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| 1 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 2 | Preparation and characterization of capric-palmitic-stearic acid ternary eutectic mixture/expanded vermiculite composites as form-stabilized thermal energy storage materials显示文摘In this study, a composite of form-stable phase change materials(FSPCMs) were prepared by the incorporation of a eutectic mixture of capric–palmitic–stearic acid(CA–PA–SA) into expanded vermiculite(EV)via vacuum impregnation. In the composites, CA–PA–SA was utilized as a thermal energy storage material,and EV served as the supporting material. X-ray diffraction and Fourier transform infrared spectroscopy results demonstrated that CA–PA–SA and EV in the composites only undergo physical combination, not a chemical reaction. Scanning electron microscopy images indicated that CA–PA–SA is sufficiently absorbed in the expanded vermiculite porous network. According to differential scanning calorimetry results, the70 wt% CA–PA–SA/EV sample melts at 19.3℃ with a latent heat of 117.6 J/g and solidifies at 17.1℃ with a latent heat of 118.3 J/g. Thermal cycling measurements indicated that FSPCMs exhibit adequate stability even after being subjected to 200 melting–freezing cycles. Furthermore, the thermal conductivity of the composites increased by approximately 49.58% with the addition of 5 wt% of Cu powder. Hence,CA–PA–SA/EV FSPCMs are effective latent heat thermal energy storage building materials. | Weiyi Zhang Xiaoguang Zhang Zhaohui Huang Zhaoyu Yin Ruilong Wen Yaoting Huang Xiaowen Wu Xin Min | 2018 | Journal of Materials Science & Technology2018，34，2： | 8 |
| 3 | Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2α显示文摘离氨酸(K) 特定的 demethylase 6B (KDM6B ) 是 histone H3K27 demethylase,它明确地催化 H3 lysine-27 tri/dimethylation (H3K27me3/2 ) 的 demethylation。KDM6B 能由支持与 RNA 聚合酶 II 和相关延伸因素被联系的 transcriptional 延伸激活基因抄写。KDM6B 因此为基因表示的规定是重要的。以前的研究显示了象 KDM3A, KDM4B,和 KDM4C 那样的几 histone demethylases 被组织缺氧可诱导的因素(HIF ) 调整。但是, KDM6B 上的组织缺氧的效果充分没被理解。在这研究,我们发现 KDM6B mRNA 和蛋白质的表示层次在组织缺氧下面是平常地起来调整的(1% O 2) 或模仿组织缺氧(desferrioxamine mesylate 或 CoCl 2 处理)(P < 0.05 ) 。RNAi 的结果证明 KDM6B 的起来规定依赖于 HIF-2,然而并非在 HIF-1 上。染色质 immunoprecipitation 试金的结果显示在 KDM6B 倡导者(4041 ~ 4037 ) 有一个组织缺氧反应元素。Co-IP 试金的结果显示 KDM6B 能与 HIF-2 或 HIF-1 形成建筑群。击倒的实验暗示 KDM6B 是为 HIF-2 目标基因的一个潜在的管理者。这些数据证明 KDM6B 是 HIF-2 调整的新组织缺氧反应基因。我们的结果也证明 KDM6B 是 HIF- 的潜在的激活剂,它为组织缺氧反应基因的激活是重要的。 | Xiaoqiang Guo Zha ntao Tian Xuliang Wang Shuhong Pan Weiren Huang Yongqing Shen Yaoting Gui Xianglin Duan Zhiming Cai | 2015 | Acta Biochimica et Biophysica Sinica2015，47，2： | 5 |
| 4 | Telomerase Reverse Transcriptase Gene Promoter Mutations Help Discern the Origin of Urogenital Tumors: A Genomic and Molecular Study显示文摘 | Song Wu Peide Huang Chong Li Yi Huang Xianxin Li Yongqiang Wang Chao Chen Zhaojie Lv Aifa Tang Xiaojuan Sun Jingxiao Lu Weiping Li Jie Zhou Yaoting Gui Fangjian Zhou Daping Wang Zhiming Cai | 2013 | European Urology2013，，： | 1 |
| 5 | Evidence for GAL3ST4 mutation as the potential cause of Dectus excavatum显示文摘 | Song Wu Xiaojuan Sun Weimin Zhu Yi Huang Lisha Mou Mingming Liu Xia Li Feiyang Li Xianxin Li Yong Zhang Zheng Wang Wencui Li Zesong Li Aifa Tang Yaoting Gui Rongfu Wang Weiping Li Zhiming Cai Daping Wang | 2012 | Cell Research2012，22，12： | 0 |
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