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| 1 | NON-YELLOWING2 (NYE2), a Close Paralog of NYE1, Plays a Positive Role in Chlorophyll Degradation in Arabidopsis显示文摘 | Wu, Shouxin Li, Zhongpeng Yang, Lifeng Xie, Zuokun Chen, Junyi Zhang, Wei Liu, Tianqi Gao, Shan Gao, Jiong Zhu, Yihua Xin, Jiwen Ren, Guodong Kuai, Benke | 2016 | Molecular Plant2016，9，4： | 6 |
| 2 | The Arabidopsis catalase triple mutant reveals important roles of catalases and peroxisome-derived signaling in plant development显示文摘Hydrogen peroxide(H_2O_2)is generated in many metabolic processes.As a signaling molecule,H_2O_2plays important roles in plant growth and development,as well as environmental stress response.In Arabidopsis,there are three catalase genes,CAT1,CAT2,and CAT3.The encoded catalases are predominately peroxisomal proteins and are critical for scavenging H_2O_2.Since CAT1 and CAT3 are linked on chromosome 1,it has been almost impossible to generate cat1/3 and cat1/2/3 mutants by traditional genetic tools.In this study,we constructed cat1/3 double mutants and cat1/2/3 triple mutants by CRISPR/Cas9 to investigate the role of catalases.The cat1/2/3 triple mutants displayed severe redox disturbance and growth defects under physiological conditions compared with wild-type and the cat2/3 double mutants.Transcriptome analysis showed a more profound transcriptional response in the cat1/2/3 triple mutants compared to the cat2/3 mutants.These differentially expressed genes are involved in plant growth regulation as well as abiotic and biotic stress responses.In addition,expression of OXI1(OXIDATIVE SIGNAL INDUCIBLE 1)and several MAPK cascade genes were changed dramatically in the catalase triple mutant,suggesting that H_2O_2produced in peroxisomes could serve as a peroxisomal retrograde signal. | Tong Su Pingping Wang Huijuan Li Yiwu Zhao Yao Lu Peng Dai Tianqi Ren Xiaofeng Wang Xuezhi Li Qun Shao Dazhong Zhao Yanxiu Zhao Changle Ma | 2018 | Journal of Integrative Plant Biology2018，60，7： | 3 |
| 3 | Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway显示文摘Ammonia plays an important role in cellular metabolism.However,ammonia is considered a toxic product.In bone marrow-derived mesenchymal stem cells,multipotent stem cells with high expression of glutamine synthetase(GS)in bone marrow,ammonia and glutamate can be converted to glutamine via glutamine synthetase activity to support the proliferation of MSCs.As a major nutritional amino acid for biosynthesis,glutamine can activate the Akt/mTOR/S6k pathway to stimulate cell proliferation.The activation of mTOR can promote cell entry into S phase,thereby enhancing DNA synthesis and cell proliferation.Our studies demonstrated that mesenchymal stem cells can convert the toxic waste product ammonia into nutritional glutamine via GS activity.Then,the Akt/mTOR/S6k pathway is activated to promote bone marrow-derived mesenchymal stem cell proliferation.These results suggest a new therapeutic strategy and potential target for the treatment of diseases involving hyperammonemia. | Yu Liu Xiangxian Zhang Wei Wang Ting Liu Jun Ren Siyuan Chen Tianqi Lu Yan Tie Xia Yuan Fei Mo Jingyun Yang Yuquan Wei Xiawei Wei | 2022 | Bone Research2022，10，4： | 1 |
| 4 | Automated brain tumor segmentation from multimodal MRI data based on Tamura texture feature and an ensemble SVM classifier显示文摘Purpose–Theprecisesegmentation ofbraintumors isthe mostimportantandcrucialstepintheir diagnosis and treatment.Due to the presence of noise,uneven gray levels,blurred boundaries and edema around the brain tumor region,the brain tumor image has indistinct features in the tumor region,which pose a problem for diagnostics.The paper aims to discuss these issues.Design/methodology/approach–In this paper,the authors propose an original solution for segmentation using Tamura Texture and ensemble Support Vector Machine(SVM)structure.In the proposed technique,124 features of each voxel are extracted,including Tamura texture features and grayscale features.Then,these features are ranked using the SVM-Recursive Feature Elimination method,which is also adopted to optimize the parameters of the Radial Basis Function kernel of SVMs.Finally,the bagging random sampling method is utilized to construct the ensemble SVM classifierbased on a weighted voting mechanism to classify the types of voxel.Findings–The experiments are conducted over a sample data set to be called BraTS2015.The experiments demonstrate that Tamura texture is very useful in the segmentation of brain tumors,especially the feature of line-likeness.The superior performance of the proposed ensemble SVM classifier is demonstrated by comparison with single SVM classifiers as well as other methods.Originality/value–The authors propose an original solution for segmentation using Tamura Texture and ensemble SVM structure. | Li Na Xiong Zhiyong Deng Tianqi Ren Kai | 2019 | International Journal of Intelligent Computing and Cybernetics2019，12，4： | 1 |
| 5 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 6 | Developments in stability and passivation strategies for black phosphorus显示文摘Black phosphorus(BP),a promising two-dimensional layer material,has attracted increasing attention due to its high carrier mobility,thickness-dependent tunable bandgap,in-plane anisotropy,and other advantageous characteristics.Because of these excellent characteristics,BP has been considered for applications in optics,electronics,optoelectronics,sensors,and energy storage.However,early studies found that BP has high chemical activity due to the lone pair electrons of P atoms on the surface and edges,resulting in rapid degradation under ambient conditions and limiting many applications.Recently,these thorny issues have been alleviated through superior physical and chemical passivation techniques,and passivated BP can be used in various devices under ambient and water conditions with excellent performance over a long period.This review,highlights the critical problems addressed in solving the serious instability of BP in a harsh environment by effective passivation technology.These unique strategies can provide more researchers with a fundamental study of the fascinating properties of BP.Finally,we found that passivated BP not only showed good stability under ambient conditions but also exhibited excellent performance compared with the original BP.Therefore,it is anticipated that this overview can contribute to the application of BP. | Haizeng Song Han Wu Tianqi Ren Shancheng Yan Tianhong Chen Yi Shi | 2021 | Nano Research2021，14，12： | 1 |
| 7 | Distribution of antibiotic-resistant bacteria in chicken manure and manure-fertilized vegetables显示文摘 | YANG Qingxiang REN Siwei NIU Tianqi | 2014 | Environ Sci Pollut Res2014，21，2： | 1 |
| 8 | Highly active CoP-CO_(2)N confined in nanocarbon enabling efficient electrocatalytic immobilizing-conversion of polysulfide targeting high-rate lithium-sulfur batteries显示文摘Lithium-sulfur batteries suffer from poor cycling stability because of the intrinsic shuttling effect of intermediate polysulfides and sluggish reaction kinetics,especially at high rates and high sulfur loading.Herein,we report the construction of a CoP-CO_(2)N@N-doped carbon polyhedron uniformly anchored on three-dimensional carbon nanotubes/graphene(CoP-CO_(2)N@NC/CG)scaffold as a sulfur reservoir to achieve the trapping-diffusion-conversion of polysulfides.Highly active CoP-CO_(2)N shows marvelous catalytic effects by effectively accelerating the reduction of sulfur and the oxidation of Li_(2)S during the discharging and charging process,respectively,while the conductive NC/CG network with massive mesoporous channels ensures fast and continuous long-distance electron/ion transportation.DFT calculations demonstrate that the CoP-CO_(2)N with excellent intrinsic conductivity serves as job-synergistic immobilizing-conversion sites for polysulfides through the formation of P…Li/N…Li and Co…S bonds.As a result,the S@CoP-CO_(2)N@NC/CG cathode(sulfur content 1.7 mg cm^(-2))exhibits a high capacity of988 mAh g^(-1)at 2 C after 500 cycles,which is superior to most of the electrochemical performance reported.Even under high sulfur content(4.3 mg cm^(-2)),it also shows excellent cyclability with high capacity at 1 C. | Xiaojun Zhao Tianqi Gao Wenhao Ren Chuan Zhao Zhi-Hong Liu Linbo Li | 2022 | Journal of Energy Chemistry2022，，12： | 1 |
| 9 | Distribution of antibiotic-resistant bacteria in chicken manure and manure-fertilized vegetables显示文摘 | Qingxiang Yang Siwei Ren Tianqi Niu Yuhui Guo Shiyue Qi Xinkuan Han Dong Liu Feng Pan | 2014 | Environmental Science and Pollution Research2014，，2： | 1 |
| 10 | Methyl Group in Isocopalane Derivative Showed an Unusual Negative 1H NMR Chemical Shift显示文摘An unusual negative 1H NMR chemical shift of methyl group was discovered in condensation product of isoco-palane diterpenoid with p-toluenesulfonyl hydrazide.2D NMR,computational studies and single-crystal X-ray dif-fraction analysis showed that the C-20 methyl group was shielded. | Xiong Xiao Tianqi Chen Fengfeng Zhang Jiagao Cheng Peiying Wu Jiangmeng Ren Bubing Zeng | 2015 | Chinese Journal of Chemistry2015，33，6： | 0 |
| 11 | Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human A CE2-transgenic mice显示文摘The development of animal models for COVID-19 is essential for basic research and drug/vaccine screening.Previously reported COVID-19 animal models need to be established under a high biosafety level condition for the utilization of live SARS-CoV-2,which greatly limits its application in routine research.Here,we gen erate a mouse model of COVID-19 un der a gen eral laboratory condition that captures multiple characteristics of SARS-CoV-2-induced acute respiratory distress syndrome(ARDS)observed in huma ns.Briefly,human ACE2-tra nsge nic(MCE2)mice were in tratracheally in stilled with the formaldehyde-inactivated SARS-CoV-2,resulting in a rapid weight loss and detrimental changes in lung structure and function.The pulmonary pathologic changes were characterized by diffuse alveolar damage with pulmonary consolidation,hemorrhage,necrotic debris,and hyaline membrane formation.The production of fatal cytokines(IL-β,TNF-α,and IL-6)and the infiltration of activated neutrophils,inflammatory monocyte-macrophages,and T cells in the lung were also determined,suggesting the activation of an adaptive immune response.Therapeutic strategies,such as dexamethasone or passive antibody therapy,could effectively ameliorate the disease progression in this model.Therefore,the established mouse model for SARS-CoV-2-induced ARDS in the current study may provide a robust tool for researchers in the standard open laboratory to investigate the pathological mechanisms or develop new therapeutic strategies for COVID-19 and ARDS. | Zhenfei Bi Weiqi Hong Haiying Que Cai He Wenyan Ren Jingyun Yang Tianqi Lu Li Chen Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 12 | A Label-free Photoelectrochemical Sensor Based on Bi_(2)S_(3)@Nitrogen Doped Graphene Quantum Dots for Ascorbic Acid Determination显示文摘We report a photoelectrochemical(PEC)sensor for selective detection of ascorbic(AA)by introducing Z-scheme Bi_(2)S_(3)@nitrogen doped graphene quantum dots(Bi_(2)S_(3)@NGQDs)heterojunctions as efficient photoactive species.The Bi_(2)S_(3)@NGQDs were successfully prepared by a simple hydrothermal process,and the microstructures and components were investigated by various characterized techniques.The photocurrent of the Bi_(2)S_(3)@NGQDs-based sensor increased significantly in the presence of AA and showed excellent selectivity and stability for AA detection in the presence of some other antioxidants and small molecules.A wide linear range of 0.1–5µmol/L and 5–1380µmol/L was achieved for the AA detection with a detection limit of 36 nmol/L(S/N=3).Moreover,the proposed PEC sensor achieved the determination of AA in real red peppers and commercially available vitamin C tablets samples. | WU Zhifang LIANG Zhishan HE Ziqian WANG Tianqi XIAO Ren HAN Fangjie ZHAO Zhengzheng HAN Dongfang HAN Dongxue NIU Li | 2022 | Chemical Research in Chinese Universities2022，38，6： | 0 |
| 13 | Multi-Scale Numerical Simulation of Flow,Heat and Mass Transfer Behaviors in Dense Gas-Solid Flows:A Brief Review显示文摘Dense gas-solid flows are very common in actual production and industrial fields,so it is significant to understand their hydrodynamic characteristics and heat and mass transfer behaviors.This article provides a brief review of multi-scale numerical simulation of flow,heat and mass transfer behaviors in dense gas-solid flows.It describes multiscale models(direct numerical simulation,discrete particle model,and two-fluid model)and the results of related research.Finally,it discusses possible future developments in research on the flow,heat and mass transfer characteristics of dense gas-solid two-phase flows. | HE Yurong REN Anxing TANG Tianqi WANG Tianyu | 2022 | Journal of Thermal Science2022，31，3： | 0 |
| 14 | Modulating reaction pathways of formic acid oxidation for optimized electrocatalytic performance of PtAu/CoNC显示文摘Formic acid oxidation(FAO)is a typical anode reaction in fuel cells that can be facilitated by modulating its direct and indirect reaction pathways.Herein,PtAu bimetallic nanoparticles loaded onto Co and N co-doping carbon nanoframes(CoNC NFs)were designed to improve the selectivity of the direct reaction pathway for efficient FAO.Based on these subtle nanomaterials,the influences of elemental composition and carbon-support materials on the two pathways of FAO were investigated in detail.The results of fuel cell tests verified that the appropriate amount of Au in PtAu/CoNC can promote a direct reaction pathway for FAO,which is crucial for enhancing the oxidation efficiency of formic acid.In particular,the obtained PtAu/CoNC with an optimal Pt/Au atomic ratio of 1:1(PtAu/CoNC-3)manifests the best catalytic performance among the analogous obtained Pt-based electrocatalysts.The FAO mass activity of the PtAu/CoNC-3 sample reached 0.88 A·mg_(Pt)^(-1),which is 26.0 times higher than that of Pt/C.The results of first-principles calculation and CO stripping jointly demonstrate that the CO adsorption of PtAu/CoNC is considerably lower than that of Pt/CoNC and PtAu/C,which indicates that the synergistic effect of Pt,Au,and CoNC NFs is critical for the resistance of Pt to CO poisoning.This work is of great significance for a deeper understanding of the oxidation mechanism of formic acid and provides a feasible and promising strategy for enhancing the catalytic performance of the catalyst by improving the direct reaction pathway for FAO. | Mengchao Liang Tianyu Xia Han Gao Kai Zhao Tianqi Cao Meng Deng Xiaoyan Ren Shunfang Li Haizhong Guo Rongming Wang | 2022 | Nano Research2022，15，2： | 0 |
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