|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Kinematics and Dynamics Hessian Matrices of Manipulators Based on Screw Theory显示文摘The complexity of the kinematics and dynamics of a manipulator makes it necessary to simplify the modeling process.However,the traditional representations cannot achieve this because of the absence of coordinate invariance.Therefore,the coordinate invariant method is an important research issue.First,the rigid-body acceleration,the time derivative of the twist,is proved to be a screw,and its physical meaning is explained.Based on the twist and the rigid-body acceleration,the acceleration of the end-effector is expressed as a linear-bilinear form,and the kinematics Hessian matrix of the manipulator(represented by Lie bracket)is deduced.Further,Newton-Euler's equation is rewritten as a linear-bilinear form,from which the dynamics Hessian matrix of a rigid body is obtained.The formulae and the dynamics Hessian matrix are proved to be coordinate invariant.Referring to the principle of virtual work,the dynamics Hessian matrix of the parallel manipulator is gotten and the detailed dynamic model is derived.An index of dynamical coupling based on dynamics Hessian matrix is presented.In the end,a foldable parallel manipulator is taken as an example to validate the deduced kinematics and dynamics formulae.The screw theory based method can simplify the kinematics and dynamics of a manipulator,also the corresponding dynamics Hessian matrix can be used to evaluate the dynamical coupling of a manipulator. | ZHAO Tieshi GENG Mingchao CHEN Yuhang LI Erwei YANG Jiantao | 2015 | Chinese Journal of Mechanical Engineering2015，28，2： | 22 |
| 2 | Challenges and recent progress in thermal management with heat pipes for lithium-ion power batteries in electric vehicles显示文摘Electric vehicles(EVs)are globally undergoing rapid developments,and have great potentials to replace the traditional vehicles based on fossil fuels.Power-type lithium-ion batteries(LIBs)have been widely used for EVs,owing to high power densities,good charge/discharge stability,and long cycle life.The driving ranges and acceleration performances are gaining increasing concerns from customers,which depend highly on the power level of LIBs.With the increase in power outputs,rising heat generation significantly affects the battery performances,and in particular operation safety.Meanwhile,the cold-start performance is still an intractable problem under extreme conditions.These challenges put forward higher requirements for a dedicated battery thermal management system(BTMS).Compared to traditional BTMSs in EVs,the heat pipe-based BTMS has great application prospects owing to its compact structure,flexibility,low cost,and especially high thermal conductivity.Encompassing this topic,this review first introduces heat generation phenomena and temperature characteristics of LIBs.Multiple abuse conditions and thermal runaway issues are described afterward.Typical cooling and preheating methods for designing a BTMS are also discussed.More emphasis on this review is put on the use of various heat pipes for BTMSs to enhance the thermal performances of LIBs.For lack of wide application in actual EVs,more efforts should be made to extend the use of heat pipes for constructing an energy-efficient,cost-effective,and reliable BTMS to improve the performances and safety of EVs. | HUANG Yao TANG Yong YUAN Wei FANG GuoYun YANG Yang ZHANG XiaoQing WU YaoPeng YUAN YuHang WANG Chun LI JinGuang | 2021 | Science China(Technological Sciences)2021，64，5： | 10 |
| 3 | The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation显示文摘Interleukin(IL)17-producing T helper(Th17)cells play critical roles in the clearance of extracellular bacteria and fungi as well as the pathogenesis of various autoimmune diseases,such as multiple sclerosis,psoriasis,and ulcerative colitis.Although a global transcriptional regulatory network of Th17 cell differentiation has been mapped recently,the participation of epigenetic modifications in the differentiation process has yet to be elucidated.We demonstrated here that histone H3 lysine-27(H3K27)demethylation,predominantly mediated by the H3K27 demethylase Jmjd3,crucially regulated Th17 cell differentiation.Activation of naı¨ve CD41 T cells immediately induced high expression of Jmjd3.Genetic depletion of Jmjd3 in CD41 T cells specifically impaired Th17 cell differentiation both in vitro and in vivo.Ectopic expression of Jmjd3 largely rescued the impaired differentiation of Th17 cells in vitro in Jmjd3-deficientCD41 T cells.Importantly,Jmjd3-deficient mice were resistant to the induction of experimental autoimmune encephalomyelitis(EAE).Furthermore,inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppressed Th17 cell differentiation in vitro.At the molecular level,Jmjd3 directly bound to and reduced the level of H3K27 trimethylation(me3)at the genomic sites ofRorc,which encodes the masterTh17 transcription factorRorgt,and Th17 cytokine genes such as Il17,Il17f,and Il22.Therefore,our studies established acritical role of Jmjd3-mediatedH3K27demethylation inTh17 cell differentiation andsuggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses. | Zhi Liu Wei Cao Longxia Xu Xi Chen Yu Zhan Qian Yang Sanhong Liu Pengfei Chen Yuhang Jiang Xiaohua Sun Yu Tao Yiming Hu Cuifeng Li Qi Wang Ying Wang Charlie Degui Chen Yufang Shi Xiaoren Zhang | 2015 | Journal of Molecular Cell Biology2015，7，6： | 6 |
| 4 | Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes显示文摘Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication. | Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui Yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin Yang Tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong | 2022 | Molecular Plant2022，15，2： | 5 |
| 5 | Rod-shaped thiocyanate-induced abnormal band gap broadening in SCN^- doped CsPbBr3 perovskite nanocrystals显示文摘 | Yongbing Lou Yandan Niu Dongwen Yang Qiaoling Xu Yuhang Hu Ying Shen Jing Ming Jinxi Chen Lijun Zhang Yixin Zhao | 2018 | Nano Research2018，11，5： | 5 |
| 6 | Lignin derived multi-doped(N, S, Cl) carbon materials as excellent electrocatalyst for oxygen reduction reaction in proton exchange membrane fuel cells显示文摘Nowadays,hierarchically macro-/meso-/microporous 3D carbon materials have been paid more attention due to their imaginative application potential in specific electrochemistry.Here,we report a dualtemplate strategy using eutectic NaCl/ZnCl2 melt as airtight and swelling agent to obtain 3D mesoporous skeleton structured carbon from renewable lignin.The prepared lignin-derived biocarbon material(LN-3-1)has a high specific surface area(1289 m^2 g^-1),a large pore volume(2.80 cm^3 g^-1),and a well-connected and stable structure.LN-3-1 exhibits extremely high activity and stability in acidic medium for oxygen reduction reaction(ORR),superior to Pt/C catalyst and most non noble-metal catalysts reported in recent literatures.The prepared carbon material was used as a cathode catalyst to assemble a H2-O2 single fuel cell,and its excellent catalytic performance has been confirmed with the maximum power density of 779 mW cm^-2,which is one of the highest power densities among non-metallic catalysts so far.Density functional theory(DFT)calculations indicate that the synergy of chlorine and nitrogen reconciles the intermediate adsorption energies,leading to an appropriate theoretical ORR onset potential.We develop a cost-effective and highly efficient method to prepare biocarbon catalyst for ORR in proton-exchange membrane fuel cells. | Yixing Shen Yuhang Li Guangxing Yang Qiao Zhang Hong Liang Feng Peng | 2020 | Journal of Energy Chemistry2020，29，5： | 5 |
| 7 | Efficacy of moxibustion by stimulating acupoints of Danzhong(CV 17) and Ganshu(BL 18) on hyperplasia of mammary gland in rats显示文摘OBJECTIVE: To evaluate the efficacy of moxibustion, through stimulating acupoints of Danzhong(CV 17) and Ganshu(BL 18) in rats with hyperplasia of mammary gland(HMG) which induced by estrogen and progestogen.METHODS: Thirty female Sprague-Dawley rats were randomly divided into saline control group,HMG model group, and HMG moxibustion group with 10 in each group. Saline control was the group injected by saline. HMG model were created by injection of estrogen and progestogen. Moxibustion group was also injected of estrogen and progesto-gen with moxibustion at the same time. The Changes of nipple diameter and height were measured.The rats' skin temperature was recorded by an infrared thermal camera at the nipples, mammary areas,Danzhong(CV 17) and Ganshu(BL 18). Pathological changes of mammary gland in rats were also observed under light microscope.RESULTS: The diameter and height of the nipples in model group were prominently bigger and higher than that in control group(P < 0.01). The diameter and height in moxibustion group were prominently smaller and lower than that in model group(P < 0.01), and there was no significant difference between moxibustion group and control group.Compared with control group, skin temperature of the nipples, mammary area, and acupoints Danzhong(CV 17) and Ganshu(BL 18) decreased prominently in model group(P < 0.01-0.05). Compared with model group, skin temperature of that in moxibustion group increased prominently(P <0.05).CONCLUSION: Treatment with moxibustion can effectively decrease the HMG rats' nipple diameter and height, and increase the skin temperature in HMG model rats at the nipples, mammary areas,Danzhong(CV 17) and Ganshu(BL 18). This study convinces the therapeutic effect of moxibustion on mammary gland hyperplasia. | Yang Jiamin Wu Jihui Shen Xiaoyu Zhang Mei Liu Zhenzhen Qi Dandan Zhou Jin Cui Xiao Zhang Lufen Li Yuhang | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 3 |
| 8 | Efficient singlet oxygen generation by excitonic energy transfer on ultrathin g-C_(3)N_(4) for selective photocatalytic oxidation of methyl-phenyl-sulfide with O_(2)显示文摘Efficient generation of singlet oxygen(1 O_(2)) by an excitonic ene rgy transfer process is highly desired on a semiconductor photocatalyst for selective oxidation of methyl phenyl sulfide(MPS).Herein,it is demonstrated that a large amount of 1 O_(2) is produced on pristine graphitic carbon nitride(CN) nanosheet compared with bismuth oxybromide(BiOBr) and comme rcial P25 titanium dioxide(TiO_(2)).This leads to a certain photoactivity of CN for MPS oxidation.The observed ~77% selectivity for CN depends on the competitive results of excitonic energy transfer for 1 O_(2) formation and charge carrier separation for superoxide radical(O_(2)·) production,which are based on the phosphorescence spectra and electron paramagnetic resonance signals,respectively.Moreover,ultrathin CN nanosheets are synthesized by thermal treatment with the cyanuric acid-melamine hydrogen bonded aggregates as precursors.It is confirmed that the amount of produced 1 O_(2) could be increased by decreasing the thickness of resultant CN nanosheets.The optimized ultrathin CN nanosheet(~4 nm) exhibits excellent photoactivity with high selectivity(~99%).It is suggested that the excitonic energy transfer for 1 O_(2) formation is close related to the intrinsic exciton binding energy and the two-dimensional quantum confinement effect.This work establishes a basic mechanistic understanding on the excitonic processes in CN,and develops a feasible route to design CN-based photocatalysts for efficient 1 O_(2) generation. | Fan Yang Xiaoyu Chu Jianhui Sun Yuhang Zhang Zhijun Li Haiyue Liu Linlu Bai Yang Qu Liqiang Jing | 2020 | Chinese Chemical Letters2020，31，10： | 3 |
| 9 | FT5a interferes with the Dt1-AP1 feedback loop to control flowering time and shoot determinacy in soybean显示文摘Flowering time and stem growth habit determine inflorescence architecture in soybean, which in turn influences seed yield. Dt1, a homolog of Arabidopsis TERMINAL FLOWER 1(TFL1), is a major controller of stem growth habit, but its underlying molecular mechanisms remain unclear.Here, we demonstrate that Dt1 affects node number and plant height, as well as flowering time,in soybean under long-day conditions. The b ZIP transcription factor FDc1 physically interacts with Dt1, and the FDc1-Dt1 complex directly represses the expression of APETALA1(AP1). We propose that FT5 a inhibits Dt1 activity via a competitive interaction with FDc1 and directly upregulates AP1. Moreover, AP1 represses Dt1 expression by directly binding to the Dt1 promoter, suggesting that AP1 and Dt1 form a suppressive regulatory feedback loop to determine the fate of the shoot apical meristem. These findings provide novel insights into the roles of Dt1 and FT5 a in controlling the stem growth habit and flowering time in soybean, which determine the adaptability and grain yield of this important crop. | Lin Yue Xiaoming Li Chao Fang Liyu Chen Hui Yang Jie Yang Zhonghui Chen Haiyang Nan Linnan Chen Yuhang Zhang Haiyang Li Xingliang Hou Zhicheng Dong James LWeller Jun Abe Baohui Liu Fanjiang Kong | 2021 | Journal of Integrative Plant Biology2021，63，6： | 3 |
| 10 | Vision-based obstacle avoidance for flapping-wing aerial vehicles显示文摘Dear editor,The flapping-wing aerial vehicle is a type of bionic robot imitating the flight of birds and insects that generates lift and thrust through the active movement of wings [1].Its bionic shape has unique advantages in reconnaissance missions [2].The areas that flapping-wing aerial vehicles need to navigate during their flights may be highly complex and uncertain. | Qiang FU Yuhang YANG Xiangyang CHEN Yalin SHANG | 2020 | Science China(Information Sciences)2020，63，7： | 3 |
| 11 | Improved Denoising Autoencoder for Maritime Image Denoising and Semantic Segmentation of USV显示文摘Unmanned surface vehicle(USV)is currently a hot research topic in maritime communication network(MCN),where denoising and semantic segmentation of maritime images taken by USV have been rarely studied.The former has recently researched on autoencoder model used for image denoising,but the existed models are too complicated to be suitable for real-time detection of USV.In this paper,we proposed a lightweight autoencoder combined with inception module for maritime image denoising in different noisy environments and explore the effect of different inception modules on the denoising performance.Furthermore,we completed the semantic segmentation task for maritime images taken by USV utilizing the pretrained U-Net model with tuning,and compared them with original U-Net model based on different backbone.Subsequently,we compared the semantic segmentation of noised and denoised maritime images respectively to explore the effect of image noise on semantic segmentation performance.Case studies are provided to prove the feasibility of our proposed denoising and segmentation method.Finally,a simple integrated communication system combining image denoising and segmentation for USV is shown. | Yuhang Qiu Yongcheng Yang Zhijian Lin Pingping Chen Yang Luo Wenqi Huang | 2020 | China Communications2020，17，3： | 2 |
| 12 | Influence of Sanao Tang on urine volume and expression of aquaporin 2 in rats with respiratory function impairment induced by passive smoking and lipopolysaccharide显示文摘OBJECTIVE: To investigate the effect of Sanao Tang(SAT) on urine volume and the expression of aquaporin-2(AQP2) in rats with lung dysfunction induced by passive smoking and lipopolysaccharide.METHODS: Totally 45 healthy Specific pathogen Free Wistar Rats were randomized into 3 groups:normal control group, model group and SAT group.A rat model of respiratory dysfunction induced by exposure to cigarette smoking and lipopolysaccharide(LPS). Lavage of decoction of the Chinese medicine was performed for rats in the SAT group. Anires 2005 System was used to analyze the pulmonary function. Urine of rats was collected through metabolism cage method. Enzyme-linked immunosorbent assay(ELISA) was used to determine content of antidiuretic hormone(ADH), angiotensin Ⅱ(AngⅡ), atrial natriuretic factor(ANP), endothelin 1(ET-1), nitric oxide(NO) and prostaglandin E2(PGE2) in serum, lung and kidney. The expression of AQP2 in rat renal tissue was determined with real-time fluorescence quantitative PCR(RT-PCR).RESULTS:(a) In comparison with the normal control, It was found that enforced vital capacity(FVC),1-second forced expiratory volume/forced vital capacity%(FEV1/FVC%), 24 h urine volume content of NO and PGE2 were decreased, while AQP2 m RNA level and content of ADH, Agn Ⅱ, ANP and ET-1were increased in the model group with statistical significance(P < 0.05).(b) In comparison with the model group, It was found that FVC, FEV1, FEV1/FVC%, 24 h urine volume, content of PGE2 and NO decreased, while AQP2 m RNA level, content of ANP,ADH and AngⅡ decreased in the SAT group with statistical significance(P < 0.05).CONCLUSION: SAT might effectively regulate the urine volume in the modeled rats; ADH, Ang Ⅱ,ANP, ET-1, NO and PGE2 might play an important role in the regulation on urine volume by lungs.This might be the mechanisms underpinning the function of lung governing water passage in terms of the theory of Traditional Chinese Medicine. | Zhang Jinchao Sun Yan Zhang Shujing Gao Yushan Wang Zhenyi Liu Xiaolei Yang Jiamin Li Yuhang | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 2 |
| 13 | Analysis of molecular variation in porcine reproductive and respiratory syndrome virus in China between 2007 and 2012显示文摘In the present study, 89 porcine reproductive and respiratory syndrome virus(PRRSV) isolates in China during 2007 to 2012 were randomly selected from the GenBank genetic sequence database. Evolutionary characteristics of these isolates were analyzed based on the sequences of non-struc-tural protein 2(Nsp2) and glycoprotein 5(GP5). The genetic variations of the isolates were also compared with six representative strains. The results showed that a high degree of genetic diversity exists among the PRRSV population in China. Highly pathogenic PRRSV isolates, with a discon-tinuous deletion of a 30 amino acid residue in the Nsp2 region, remained the most dominant virus throughout 2007–2012 in China. Owing to the extensive use of representative vaccine strains, natu-ral recombination events occurred between strains. Three isolates – HH08, DY, and YN-2011 – were more closely related to vaccine strains than the other isolates. Both YN-2011 and DY were the evolu-tionary products of recombination events between strains SP and CH-1R. The results of the present study provide useful information for the epidemiology of PRRSV as well as for vaccine development. | Yuhang Cao Hongsheng Ouyang Mingjun Zhang Fuwang Chen Xin Yang Daxing Pang Linzhu Ren | 2014 | Virologica Sinica2014，29，3： | 2 |
| 14 | Single‑Atom Cobalt‑Based Electrochemical Biomimetic Uric Acid Sensor with Wide Linear Range and Ultralow Detection Limit显示文摘Uric acid(UA)detection is essential in diagnosis of arthritis,preeclampsia,renal disorder,and cardiovascular diseases,but it is very challenging to realize the required wide detection range and low detection limit.We present here a single-atom catalyst consisting of Co(Ⅱ)atoms coordinated by an average of 3.4 N atoms on an N-doped graphene matrix(A-Co-NG)to build an electrochemical biomimetic sensor for UA detection.The A-Co-NG sensor achieves a wide detection range over 0.4-41,950μM and an extremely low detection limit of 33.3±0.024 nM,which are much better than previously reported sensors based on various nanostructured materials.Besides,the A-Co-NG sensor also demonstrates its accurate serum diagnosis for UA for its practical application.Combination of experimental and theoretical calculation discovers that the catalytic process of the A-Co-NG toward UA starts from the oxidation of Co species to form a Co^3+-OH-UA*,followed by the generation of Co^3+-OH+^*UA_H,eventually leading to N-H bond dissociation for the formation of oxidized UA molecule and reduction of oxidized Co^3+to Co^2+for the regenerated A-Co-NG.This work provides a promising material to realize UA detection with wide detection range and low detection limit to meet the practical diagnosis requirements,and the proposed sensing mechanism sheds light on fundamental insights for guiding exploration of other biosensing processes. | Fang Xin Hu Tao Hu Shihong Chen Dongping Wang Qianghai Rao Yuhang Liu Fangyin Dai Chunxian Guo Hong Bin Yang Chang Ming Li | 2021 | Nano-Micro Letters2021，13，1： | 2 |
| 15 | Moisture-resistant,stretchable NO_(x)gas sensors based on laser-induced graphene for environmental monitoring and breath analysis显示文摘The accurate,continuous analysis of healthcare-relevant gases such as nitrogen oxides(NOx)in a humid environment remains elusive for low-cost,stretchable gas sensing devices.This study presents the design and demonstration of a moisture-resistant,stretchable NO_(x)gas sensor based on laser-induced graphene(LIG).Sandwiched between a soft elastomeric substrate and a moisture-resistant semipermeable encapsulant,the LIG sensing and electrode layer is first optimized by tuning laser processing parameters such as power,image density,and defocus distance.The gas sensor,using a needlelike LIG prepared with optimal laser processing parameters,exhibits a large response of 4.18%o ppm^(-1)to NO and 6.66%o ppm^(-1)to NO_(2),an ultralow detection limit of 8.3 ppb to NO and 4.0 ppb to NO_(2),fast response/recovery,and excellent selectivity.The design of a stretchable serpentine structure in the LIG electrode and strain isolation from the stiff island allows the gas sensor to be stretched by 30%.Combined with a moisture-resistant property against a relative humidity of 90%,the reported gas sensor has further been demonstrated to monitor the personal local environment during dfferent times of the day and analyze human breath samples to classify patients with respiratory diseases from healthy volunteers.Moisture-resistant,stretchable NO_(x)gas sensors can expand the capability of wearable devices to detect biomarkers from humans and exposed environments for early disease diagnostics. | Li Yang Guanghao Zheng Yaoqian Cao Chuizhou Meng Yuhang Li Huadong Ji Xue Chen Guangyu Niu Jiayi Yan Ye Xue Huanyu Cheng | 2022 | Microsystems & Nanoengineering2022，8，4： | 2 |
| 16 | Oblique detonation wave triggered by a double wedge in hypersonic flow显示文摘Pressure-gain combustion has gained attention for airbreathing ramjet engine applications owing to its better thermodynamic efficiency and fuel consumption rate. In contrast with traditional detonation induced by a single wedge, the present study considers oblique shock interactions attached to double wedges in a hypersonic combustible flow. The temperature/pressure increases sharply across the interaction zone that initiates an exothermic reaction, finally resulting in an Oblique Detonation Wave(ODW). Compared with the case for a single-wedge ODW, the double-wedge geometry has great potential to control the initiation of the ODW. As a tentative study, two-dimensional compressible Euler equations with a two-step induction-reaction kinetic model are used to solve the detonation dynamics triggered by a double wedge. The effects of the wedge angles and wedge corner locations on the initiation structures are investigated numerically.The results show an ODW complex comprising three Oblique Shock Waves(OSWs), an induction zone, a curved detonation front, and an unburned/low-temperature gas belt close to the surface of the second wedge. Both the increasing wedge angle and downstream wedge corner location lead to an abrupt OSW–ODW transition type, whereas the former corresponds to the shock–shock interaction and the later has a greater effect on the exothermic chemical process. Analysis of the shock polar and flow scale confirms that the OSW–ODW initiation structure mainly depends on the coupling of shocks and heat release in a confined initiation zone. | Honghui TENG Yuhang ZHANG Pengfei YANG Zonglin JIANG | 2022 | Chinese Journal of Aeronautics2022，35，4： | 2 |
| 17 | Reciprocal regulation between the negative regulator PP2CG1 phosphatase and the positive regulator OST1 kinase confers cold response in Arabidopsis显示文摘Protein phosphorylation and dephosphorylation have been reported to play important roles in plant cold responses.In addition,phospho-regulatory feedback is a conserved mechanism for biological processes and stress responses in animals and plants.However,it is less well known that a regulatory feedback loop is formed by the protein kinase and the protein phosphatase in plant responses to cold stress.Here,we report that OPEN STOMATA 1(OST1)and PROTEIN PHOSPHATASE 2C G GROUP 1(PP2CG1)reciprocally regulate the activity during the cold stress response.The interaction of PP2CG1 and OST1 is inhibited by cold stress,which results in the release of OST1 at the cytoplasm and nucleus from suppression by PP2CG1.Interestingly,cold-activated OST1 phosphorylates PP2CG1 to suppress its phosphatase activity,thereby amplifying cold signaling in plants.Mutations of PP2CG1 and its homolog PP2CG2 enhance freezing tolerance,whereas overexpression of PP2CG1 decreases freezing tolerance.Moreover,PP2CG1 negatively regulates protein levels of C-REPEAT BINDING FACTORs(CBFs)under cold stress.Our results uncover a phosphor/dephosphor-regulatory feedback loop mediated by PP2CG1 phosphatase and OST1 protein kinase in plant cold responses. | Jian Lv Jingyan Liu Yuhang Ming Yiting Shi Chunpeng Song Zhizhong Gong Shuhua Yang Yanglin Ding | 2021 | Journal of Integrative Plant Biology2021，63，8： | 2 |
| 18 | Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity显示文摘Tendinopathy is a common musculoskeletal disorder which results in chronic pain and reduced performance.The therapeutic effect of stem cell derived-small extracellular vesicles(sEVs)for tendinopathy has been validated in recent years.However,whether large extracellular vesicles(lEVs),another subset of extracellular vesicles,possesses the ability for the improvement of tendinopathy remains unknown.Here,we showed that lEVs secreted from iPSC-derived MSCs(iMSC-lEVs)significantly mitigated pain derived from tendinopathy in rats.Immuno-histochemical analysis showed that iMSC-lEVs regulated the heterogeneity of infiltrated macrophages and several inflammatory cytokines in rat tendon tissue.Meanwhile,in vitro experiments revealed that the M1 pro-inflammatory macrophages were repolarized towards M2 anti-inflammatory macrophages by iMSC-lEVs,and this effect was mediated by regulating p38 MAPK pathway.Moreover,liquid chromatography-tandem mass spectrometry analysis identified 2208 proteins encapsulated in iMSC-lEVs,including 134 new-found proteins beyond current Vesiclepedia database.By bioinformatics and Western blot analyses,we showed that DUSP2 and DUSP3,the negative regulator of p38 phosphorylation,were enriched in iMSC-lEVs and could be transported to macrophages.Further,the immunomodulatory effect of iMSC-lEVs on macrophages was validated in explant tendon tissue from tendinopathy patients.Taken together,our results demonstrate that iMSC-lEVs could reduce inflammation in tendinopathy by regulating macrophage heterogeneity,which is mediated via the p38 MAPK pathway by delivery of DUSP2 and DUSP3,and might be a promising candidate for tendinopathy therapy. | Teng Ye Zhengsheng Chen Jieyuan Zhang Lei Luo Renzhi Gao Liangzhi Gong Yuhang Du Zongping Xie Bizeng Zhao Qing Li Yang Wang | 2023 | Bioactive Materials2023，，3： | 2 |
| 19 | Insights into the sandwich-like ultrathin Ni-doped MoS_(2)/rGO hybrid as effective sulfur hosts with excellent adsorption and electrocatalysis effects for lithium-sulfur batteries显示文摘The design of sulfur hosts with high conductivity,large specific surface area,strong adsorption and electrocatalytic ability is crucial to advance high performance lithium-sulfur batteries.Herein,a novel ultrathin sandwich-type Ni-doped MoS_(2)/reduced graphene oxide(denote as Ni-doped MoS_(2)/rGO) hybrid is developed as a sulfur host through a simple one-step hydrothermal route.The two-dimensional layered structure Ni-doped MoS_(2)/rGO hybrid with heterostructure and heteroatom architecture defects not only plays a key role in adsorption of lithium polysulfide but also catalyzes on redox kinetics of sulfur and polysulfide species.Meanwhile,it can contribute to the large specific surface area for Li_(2) S/S_8 deposition,fast Li-ion and electron transportation,thus enhancing the electrocatalytic properties,as confirmed firstly by cyclic voltammetry(CV) results.Due to the adsorption-catalytic synergistic effect,the Ni-doped MoS_(2)/rGO cathode exhibits high specific capacity(1343.6 mA h g^(-1) at 0.2 C,921.6 mA h g^(-1) at 1 C),high coulombic efficiency and an outstanding cycle stability(with the low attenuation rate of 0.077% per cycle over 140 cycles at 0.5 C and 0.11% per cycle over 400 cycles at 1 C,respectively).This work proposes some inspiration for exploring the construction of advanced lithium-sulfur batteries through the rational design defects of atomic structure and electronic states of MoS_(2) as sulfur host. | Ran Zhang Yutao Dong Mohammed AAl-Tahan Yingying Zhang Ruipeng Wei Yuhang Ma Changchun Yang Jianmin Zhang | 2021 | Journal of Energy Chemistry2021，30，9： | 2 |
| 20 | Analysis of geomet- rical non-full-similar scale model based on similarity theo- rem 显示文摘 | Yang Yuhang Qu Xilong Luo Yiping | 2011 | Advanced Materials Research2011，216，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员