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| 1 | Circular HDAC9/microRNA-138/Sirtuin-1 Pathway Mediates Synaptic and Amyloid Precursor Protein Processing Deficits in Alzheimer’s Disease显示文摘Synaptic dysfunction and abnormal processing of amyloid precursor protein(APP) are early pathological features in Alzheimer’s disease(AD). Recently, noncoding RNAs such as micro RNAs(mi RNAs) and circular RNAs(circ RNAs) have been reported to contribute to the pathogenesis of AD. We found an age-dependent elevation of mi R-138 in APP/PS1(presenilin-1) mice. Mi R-138 inhibited the expression of ADAM10 [a disintegrin and metalloproteinase domain-containing protein 10], promoted amyloid beta(Ab) production, and induced synaptic and learning/memory deficits in APP/PS1 mice, while its suppression alleviated the AD-like phenotype in these mice. Overexpression of sirtuin 1(Sirt1), a target of mi R-138, ameliorated the mi R-138-induced inhibition of ADAM10 and elevation of Ab in vitro. The circ RNA HDAC9(circ HDAC9) was predicted to contain a mi R-138 binding site in several databases. Its expression was inversely correlated with mi R-138 in both Ab-oligomertreated N2 a cells and APP/PS1 mice, and it co-localized with mi R-138 in the cytoplasm of N2 a cells. Circ HDAC9 acted as a mi R-138 sponge, decreasing mi R-138 expression, and reversing the Sirt1 suppression and excessive Ab production induced by mi R-138 in vitro. Moreover,circ HDAC9 was decreased in the serum of both AD patients and individuals with mild cognitive impairment.These results suggest that the circ HDAC9/mi R-138/Sirt1 pathway mediates synaptic function and APP processing in AD, providing a potential therapeutic target for its treatment. | Yanjun Lu Lu Tan Xiong Wang | 2019 | Neuroscience Bulletin2019，35，5： | 20 |
| 2 | Great flood in the middle-lower Yellow River reaches at 4000 a BP inferred from accurately-dated stalagmite records显示文摘Recently,Wu et al.[1]suggested an earthquake-induced landslide dam outburst flood on the eastern Tibetan Plateau at 1920BCE(3870 a BP,BP denotes year before 1950 CE)caused the Great Flood in the middle-lower Yellow River reaches,and resulted in the founding of Xia Dynasty at 3850 a BP.This age is$150–300younger than the previously estimated age of the Xia Dynasty[2].While the geological evidence of the outburst flood。 | Liangcheng Tan Chuan-Chou Shen Yanjun Cai Hai Cheng R.Lawrence Edwards | 2018 | Science Bulletin2018，63，4： | 16 |
| 3 | Application of Avaatech X-ray fluorescence core-scanning in Sr/Ca analysis of speleothems显示文摘Application of X-ray fluorescence core-scanning(XRF-CS) on both marine and lake sediments has achieved remarkable results. However, its application has not been widely extended to the research on speleothems. In this study, we measure the Sr abundance and the Sr/Ca ratios of three stalagmites(two aragonite stalagmites, one calcite stalagmite) using the state-of-the-art fourth-generation Avaatech high-resolution XRF core scanner. Through comparisons among different scan paths and among different scan resolutions, as well as comparisons with inductively coupled plasma optical emission spectrometer(ICP-OES), Itrax XRF, and Artax XRF results, we confirm that the Avaatech XRF core scanner could precisely, quickly, and nondestructively analyze the high-resolution Sr abundance of speleothems. Furthermore, we combine the stalagmite δ^(18)O records to explore the paleoclimatic significance of the measured stalagmite Sr/Ca. | Dong LI Liangcheng TAN Fei GUO Yanjun CAI Youbin SUN Gang XUE Xing CHENG Hong YAN Hai CHENG R.Lawrence EDWARDS Yongli GAO Jessica KELLEY | 2019 | Science China Earth Sciences2019，62，6： | 7 |
| 4 | A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro显示文摘Highly virulent porcine epidemic diarrhea virus(PEDV)strains re-emerged and circulated in China at the end of 2010,causing significant economic losses in the pork industry worldwide.To understand the genetic dynamics of PEDV during its passage in vitro,the PEDV G2 strain FJzzl was serially propagated in Vero cells for up to 200 passages.The susceptibility and adaptability of the FJzzl strain increased gradually as it was serially passaged in vitro.Sequence analysis revealed that amino acid(aa)changes were mainly concentrated in the S glycoprotein,which accounted for 72.22%-85.71%of all aa changes.A continuous aa deletion(^(55)I^(56)G^(57)E→^(55)K^(56)Δ^(57)Δ)occurred in the N-terminal domain of S1(Sl-NTD).To examine how the aa changes affected its virulence,FJzzl-F20 and FJzzl-F200 were selected to simultaneously evaluate their pathogenicity in suckling piglets.All the piglets in the FJzzl-F20-infected group showed typical diarrhea at 24 h postinfection,and the piglets died successively by 48 h postinfection.However,the clinical signs of the piglets in the FJzzl-F200-infected group were significantly weaker,and no deaths occurred.The FJzzl-F200-infected group also showed a lower level of fecal viral shedding and lower viral loads in the intestinal tissues,and no obvious histopathological lesions.TypeⅠandⅢinterferon were induced in the FJzzl-F200 infection group,together with pro-inflammatory cytokines,such as TNF-α,IL-1βand IL-8.These results indicate that the identified genetic changes may contribute to the attenuation of FJzzl strain,and the attenuated FJzzl-F200 may have the potential for developing PEDV live-attenuated vaccines. | Pengfei Chen Xiongwei Zhao Shuting Zhou Tianxing Zhou Xiangmei Tan Xia Wu Wu Tong Fei Gao Lingxue Yu Yifeng Jiang Hai Yu Zhibiao Yang Guangzhi Tong Yanjun Zhou | 2021 | Virologica Sinica2021，36，5： | 4 |
| 5 | Expression profile of circular RNAs in myocardial ischemia/reperfusion with and without intermittent hypobaric hypoxia preconditioning显示文摘Dear Editor,Myocardial injury following ischemia/reperfusion(I/R)is a common clinical scenario in patients suffering from ischemic heart disease(Hausenloy et al.,2016).The involvement of proteins and signaling pathways is well studied in myocardial I/R injury and protection(Hausenloy et al.,2016;Yang et al.,2012),however,more than 98%of the transcriptional output in mammals are noncoding RNAs(ncRNAs).These products range from short microRNAs(miRNAs)to long noncoding RNAs(lncRNAs,Das et al.,2018)and modulate critical pathophysiologic mechanisms,such as apoptosis,oxidative stress,Ca2+overload and inflammation,during myocardial I/R injury and protection(Das et al.,2018). | Jiliang Tan Shanshan Gu Yanjun Zheng Huangtian Yang | 2019 | Science China(Life Sciences)2019，62，8： | 3 |
| 6 | Early Paleozoic adakite in the Liuyuan area from the Beishan orogenic belt,NW Gansu Province:Petrogenesis and implication for tectonic setting显示文摘The Liuyuan area,which is located on the southern margin of the Beishan orogenic belt,develops abundant Early Paleozic granitoids.SHRIMP zircon U-Pb dating yielded a weighted mean 206Pb/238U age of 421±8 Ma for the Liuyuan granodiorite(Zhao Zehui et al.,2007),implying its Late Silurian intrusion.Geochemical compositions showed that the Liuyuan granodiorite is characterized by high SiO2(65.01%-67.31%),A12O3(17.17%-18.05%) and Na2O(Na2O/K2O=1.67-1.87) but low Mg# contents calculated as 100×Mg2+/(Mg2++∑Fe2+) from 28.77 to 31.15,as well as being enriched in Sr(472×10-6-517×10-6) but depleted in Yb(1.2×10-6-1.42×10-6) and Y(12.8×10-6-14×10-6).The REEs are characterized by right-inclined patterns with LREE enrichment,HREE depletion and slightly negative Eu anomalies(Eu/Eu*=0.91-0.97).Major and trace elements indicate that the granodiorite is an adakite.The Nb/Ta values of the granodiorite vary from 10.80 to 18.01 and Nb/U from 6.32 to 10.09,both lying between the values of the crust and the mantle.The rock has low εNd(t) values(-2.5--0.8) and high ISr(0.706321-0.706495).Geochemical and Sr-Nd isotopic compositions indicate that the Liuyuan granodiorite is possibly derived from partial melting of thickening lower crust,related to mantle underplating.The Yb-Ta and Y+Nb-Rb discriminant diagrams imply the Liuyuan granodiorite intruded in a local extensional tectonic setting during late collision.Combined with previous studies on geochronology,geochemistry and tectonic setting of granitoids,we interprete that the constraint of this adakite in the Liuyuan area indicates that the tectonic setting may have transformed from collision to extension during the Early Devonian. | Li, Yanjun Wei, Junhao Tan, Jun Fu, Lebing Liu, Xuntao Kong, Lingjun Jiang, Yongjian Shi, Wenjie | 2011 | Chinese Journal Of Geochemistry2011，30，2： | 2 |
| 7 | The variation of summer monsoon precipitation in central China since the last deglaciation显示文摘 | Yanjun Cai Liangcheng Tan Hai Cheng Zhisheng An R. Lawrence Edwards Megan J. Kelly Xinggong Kong Xianfeng Wang | 2009 | Earth and Planetary Science Letters2009，，1： | 2 |
| 8 | Summer monsoon precipitation variations in central China over the past750years derived from a high-resolution absolute-dated stalagmite显示文摘 | Tan Liangcheng Cai Yanjun Cheng Hai | 2009 | Palaeogeography Palaeoclimatology Palaeoecology2009，280，34： | 1 |
| 9 | Quantification constraints on time gap for comagmatic gold deposits:Evidence from chronological statistics显示文摘The time gap between diagenesis and mineralization (TGDM) for comagmatic gold deposits (CGD) plays an important role in confirming the genetic relationship between gold deposits and their related intrusions. With the help of preciously published isotopic ages of some typical gold deposits and their related rocks in China,the authors have discussed and quantified the distribution characteristics and scope of the TGDM. Statistical analyses and Kolmogorov tests showed that mineralizing events are either contemporaneous with or slightly postdate their cognate magma. The TGDM conforms with normal distributions at a 0.05 confidence level and clusters between 0 and 16.0 Ma with a mean of 7.0 Ma. Thus,if the TGDM of CGD is less than 16.0 Ma,it is reasonable to consider,with the aid of other evidence,the possibility of its comagmatic genetic affiliation. The authors also emphasized that to get a precise time gap it is necessary to strengthen the diagenesis-mineralization geological background of the deposits studied,and to pay attention to the study of time gap in combination with trace elements and isotope tracing. | TAN Jun WEI Junhao LI Shuiru ZHANG Chunhua LI Yanjun GUO Lingli YAN Yunfei | 2008 | Chinese Journal Of Geochemistry2008，27，4： | 1 |
| 10 | Stable isotope composition alteration produced by the aragonite-to-calcite transformation in speleothems and implications for paleoclimate reconstructions显示文摘 | Zhang Haiwei Cai Yanjun Tan Liangcheng | 2014 | Sedimentary Geology2014，309，： | 1 |
| 11 | Triple-functional bone adhesive with enhanced internal fixation,bacteriostasis and osteoinductive properties for open fracture repair显示文摘At present,effective fixation and anti-infection implant materials represent the mainstay for the treatment of open fractures.However,external fixation can cause nail tract infections and is ineffective for fixing small fracture fragments.Moreover,closed reduction and internal fixation during the early stage of injury can lead to potential bone infection,conducive to bone nonunion and delayed healing.Herein,we designed a bone adhesive with anti-infection,osteogenic and bone adhesion fixation properties to promote reduction and fixation of open fractures and subsequent soft tissue repair.It was prepared by the reaction of gelatin(Gel)and oxidized starch(OS)with vancomycin(VAN)-loaded mesoporous bioactive glass nanoparticles(MBGNs)covalently cross-linked with Schiff bases.Characterization and adhesion experiments were conducted to validate the successful preparation of the Gel-OS/VAN@MBGNs(GOVM-gel)adhesive.Meanwhile,in vitro cell experiments demonstrated its good antibacterial effects with the ability to stimulate bone marrow mesenchymal stem cell(BMSCs)proliferation,upregulate the expression of alkaline phosphatase(ALP)and osteogenic proteins(RunX2 and OPN)and enhance the deposition of calcium nodules.Additionally,we established a rat skull fracture model and a subcutaneous infection model.The histological analysis showed that bone adhesive enhanced osteogenesis,and in vivo experiments demonstrated that the number of inflammatory cells and bacteria was significantly reduced.Overall,the adhesive could promote early reduction of fractures and antibacterial and osteogenic effects,providing the foothold for treatment of this patient population. | Yusheng Yang Shenghui Su Shencai Liu Weilu Liu Qinfeng Yang Liangjie Tian Zilin Tan Lei Fan Bin Yu Jian Wang Yanjun Hu | 2023 | Bioactive Materials2023，，7： | 1 |
| 12 | Artificial solid electrolyte interface layer based on sodium titanate hollow microspheres assembled by nanotubes to stabilize zinc metal electrodes显示文摘Recently,aqueous zinc-ion batteries with intrinsic safety,low cost,and environmental benignity have attracted tremendous research interest.However,zinc dendrites,harmful side reactions,and zinc metal corrosion stand in the way.Herein,we use lepidocrocite-type sodium titanate hollow microspheres assembled by nanotubes to constitute an artificial solid electrolyte interface layer on the zinc metal electrode.Thanks to the hierarchical structure with abundant open voids,negative-charged layered framework,low hydrophilicity,electrically insulting nature,and large ionic conductivity,the sodium titanate coating layer can effectively homogenize the electric field,promote the Zn^(2+)ion transfer,guide the Zn^(2+)ion flux,reduce the desolvation barrier,improve the exchange current density,and accommodate the plated zinc metal.Consequently,this coating layer can effectively suppress zinc dendrites and other unfavorable effects.With this coating layer,the Zn//Zn symmetric cell is able to provide an impressive cumulative zinc plating capacity of 1375 m Ah cm^(-2) at a current density of 5 m A cm^(-2).This coating layer also contributes to significantly improved electrochemical performances of Zn//MnO_(2) battery and zincion hybrid capacitor.This work offers new insights into the modifications of zinc metal electrodes. | Minfeng Chen Weijun Zhou Qinghua Tian Xiang Han Yanjun Tan Jizhang Chen Ching-Ping Wong | 2022 | Journal of Energy Chemistry2022，31，8： | 1 |
| 13 | Precipitation vari- ations of L0ngxi, northeast margin of Tibetan Plateau since AD 960 and their relationship with solar activity 显示文摘 | TAN Liangeheng CAI Yanjun YI Liang | 2008 | Climate of the Past2008，4，： | 1 |
| 14 | Quantitative temperature reconstruction based on growth rate of annually- layered stalagmite: a case study from central China显示文摘 | Tan Liangcheng Yi Liang Cai Yanjun et a | 2013 | Qua ternary Science Reviews2013，72，： | 1 |
| 15 | A multiple-proxy stalagmite record reveals historical deforestation in central Shandong, northern China显示文摘Evaluating anthropogenic impacts on regional vegetation changes during historical time is not only important for a better understanding of the Anthropocene but also valuable in improving the vegetation-climate models.In this study,we analyzed stable isotopes(δ^18O,δ^13C)and trace elements(Mg/Ca,Sr/Ca)of a stalagmite from Huangchao Cave in central Shandong,northern China.230Th and AMS14C dating results indicate the stalagmite deposited during 174BC and AD1810,with a hiatus between AD638 and 1102.Broad similarities of theδ^18O and trace elements in the stalagmite suggest they are reliable precipitation indexes.Theδ^13C of the stalagmite,a proxy of vegetation change,was generally consistent with local precipitation and temperature variations on a centennial-scale before the 15th century.It typically varied from–9.6‰to–6.3‰,indicating climate controlled C3 type vegetation during this period.However,a persistent and marked increasing trend in theδ^13C record was observed since the 15th century,resulting inδ^13C values from–7.7‰to–1.6‰in the next four centuries.This unprecedentedδ^13C change caused by vegetation deterioration cannot be explained by climate change but is fairly consistent with the dramatically increasing population and farmland in Shandong.We suggest that the increasing deforestation and reclamation in central Shandong began to affect vegetation in the mountain region of central Shandong since the 15th century and severely destroyed or even cleared the forest during the 16th–18th century. | Liangcheng TAN Wen LIU Tianli WANG Peng CHENG Jingjie ZANG Xiqian WANG Le MA Dong LI Jianghu LAN R.Lawrence EDWARDS Hai CHENG Hai XU Li AI Yongli GAO Yanjun CAI | 2020 | Science China Earth Sciences2020，63，10： | 1 |
| 16 | Summer monsoon precipitation variations in central China over the past 750<ce:hsp sp='0.25'/>years derived from a high-resolution absolute-dated stalagmite显示文摘 | Liangcheng Tan Yanjun Cai Hai Cheng Zhisheng An R. Lawrence Edwards | 2009 | Palaeogeography Palaeoclimatology Palaeoecology2009，，3： | 1 |
| 17 | Preliminary Studies of Speleothem in Central Asia显示文摘Objective The Westerlies is important in linking the Northern high latitude,North Atlantic and East Asian monsoon.The location and intensity of the Westerly jet can not only control the climate of central Asia(including northwest arid China),but also significantly influence the climate of the East Asian monsoon region.However,it | TAN Liangcheng SONG Yougui CAI Yanjun AN Zhisheng Rustam OROZBAEV Yunus MAMADJANOV Lawrence R.EDWARDS CHENG Hai LI Dong LI Yue | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 0 |
| 18 | A water-soluble β-glucan improves growth performance by altering gut microbiome and health in weaned pigs显示文摘Beta-glucan has been shown to have a beneficial effect on gastrointestinal health.This experiment was conducted to investigate the effects ofβ-glucan isolated from Agrobacterium sp.ZX09 on growth performance and intestinal health of weaning pigs.A total of 108 weaned pigs(21 d of age;6.05±0.36 kg)were randomly divided into 3 groups(6 pens/group;6 pigs/pen),and the groups were each treated with the following diets:1)basal diet,2)basal diet supplemented with 20 mg/kg olaquindox,3)basal diet supplemented with 200 mg/kgβ-glucan,for 21 d.Compared with the control group,pigs fed with200 mg/kgβ-glucan had greaterBW,average daily gain and duodenal villus height to crypt depth ratio(P<0.05).Olaquindox increased the duodenal or jejunal villus height of pigs compared withβ-glucan.Compared with the control group,β-glucan tended to increase the occludin mRNA expression in the jejunum(0.05 | Yuliang Wu Xue Li Hongnan Liu Yanjun Du Jian Zhou Lijun Zou Xia Xiong Huilin Huang Zhiliang Tan Yulong Yin | 2021 | Animal Nutrition2021，，4： | 0 |
| 19 | Down-regulation of αGal epitopes by co-transfection of α1,3-galactosidase gene and α1,2-fucosyltransferase gene显示文摘The polycarbohydrate structure of Galα1- 3Galβ1-4GluNAc-R (known as αGal epitopes of xenoantigen), produced by α1-3-galactosyltransferase (α1,3-GT) in the course of animal development, is the major xenoantigen on the cell surface of porcine which causes hyperacute rejection in pig-to-human xenotransplantation. Alpha-1,3-galactosi- dase (AGL), a hydrolytic enzyme, can remove the terminal α-1,3-galactosyl from the Galα1-3Galβ1-4GluNAc-R struc-ture resulting in cleaning αGal epitopes from the porcine cells. Alpha-1,2-fucosyltransferase (HT) can modify the sur-face carbohydrate phenotype of porcine cells, bringing about reduction of αGal epitopes expression. In this study, human AGL and HT gene were co-transfected to porcine fetal fibro-blast (PFFb) in equimolar concentration to reduce the xeno-antigen. Gene and protein of hAGL and HT were both de-tected to express at high level by RT-PCR and Western blot, respectively. There was an 84% reduction in αGal xenoanti-gen and an 82% increase in H antigen as assayed by flow cytometry in the AGL and HT gene co-transfected PFFb. The number and morphology of transgenic PFFb chromosome were normal. Findings indicate that Galα1-3Gal epitopes of PFFb could be down regulated by AGL and HT co-transfec- tion without deleterious effects on the chromosomal profile of the transgenic cell. | GONG Feng ZHANG Yangpei JIA Yanjun WANG Yingli TAN Yingxia TIAN shuguang | 2005 | Chinese Science Bulletin2005，50，23： | 0 |
| 20 | The Novel PRRSV Strain HBap4-2018 with a Unique Recombinant Pattern Is Highly Pathogenic to Piglets显示文摘Currently, various porcine reproductive and respiratory syndrome virus(PRRSV) variants emerged worldwide with different genetic characteristics and pathogenicity, increasing the difficulty of PRRS control. In this study, a PRRSV strain named HBap4-2018 was isolated from swine herds suffering severe respiratory disease with high morbidity in Hebei Province of China in 2018. The genome of HBap4-2018 is 15,003 nucleotides in length, and compared with NADC30-like PRRSV, nsp2 of HBap4-2018 has an additional continuous deletion of five amino acids. Phylogenetic analysis based on complete genome and ORF5 showed that HBap4-2018 belonged to lineage 8 of PRRSV-2, which was characterized by highly variable genome. However, HBap4-2018 was classified into lineage 1 based on phylogenetic analysis of nsp2,sharing higher amino acid homology(85.3%–85.5%) with NADC30-like PRRSV. Further analysis suggested that HBap4-2018 was a novel natural recombinant PRRSV with three recombinant fragments in the genome, of which highly pathogenic PRRSV(HP-PRRSV) served as the major parental strains, while NADC30-like PRRSV served as the minor parental strains. Five recombination break points were identified in nsp2, nsp3, nsp5, nsp9 and ORF6, respectively,presenting a novel recombinant pattern in the genome. Piglets inoculated with HBap4-2018 presented typical clinical signs with a mortality rate of 60%. High levels of viremia and obvious macroscopic and histopathological lesions in the lungs were observed, revealing the high pathogenicity of HBap4-2018 in piglets. | Pengfei Chen Xiangmei Tan Mengqin Lao Xia Wu Xiongwei Zhao Shuting Zhou Jiarong Yu Junrui Zhu Lingxue Yu Wu Tong Fei Gao Hai Yu Changlong Liu Yifeng Jiang Guangzhi Tong Yanjun Zhou | 2021 | Virologica Sinica2021，36，6： | 0 |
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