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| 1 | Tissue clearing of both hard and soft tissue organs with the PEGASOS method显示文摘织物空地技术由转织物在 3 尺寸(3-D ) 启用不透明的机关和纸巾的可视化透明。当前的组织空地方法被能与每个单个协议被清除的纸巾的有限类型限制,它不可避免地导致了存在在整个身体或身体部分成像以内盲点。包括骨头和牙齿的难纸巾仍然是要清除的最困难的机关。另外,内长的荧光的损失为基于溶剂的空地方法仍然是一颗主要担心。这里,我们发展了聚乙烯乙二醇(木钉) 联系了溶剂系统(PEGASOS ) ,它将近显示了纸巾的所有类型透明、保存的内长的荧光。骨头和牙齿能被转在变清以后将近不可见。PEGASOS 方法转了透明的整个成年老鼠身体,我们对一个成年老鼠头骨头,牙齿,大脑,肌肉,和其它填写了的图象有能力没有盲目区域的纸巾。难织物透明性使我们能重建在 3-D 的未经触动的上颚,牙齿,腿节,或膝关节。另外,我们在长距离上在亚 cellular 分辨率并且到踪迹个人神经原和轴突管理了未经触动的鼠标大脑到图象。我们也通过 vertebrae 直接设想了背面的根中心。最后,我们在长骨头的髓空间以内在 3-D 揭示了神经网络的分发模式。这些结果建议 PEGASOS 方法是为一般生物医学的研究的一个有用工具。 | Dian Jing Shiwen Zhang Wenjing Luo Xiaofei Gao Yi Men Chi Ma Xiaohua Liu Yating Yi Abhijit Bugde Bo O. Zhou Zhihe Zhao Quan Yuan Jian Q. Feng Liang Gao Woo-Ping Ge Hu Zhao | 2018 | Cell Research2018，28，8： | 18 |
| 2 | Routing valley exciton emission of a WS_(2) monolayer via delocalized Bloch modes of in-plane inversion-symmetry-broken photonic crystal slabs显示文摘The valleys of two-dimensional transition metal dichalcogenides(TMDCs)offer a new degree of freedom for information processing.To take advantage of this valley degree of freedom,on the one hand,it is feasible to control valleys by utilizing different external stimuli,such as optical and electric fields.On the other hand,nanostructures are also used to separate the valleys by near-field coupling.However,for both of the above methods,either the required low-temperature environment or low degree of coherence properties limit their further applications.Here,we demonstrate that all-dielectric photonic crystal(PhC)slabs without in-plane inversion symmetry(C_(2) symmetry)can separate and route valley exciton emission of a WS2 monolayer at room temperature.Coupling with circularly polarized photonic Bloch modes of such PhC slabs,valley photons emitted by a WS_(2) monolayer are routed directionally and are efficiently separated in the far field.In addition,far-field emissions are directionally enhanced and have long-distance spatial coherence properties. | Jiajun Wang Han Li Yating Ma Maoxiong Zhao Wenzhe Liu Bo Wang Shiwei Wu Xiaohan Liu Lei Shi Tian Jiang Jian Zi | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 3 | Concentration of circulating microparticles:a new biomarker of acute heart failure after cardiac surgery with cardiopulmonary bypass显示文摘Acute heart failure(AHF)is a severe complication after cardiac surgery with cardiopulmonary bypass(CPB).Although some AHF biomarkers have been used in clinic,they have limitations when applied in the prediction and diagnosis of AHF after cardiac surgery with CPB,and there are still no effective and specific biomarkers.We and other researchers have shown that circulating microparticles(MPs)increased in a variety of cardiovascular diseases.However,whether the concentration of circulating MPs could be a new biomarker for AHF after cardiac surgery remains unknown.Here,90 patients undergoing cardiac surgery with CPB and 45 healthy subjects were enrolled.Patients were assigned into AHF(n=14)or non-AHF(n=76)group according to the diagnosis criteria of AHF.The concentrations of circulating MPs were determined before,as well as 12 h and 3 days after operation with nanoparticle tracking analysis technique.MPs concentrations in patients before surgery were significantly higher than those of healthy subjects.Plasma levels of MPs were significantly elevated at 12 h after surgery in patients with AHF,but not in those without AHF,and the circulating MPs concentrations at 12 h after surgery were higher in AHF group compared with non-AHF group.Logistic regression analysis indicated that MPs concentration at postoperative 12 h was an independent risk factor for AHF.The area under receiver operating characteristic curve for MPs concentration at postoperative 12 h was 0.87 and the best cut-off value is 5.20×10~8 particles mL~(–1)with a sensitivity of 93%and a specificity of 70%.These data suggested that the concentration of circulating MPs might be a new biomarker for the occurrence of AHF after cardiac surgery with CPB. | Yuquan Li Haoxiang Yuan Caiyun Chen Chao Chen Jian Ma Yating Chen Yan Li Yupeng Jian Donghong Liu Zhijun Ou Jingsong Ou | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 4 | Compensatory mutations in E1,p7,NS2,and NS3 enhance yields of cell culture-infectious intergeno-typic chimeric hepatitis C virus显示文摘 | Yi M Ma Y Yates J | 2007 | J Virol2007，81，2： | 1 |
| 5 | NS3 helicase domains involved in infectious intraeellular hepatitis C virus particle assembly显示文摘 | Ma Y Yates J Liang Y | 2008 | J Virol2008，82，15： | 1 |
| 6 | Statistical analysis of the two stage mutation modle in von Hippel-Lindau disease,and in sporadic cerebellar haemangioblastoma adrenal cell carcinoma 显示文摘 | Maher ER Yates JR Ferguson-Smith MA | 1990 | J Med Genet1990，27，5： | 1 |
| 7 | Trans-eomplementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation显示文摘 | Yi M Ma Y Yates J | 2009 | PLoS pathogens2009，5，10： | 1 |
| 8 | A comparison of human prothrombin,factor lX ( Christmas factor), factor X ( Smart factor) ,and protein S显示文摘 | Di Scipio RG Hermodson MA Yates SG | 1977 | Biochemistry1977，16，4： | 1 |
| 9 | Compensatory mutations in El, p7, NS2, and NS3 enhance yields of cell culture-infectious in- tergenotypic chimerics C virus显示文摘 | YI M MA Y YATES J | 2007 | Journal of Virology2007，81，2： | 1 |
| 10 | Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide显示文摘 | Thimmulappa RK Scollick C Traore K Yates M Trush MA Liby KT | 2006 | Biochem Biophys Res Commun2006，351，4： | 1 |
| 11 | Maternal age specific rates for chromosome aberrations and factors influencing them report of a collaborative European study on 52, 965 amniocentesis显示文摘 | Ferguson-Smith MA Yates JRW | 1984 | Prenat Diagn1984，4，： | 1 |
| 12 | GPR30,but not estrogen receptor-alpha,is crucial in the treatment of experimental autoimmune encepha1omyelitis by oral ethinyl estradiol显示文摘 | Yates MA Li Y Chlebeck PJ | 2010 | BMC Immunol2010，1，： | 1 |
| 13 | Genetic evidence that EBNA1 is needed for efficient, stable latent infection by Epstein-Barr virus显示文摘 | Diamond ME Yates JL | 1999 | J Virol1999，73，4： | 1 |
| 14 | Materna age specific rotes for chromosome aberrations and factors influencing them:report of a collaborative European study on 52965 amniocenteses显示文摘 | Ferguson- Smith MA Yates JR | 1984 | Prenat Diagn1984，4，： | 1 |
| 15 | Sedative and hypnotic activities of the ethanol fraction from Fructus Schisandrae in mice and rats显示文摘 | Fang Huang Yating Xiong Lihua Xu Shiping Ma Changgui Dou | 2006 | Journal of Ethnopharmacology2006，，3： | 1 |
| 16 | Major depressive disorderin hepatitis C:an open-label trial of escitalopram 显示文摘 | Gleason OC Yates WR Philipsen MA | 2005 | Prim CareCompanion J Clin Psychiatry2005，7，5： | 1 |
| 17 | Statistical analysis of the two stage mutation model in von Hippel-Lindau disease,and in sporadic cerebellar haemangioblastoma and renal cell carcionma显示文摘 | Maher ER Yates JR Ferguson-Smith MA | 1990 | J Med Genet1990，5，： | 1 |
| 18 | Is disordered folate metabolism the basis for the genetic predisposition neural tube defects?显示文摘 | Yates JR Ferguson S MA Shenkin A | 1987 | Clin Genet1987，31，5： | 1 |
| 19 | A comparison ofhuman prothrombin, factor DC ( Christmas factor), factor X(Stuart factor), and protein S 显示文摘 | Di Scipio RG Hermodson MA Yates SG | 1977 | Biochemistry1977，16，4： | 1 |
| 20 | Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal显示文摘Female-to-male sex reversals(pseudomales)are common in lower vertebrates and have been found in natural populations,which is a concern under rapid changes in environmental conditions.Pseudomales can exhibit altered spermatogenesis.However,the regulatory mechanisms underlying pseudomale spermatogenesis remain unclear.Here,we characterized spermatogenesis in Chinese tongue sole(Cynoglossus semilaevis),a species with genetic and environmental sex determination,based on a highresolution single-cell RNA-seq atlas of cells derived from the testes of genotypic males and pseudomales.We identified five germ cell types and six somatic cell types and obtained a single-cell atlas of dynamic changes in gene expression during spermatogenesis in Chinese tongue sole,including alterations in pseudomales.We detected decreased levels of Ca^(2+)signaling pathway-related genes in spermatogonia,insufficient meiotic initiation in spermatocytes,and a malfunction of somatic niche cells in pseudomales.However,a cluster of CaSR genes and MAPK signaling factors were upregulated in undifferentiated spermatogonia of pseudomales.Additionally,we revealed that Z chromosome-specific genes,such as piwil2,dhx37,and ehmt1,were important for spermatogenesis.These results improve our understanding of reproduction after female-to-male sex-reversal and provide new insights into the adaptability of reproductive strategies in lower vertebrates. | Hong-Yan Wang Xiang Liu Jian-Yang Chen Yingyi Huang Yifang Lu Fujian Tan Qun Liu Mingming Yang Shuo Li Xianghui Zhang Yating Qin Wenxiu Ma Yingming Yang Liang Meng Kaiqiang Liu Qian Wang Guangyi Fan Rafael H.Nóbrega Shanshan Liu Francesc Piferrer Changwei Shao | 2023 | Science China(Life Sciences)2023，66，5： | 1 |
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