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| 1 | Deregulation of brain insulin signaling in Alzheimer's disease显示文摘Contrary to the previous belief that insulin does not act in the brain, studies in the last three decades have demonstrated important roles of insulin and insulin signal transduction in various functions of the central nervous system. Deregulated brain insulin signaling and its role in molecular pathogenesis have recently been reported in Alzheimer's disease(AD). In this article, we review the roles of brain insulin signaling in memory and cognition, the metabolism of amyloid β precursor protein, and tau phosphorylation. We further discuss defi ciencies of brain insulin signaling and glucose metabolism, their roles in the development of AD, and recent studies that target the brain insulin signaling pathway for the treatment of AD. It is clear now that deregulation of brain insulin signaling plays an important role in the development of sporadic AD. The brain insulin signaling pathway also offers a promising therapeutic target for treating AD and probably other neurodegenerative disorders. | Yanxing Chen Yanqiu Deng Baorong Zhang Cheng-Xin Gong | 2014 | Neuroscience Bulletin2014，30，2： | 15 |
| 2 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 3 | Carboxymethyl chitosan as a polyampholyte mediating intrafibrillar mineralization of collagen via collagen/ACP self-assembly显示文摘The significant role of the polyelectrolytic nature of non-collagenous proteins (NCPs) in regulating the in vivo mineralization of collagen provides important insights for scientists searching for analogues of NCPs to achieve in vitro collagen mineralization. Polyampholyte carboxymethyl chitosan (CMC) has both carboxyl and amino groups, which allows it to act as a cationic or anionic polyelectrolyte below or above its isoelectric point (IP), respectively. In this study, CMC was employed as the analogue of NCPs to stabilize amorphous calcium phosphate (ACP) under acidic conditions (pH < 3.5) via the formation of CMC/ACP nanocomplexes. In the presence of both ACP nanoparticles and acid collagen molecules, ACP nanoparticles could be integrated into collagen fibrils during the process of collagen self-assembly and achieve intrafibrillar mineralization of collagen in vitro (i.e., synchronous self-assembly/mineralization (SSM) of collagen). This mode of mineralization is different from established mechanisms in which mineralization follows the self-assembly (MFS) of collagen. Thus, SSM provides a new strategy for developing materials from mineralized collagen scaffolds. | Mingli Lin Huanhuan Liu Jingjing Deng Ran An Minjuan Shen Yanqiu Li Xu Zhang | 2019 | Journal of Materials Science & Technology2019，35，9： | 4 |
| 4 | Hydrophilic modification of poly(aryl sulfone) membrane materials toward highly-efficient environmental remediation显示文摘Poly(aryl sulfone)as a typical membrane material has been widely used due to excellent mechanical,chemical and thermal stability.However,the inherent hydrophobicity of poly(aryl sulfone)based membranes bears with the fouling issue during applications,which makes the membrane tending to adsorb contaminants on the surface so as to result in decreased separation performance and lifetime.In this critical review,we give a comprehensive overview on characterizations of hydrophilic membrane and diverse hydrophilic modification approaches of poly(aryl sulfone)membranes,predominantly including bulky,blending and surface modification technology.The discussions on the different modification methods have been provided in-depth.Besides,focusing on modification methods and performance of modified membranes,the related mechanisms for the performance enhancement are discussed too.At last,the perspectives are provided to guide the future directions to develop novel technology to manipulate the hydrophilicity of poly(aryl sulfone)membranes toward diverse practical and multifunctional applications. | Fan Yang Junhui Huang Lijun Deng Yanqiu Zhang Guodong Dang Lu Shao | 2022 | Frontiers of Chemical Science and Engineering2022，16，5： | 3 |
| 5 | Dysregulation of insulin signaling,glucose transporters,O-GlcNAcylation,and phosphorylation of tau and neurofilaments in the brain:Implication for Alzheimer's disease显示文摘 | Deng Yanqiu Li Bin Liu Ying | 2009 | Ame J Pathol2009，175，5： | 1 |
| 6 | Quantitative trait locus mapping of resistance to Aspergillus flavus infection using a recombinant inbred line population in maize显示文摘 | Zhitong Yin Yanqiu Wang Feifei Wu Xiao Gu Yunlong Bian Yijun Wang Dexiang Deng | 2014 | Molecular Breeding2014，，1： | 1 |
| 7 | Pinacidil,a K_(atp) channel opener,identified as a novel agonist for TRPA1显示文摘The transient receptor potential Ankyrin 1(TRPA1) cation channel is activated by various pungent and irritant compounds,and it also mediates the perception of noxious cold.Identification of different agonists for this channel is important for understanding its activation mechanism.Therefore,a screen for novel TRPA1 agonists was performed using an agonist-induced calcium influx assay.Out of 90 compounds screened,pinacidil was identified as a novel agonist for this channel.Pinacidil is a known opener of the K atp channel,for which it has an EC50 value of 1-3 μmol/L.In comparison,the EC50 value of pinacidil for TRPA1 is relatively high(260 μmol/L).Recombinant HEK-TRPA1 cells did not respond to P1075,another K atp channel opener,suggesting that the effect of pinacidil on TRPA1 was highly specific.Further studies revealed that the agonist activity of pinacidil could be blocked by the TRP channel inhibitors,ruthenium red and HC-030031.Using glutathione(GSH) and site-specific mutagenesis,we demonstrated that pinacidil could activate TRPA1 by covalent modification of the critical amino acids C619,C639 and C663 in the N-terminus of TRPA1. | MA LiangHui DENG Ying ZHANG Bi BAI YanQiu CAO Jing LI ShiYou LIU JianFeng | 2012 | Chinese Science Bulletin2012，57，15： | 1 |
| 8 | Hybridoma-derived neutralizing monoclonal antibodies against Beta and Delta variants of SARS-CoV-2 in vivo显示文摘Neutralizing monoclonal antibodies(mAb)are a major therapeutic strategy for the treatment of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection.The continuous emergence of new SARS-CoV-2 variants worldwide has increased the urgency for the development of new mAbs.In this study,we immunized mice with the receptor-binding domain(RBD)of the SARS-CoV-2 prototypic strain(WIV04)and screened 35 RBDspecific mAbs using hybridoma technology.Results of the plaque reduction neutralization test showed that 25 of the mAbs neutralized authentic WIV04 strain infection.The 25 mAbs were divided into three categories based on the competitive enzyme-linked immunosorbent assay results.A representative mAb was selected from each category(RD4,RD10,and RD14)to determine the binding kinetics and median inhibitory concentration(IC_(50))of WIV04 and two variants of concern(VOC):B.1.351(Beta)and B.1.617.2(Delta).RD4 neutralized the B.1.617.2 variant with an IC50 of 2.67 ng/mL;however,it completely lost neutralizing activity against the B.1.351 variant.RD10 neutralized both variants with an IC50 exceeding 100 ng/mL;whereas RD14 neutralized two variants with a higher IC50(>1 mg/mL).Animal experiments were performed to evaluate the protective effects of RD4 and RD10 against various VOC infections.RD4 could protect Adv-hACE2 transduced mice from B.1.617.2 infection at an antibody concentration of 25 mg/kg,while RD10 could protect mice from B.1.351 infection at an antibody concentration of 75 mg/kg.These results highlight the potential for future modifications of the mAbs for practical use. | Qianran Wang Lu Peng Yanqiu Nie Yanni Shu Huajun Zhang Zidan Song Yufeng Li Hengrui Hu Liushuai Li Xi Wang Jia Liu Jiang Li Zhengli Shi Fei Deng Yu Guo Yiwu Zhou Bing Yan Zhihong Hu Manli Wang | 2023 | Virologica Sinica2023，38，2： | 0 |
| 9 | Development of the cerebellar cortex in the mouse显示文摘The cerebellum is a highly conserved structure in the central nervous system of vertebrates,and is involved in the coordination of voluntary motor behavior.Supporting this function,the cerebellar cortex presents a layered structure which requires precise spatial and temporal coordination of proliferation,migration,differentiation,and apoptosis events.The formation of the layered structure in the developing cerebellum remains unclear.The present study investigated the development of the cerebellar cortex.The results demonstrate that the primordium of the cerebellum comprises the ependymal,mantle,and marginal layers at embryonic day 12(E12).Subsequently,the laminated cerebellar cortex undergoes cell proliferation,differentiation,and migration,and at about postnatal day 0(P0),the cerebellar cortex presents an external granular layer,a molecular layer,a Purkinje layer,and an internal granular layer.The external granular layer is thickest at P6/7 and disappears at P20.From P0 to P30,the internal granular cells and the Purkinje cells gradually differentiate and develop until maturity.Apoptotic neurons are evident in the layered structure in the developing cerebellar cortex.The external granular layer disappears gradually because of cell migration and apoptosis.The cells of the other layers primarily undergo differentiation,development,and apoptosis. | Xiangshu Cheng Jin Du Dongming Yu Qiying Jiang Yanqiu Hu Lei Wang Mingshan Li Jinbo Deng | 2011 | Neural Regeneration Research2011，6，4： | 0 |
| 10 | Graphene-reinforced metal-organic frameworks derived cobalt sulfide/carbon nanocomposites as efficient multifunctional electrocatalysts显示文摘Developing cost-effective electrocatalysts for oxygen reduction reaction(ORR),oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)is vital in energy conversion and storage applications.Herein,we report a simple method for the synthesis of graphene-reinforced CoS/C nanocomposites and the evaluation of their electrocatalytic performance for typical electrocatalytic reactions.Nanocomposites of CoS embedded in N,S co-doped porous carbon and graphene(CoS@C/Graphene)were generated via simultaneous sulfurization and carbonization of one-pot synthesized graphite oxide-ZIF-67 precursors.The obtained CoS@C/Graphene nanocomposites were characterized by X-ray diffraction,Raman spectroscopy,thermogravimetric analysis-mass spectroscopy,scanning electronic microscopy,transmission electronic microscopy,X-ray photoelectron spectroscopy and gas sorption.It is found that CoS nanoparticles homogenously dispersed in the in situ formed N,S co-doped porous carbon/graphene matrix.The CoS@C/10Graphene composite not only shows excellent electrocatalytic activity toward ORR with high onset potential of 0.89 V,four-electron pathway and superior durability of maintaining 98%of current after continuously running for around 5 h,but also exhibits good performance for OER and HER,due to the improved electrical conductivity,increased catalytic active sites and connectivity between the electrocatalytic active CoS and the carbon matrix.This work offers a new approach for the development of novel multifunctional nanocomposites for the next generation of energy conversion and storage applications. | Laicong Deng Zhuxian Yang Rong Li Binling Chen Quanli Jia Yanqiu Zhu Yongde Xia | 2021 | Frontiers of Chemical Science and Engineering2021，15，6： | 0 |
| 11 | Detection of Volatile Components in Leaves and Bark of Picrasma quassioides by GC-MS显示文摘[Objectives]This study aimed to analyze the volatile oil components of the leaves and bark of Picrasma quassioides.[Methods]The volatile oils in the leaves and bark of P.quassioides were extracted using steam distillation(SD)method and identified with gas chromatography-mass spectrometry(GC-MS).Based on the mass spectrum database(NiST08),combined with artificial spectrum analysis,referring to relevant literature,the base peak and relative abundance were compared to identify the volatile components of the leaves and bark.The relative content of each component was determined by peak area normalization method.[Results]A total of 24 and 23 chemical components were identified in the leaves and bark of P.quassioides,respectively,including 11 common components.[Conclusions]Leaf and bark are different tissues.They contain different volatile chemical components,of which the contents vary greatly.They should be treated differently in the further research and development of P.quassioides resources. | Jingni WANG Yanqiu DENG Hongzhen TANG Hui HUANG Zhenwei ZHANG | 2021 | Medicinal Plant2021，12，1： | 0 |
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