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| 1 | Environmental records of lacustrine sediments in different time scales:Sediment grain size as an example显示文摘Sediment grain size is a conventional proxy of climatic changes. Larger sediment grain size is often interpreted to indicate dry climate during lower lake level while smaller sedi- ment grain size implies wet climate during higher lake level. Through detailed study on sediment grain sizes in Lake Erhai and Lake Chenghai, this paper reveals the different indication signifi- cances of sediment grain sizes in different time scales, different resolution investigations. For long time-scale and low resolution (102a or 103a) studies, larger sediment grain size indicates lower lake level, smaller lake area and drier climate while smaller sediment grain size indicates higher lake level, larger lake area and wetter climate. For short time-scale and high resolution (a or 10a) studies, larger sediment grain size reflects more rainfall and wetter climate while smaller sediment grain size reflects less rainfall and drier climate. Environmental information revealed by lacustrine sediment records is often different in different time scales because of the variance of sedimentation resolution, sampling resolution and dating precision. Therefore, paleoclimate im- plications of environmental proxies in long time-scale and low resolution investigations could not be mechanically applied to short time-scale and high resolution studies. Only after synthetically analyzing the influence manner and extent of all factors on the sediment records in different time scales, can credible conclusions be obtained. | CHEN Jing’an1, WAN Guojiang1, David Dian Zhang2, ZHANG Feng1 & HUANG Ronggui1 1. State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China 2. Department of Geography and Geology, University of Hong Kong, Pokfulam Road, Hong Kong, China | 2004 | Science China Earth Sciences2004，47，10： | 27 |
| 2 | Tissue clearing of both hard and soft tissue organs with the PEGASOS method显示文摘织物空地技术由转织物在 3 尺寸(3-D ) 启用不透明的机关和纸巾的可视化透明。当前的组织空地方法被能与每个单个协议被清除的纸巾的有限类型限制,它不可避免地导致了存在在整个身体或身体部分成像以内盲点。包括骨头和牙齿的难纸巾仍然是要清除的最困难的机关。另外,内长的荧光的损失为基于溶剂的空地方法仍然是一颗主要担心。这里,我们发展了聚乙烯乙二醇(木钉) 联系了溶剂系统(PEGASOS ) ,它将近显示了纸巾的所有类型透明、保存的内长的荧光。骨头和牙齿能被转在变清以后将近不可见。PEGASOS 方法转了透明的整个成年老鼠身体,我们对一个成年老鼠头骨头,牙齿,大脑,肌肉,和其它填写了的图象有能力没有盲目区域的纸巾。难织物透明性使我们能重建在 3-D 的未经触动的上颚,牙齿,腿节,或膝关节。另外,我们在长距离上在亚 cellular 分辨率并且到踪迹个人神经原和轴突管理了未经触动的鼠标大脑到图象。我们也通过 vertebrae 直接设想了背面的根中心。最后,我们在长骨头的髓空间以内在 3-D 揭示了神经网络的分发模式。这些结果建议 PEGASOS 方法是为一般生物医学的研究的一个有用工具。 | Dian Jing Shiwen Zhang Wenjing Luo Xiaofei Gao Yi Men Chi Ma Xiaohua Liu Yating Yi Abhijit Bugde Bo O. Zhou Zhihe Zhao Quan Yuan Jian Q. Feng Liang Gao Woo-Ping Ge Hu Zhao | 2018 | Cell Research2018，28，8： | 18 |
| 3 | Four Triterpene Oligoglycosides from the seeds of Aesculus Chinensis显示文摘A pair of novel geometrically isomeric triterpenoid saponins named escins IVa and IVb .together with known escins la and fo. were isolated from the seeds of Aesculus chinensis. Their structures were determined on the basis of spectroscopic evidences and comparison. | Jing ZHAO Xiu Wei YANG Yu Xin CUI Xue Hui LIU Shu Yan LIU Hong Ying ZHI Ji Yong CHEN Fa Bing ZHU Yun Li XUE and Dian Bo LIU (National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University ,Beijing 1 00083)(Yantai Luye Pharmaceutical | 1999 | Chinese Chemical Letters1999，10，4： | 5 |
| 4 | The role of microRNAs in bone remodeling显示文摘Bone remodeling is balanced by bone formation and bone resorption as well as by alterations in the quantities and functions of seed cells, leading to either the maintenance or deterioration of bone status. The existing evidence indicates that micro RNAs(mi RNAs), known as a family of short non-coding RNAs, are the key post-transcriptional repressors of gene expression,and growing numbers of novel mi RNAs have been verified to play vital roles in the regulation of osteogenesis, osteoclastogenesis,and adipogenesis, revealing how they interact with signaling molecules to control these processes. This review summarizes the current knowledge of the roles of mi RNAs in regulating bone remodeling as well as novel applications for mi RNAs in biomaterials for therapeutic purposes. | Dian Jing Jin Hao Yu Shen Ge Tang Mei-Le Li Shi-Hu Huang Zhi-He Zhao | 2015 | International Journal of Oral Science2015，7，3： | 4 |
| 5 | A Family of Nonnormal Cayley Digraphs | Yan Quan FENG Dian Jun WANG Jing Lin CHEN | 2001 | Acta Mathematica Sinica,English Series2001，17，1： | 3 |
| 6 | High electrocatalytic hydrogen evolution activity on a coupled Ru and CoO hybrid electrocatalyst显示文摘Hydrogen evolution reaction (HER) is an essential step in converting renewable energy to clean hydrogen fuel. Exploring highly efficient, stable and cost-effective electrocatalysts is of crucial significance for sustainable HER. Here, we report the design of a coupled ruthenium/cobalt oxide (Ru/CoO) hybrid electrocatalyst for alkaline HER. In this hybrid metal/oxide system, the complicated alkaline HER pathways are overall facilitated;oxygen (O)-vacancy-abundant oxide enhances water splitting and Ru promotes successive hydrogen intermediates to generate hydrogen. The resulting Ru/CoO hybrid electrocatalyst exhibits significantly promoted catalytic activity compared with benchmark Ru catalyst, displaying an overpotential of 55 mV to generate a HER current density of 10 mA cm^-2, comparable with the state-of-the-art Pt/C catalyst and the most efficient alkaline HER electrocatalysts. Furthermore, the strong interaction of Ru nanoparticles with oxide support and the in-situ growth of oxide support on conductive substrate guarantee the long-term stability of as-fabricated Ru/CoO hybrid electrocatalyst. This newly designed hybrid catalyst with abundant metal/oxide interfaces may pave a new pathway for exploring efficient and stable HER electrocatalysts. | Jia-Xin Guo Dong-Yang Yan Kang-Wen Qiu Chuan Mu Dian Jiao Jing Mao Hui Wang Tao Ling | 2019 | Journal of Energy Chemistry2019，28，10： | 3 |
| 7 | NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts显示文摘The adaptor protein NUMB is involved in asymmetric division and cell fate determination and recognized as an antagonist of Notch.Previous studies have proved that Notch activation in osteoblasts contributes to a high bone mass. In this study, however, an osteopenic phenotype was found in 9-week-old mice using osteoblastic specific Col1a1–2.3-Cre to ablate both Numb and its homologue Numbl. The trabecular bone mass decreased dramatically while the cortical bone mass was unaffected. Here, the Notch signal was not activated,while the tensin homologue deleted on human chromosome 10(PTEN), which dephosphorylates phosphatidylinositide 3-kinases, was elevated, attenuating protein kinase B(Akt). The ubiquitination assay revealed that NUMB may physiologically promote PTEN ubiquitination in the presence of neural precursor cell-expressed developmentally downregulated protein 4–1. In addition, the deficiency of Numb/Numbl also activated the Hedgehog pathway through GLI1. This process was found to improve the ratio of the receptor activator of nuclear factor-k B ligand to osteoprotegerin, which enhanced the differentiation of osteoclasts and bone resorption. In conclusion, this study provides an insight into new functons of NUMB and NUMBL on bone homeostasis. | Ling Ye Feng Lou Fanyuan Yu Demao Zhang Chenglin Wang Fanzi Wu Xin Li Yilin Ping Xiao Yang Jing Yang Dian Chen Bo Gao Dingming Huang Peng Liu | 2018 | Bone Research2018，6，4： | 3 |
| 8 | Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis显示文摘The maturation and function of osteoblasts(OBs)rely heavily on the reversible phosphorylation of signaling proteins.To date,most of the work in OBs has focused on phosphorylation by tyrosyl kinases,but little has been revealed about dephosphorylation by protein tyrosine phosphatases(PTPases).SHP2(encoded by PTPN11)is a ubiquitously expressed PTPase.PTPN11 mutations are associated with both bone and cartilage manifestations in patients with Noonan syndrome(NS)and metachondromatosis(MC),although the underlying mechanisms remain elusive.Here,we report that SHP2 deletion in bone gamma-carboxyglutamate protein-expressing(Bglap+)bone cells leads to massive osteopenia in both trabecular and cortical bones due to the failure of bone cell maturation and enhanced osteoclast activity,and its deletion in Bglap+chondrocytes results in the onset of enchondroma and osteochondroma in aged mice with increased tubular bone length.Mechanistically,SHP2 was found to be required for osteoblastic differentiation by promoting RUNX2/OSTERIX signaling and for the suppression of osteoclastogenesis by inhibiting STAT3-mediated RANKL production by osteoblasts and osteocytes.These findings are likely to explain the compromised skeletal system in NS and MC patients and to inform the development of novel therapeutics to combat skeletal disorders. | Lijun Wang Huiliang Yang Jiahui Huang Shaopeng Pei Liyun Wang Jian Q.Feng Dian Jing Hu Zhao Henry M.Kronenberg Douglas C.Moore Wentian Yang | 2021 | Bone Research2021，9，1： | 3 |
| 9 | c-Met Is a Marker of Pancreatic Cancer Stem Cells and Therapeutic Target显示文摘 | Chenwei Li Jing–Jiang Wu Mark Hynes Joseph Dosch Bedabrata Sarkar Theodore H. Welling Marina Pasca di Magliano Diane M. Simeone | 2011 | Gastroenterology2011，，6： | 3 |
| 10 | Solving SAT problem by heuristic polarity decision-making algorithm显示文摘This paper presents a heuristic polarity decision-making algorithm for solving Boolean satisfiability (SAT). The algorithm inherits many features of the current state-of-the-art SAT solvers, such as fast BCP, clause recording, restarts, etc. In addition, a preconditioning step that calculates the polarities of variables according to the cover distribution of Karnaugh map is introduced into DPLL procedure, which greatly reduces the number of conflicts in the search process. The proposed approach is implemented as a SAT solver named DiffSat. Experiments show that DiffSat can solve many 'real-life' instances in a reasonable time while the best existing SAT solvers, such as Zchaff and MiniSat, cannot. In particular, DiffSat can solve every instance of Bart benchmark suite in less than 0.03 s while Zchaff and MiniSat fail under a 900 s time limit. Furthermore, DiffSat even outperforms the outstanding incomplete algorithm DLM in some instances. | JING MingE ZHOU Dian TANG PuShan ZHOU XiaoFang ZHANG Hua | 2007 | Science in China(Series F)2007，50，6： | 3 |
| 11 | Metabolic risk factors associated with sudden cardiac death(SCD)during acute myocardial ischemia显示文摘Sudden cardiac death(SCD)is the leading cause of death worldwide.Myocardial ischemia(MI)is the most common underlying causal disorder for SCD.Metabolic risks leading to SCD during acute MI are still not fully understood.Here,using tissue metabolomics,we aimed to investigate myocardial metabolic alterations relevant to SCD events in an acute MI rat model induced by coronary artery ligation(CAL).Thirty-four rats were successfully performed CAL,of which 13 developed lethal ventricular tachyarrhythmia(LVTA)-SCD and 7 developed severe atrioventricular block(AB)-SCD.Fourteen rats that survived within 70 min after the ligation were served as peer controls.The partial least squares-discriminant analysis plots demonstrated clear separations between the SCD rats and controls,indicating obvious differences in myocardial metabolome between these rats.The levels of isoleucine,lactate,glutamate choline,phosphorylcholine,taurine and asparagine in ischemic myocardia were positively associated with LVTA-SCD events;in contrast,the levels of alanine,urea,phenylalanine,linoleic acid,elaidic acid and stearic acid were inversely correlated with LVTA-SCD events.The levels of glutamate and urea were positively and negatively relevant to AB-SCD events,respectively.The dangerous metabolites indicated that lower levels of energy substrates,severe hypoxia,the inhibition of transamination and hyper sympathetic excitement and reactive oxygen species in myocardia were vulnerable to SCD during acute MI.The results suggest fatal metabolic alterations correlated with SCD events during acute MI,which could offer novel clues for the prevention or treatment of acute MI-related SCD. | Dian Wang Xingxing Wang Jiayan Wu Ruibing Su Jing Kong Xiaojun Yu | 2017 | Forensic Sciences Research2017，2，3： | 2 |
| 12 | Synthesis and Crystal Structure of N-((3-(2-nitrophenyl) propanoyl)oxy)-N-phenylbenzamide显示文摘The title compound N-((3-(2-nitrophenyl) propanoyl)oxy)-N-phenylbenzamide(C22H18N2O5,Mr = 390.38) was synthesized with nitrobenzene as the starting materials and structurally characterized by 1H NMR,13 C NMR,IR,H RMS(E-SI) and single-crystal X-ray diffraction.The crystalline structure of the title compound was studied in detail.The single-crystal X-ray diffraction revealed that the compound crystallizes in monoclinic,space group P21/n,with a = 14.4481(7),b = 8.0089(5),c = 16.6808(9) ?,α = 90.00(5),β = 100.069(5),γ = 90.00(5)°,Mr = 390.38,V = 1900.46(18) ?3,Z = 4,Dc = 1.364 g/cm-3,μ = 0.098,F(000) = 816.0,the final R = 0.0530 and w R = 0.1141 for 2525 observed reflections(I > 2σ(I)),R(all data) = 0.0813,w R(all data) = 0.1335,completeness to theta of 26.020 is 99.8% and GOF = 1.085.The crystal structure contains three branched chains with its center placed at the midpoint of N.The phenyl ring(C(8)~C(13)) makes a dihedral angle of 83.5(1) ℃ with the phenyl ring(C(1)~C(6)),and 80.5(1) ℃with the nitro-substituted benzene ring(C(17)~C(22)),indicating that the three rings are not coplanar.Hydrogen bonds(C(10)–H(10)···O(3)),(C(15)–H(15B)···O(4) and C(16)–H(16B)···O(4)) together with π-π stacking interactions stabilize the structure of the molecule.The preliminary biological test shows that the title compound has good antitumor activity against A549 in vitro with the IC50 value of 3.17 μmol. | LIU Xiao-Feng ZHANG Yang LI Jing ZHAO Jing-Si XI Na HE Dian | 2015 | Chinese Journal of Structural Chemistry2015，34，5： | 2 |
| 13 | Spatio-temporal Evolution on Geographic Boundaries of HFRS Endemic Areas in Shandong Province, China显示文摘Objective To take effective strategies and measures for the prevention and control of hemorrhagic fever with renal syndrome(HFRS) endemic areas by investigating its dynamic geographical boundaries in Shandong Province, China. Methods The incidence of HFRS from 1982 to 2008 in Shandong Prvince, China, was detected with inverse distance weighting(IDW) interpolation based on geographical information system(GIS). Dynamic geographical boundaries of HFRS endemic areas in Shandong Province, China, were analyzed by geographical boundary analysis. Results The HTN-type endemic areas of HFRS were located in Linyi City in phase 1(1982-1986), the SEO-type endemic areas of HFRS were located in Jining City in phase 2(1987-2003), and the endemic areas of HFRS in Jining City gradually disappeared and the endemic areas of HFRS with mixed-types of reservoir rodents were located in Linyi City in phase 3(2004-2008). Meanwhile, new endemic areas emerged in the northwestern Shandong province, China. Conclusion The SEO-type endemic areas of HFRS are located in western Shandong Province, China, and the HTN-type endemic areas of HFRS are located eastern Shandong Province, Chin, indicating that the endemic areas of HFRS should be vaccinated and rodents should be controlled. | LIU Yan Xun WANG Zhi Qiang GUO Jing TANG Fang SUN Xiu Bin XUE Fu Zhong KANG Dian Min | 2013 | Biomedical and Environmental Sciences2013，26，12： | 2 |
| 14 | Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine‑resistant treatment‑refractory schizophrenia:a 12‑week randomized,double‑blind,placebo‑controlled trial显示文摘Background:Although clozapine is an effective option for treatment-resistant schizophrenia(TRS),there are still 1/3 to 1/2 of TRS patients who do not respond to clozapine.The main purpose of this randomized,double-blind,placebocontrolled trial was to explore the amisulpride augmentation efficacy on the psychopathological symptoms and cognitive function of clozapine-resistant treatment-refractory schizophrenia(CTRS)patients.Methods:A total of 80 patients were recruited and randomly assigned to receive initial clozapine plus amisulpride(amisulpride group)or clozapine plus placebo(placebo group).Positive and Negative Syndrome Scale(PANSS),Scale for the Assessment of Negative Symptoms(SANS),Clinical Global Impression(CGI)scale scores,Repeatable Battery for the Assessment of Neuropsychological Status(RBANS),Treatment Emergent Symptom Scale(TESS),laboratory measurements,and electrocardiograms(ECG)were performed at baseline,week 6,and week 12.Results:Compared with the placebo group,amisulpride group had a lower PANSS total score,positive subscore,and general psychopathology subscore at week 6 and week 12(PBonferroni<0.01).Furthermore,compared with the placebo group,the amisulpride group showed an improved RBANS language score at week 12(PBonferroni<0.001).Amisulpride group had a higher treatment response rate(P=0.04),lower scores of CGI severity and CGI efficacy at week 6 and week 12 than placebo group(PBonferroni<0.05).There were no differences between the groups in body mass index(BMI),corrected QT(QTc)intervals,and laboratory measurements.This study demonstrates that amisulpride augmentation therapy can safely improve the psychiatric symptoms and cognitive performance of CTRS patients. | Ming‑Huan Zhu Zhen‑Jing Liu Qiong‑Yue Hu Jia‑Yu Yang Ying Jin Na Zhu Ying Huang Dian‑Hong Shi Min‑Jia Liu Hong‑Yang Tan Lei Zhao Qin‑Yu Lv Zheng‑Hui Yi Feng‑Chun Wu Ze‑Zhi Li | 2023 | Military Medical Research2023，10，4： | 1 |
| 15 | Antioxidant activities of different fractions of polysaccharide purified from Gynostemma pentaphyllum Makino显示文摘 | Wang Zhao - jing Luo Dian - hua | 2007 | Carbohydrate Polymers2007，68，： | 1 |
| 16 | Eleetroacupuncture improves neurological deficits and enhances proliferation and differentiation of endogenous nerve stem ceils in rats with focal cerebral ischemia 显示文摘 | Jing Tao Xie - Hua Xue Li - Dian Chen | 2010 | Neurol Res2010，32，2： | 1 |
| 17 | Dielectric properties of tomatoes assisting in the development of microwave pasteurization and sterilization processes显示文摘 | Jing Peng Juming Tang Yang Jiao Stewart G. Bohnet Diane M. Barrett | 2013 | LWT - Food Science and Technology2013，，： | 1 |
| 18 | Test factors affecting the performance of zinc–air battery显示文摘Zinc-air batteries provide a great potential for future large-scale energy storage.We assess the test factors that mainly affect the measured power density of the zinc-air battery.By fitting the polarization curves of the zinc-air batteries,we reveal the effect of testing parameters(electrode distance,electrolyte concentration,and oxygen flux)and preparation of catalysts ink on the activation,ohm,and concentration polarizations of the zinc-air battery.Finally,recommendations on evaluating the potentials of non-noblemetal electrocatalysts for applications in zinc-air batteries were given. | Dian Jiao Ziang Ma Jisi Li Yajing Han Jing Mao Tao Ling Shizhang Qiao | 2020 | Journal of Energy Chemistry2020，29，5： | 1 |
| 19 | Obesity rather than Metabolic Syndrome is a Risk Factor for Subclinical Hypothyroidism and Thyroid Autoimmunity显示文摘In recent years,the incidences of thyroid diseases have gradually increased,and they may be associated with the development of diagnostic technologies,elevated public health awareness,nuclear radiation,environmental pollution,changes in lifestyle,work stress,excessive iodine intake,and other factors.Because obesity can cause changes to the hypothalamic-pituitary-thyroid axis and deiodinase[1],obesity may be closely related to the high rate of thyroid diseases. | YAO Jin Yin LIU Peng ZHANG Wei WANG Ke Wei LYU Chun Peng ZHANG Zhi Wei CHEN Xiang Lan CHEN Yi WANG Xue Song DING Yong Xia MA Li Jun WANG Jing SUN Dian Jun | 2021 | Biomedical and Environmental Sciences2021，34，10： | 1 |
| 20 | Mapping of individual sensory nerve axons from digits to spinal cord with the transparent embedding solvent system显示文摘Achieving uniform optical resolution for a large tissue sample is a major challenge for deep imaging.For conventional tissue clearing methods,loss of resolution and quality in deep regions is inevitable due to limited transparency.Here we describe the Transparent Embedding Solvent System(TESOS)method,which combines tissue clearing,transparent embedding,sectioning and block-face imaging.We used TESOS to acquire volumetric images of uniform resolution for an adult mouse whole-body sample.The TESOS method is highly versatile and can be combined with different microscopy systems to achieve uniformly high resolution.With a light sheet microscope,we imaged the whole body of an adult mouse,including skin,at a uniform 0.8×0.8×3.5μm^(3) voxel resolution within 120 h.With a confocal microscope and a 40×/1.3 numerical aperture objective,we achieved a uniform sub-micron resolution in the whole sample to reveal a complete projection of individual nerve axons within the central or peripheral nervous system.Furthermore,TESOS allowed the first mesoscale connectome mapping of individual sensory neuron axons spanning 5 cm from adult mouse digits to the spinal cord at a uniform sub-micron resolution. | Yating Yi Youqi Li Shiwen Zhang Yi Men Yuhong Wang Dian Jing Jiayi Ding Qingjie Zhu Zexi Chen Xingjun Chen Jun-Liszt Li Yilong Wang Jun Wang Hanchuan Peng Li Zhang Wenjing Luo Jian Q.Feng Yongwen He Woo-Ping Ge Hu Zhao | 2024 | Cell Research2024，34，2： | 0 |
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