°-50°)with NW(315°-355°)and SW(180°-235°)dip hosting No.Ⅰorebodies and the steep dip types(74°-90°)with NE(45°-85°)and SE(95°-165°)dip hosting No.Ⅲorebodies.These faults/fractures crosscut altered Linglong granite of footwall of the Jiaojia fault zone as rhombohedrons that promoted the connection between fractures in the K-feldspar alteration zone and fluid flow passages near the main fault face.Research results indicate No.Ⅰand No.Ⅲorebodies should be derived from the same mineralization event and belong to different orebody types in different mineralization sites under the same structural networks. | Huanlong Hu Shuangliang Liu Hong-Rui Fan Kuifeng Yang Yabin Zuo Yachun Cai | 2020 | Journal of Earth Science2020，31，3： | 1 |
| 4 | Advances in Ecological Applications of Fengyun Satellite Data显示文摘In recent years,the remote sensing based on meteorological satellite observations has become an important tool for assessing global ecological conditions.Since the early 2000,Fengyun(FY)satellite data have been widely used to derive the key parameters of ecological environment in China.An integrated earth-observation system has been developed in China through using FY satellite data,including retrievals the key ecological parameters as well as to constructions of long-term data records of vegetation index,land surface temperature,net primary production,vegetation health index,and so on.Considerable progress has thus been made in the application and service for prevention of air pollution,management and control of ecological redline,ecological monitoring for the Belt and Road Initiative,and assessment of ecological environment for human settlement.In order to monitor the ecological parameters in real time and with a full dynamic coverage,it is necessary to improve the technology in application of ecological remote sensing from meteorological satellites,and further enhance the ecological meteorological service. | Xiuzhen HAN Hao GAO Jun YANG Yachun LI Weicheng GENG | 2021 | Journal of Meteorological Research2021，35，5： | 1 |
| 5 | Cs_(3)Bi_(2)l_(9)-hydroxyapatite composite waste forms for cesium and iodine immobilization显示文摘Perovskite-based ceramic composites were developed as potential waste form materials for immobilizing cesium(Cs)and iodine(I)with high waste loadings and chemical durability.The perovskite Cs_(3)Bi_(2)I_(9)has high Cs(22 wt%)and I(58 wt%)content,and thus can be used as a potential host phase to immobilize these critical radionuclides.In this work,the perovskite Cs_(3)Bi_(2)I_(9)phase was synthesized by a cost effective solution-based approach,and was embedded into a highly durable hydroxyapatite matrix by spark plasma sintering to form dense ceramic composite waste forms.The chemical durabilities of the monolithic Cs_(3)Bi_(2)I_(9)and Cs_(3)Bi_(2)I_(9)-hydroxyapatite composite pellets were investigated by static and semi-dynamic leaching tests,respectively.Cs and I are incongruently released from the matrix for both pure Cs_(3)Bi_(2)I_(9)and composite structures.The normalized Cs release rate is faster than that of I,which can be explained by the difference in the strengths between Cs-I and Bi-I bonds as well as the formation of insoluble micrometer-sized BiOI precipitates.The activation energies of elemental releases based on dissolution and diffusion-controlled mechanisms are determined with significantly higher energy barriers for dissolution from the composite versus that of the monolithic Cs_(3)Bi_(2)I_(9).The ceramic-based composite waste forms exhibit excellent chemical durabilities and waste loadings,commensurate with the state-of-the-art glass-bonded perovskite composites for I and Cs immobilization. | Kun YANG Yachun WANG Junhua SHEN Spencer M.SCOTT Brian J.RILEY John D.VIENNA Jie LIAN | 2022 | Journal of Advanced Ceramics2022，11，5： | 0 |
| 6 | Characteristics and main control factors of Ordovician shoal dolomite gas reservoir in Gucheng area,Tarim Basin,NW China显示文摘Based on seismic, drilling data and experimental analysis, the characteristics and main controlling factors of shoal dolomite gas reservoir in the third member of Ordovician Yingshan Formation of Gucheng area, Tarim basin were examined.The study shows that the dolomite gas reservoir in Gucheng area is lithologic gas reservoir controlled by shoal and fault jointly,and its formation is mainly attributed to the following factors:(1) The continuously developing paleotectonic structure has been in the direction of gas migration and accumulation;(2) The large area of medium-high energy grain bank deposited in gentle slope environment is the material basis for the formation of dolomite reservoir;(3) Atmospheric water leaching and dolomitization and fluid dissolution in fault zone are the key factors for the formation of high-quality dolomite reservoir;(4)The natural gas comes from cracking of the ancient oil reservoir and hydrocarbon generation of dispersed organic matter in source rocks, and the NNE-trending strike-slip fault is the dominant channel for vertical migration of natural gas;(5) Limestone cap rocks in the first and second members of Yingshan Formation provide direct sealing for the formation of gas reservoir there. On the basis of comprehensive analysis, it is pointed out that the Gucheng area has three grain shoal zones in the third member of Yingshan Formation in nearly S-N direction, which together with seven strike-slip fault zones in NNE direction control the development of shoal dolomite gas reservoir. | FENG Jun ZHANG Yajin ZHANG Zhenwei FU Xiaofei WANG Haixue WANG Yachun LIU Yang ZHANG Junlong LI Qiang FENG Zihui | 2022 | Petroleum Exploration and Development2022，49，1： | 0 |
| 7 | An epi-allele of SMS causes Sanming dominant genic male sterility in rice显示文摘Male sterility is an important trait in rice for hybrid rice(Oryza sativa)breeding.However,the factors involved in dominant male sterility are largely unknown.Here,we identified a gene from Sanming dominant genic male sterile rice,named Sanming dominant male sterility(SMS),and reported that an epi-allele of this locus contributes to male sterility.Segregation analysis attributed dominant male sterility to a single locus,SMS,which we characterized using a male-sterile near isogenic line(NIL)of rice cultivar 93-11.The SMS locus was heterozygous in the male-sterile 93-11 NIL,containing an epi-allele identical to that in 93-11,and an epi-allele identical to that in rice cultivar Nipponbare,which we refer to as SMS9 and SMSN,respectively.SMS9is silent and hyper-methylated,whereas SMSNis expressed and hypo-methylated in the 93-11 NIL.Overexpressing SMSNled to male sterility.Mutations in SMS rescued the male sterility of the 93-11 NIL.Interestingly,we observed the duplication of SMSN in Nipponbare,but did not observe the duplication of SMS9in 93-11.Together,these findings suggest that the reduced methylation and enhanced expression of the SMSNepi-allele in the 93-11 NIL is responsible for its role in conferring dominant male sterility. | Yachun Yang Cheng Zhang Hao Li Zeyuan Yang Zuntao Xu Dewei Tai Dahu Ni Pengcheng Wei Chengxin Yi Jianbo Yang Yong Ding | 2023 | Science China(Life Sciences)2023，66，12： | 0 |
| 8 | Isolation and Growth Characteristics of SARS-CoV-2 in Vero Cell显示文摘Dear Editors,The coronavirus disease 2019(COVID-19),caused by SARS-CoV-2,broke out in early December 2019 has escalated into a global pandemic(Lai et al.2020).Till the May 20 th 2020,more than 4,700,000 people were infected and the number is still increasing especially in Europe,North America and Asia(http://gffzze7c39cdc9e894ca6skv6nv5f0vqob6kpf.ffgz.tsg.suse.edu.cn/). | Pingping Yao Yachun Zhang Yisheng Sun Yulin Gu Fang Xu Bo Su Chen Chen Hangjing Lu Dehui Wang Zhangnv Yang Biao Niu Jiancai Chen Lixia Xie Lei Chen Yajing Zhang Hui Wang Yuying Zhao Yue Guo Juncheng Ruan Zhiyong Zhu Zhenfang Fu Dayong Tian Qi An Jianmin Jiang Hanping Zhu | 2020 | Virologica Sinica2020，35，3： | 0 |
| 9 | Habenula,a potential central target for glucose metabolism in type 2 diabetes显示文摘The role of the habenular nucleus(Hb)in the pathogenesis of depression has been thoroughly studied,but whether it functions in the pathogenesis of diabetes remains unknown.In this study,type 2 diabetes(T2DM)rats,which induced by the high-carbohydrate and fat diet combined with STZ were employed.The functions of Hb were suppressed by application of electrical lesion.Compared with the sham group,the expression levels of AMPK phosphorylation and insulin receptor were significantly increased,whereas glucose-6-phosphatase and phosphoenolpyruvate carboxylated kinase was reduced,in the liver of the Hb lesions group. | Qu Peng Wang Yachun Sun Yimeng Xu Zichen Yang Limin | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 10 | SDF5 Encoding P450 Protein Is Required for Internode Elongation in Rice显示文摘Plant height is a critical trait for yield in rice(Oryza sativa),and gibberellic acid(GA)is involved in modulating rice height.Here,we identified the semi-dwarf 5(sdf5)mutant by screening a rice T-DNA insertion mutant library using genome-resequencing.sdf5 contains a T-DNA insertion that causes the ectopic expression of LOC_Os05g34325,which encodes a 14-α-demethylase cytochrome P450(CYP51)protein.Levels of the active GA species GA1 and GA4 were reduced in the sdf5 mutant,and the semi-dwarf phenotype of the sdf5 mutant was rescued by exogenous GA4.In addition to its semi-dwarf height,the sdf5 mutant exhibited compact plant architecture,dark green leaves and low 1000-grain weight.Together,these results suggest that SDF5 is involved in GA biosynthesis pathway and modulates rice height and plant development. | Yang Yachun Li Juan Li Hao Xu Zuntao Qin Ruiying Wu Wenge Wei Pengcheng Ding Yong YANG Jianbo | 2021 | Rice science2021，28，4： | 0 |
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