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| 1 | A NAC transcription factor, NOR-like1, is a new positive regulator of tomato fruit ripening显示文摘Ripening of the model fruit tomato(Solanum lycopersicum)is controlled by a transcription factor network including NAC(NAM,ATAF1/2,and CUC2)domain proteins such as No-ripening(NOR),SlNAC1,and SlNAC4,but very little is known about the NAC targets or how they regulate ripening.Here,we conducted a systematic search of fruit-expressed NAC genes and showed that silencing NOR-like1(Solyc07g063420)using virus-induced gene silencing(VIGS)inhibited specific aspects of ripening.Ripening initiation was delayed by 14 days when NOR-like1 function was inactivated by CRISPR/Cas9 and fruits showed obviously reduced ethylene production,retarded softening and chlorophyll loss,and reduced lycopene accumulation.RNA-sequencing profiling and gene promoter analysis suggested that genes involved in ethylene biosynthesis(SlACS2,SlACS4),color formation(SlGgpps2,SlSGR1),and cell wall metabolism(SlPG2a,SlPL,SlCEL2,and SlEXP1)are direct targets of NOR-like1.Electrophoretic mobility shift assays(EMSA),chromatin immunoprecipitation-quantitative PCR(ChIP-qPCR),and dual-luciferase reporter assay(DLR)confirmed that NOR-like1 bound to the promoters of these genes both in vitro and in vivo,and activated their expression.Our findings demonstrate that NOR-like1 is a new positive regulator of tomato fruit ripening,with an important role in the transcriptional regulatory network. | Ying Gao Wei Wei Xiaodan Zhao Xiaoli Tan Zhongqi Fan Yiping Zhang Yuan Jing Lanhuan Meng Benzhong Zhu Hongliang Zhu Jianye Chen Cai-Zhong Jiang Donald Grierson Yunbo Luo Da-Qi Fu | 2018 | Horticulture Research2018，5，1： | 9 |
| 2 | Study on the simulation of transparency of Lake Taihu under different hydrodynamic conditions显示文摘It was indicated in this study that there were negative relations between the concentrations of suspended solid (SS) and transparency according to the analysis of measured data of Lake Taihu. Their relations in pervious studies were reviewed, which showed that the changes of transparency in Lake Taihu could be reflected by simulating suspended solid concentration (SSC). Measured data showed that the changes of SSC with wind speed were similar at different water depths.SSC increased with the increasing of wind speed. Both wave and lake current of Lake Taihu had positive relations with SSC. However, wave was the main factor affecting sediment suspension, while flow took the second place. In this study, a numerical model coupling lake current, wave and SSC of Lake Taihu was developed. In the SS model, the combined effects of wave and current were included.The amounts of suspended and deposited sediments near the lake bed surface layer were treated separately. The stochastic characteristics of turbulent flow pulsation near lake beds were also considered, and the start-up conditions of sediment suspension were introduced to the model. The model elucidated the mutual exchange processes between sediment particles in SS and active sediments within and on the bed surface layer. Simulated results showed that lake current had relatively significant effects on the SSC at littoral areas of Lake Taihu, while SSC at the central area of the lake was mainly influenced by wave. The changes of transparency with SSC were simulated for Lake Taihu using this model. Calculated results were validated by measured data with good fitness, which indicated that the model is basically suitable for the simulation and prediction of transparency of Lake Taihu. | PANG Yong, LI Yiping & LUO Liancong College of Environmental Science and Engineering, Hohai University, Nanjing 210098, China Nanjing Institute of Geography & Limnology, Chinese Academy of Sciences, Nanjing 210098, China | 2006 | Science China Earth Sciences2006，49，z1： | 7 |
| 3 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 4 | Traditional Chinese Medicine for the treatment of influenza: a systematic review and Meta-analysis of randomized controlled trials显示文摘OBJECTIVE: To justify the clinical use of Traditional Chinese Medicine(TCM) in the treatment of influenza.METHODS: MEDLINE, EMBASE, Chinese Biomedical Literature Database, China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang Database and the Cochrane Database of Systematic Reviews were searched from thedate of inception until January 1,2013, for the literature on treatment of influenza with TCM.RESULTS: A total of 7 randomized controlled trials were identified and reviewed. Of these trials, 2 compared a(modified) prescription of TCM with oseltamivir and 5 compared a patent traditional Chinese drug with oseltamivir. Based on the Meta-analysis,compared to oseltamivir, the(modified) prescription had similar effect in defervescence [WMD=5.66, 95% CI(﹣32.02, 43.35), P=0.77] and viral shedding [WMD=﹣ 6.21, 95% CI(﹣84.19, 71.76), P=0.88], and the patent traditional Chinese drug also had similar effect in viral shedding [WMD=﹣ 0.24,95% CI(﹣4.79, 4.31), P=0.92] but more effective in defervescence [WMD=﹣4.65, 95%CI(﹣8.91, ﹣0.38),P=0.03].CONCLUSION: TCM has potential positive effects in the treatment of influenza. | Chunya Wang Hao Wang Xinying Liu Dongping Xu Yiping Tang Ping Luo | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 5 |
| 5 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 6 | Review of protection and fault handling for a flexible DC grid显示文摘With the development of power electronics technology,the flexible DC grid will play a significant role in promoting the transformation and reformation of the power grid.It is immune to commutation failure and has high flexibility in power control and renewable energy grid integration.However,the protection and fault handling technology for a flexible DC grid is a big challenge because of the limited overcurrent capability of the converters.This paper summarizes the development of the flexible DC grid,and analyzes the fault characteristics in detail.Next,the applicability,advantages and disadvantages of the existing protection principle,fault isolation and recovery schemes are reviewed.Finally,the key problems and development trend of the future flexible DC grid are pointed out and forecasted respectively. | Jinghan He Keao Chen Meng Li Yiping Luo Chenguang Liang Yin Xu | 2020 | Protection and Control of Modern Power Systems2020，5，1： | 5 |
| 7 | Debrominated and methoxylated polybrominated diphenyl ether metabolites in rainbow trout(Oncorhynchus mykiss) after exposure to decabromodiphenyl ether显示文摘Decabromodiphenyl ether(BDE209) is the primary component in a commonly used flame retardant.Previous studies had proved that BDE209 itself was not toxic,while its metabolites including debrominated diphenyl ethers(De-BDEs) and methoxylated brominated diphenyl ethers(MeO-BDEs) posed a potential threat to organisms.Many studies had indicated that BDE209 could metabolize quickly in mammals,but lacking in the basic data about the metabolism of BDE209 in fish.In the present study,two replicate treatment groups of rainbow trout(Oncorhynchus mykiss) were exposed to BDE209 via a single intraperitoneal injection approximately 100 and 500 ng/g,respectively.Muscle,liver and blood samples were collected to analyze the specific metabolites on day 1 and day 28 post injection.The highest concentration of BDE209 was detected in muscle tissues,from 796.1 ng/g wet weight(day 1) to 687.1 ng/g wet weight(day 28) in high dose group,suggesting that BDE209 could accumulate slightly in muscle tissues.However,BDE209 was not detected in the blood for all treatments.Most congeners of De-BDEs were found in muscle and liver tissues,with the highest concentration in the liver.The main De-BDEs were nona-,octa-,hepta-and penta-De-BDEs.A total of seven MeO-BDE metabolites were observed among different fish tissues.Blood had the highest contribution of the MeO-BDE metabolites.Each MeO-BDE congener increased over the 28 days.These results in contrast to other studies suggested possible species-specific differences in metabolic abilities. | Chenglian Feng,Yiping Xu,Yue He,Qian Luo,Jinmiao Zha,Zijian Wang State Key Laboratory of Environmental Aquatic Chemistry,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China. | 2010 | Journal of Environmental Sciences2010，22，9： | 4 |
| 8 | Phase selection during solidification of undercooled Ni_(70.2)Si_(29.8) eutectic alloy显示文摘在冷却下面的高度(大约 392 K ) 在体积被完成最容易溶解的 Ni 70.2 Si 29.8 合金通过与周期的过热相结合的玻璃 fluxing 融化。这被发现亚稳的阶段 Ni 3 Si 2 并且非最后被获得通过慢团结以后什么时候在冷却下面超过 240 K。亚稳的阶段被使用 X 光检查衍射和微分扫描热量测定(DSC ) 的方法证实。基于免费精力最小和短暂成核理论的原则,阶段选择融化在凉下来的最容易溶解的 Ni 70.2 Si 29.8 融化。从在凉下来的 Ni 70.2 Si 29.8 融化被归功于到竞争成核与在冷却下面,即在冷却下面的高度便于亚稳的阶段的优先的成核。 | Yiping Lu Tingju Li Fu Yabo Sun Jianbo LUO Dawei Gencang Yang Yaohe Zhou | 2009 | Progress in Natural Science:Materials International2009，19，11： | 4 |
| 9 | B7-DC (PD-L2) costimulation of CD4^(+) T-helper 1 response via RGMb显示文摘The role of B7-DC in T-cell responses remains controversial because both coinhibitory and costimulatory functions have been reported in various experimental systems in vitro and in vivo.In addition to interacting with the coinhibitory receptor PD-1,B7-DC has also been shown to bind repulsive guidance molecule b(RGMb).The functional consequences of the B7-DC/RGMb interaction,however,remain unclear.More than a decade ago,we reported that replacement of a murine B7-DC mutant lysine with serine(K113S)at positive 113 resulted in a loss of binding capacity to PD-1.Nevertheless,K113S remained costimulatory for T cells in vitro,implicating a dual functionality for B7-DC in T-cell responses.Here we show that recombinant K113S protein interacts with RGMb with a similar affinity to wild-type B7-DC.More importantly,K113S costimulates CD4^(+)T-cell responses via RGMb and promotes Th1 polarization.RGMb is expressed on the surface of naive mouse T cells,macrophages,neutrophils and dendritic cells.Finally,K113S/RGMb costimulation suppresses Th2-mediated asthma and ameliorates small airway inflammation and lung pathology in an experimental mouse model.Our findings indicate that RGMb is a costimulatory receptor for B7-DC.These findings from the K113S variant provide not only a possible explanation for the B7-DC-triggered contradictory effects on T-cell responses,but also a novel approach to investigate the B7-DC/PD-1/RGMb axis.Recombinant K113S or its derivatives could potentially be developed as an agonist for RGMb to costimulate the Th1 response without triggering PD-1-mediated T-cell inhibition. | Xinxin Nie Wenni Chen Ying Zhu Baozhu Huang Weiwei Yu Zhanshuai Wu Sizheng Guo Yiping Zhu Liqun Luo Shengdian Wang Lieping Chen | 2018 | Cellular & Molecular Immunology2018，15，10： | 3 |
| 10 | Forecasting of COVID-19: spread with dynamic transmission rate显示文摘The COVID-19 was firstly reported in Wuhan,Hubei province,and it was brought to all over China by people travelling for Chinese New Year.The pandemic coronavirus with its catastrophic effects is now a global concern.Forecasting of COVID-19 spread has attracted a great attention for public health emergency.However,few re-searchers look into the relationship between dynamic transmission rate and preventable measures by authorities.In this paper,the SEIR(Susceptible Exposed Infectious Recovered)model is employed to investigate the spread of COVID-19.The epidemic spread is divided into two stages:before and after intervention.Before intervention,the transmission rate is assumed to be a constant since individual,community and government response has not taken into place.After intervention,the transmission rate is reduced dramatically due to the societal actions or measures to reduce and prevent the spread of disease.The transmission rate is assumed to follow an exponential function,and the removal rate is assumed to follow a power exponent function.The removal rate is increased with the evolution of the time.Using the real data,the model and parameters are optimized.The transmission rate without measure is calculated to be 0.033 and 0.030 for Hubei and outside Hubei province,respectively.After the model is established,the spread of COVID-19 in Hubei province,France and USA is predicted.From results,USA performs the worst according to the dynamic ratio.The model has provided a mathematical method to evaluate the effectiveness of the government response and can be used to forecast the spread of COVID-19 with better performance. | Yiping Zeng Xiaojing Guo Qing Deng Shengfeng Luo Hui Zhang | 2020 | Journal of Safety Science and Resilience2020，1，2： | 2 |
| 11 | Statistical Analysis of Regularity of Pesticide Residues in Vegetables Produced in Inner Mongoli显示文摘[Objective]The paper was to study regularity of pesticide residues in vegetables produced in Inner Mongolia.[Method]Mathematical statistic analysis was carried out on 6 800 samples of veggies,fruits,leguminous vegetables,nuts and seeds produced in Inner Mongolia.[Result]The dominated vegetables in Inner Mongolia were green leafy vegetables,solanaceous vegetables and melon vegetables,and their yields accounted for 70%of the total vegetables production.Since 2003,with the rapid increase of detected vegetable numbers,the status of vegetable quality safety had entered into a new stage of sustainable steady after a rapid decline or periodic fluctuation,and the differences in safety levels were obvious,of which the range of exceeding standard rate of pesticide residues in solanaceous vegetables,melon vegetables and leguminous vegetables(about 55%of the total vegetables)was under 2%,with average values of 1.1%,1.6%and 3.1%,respectively.They belonged to stable type.The exceeding standard rate of pesticide residues in green leafy vegetables and Chinese cabbage group(about 30%of total vegetables)presented a decreasing trend year by year,wondering in the range of 7%-10%.They belonged to main risk type.The time period of exceeding standard of pesticide residues in root vegetables and cole vegetables was under predictable,and its exceeding standard rate in some years was over 5%(amplitude variation is over 15percentage points).They belonged to random risk type.The kinds of pesticides,which exceeding standard rate in vegetables were relatively intensive,presented variance in different vegetable species.70%of the pesticides belonged to intermittent over-limits and the probability was below 5%.About 20%tradition pesticides often exceeded standard and their probabilities were over 30%.The exceeding standard of organophosphorus and carbamates pesticides in vegetables presented a decreasing tend,while the risk of some new pesticides containing nitrogen element and high effective pyrethroids showed an increasing tendency.[Conclusion]The paper provided decision making services for agricultural management departments. | Fujin ZHANG Dekun HOU Jiang HE Tianyun GAO Hong LUO Songyan LANG Xinxin ZHANG Yiping YAO | 2013 | Agricultural Science & Technology2013，14，10： | 2 |
| 12 | Stabilization for multi-group coupled stochastic models by delay feedback control and nonlinear impulsive control显示文摘Stabilization for multi-group coupled models stochastic by delay feedback control and nonlinear impulsive control are considered in this paper. Using graph theory and Lyapunov method, some sufficient conditions are acquired by some control methods. Those criteria are easier to verify and no need to solve any linear matrix inequalities. These results can be designed more easily in practice. At last, the effectiveness and advantage of the theoretical results are verified by an example. | Chaolong ZHANG Feiqi DENG Yiping LUO | 2018 | Science China(Information Sciences)2018，61，7： | 2 |
| 13 | Event-triggered bipartite consensus over cooperation-competition networks under DoS attacks显示文摘This paper addresses the bipartite consensus over cooperation-competition networks affected by denial-of-service(DoS) attacks.Consider that a network consists of multiple interactive agents, and the relationship between neighboring agents is cooperative or competitive. Meanwhile, information transmission among the agents is unavailable during the intervals of attacks. In order to save communication resources and exclude the Zeno behavior, an event-triggered scheme depending on the sampled-data information from neighboring agents is proposed, and efficient defense strategies in response to the attacks are put forward.Suppose that the frequency and duration of DoS attacks meet certain requirements, then according to the signed graph theory,the La Salle’s invariance principle, and the convergence of monotone sequences, the results of bipartite consensus via the eventtriggered protocol are provided, which are mainly related to the communication topology of the network, the sampling period,and the threshold parameters in the event-triggered scheme. It is shown that the bipartite consensus is realized even though the DoS attacks take place frequently. Furthermore, this paper discusses the bipartite consensus in the presence of DoS attacks with a random unsuccessful rate. Finally, numerical simulations illustrate the theoretical results. | HU AiHua PARK J H CAO JinDe HU ManFeng LUO YiPing | 2021 | Science China(Technological Sciences)2021，64，1： | 2 |
| 14 | 显示文摘 | Haosu Luo Tianhou He | 2002 | Solid State Communications2002，123，： | 1 |
| 15 | 显示文摘 | Haosu Luo Tianhou He | 2003 | Mater Res Bull2003，38，： | 1 |
| 16 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 17 | Stabilization of Fe-Pd bimetallic nanoparticles with so-dium carboxymethyl cellulose for catalytic reduction of para-nitrochlorobenzene in water显示文摘 | Dong Tingting Luo Hanjin Wang Yiping | 2011 | Desalination2011，271，123： | 1 |
| 18 | Growth and electrical properties of Pb(Sc1/2 Nb1/2)O3-Pb (Mg1/3 Nb2/3)O3-PbTiO3 ternary single crystals by a modified Bridgman technique显示文摘 | GUO Yiping XU Haiqing LUO Haosu | 2001 | J Cryst Growth2001，226，： | 1 |
| 19 | Peculiar properties of a high curie temperature Pb(In1/2Nb1/2)O3-PbTiO3 single crystal grown by the modified Bridgman technique显示文摘 | GUO Yiping LUO Haosu HE Tianhou | 2002 | Solid State Comunications2002，123，： | 1 |
| 20 | Fabrication of SiCN MEMS by Photopolymerization of Pre-ceramic Polymer显示文摘 | Liew Li-Anne Liu Yiping Luo Ruiling | 2002 | Sensors and Actuators2002，95，： | 1 |
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