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| 1 | Diagnostic value of glypican-3 in serum and liver for primary hepatocellular carcinoma显示文摘AIM:To evaluate the diagnostic value of glypican-3(GPC3) in serum and liver for primary hepatocellular carcinoma(HCC).METHODS:Serum levels of GPC3 and α-fetoprotein(AFP) were measured in 75 patients with primary HCC and 32 patients with liver cirrhosis.Expression of GPC3 and AFP in 58 HCC and 12 cirrhotic specimens was detected with immunohistochemical staining.RESULTS:When the cut-off value of serum GPC3 was set at 300 ng/L,its sensitivity and specificity for HCC were 47.0% and 93.5%,respectively.Among the 14 patients with HCC at stage according to the Barcelona Clinic Liver Cancer staging system,the serum GPC3 level was higher than 300 ng/L in 50%(7/14) patients,the serum AFP level was not ≥ 400 μg/L in any patient.Combined serum AFP and GPC3 significantly increased the sensitivity to the diagnosis of HCC.The GPC3 expression was detected in cytoplasm of HCC cells but not in hepatocytes and bile ducts of benign tumors.Among the 58 HCC patients,the GPC3 was expressed in 100%(28/28) patients with their serum AFP level ≥ 400 μg/L,and in 90%(27/30) patients with their AFP level < 400 μg/L,respectively.The GPC3 was weakly or negatively expressed in all paracarcinomatous and cirrhotic tissue samples.AFP positive HCC cells were only found in 1 out of the 58 HCC patients.CONCLUSION:GPC3 protein is a sensitive and specific serum marker for diagnosis of early HCC.Its expression in liver tissues can be used to discriminate tumor cells from benign hepatic cells. | Hui Liu Li-Jie Zhang Peng Li Yun Zhai Yu-Fen Tan Ning Li Hui-Guo Ding Chun-Feng Qu | 2010 | World Journal of Gastroenterology2010，16，35： | 57 |
| 2 | Disruption of phytoene desaturase gene results in albino and dwarf phenotypes in Arabidopsis by impairing chlorophyll, carotenoid, and gibberellin biosynthesis显示文摘类胡萝卜素在植物和 phytoene desaturase 基因(PDS3 ) 在许多生理的过程起一个重要作用把重要的酶之一编码为类胡萝卜素生合成小径。这里,我们报导 T-DNA 插入异种 ofPDS3 基因的鉴定和分析。功能的互补证实 thepds3 异种的白化体和矮子显型源于 PDS3 基因的功能的混乱。叶绿体开发在 pds3 异种在专业版质体阶段被逮捕。进一步的分析证明高级 ofphytoene 在 pds3 异种被积累。外长的 GA (3 ) 的增加能部分救矮子显型,建议 pds3 异种的矮子显型可能由于 GAdeficiency。Microarray 和 RT-PCR 分析证明那破坏 PDS3 基因导致了涉及至少 20 条新陈代谢的小径的基因表示变化,包括在类胡萝卜素,叶绿素,和 GA 的许多基因的抑制生合成小径。我们的数据建议在 pds3 异种的积累的 phytoene 可能在某些否定反馈起一个重要作用影响多样的细胞的小径的基因表示。 | Genji Qin Hongya Gu Ligeng Ma Yiben Peng Xing Wang Deng Zhangliang Chen Li-Jia Qu | 2007 | Cell Research2007，17，5： | 39 |
| 3 | Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis显示文摘在哺乳动物的精子发生被 piRNA 表示的二个波浪描绘:一个人对应于负责的经典 piRNAs 因为 silencing retrotransponsons 和第二个波浪主要在 pachytene spermatocytes 从 nontransposon intergenic 区域被导出,但是这些 pachytene piRNAs 的功能大部分是未知的。这里,我们在在老鼠伸长指示巨大的 mRNA 消除报导 pachytene piRNAs 的参与 spermatids (ES ) 。我们证明包含鼠科的 PIWI (MIWI ) 和 deadenylase CAF1 的导致 piRNA 的 silencing 建筑群(pi-RISC ) 有选择地在 ES 被装配,它负责经由在体的房间类似于 miRNAs 的行动的机制导致 mRNA deadenylation 和腐烂。如此的一个高度安排的节目看起来充分利用 pachytene piRNAs 的能力从 nontransposon intergenic 区域导出的多样化的指向的庞大的全部剧目。这些调查结果建议 pachytene piRNAs 负责为精子生产作准备,从 ES 使广阔细胞的节目失去活性。 | Lan-Tao Gou Peng Dai Jian-Hua Yang Yuanchao Xue Yun-Ping Hu Yu Zhou Jun-Yan Kang Xin Wang Hairi Li Min-Min Hua Shuang Zhao Si-Da Hu Li-Gang Wu Hui-Juan Shi Yong Li Xiang-Dong Fu Liang-Hu Qu En-Duo Wang Mo-Fang Liu | 2014 | Cell Research2014，24，6： | 39 |
| 4 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 5 | Os isotopic compositions of a cobalt-rich ferromanganese crust profile in Central Pacific显示文摘187Os/188Os ratios in all sub-layers of the Co-rich ferromanganese crust MP5D17 from Line Seamount in Central Pacific have been systematically determined. The 187Os/188Os values in this crust are highly variable, ranging from 0.4262 to 1.0155. From the bottom to the top, the os-mium isotopic ratios of the crust display a regular variation trend, which correlates well with its changes in structure and texture in the vertical profile. In comparison with the evolu-tion curve of Os isotopic composition in seawater over the past 80 Ma, a similar evolution tendency can be found with respect to the Os isotopic composition of the crust in this study. It is preliminarily concluded that the crust MP5D17 began to grow at about 72 Ma, and underwent three growth hiatuses, corresponding to the geological ages of 64, 53 and 37 Ma, respectively. | FU Yazhou PENG Jiantang QU Wenjun HU Ruizhong SHI Xuefa DU Andao | 2005 | Chinese Science Bulletin2005，50，18： | 13 |
| 6 | Effect of b value on monitoring therapeutic response by diffusion-weighted imaging显示文摘AIM: To explore the diffusion gradient b-factor that optimizes both apparent diffusion coefficient (ADC) measurement and contrast-to-noise (CNR) for assessing tumor response to transarterial chemoembolization (TACE) in a rabbit model. METHODS: Twelve New Zealand white rabbits bearing VX2 tumors in the liver were treated with TACE. Diffusion-weighted imaging (DWI) with various b values was performed using the same protocol before and 3 d after treatment with TACE. ADC values and CNR of each tumor pre-and post-treatment with different b factors were analyzed. Correlation between ADC values and extent of necrosis in histological specimens was analyzed by a Pearson's correlation test.RESULTS: The quality of diffusion-weighted images diminished as the b value increased. A substantial decrease in the mean lesion-to-liver CNR was observed on both pre-and post-treatment DW images, the largest difference in CNR pre-and post-treatment was manifested at a b value of 1000 s/mm2 (P = 0.036 ). The effect of therapy on diffusion early after treatment was shown by a significant increase in ADCs (P = 0.007), especially with large b factors (≥ 600 s/mm2). The mean percentage of necrotic cells present within the tumor was 76.3%-97.5%. A significant positive correlation was found between ADC values and the extent of necrosis with all b values except for b200, a higher relative coefficient between ADC values and percentage of necrosis was found on DWI with b1000 and b2000 (P= 0.002 and 0.006, respectively). CONCLUSION: An increasing b value of up to 600 s/mm2 would increase ADC contrast pre-and post-treatment, but decrease image quality. Taking into account both CNR and ADC measurement, diffusion-weighted imaging obtained with a b value of 1000 s/mm2 is recommended for monitoring early hepatic tumor response to TACE. | Zhao-Xia Jiang Wei-Jun Peng Wen-Tao Li Feng Tang Shi-Yuan Liu Xu-Dong Qu Jian-Hua Wang Hong-Feng Lu | 2008 | World Journal of Gastroenterology2008，14，38： | 13 |
| 7 | Novel detection method for infrared small targets using weighted information entropy显示文摘This paper presents a method for detecting the small infrared target under complex background. An algorithm, named local mutation weighted information entropy (LMWIE), is proposed to suppress background. Then, the grey value of targets is enhanced by calculating the local energy. Image segmentation based on the adaptive threshold is used to solve the problems that the grey value of noise is enhanced with the grey value improvement of targets. Experimental results show that compared with the adaptive Butterworth high-pass filter method, the proposed algorithm is more effective and faster for the infrared small target detection. | Xiujie Qu He Chen Guihua Peng | 2012 | Journal of Systems Engineering and Electronics2012，23，6： | 13 |
| 8 | Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4显示文摘补充 32 的反应基因(RGC-32 ) 是涉及房间的增长,区别和迁居的一个房间周期管理者并且也在 angiogenesis 被含有。这里,我们证明在巨噬细胞的那 RGC-32 表情被 IL-4 导致并且由 LPS 减少了,显示在 RGC-32 表示和 M2 极化之间的一个连接。我们证明 RGC-32 的增加的表示或者激活的巨噬细胞,这蛋白质在压制支持 inflammatory cytokine IL-6 的生产并且支持反煽动性的调停人 TGF-β 的生产是特征的;。与一致在 vitro,数据, RGC-32 高级的联系肿瘤的巨噬细胞(TAM ) 快车,和这个表达式被导出肿瘤的腹水的液体以一种 M-CSF- 或 IL-4-dependent 方式导致。一起,这些结果为 M2 巨噬细胞极化作为一个标记建立 RGC-32 并且显示这蛋白质是为癌症免疫疗法的一个潜在的目标,指向联系肿瘤的巨噬细胞。 | Peng Zhao Daiqing Gao Qingjie Wang Bingfeng Song Qianqian Shao Jintang Sun Chunyan Ji Xingang Li Peng Li Xun Qu | 2015 | Cellular & Molecular Immunology2015，12，6： | 12 |
| 9 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 10 | Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway显示文摘 | Libin Song Xiangyuan Chen Peng Wang Song Gao Chao Qu Luming Liu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 10 |
| 11 | Pathogenetic mechanisms in gastric cancer显示文摘Gastric cancer(GC) is a major public health issue as the fourth most common cancer and the second leading cause of cancer-related death. Recent advances have improved our understanding of its molecular pathogenesis,as best exemplified by elucidating the fundamental role of several major signaling pathways and related molecular derangements. Central to these mechanisms are the genetic and epigenetic alterations in these signaling pathways,such as gene mutations,copy number variants,aberrant gene methylation and histone modification,nucleosome positioning,and microRNAs. Some of these genetic/epigenetic alterations represent effective diagnostic and prognostic biomarkers and therapeutic targets for GC. This information has now opened unprecedented opportunities for better understanding of the molecular mechanisms of gastric carcinogenesis and the development of novel therapeutic strategies for this cancer. The pathogenetic mechanisms of GC are the focus of this review. | Jing Shi Yi-ping Qu peng Hou | 2014 | World Journal of Gastroenterology2014，20，38： | 9 |
| 12 | A refined coherent point drift(CPD)algorithm for point set registration显示文摘The coherent point drift (CPD) algorithm is a powerful approach for point set registration. However, it suffers from a serious problem-there is a weight parameter w that reflects the assumption about the amount of noise and number of outliers in the Gaussian mixture model, and its value has an influence on the point set registration performance In the original CPD algorithm, the value of w is set manually, and hence an improper value will lead to poor registration results. To solve this problem, a fully automatic algorithm for the selection of an optimal weight parameter is proposed using a hybrid optimization scheme that combines the genetic algorithm with the Nelder-Mead simplex method. The experiments show that the refined CPD algorithm is more effective and extends the original CPD algorithm in its methodology and applications. | WANG Peng WANG Ping QU ZhiGuo GAO YingHui SHEN ZhenKang | 2011 | Science China(Information Sciences)2011，54，12： | 9 |
| 13 | Multifunctional roles of carbon-based hosts for Li-metal anodes:A review显示文摘With its high theoretical capacity,lithium(Li)metal is recognized as the most potential anode for realizing a high-performance energy storage system.A series of questions(severe safety hazard,low Coulombic efficiency,short lifetime,etc.)induced by uncontrollable dendrites growth,unstable solid electrolyte interface layer,and large volume change,make practical application of Li-metal anodes still a threshold.Due to their highly appealing properties,carbon-based materials as hosts to composite with Li metal have been passionately investigated for improving the performance of Li-metal batteries.This review displays an overview of the critical role of carbon-based hosts for improving the comprehensive performance of Li-metal anodes.Based on correlated mainstream models,the main failure mechanism of Li-metal anodes is introduced.The advantages and strategies of carbon-based hosts to address the corresponding challenges are generalized.The unique function,existing limitation,and recent research progress of key carbon-based host materials for Li-metal anodes are reviewed.Finally,a conclusion and an outlook for future research of carbon-based hosts are presented.This review is dedicated to summarizing the advances of carbon-based materials hosts in recent years and providing a reference for the further development of carbonbased hosts for advanced Li-metal anodes. | Xiaolin Yan Liang Lin Qiulin Chen Qingshui Xie Baihua Qu Laisen Wang Dong-Liang Peng | 2021 | Carbon Energy2021，3，2： | 8 |
| 14 | No association between low-dose reserpine use and depression in older hypertensive patient: result of a multicenter, cross-sectional study显示文摘Background Reserpine is currently used by millions of Chinese hypertensive patients, in spite of the continued concern of its depressogenic effect, even when used in low dose. This study aimed to investigate the association between low-dose reserpine use and depression in older Chinese hypertensive patient. Methods In this cross-sectional, case-control study, we recruited patient aged 60 years or over who had regularly taken one or two tables of “compound reserpine and triamterene tablets (CRTTs)” for more than one year (reserpine user) from 26 community health centers located in 10 provinces in China. For each patient who took CRTTs, we selected an age (within five years) and sex matched hypertensive patient who had never taken any drugs containing reserpine (non-reserpine user) as control. Depressive symptoms were evaluated using a Chinese depression scale adapted from the Zung Self-Rating Depression Scale. Demographic, clinical data and laboratory examination results within six months were collected. Results From August 2018 to December 2018, 787 reserpine user and 787 non-reserpine user were recruited. The mean age of all study subjects was 70.3 years, with about equal numbers of males and females. The mean depression score was 40.4 in reserpine users and 40.6 in non-reserpine users (P = 0.7). The majority of study subject had a depression score < 53 (87.6% in reserpine users and 88.2% in non-reserpine users, respectively). There were no significant differences in the prevalence of mild, moderate or severe depression in reserpine users and non-reserpine users. Conclusions There is no association between low-dose reserpine use and depression in older hypertensive patient. The role of reserpine in the treatment and control of hypertension should be reconsidered;and further studies, especially randomized, controlled clinical trials to compare efficacy and safety of reserpine and other widely recommended anti-hypertensive agents are needed. | Guo-Hua ZHU Xi-Peng SUN Jing LI Lin PI Hai-Qin TANG Hai-Qing GAO Hong-Liang CONG Peng QU Xin-Zheng LU Xin-Jun ZHANG Luo-Sha ZHAO Yi-Fang GUO Dong-Xia LIU Liang-Qing ZHANG Hua TANG Yi-Xin HU Li FAN Qi HUA | 2019 | Journal of Geriatric Cardiology2019，16，8： | 8 |
| 15 | Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19显示文摘The coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 was identified in December 2019.The symptoms include fever,cough,dyspnea,early symptom of sputum,and acute respiratory distress syndrome(ARDS).Mesenchymal stem cell(MSC)therapy is the immediate treatment used for patients with severe cases of COVID-19.Herein,we describe two confirmed cases of COVID-19 in Wuhan to explore the role of MSC in the treatment of COVID-19.MSC transplantation increases the immune indicators(including CD4 and lymphocytes)and decreases the inflammation indicators(interleukin-6 and C-reactive protein).High-flow nasal cannula can be used as an initial support strategy for patients with ARDS.With MSC transplantation,the fracrion of inspired O2(Fi02)of the two patients gradually decreased while the oxygen saturation(Sa02)and partial pressure of oxygen(P02)improved.Additionally,the patients9 chest computed tomography showed that bilateral lung exudate lesions were adsorbed after MSC infusion.Results indicated that MSC transplantation provides clinical data on the treatment of COVID-19 and may serve as an alternative method for treating COVID-19,particularly in patients with ARDS. | Lingling Tang Yingan Jiang Mengfei Zhu Lijun Chen Xiaoyang Zhou Chenliang Zhou Peng Ye Xiaobei Chen Baohong Wang Zhenyu Xu Qiang Zhang Xiaowei Xu Hainv Gao Xiaojun Wu Dong Li Wanli Jiang Jingjing Qu Charlie Xiang Lanjuan Li | 2020 | Frontiers of Medicine2020，14，5： | 8 |
| 16 | A semi-physical sediment yield model for estimation of suspended sediment in loess region显示文摘Sediment yield is a complex function of many environmental factors including climate,hydrology,vegetation,basin topography,soil types,and land cover.We present a new semi-physical watershed sediment yield model for the estimation of suspended sediment in loess region.This model is composed by three modules in slope,gully,and stream phases.For slope sediment yield,a balance equation is established based on the concept of hydraulic erosion capacity and soil erosion resistance capacity.According to the statistical analysis of watershed characteristics,we use an exponential curve to approximately describe the spatial variability of watershed soil erosion resistance capacity.In gully phase,the relationship between gully sediment concentration and flow velocity is established based on the Bagnold' stream power function.In the stream phase,we assume a linear dependence of the sediment volume in the reach on the weighted sediment input and output.The proposed sediment yield model is operated in conjunction with a conceptual hydrologic model,and is tested over 16 regions including testing grounds,and small,medium and large watersheds in the loess plateau region in the mid-reach of Yellow River.Our results indicate that the model is reasonable in structure and is able to provide a good simulation of sediment generation and transportation processes at both flood event scale and inter-annual time scale.The proposed model is generally applicable to the watersheds with soil texture similar to that of the loess plateau region in the Yellow River basin in China. | Wei Si Weimin Bao Peng Jiang Liping Zhao Simin Qu | 2017 | International Journal of Sediment Research2017，32，1： | 7 |
| 17 | No expenditure difference among patients with liver cancer at stageⅠ-ⅣV:Findings from a multicenter cross-sectional study in China显示文摘Objective:The number of liver cancer patients in China accounts for more than half of the world.However,China currently lacks national,multicenter economic burden data,and meanwhile,measuring the differences among different subgroups will be informative to formulate corresponding policies in liver cancer control.Thus,the aim of the study was to measure the economic burden of liver cancer by various subgroups.Methods:A hospital-based,multicenter and cross-sectional survey was conducted during 2012・2014,covering 39 hospitals and 21 project sites in 13 provinces across China.The questionnaire covers clinical information,sociology,expenditure,and related variables.All expenditure data were reported in Chinese Yuan(CNY)using 2014 values.Results:A total of 2,223 liver cancer patients were enrolled,of whom 59.61%were late-stage cases(III-IV),and 53.8%were hepatocellular carcinoma.The average total expenditure per liver cancer patient was estimated as 53,220 CNY,including 48,612 CNY of medical expenditures(91.3%)and 4,608 CNY of non-medical expenditures(8.7%).The average total expenditures in stage I,H,m and stage IV were 52,817 CNY,50,877 CNY,50,678 CNY and 54,089 CNY(P>0.05),respectively.Non-medical expenditures including additional meals,additional nutrition care,transportation,accommodation and hired informal nursing were 1,453 CNY,839 CNY,946 CNY,679 CNY and 200 CNY,respectively.The one-year out-of-pocket expenditure of a newly diagnosed patient was 24,953 CNY,and 77.2%of the patients suffered an unmanageable financial burden.Multivariate analysis showed that overall expenditure differed in almost all subgroups(P<0.05),except for sex,clinical stage,and pathologic type.Conclusions:There was no difference in treatment expenditure for liver cancer patients at different clinical stages,which suggests that maintaining efforts on treatment efficacy improvement is important but not enough.To fiirtherly reduce the overall economic burden from liver cancer,more effort should be given to primary and secondary prevention strategies. | Haike Lei Lin Lei Jufang Shi Yongzhong Wu Ling Liang Huiyao Huang Mei He Fangzhou Bai Maomao Cao Hui Qiu Yuting Wang Chengcheng Liu Jia Du Hong Wang Yan Zhang Mengdi Cao Ji Peng Ni Li Chunfeng Qu Min Dai Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 7 |
| 18 | Distinguishing transgenic from non-transgenic Arabidopsis plants by ~1H NMR-based metabolic fingerprinting显示文摘We have recently reported the construction of an nuclear magnetic resonance (NMR)-based metabonomics study platform, Automics. To examine the application of Automics in transgenic plants, we performed metabolic fingerprinting analysis, i.e., 1H NMR spectroscopy and multivariate analysis, on wild-type and transgenic Arabidopsis. We found that it was possible to distinguish wild-type from four transgenic plants by PLS-DA following application of orthogonal signal correction (OSC). Scores plot following OSC clearly demon-strates significant variation between the transgenic and non-transgenic groups, suggesting that the metabolic changes among wild-type and transgenic lines are possibly associated with transgenic event. We also found that the major contributing metabolites were some specific amino acids (i.e., threonine and alanine), which could correspond to the insertion of the selective marker BAR gene in the transgenic plants. Our data suggests that NMR-based metabonomics is an efficient method to distinguish fingerprinting difference between wild-type and transgenic plants, and can potentially be applied in the bio-safety assessment of transgenic plants. | Yanfei Ren Tao Wang Yufa Peng Bin Xia Li-Jia Qu | 2009 | Journal of Genetics and Genomics2009，36，10： | 7 |
| 19 | Visible-light-driven enhanced antibacterial and biofilm elimination activity of graphitic carbon nitride by embedded Ag nanoparticles显示文摘有 photocatalytic 活动的半导体 nanomaterials 为许多应用有潜力。支持 photocatalytic 活动的一个有效方法在一个半导体上正在扔高贵金属 nanoparticles (NP ) ,自从 NP 作为禁止 photoexcited 电子洞对的快再结合并且从而提高反应的氧种类(ROS ) 的产生的优秀电子领受人扮演的高贵金属。此处,一个高度有效的平台, graphitic 碳氮化物( g-C <潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”>有嵌入的 Ag nanoparticles 的 4 ) nanosheets ( Ag/g-C <潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 ),被综合由一灵巧的线路。在可见轻照耀下面, Ag/g-C 的 ROS 生产<潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 nanohybrids 极大地与太古的 g-C 相比被改进<潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 nanosheets ,并且而且, nanohybrids 显示出驱散细菌的 biofilms 的提高的抗菌剂功效和能力。我们第一次证明 Ag/g-C < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 nanohybrids 是在可见的光下面的有效杀菌代理人照耀,和罐头也为 biofilm 提供一个新方法消除。Ag/g-C 的提高的抗菌剂性质和破坏 biofilm 能力 < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 nanohybrids 可以为许多提供生物医学的应用。 | Wei Bing Zhaowei Chen Hanjun Sun Peng Shi Nao Gao Jinsong Ren Xiaogang Qu | 2015 | Nano Research2015，8，5： | 7 |
| 20 | Clinical Practice Guideline for Allergic Rhinitis Treatment with Acupuncture显示文摘With reference to international guidelines for the development of tools—Grading of Recommendations Assessment,Development and Evaluation(GRADE)system approach and reasoning,this practice guideline has been drafted reflecting the characteristics of acupuncture to improve effectiveness and safety of acupuncture treatment for allergic rhinitis.This guideline includes outlining the acupuncture diagnosis and treatment principles for allergic rhinitis,suggesting recommendations and related evidence for the acupuncture treatment of allergic rhinitis,and defining operating methods and precautions for the acupuncture treatment of allergic rhinitis. | CHEN Sheng GUO Sheng-nan Federico Marmori WANG Jun BAI Peng ZHANG Jia-jia QU Shu-han ZHAO Ji-ping | 2021 | Chinese Journal of Integrative Medicine2021，27，2： | 6 |
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