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| 1 | AOX contamination status and genotoxicity of AOX-bearing pharmaceutical wastewater显示文摘Adsorbable organic halogens(AOX) are a general indicator for the total amount of compounds containing organically bonded halogens. AOX concentrations and components were investigated along the wastewater treatment process in four large-scale pharmaceutical factories of China, and genotoxicity based on the SOS/umu test was also evaluated. The results showed that AOX concentrations in wastewater of four factories ranged from 4.6 to 619.4 mg/L, which were high but greatly different owing to differences in the raw materials and products. The wastewater treatment process removed 50.0%–89.9% of AOX, leaving 1.3–302.5 mg/L AOX in the effluents. Genotoxicity levels ranged between 2.1 and 68.0 μg 4-NQO/L in the raw wastewater and decreased to 1.2–41.2 μg 4-NQO/L in the effluents of the wastewater treatment plants(WWTPs). One of the main products of factory I, ciprofloxacin, was identified as the predominant contributor to its genotoxicity. However, for the other three factories, no significant relationship was observed between genotoxicity and detected AOX compounds. | Yawei Xie Lujun Chen Rui Liu | 2017 | Journal of Environmental Sciences2017，29，2： | 15 |
| 2 | Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers显示文摘 | Chen Wu Yuanyuan Xie Feng Gao Yanan Wang Yawei Guo Huanna Tian Yanshuang Li Wufang Fan | 2013 | Gene2013，，1： | 2 |
| 3 | Shear strength of an unsaturated weakly expansive soil显示文摘To study the weakly expansive clay obtained from a slope along Wuhan-Shiyan expressway in Hubei Province,soil-water property tests and some unsaturated triaxial tests with suction control were conducted,and the soil-water retention curve(SWRC) and unsaturated shear strength of this soil were obtained.Results show that the air-entry suction and the residual degree of saturation of the tested soil are 106 kPa and 8%,respectively.The boundary effect zone and the transition zone can be identified on the desorption curve,but the residual zone is not so obvious.The unsaturated shear strength increases as suction increases within the range of controlled suction in the test,and friction angle,~b,in the triaxial shear test is 17.6°.Based on the results,constitutive models for predicting the unsaturated shear strength using the SWRC were evaluated,and comparisons between prediction and measurement were made.It is concluded that for engineering purpose,the constitutive model should be carefully selected based on soil properties when predicting the unsaturated shear strength using the SWRC. | Weimin Ye Yawei Zhang Bao Chen Xiuhan Zhou Qiang Xie | 2010 | Journal of Rock Mechanics and Geotechnical Engineering2010，2，2： | 2 |
| 4 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
| 5 | Synthesis of starch esters in ionic liquids 显示文摘 | Xie Wenlai Shao Li Liu Yawei | 2010 | Journal of Applied Polymer Science2010，116，1： | 1 |
| 6 | A summary of seismic activities in and around China in 2021显示文摘In this article,we review the general characteristics of seismicity in and around China and the overall statistics of earthquake damage in 2021,focusing on several significant events and related scientific topics.Among them,the largest event is the M_(S)7.4 Madoi earthquake in Qinghai Province,northwest China.The event marks another M_(S)≥7 earthquake occurring near the boundary of the Bayan Har Block that has ended a remarkable quiescence of the M_(S)≥7 earthquakes within the Chinese mainland.In addition,the M_(S)6.4 Yangbi earthquake in Yunnan Province,southwest China draws the most attention because of its abundant foreshocks,which are well recorded by the densely distributed seismic stations in the surrounding regions.Regarding this event,we review several recent publications focusing on the Gutenberg-Richter b-value change and the physical mechanism of foreshocks associated with this sequence.The M_(S)6.0 Luxian earthquake in Sichuan Province,southwest China has caused serious damage with a relatively low magnitude,partly because the focal depth of the mainshock is relatively shallow (3.5 km).It is another strong earthquake occurring within the southeast Sichuan basin with low historical seismicity yet has increased significantly since 2015,probably due to shale gas development and associated hydraulic fracturing. | Yanyan Han Yang Zang Lingyuan Meng Yue Wang Shiguang Deng Yawei Ma Mengyu Xie | 2022 | Earthquake Research Advances2022，2，3： | 0 |
| 7 | Comparative study on hemodynamic environments around patient-specific carotid atherosclerotic plaques with different symmetrical features显示文摘Atherosclerotic plaque near the carotid sinus is a key risk factor for ischemic stroke.Although disturbed hemodynamic environments around atherosclerotic plaque had been investigated in many studies,the effect of their symmetrical features,especially longitudinal asymmetrical characteristics,had not been comparatively studied.In this study,three-dimensional carotid bifurcation models were established based on CT images of three patients with 50%stenosis and with different symmetrical features of carotid atherosclerotic plaques including concentric plaque,eccentric plaque,or eccentric longitudinal asymmetrical plaque.A healthy subject was chosen as the control.Wall shear stress(WSS)and oscillating shear index in the regions of upstream,downstream,downstream shoulders and regions around the point of maximum stenosis were analyzed.The results indicated that the maximum WSS around the eccentric longitudinal asymmetrical plaque were 8.6 times larger than that of the eccentric plaque and 1.9 times larger than that of the concentric plaque.And the distributions of WSS and OSI around the eccentric longitudinal asymmetric plaque were more disordered than those of the others.Our results highlighted the risk of the eccentric longitudinal asymmetrical plaque on plaque development and rupture and might provide a new index for evaluating the development of atherosclerosis. | Xianghui Gong Zhuqing Liang Yawei Wang Chi Zhang Sheng Xie Yubo Fan | 2021 | Medicine in Novel Technology and Devices2021，，3： | 0 |
| 8 | Study on the assimilation of the sulphate reaction rates based on WRF-Chem/DART显示文摘Sulphate(SO_(4)^(2-))is a main component of PM_(2.5)in China.The chemical formation mechanisms of sulphate are complex,and many air quality models have been used to analyse these mechanisms.To improve the accuracy of Weather Research Forecast-Chemistry(WRF-Chem)on sulphate,an alternative method is proposed in this paper.Moreover,data assimilation is performed to adjust the chemical reaction rates of sulphate.Based on the original reactions,a new sulphate parameterisation scheme,which includes two hypothetical reactions and six undetermined parameters,was added.Based on the WRF-Chem/DART(Data Assistance Research Testbed)system,the near-ground concentrations of SO_(4)^(2-),SO_(2),NO_(2),O_(3)and particulate matter are assimilated to adjust the six parameters.After adjusting the parameters,the new scheme can effectively solve the underestimation of SO_(4)^(2-)and overestimation of SO_(2).The simulation of SO_(4)^(2-)improved as the mean bias changed from-13.1μg m^(-3)to 3.5μg m^(-3)while SO_(2)improved from 17.0μg m^(-3)to 6.3μg m^(-3).The temporal and spatial variation characteristics predicted by the new scheme are consistent with the theoretical research results,indicating that the complex mechanism of sulphate formation could be replaced by the temporal and spatial variation characteristics predicted by the new scheme and that the parameters can be adjusted by data assimilation.Furthermore,the reaction rates of the SO_(4)^(2-)parameterisation scheme of the WRF-Chem model are improved in this study,and a new method for improving the accuracy of the air quality model is provided. | Congwu HUANG Chaoqun MA Tijian WANG Yawei QU Mengmeng LI Shu LI Bingliang ZHUANG Min XIE | 2023 | Science China Earth Sciences2023，66，10： | 0 |
| 9 | Research on Measurement Method of Muffler Performance under High Temperature and High-Speed Airflow Conditions显示文摘Ignoring the influence of flow velocity and flow temperature on muffling performance,performance tests were conducted without airflow in the development phase of the muffler which accounts to the difficulty of obtaining a perfect match between the actual noise reduction effect and the design goal.Based on the two-load test theory,a set of high-temperature and high-speed airflow simulation measurement devices for the muffler has been built.In order to avoid the impact of high-temperature and high-speed airflow on the sensor,a high temperature resistant sensor holder has been designed for the test rig.The sound pressure has been measured in the pipe by using the lead-out measurement.In addition,a variable impedance load is placed at the end of the test tube to realize the switch between two different impedance loads by the wave handle of the variable impedance load.A sound source correction method is proposed to decrease the random fluctuation of the spectral characteristics of the output noise signal,which is caused by the acoustic impedance variation at the connection between the transition pipeline and the combined sound source system.Finally,an acoustic software has been used to calculate the transmission loss of the muffler in the presence of high temperature airflow.In comparing the experimental measurements and the simulation results,the small difference shows that:the bench not only can effectively simulate high-temperature and flow velocity environment of the engine but also accurately test the transmission loss of the muffler. | Liping Xie Chihua Lu Zhien Liu Yawei Zhu | 2020 | Journal of Beijing Institute of Technology2020，29，2： | 0 |
| 10 | Single-cell analyses identify anaphase-promoting complex subunit 11 as a switch controlling neuronal differentiation of glioblastoma cells显示文摘Glioblastoma(GBM)is the most common and lethal malignancy in the central nervous system.1 One of the major difficulties in treatment is that the initial clinical diagnosis of GBM is already WHO grade IV,without recognizable lower-grade precursor lesions.Copy number variations(CNVs)were found to appear in malignant cells several years before the initial diagnosis of GBM.2 Less differentiation and more aggressive phenotypes were observed in GBM cells with a higher degree of CNVs.3 Additionally,CNVs provide more accurate stratification of clinical outcomes than does the WHO grade system.4 Therefore,we reasoned that differentially expressed genes(DEGs)among GBM cells with different CNV statuses would be significant for the aggressiveness of GBM.Here we leveraged the single-cell RNA-sequencing(scRNA-seq)to construct the CNV profile of GBM at single-cell resolution,divided GBM cells into different clusters according to their CNV statuses,and investigated the molecular functions of DEGs among GBM clusters.Through a series of experiments,we identified anaphase-promoting complex subunit 11(ANAPC11)as a switch controlling the neuronal differentiation of GBM cells,providing a novel alternative for the development of differentiation-inducing therapy to overcome GBM. | Runwei Yang Ziyu Wang Songtao Qi Bowen Ni Jinglin Guo Kaishu Li Haimin Song Sidi Xie Yunxiao Zhang Xirang Wang Chunmao He Guanglong Huang Yawei Liu | 2023 | Genes & Diseases2023，10，5： | 0 |
| 11 | An Innovation of Evaluation and Design of Vehicle Acceleration Sound Based on EEG Signals显示文摘There is a bottleneck in the design of vehicle sound that the subjective perception of sound quality that combines multiple psychological factors fails to be accurately and objectively quantified.Therefore,EEG signals are introduced in this paper to investigate the evaluation and design method of vehicle acceleration sound with powerful sound quality.Firstly,the experiment of EEG acquisition and subjective evaluation under the stimulation of powerful vehicle sounds is conducted,respectively,then three physiological EEG features of PSD_β,PSD_γand DE are constructed to evaluate the vehicle sounds based on the correlation analysis algorithms.Subsequently,the Adaptive Genetic Algorithm(AGA)is proposed to optimize the Elman model,where an intelligent model(AGA–Elman)is constructed to objectively predicate the perception of subjects for the vehicle sounds with powerful sound quality.The results demonstrate that the error of the constructed AGA–Elman model is only 2.88%,which outperforms than the traditional BP and Elman model;Finally,two vehicle acceleration sounds(Design1 and Design2)are designed based on the constructed AGA–Elman model from the perspective of order modulation and frequency modulation,which provide the acoustic theoretical guidance for the design of vehicle sound incorporating the EEG signals. | Liping Xie XinYou Lin Wan Chen Zhien Liu Yawei Zhu | 2024 | Journal of Bionic Engineering2024，21，1： | 0 |
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