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| 1 | Two gap-free reference genomes and a global view of the centromere architecture in rice显示文摘Rice(Oryza sativa),a major staple throughout the world and a model system for plant genomics and breeding,was the first crop genome sequenced almost two decades ago.However,reference genomes for all higher organisms to date contain gaps and missing sequences.Here,we report the assembly and analysis of gap-free reference genome sequences for two elite O.sativa xian/indica rice varieties,Zhenshan 97 and Minghui 63,which are being used as a model system for studying heterosis and yield.Gap-free reference genomes provide the opportunity for a global view of the structure and function of centromeres.We show that all rice centromeric regions share conserved centromere-specific satellite motifs with different copy numbers and structures.In addition,the similarity of CentO repeats in the same chromosome is higher than across chromosomes,supporting a model of local expansion and homogenization.Both genomes have over 395 non-TE genes located in centromere regions,of which∼41%are actively transcribed.Two large structural variants at the end of chromosome 11 affect the copy number of resistance genes between the two genomes.The availability of the two gap-free genomes lays a solid foundation for further understanding genome structure and function in plants and breeding climate-resilient varieties. | Jia-Ming Song Wen-Zhao Xie Shuo Wang Yi-Xiong Guo Dal-Hoe Koo Dave Kudrna Chenbo Gong Yicheng Huang Jia-Wu Feng Wenhui Zhang Yong Zhou Andrea Zuccolo Evan Long Seunghee Lee Jayson Talag Run Zhou Xi-Tong Zhu Daojun Yuan Joshua Udall Weibo Xie Rod AWing Qifa Zhang Jesse Poland Jianwei Zhang Ling-Ling Chen | 2021 | Molecular Plant2021，14，10： | 9 |
| 2 | Effects of stress dependent electrochemical reaction on voltage hysteresis of lithium ion batteries显示文摘Intercalation of lithium ions into the electrodes of lithium ion batteries is affected by the stress of active materials, leading to energy dissipation and stress dependent voltage hysteresis. A reaction-diffusion-stress coupling model is established to investigate the stress effects under galvanostatic and potentiostatic operations. It is found from simulations that the stress hysteresis contributes to the voltage hysteresis and leads to the energy dissipation. In addition, the stress induced voltage hysteresis is small in low rate galvanostatic operations but extraordinarily significant in high rate cases. In potentiostatic operations, the stresses and stress induced overpotentials increase to a peak value very soon after the operation commences and decays all the left time. Therefore,a combined charge-discharge operation is suggested, i.e., first the galvanostatic one and then the potentiostatic one. This combined operation can not only avoid the extreme stress during operations so as to prevent electrodes from failure but also reduce the voltage hysteresis and energy dissipation due to stress effects. | Haoliang LI Yicheng SONG Bo LU Junqian ZHANG | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，10： | 3 |
| 3 | Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways显示文摘The immune system initiates robust immune responses to defend against invading pathogens or tumor cells and protect the body from damage,thus acting as a fortress of the body.However,excessive responses cause detrimental effects,such as inflammation and autoimmune diseases.To balance the immune responses and maintain immune homeostasis,there are immune checkpoints to terminate overwhelmed immune responses.Pathogens and tumor cells can also exploit immune checkpoint pathways to suppress immune responses,thus escaping immune surveillance.As a consequence,therapeutic antibodies that target immune checkpoints have made great breakthroughs,in particular for cancer treatment.While the overall efficacy of immune checkpoint blockade(ICB)is unsatisfactory since only a small group of patients benefted from ICB treatment.Hence,there is a strong need to search for other targets that improve the efficacy of ICB.Ubiquitination is a highly conserved process which participates in numerous biological activities,including innate and adaptive immunity.A growing body of evidence emphasizes the importance of ubiquitination and its reverse process,deubiquitination,on the regulation of immune responses,providing the rational of simultaneous targeting of immune checkpoints and ubiquitination/deubiquitination pathways to enhance the therapeutic efficacy.Our review will summarize the latest findings of ubiquitination/deubiquitination pathways for anti-tumor immunity,and discuss therapeutic significance of targeting ubiquitination/deubiquitination pathways in the future of immunotherapy. | Jiaxin Liu Yicheng Cheng Ming Zheng Bingxiao Yuan Zimu Wang Xinying Li Jie Yin Mingxiang Ye Yong Song | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 4 | Two-way coupled analysis of lithium diffusion and diffusion induced finite elastoplastic bending of bilayer electrodes in lithium-ion batteries显示文摘A fully coupling model for the diffusion induced finite elastoplastic bending of bilayer electrodes in lithium-ion batteries is proposed. The effect of the mechanical stress on the lithium diffusion is accounted for by the mechanical part of the chemical potential derived from the Gibbs free energy along with the logarithmic stress and strain. Eight dimensionless parameters, governing the stress-assisted diffusion and the diffusion induced elastoplastic bending, are identified. It is found that the finite plasticity starting from the interface of the bilayer increases the chemical potential gradient and thereby facilitates the lithium diffusion. The full plastic flow makes the abnormal lithium concentration distribution possible, i.e., the concentration at the lithium inlet can be lower than the concentration at the interface(downstream). The increase in the thickness of the active layer during charging is much larger than the eigen-stretch due to lithiation, and this excess thickening is found to be caused by the lithiation induced plastic yield. | Jun YIN Xianjun SHAO Bo LU Yicheng SONG Junqian ZHANG | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，11： | 2 |
| 5 | Small-Animal PET of Tumor Damage Induced by Photothermal Ablation with ^sup 64^Cu-Bis-DOTA-Hypericin显示文摘 | Song Shaoli Xiong Chiyi Zhou Min Lu Wei Huang Qian Ku Geng Zhao Jun Flores Leo G Ni Yicheng Li Chun | 2011 | The Journal of Nuclear Medicine2011，，5： | 1 |
| 6 | Adaptive spacecraft attitude tracking controller design based on similar skew-symmetric structure 显示文摘 | LILT Yicheng ZHANG Tao SONG Jingyan | 2010 | Chinese Journal of Aeronau- tics: Science Direct2010，23，： | 1 |
| 7 | Internet of Things Intrusion Detection System Based on Convolutional Neural Network显示文摘In recent years, the Internet of Things (IoT) technology has developedby leaps and bounds. However, the large and heterogeneous networkstructure of IoT brings high management costs. In particular, the low costof IoT devices exposes them to more serious security concerns. First, aconvolutional neural network intrusion detection system for IoT devices isproposed. After cleaning and preprocessing the NSL-KDD dataset, this paperuses feature engineering methods to select appropriate features. Then, basedon the combination of DCNN and machine learning, this paper designs acloud-based loss function, which adopts a regularization method to preventoverfitting. The model consists of one input layer, two convolutional layers,two pooling layers and three fully connected layers and one output layer.Finally, a framework that can fully consider the user’s privacy protection isproposed. The framework can only exchange model parameters or intermediateresults without exchanging local individuals or sample data. This paperfurther builds a global model based on virtual fusion data, so as to achievea balance between data privacy protection and data sharing computing. Theperformance indicators such as accuracy, precision, recall, F1 score, and AUCof the model are verified by simulation. The results show that the model ishelpful in solving the problem that the IoT intrusion detection system cannotachieve high precision and low cost at the same time. | Jie Yin Yuxuan Shi Wen Deng Chang Yin Tiannan Wang Yuchen Song Tianyao Li Yicheng Li | 2023 | Computers, Materials & Continua2023，，4： | 0 |
| 8 | Analysis of diffusion induced elastoplastic bending of bilayer lithium-ion battery electrodes显示文摘Bilayer electrode, composed of a current collector layer and an active material layer, has great potential in applications of in-situ electrochemical experiments due to the bending upon lithiation. This paper establishes an elastoplastic theory for the lithiation induced deformation of bilayer electrode with consideration of the plastic yield of current collector. It is found that the plastic yield of current collector reduces the restriction of current collector to an active layer, and therefore, enhances in-plane stretching while lowers down the rate of electrode bending. Key parameters that influence the elastoplastic deformation are identified. It is found that the smaller thickness ratio and lower elastic modulus ratio of current collector to an active layer would lead to an earlier plastic yield of the current collector, the larger in-plane strain, and the smaller bending curvature, due to balance between the current collector and the active layer. The smaller yield stress and plastic modulus of current collector have similar impacts on the electrode deformation. | Dawei LI Zongzan LI Yicheng SONG Junqian ZHANG | 2016 | Applied Mathematics and Mechanics(English Edition)2016，37，5： | 0 |
| 9 | A modified pulse charging method for lithium-ion batteries by considering stress evolution,charging time and capacity utilization显示文摘The stress evolution, total charging time and capacity utilization of pulse charging (PC) method are investigated in this pape匚 It is found that compared to the conventional constant current (CC) charging method, the PC method can accelerate the charging process but will inevitably cause an increase in stress and a decrease in capacity. The charging speed for PC method can be estimated by the mean current. By introducing stress control, a modified PC method called the PCCC method, which starts with a PC operation followed by a CC operation, is proposed. The PCCC method not only can accelerate charging process but also can avoid the stress raising and capacity loss occurring in the PC method. Furthermore, the optimal pulsed current density and switch time in the PCCC method is also discussed. | Yanfei ZHAO Bo LU Yicheng SONG Junqian ZHANG | 2019 | Frontiers of Structural and Civil Engineering2019，13，2： | 0 |
| 10 | A pre-strain strategy of current collectors for suppressing electrode debonding in lithium-ion batteries显示文摘The interfacial debonding between the active layer and the current collector has been recognized as a critical mechanism for battery fading,and thus has attracted great efforts focused on the related analyses.However,much still remains to be studied regarding practical methods for suppressing electrode debonding,especially from the perspective of mechanics.In this paper,a pre-strain strategy of current collectors to alleviate electrode debonding is proposed.An analytical model for a symmetric electrode with a deformable and limited-thickness current collector is developed to analyze the debonding behavior involving both a pre-strain of the current collector and an eigen-strain of the active layers.The results reveal that the well-designed pre-strain can significantly delay the debonding onset(by up to 100%)and considerably reduce the debonding size.The critical values of the pre-strain are identified,and the pre-strain design principles are also provided.Based on these findings,this work sheds light on the mechanical design to suppress electrode degradation. | Bo RUI Bo LU Yicheng SONG Junqian ZHANG | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，4： | 0 |
| 11 | Understanding Modulus Variation of the Active Layers of Silicon Composite Electrodes显示文摘The variation of the effective modulus of silicon composite electrodes,which is a fundamental feature to analyze the coupled mechanical–electrochemical behavior of Si-based electrodes in high-capacity lithium-ion batteries,remains qualitatively controversial.To clarify the contradictory experimental results,numerical modeling of a representative volume element with silicon particles,carbon-binder domains(CBDs),and pores has been performed for the lithiation process.The key parameters for modulus variation were identified and evaluated.A mesostructure change is proposed to be a crucial mechanism that affects the modulus variation,and silicon softening is another key mechanism.Silicon softening and the decreasing CBD volume fraction collectively result in a decrease in the effective modulus of the composite,whereas an increase in the silicon volume fraction along with a decrease in porosity has the opposite effect.The findings of this work provide an in-depth and fundamental understanding of the mechanical properties of silicon composite electrodes. | Bowen Sun Yanfei Zhao Yicheng Song Junqian Zhang Bo Lu | 2022 | Acta Mechanica Solida Sinica2022，35，6： | 0 |
| 12 | Studies on the relationship between the senescence of Leydig cells and the regulation of insulin/IGF-1 signaling pathway in rats delayed by Heshouwuyin显示文摘This work aims to investigate the relationship between the senescence of testicular Leydig cells and the regulation of insulin/IGF-1 signaling pathway in rats delayed by Heshouwuyin.The oxidative damage technique was used to establish Leydig cell aging model.Flow cytometry was used to detect the changes of cell cycle in each group.Detection of mRNA and protein expression levels of key genes of insulin/IGF-1 signaling pathway in Leydig cells by Real-time PCR,immunofluorescence and Western blotting.Cells were treated with insulin receptor/IGF receptor specific inhibitor BMS 754807,flow cytometry was used to detect the apoptotic level of Leydig cells.The results showed that compared with the normal group,the proportion ofβgalactosidase positive cells in the aging group was more than 60%(P<0.05),and the proportion of G1 phase increased significantly,while that of S phase decreased significantly(P<0.05);Changes in the expression of key genes of the insulin/IGF-1 signaling pathway:The expression levels of INSR,IRS1,IRS2,IGF-1 mRNA and protein in the aging group were significantly lower than those in the normal group(P<0.05),and the mRNA expression of IGFBP3 was significantly higher than in the normal group(P<0.05),Heshouwuyin can reverse the above phenomenon. | Song Yicheng Jiang Liping Niu Shuang Duan Yulei Zhu Juan Niu Siyun Qi Feng | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 13 | Analysis of thermal management and anti-mechanical abuse of multi-functional battery modules based on magneto-sensitive shear thickening fluid显示文摘Electric vehicles(EVs)have garnered significant attention as a vital driver of economic growth and environmental sustainability.Nevertheless,ensuring the safety of high-energy batteries is now a top priority that cannot be overlooked during large-scale applications.This paper proposes an innovative active protection and cooling integrated battery module using smart materials,magneto-sensitive shear thickening fluid(MSTF),which is specifically designed to address safety threats posed by lithium-ion batteries(LIBs)exposed to harsh mechanical and environmental conditions.The theoretical framework introduces a novel approach for harnessing the smoothed-particle hydrodynamics(SPH)methodology that incorporates the intricate interplay of non-Newtonian fluid behavior,capturing the fluid-structure coupling inherent to the MSTF.This approach is further advanced by adopting an enhanced Herschel-Bulkley(H-B)model to encapsulate the intricate rheology of the MSTF under the influence of the magnetorheological effect(MRE)and shear thickening(ST)behavior.Numerical simulation results show that in the case of cooling,the MSTF is an effective cooling medium for rapidly reducing the temperature.In terms of mechanical abuse,the MSTF solidifies through actively applying the magnetic field during mechanical compression and impact within the battery module,resulting in 66%and 61.7%reductions in the maximum stress within the battery jellyroll,and 31.1%and 23%reductions in the reaction force,respectively.This mechanism effectively lowers the risk of short-circuit failure.The groundbreaking concepts unveiled in this paper for active protection battery modules are anticipated to be a valuable technological breakthrough in the areas of EV safety and lightweight/integrated design. | Yang XIONG Bo LU Yicheng SONG Junqian ZHANG | 2024 | Applied Mathematics and Mechanics(English Edition)2024，45，3： | 0 |
| 14 | Prelithiation design for suppressing delamination in lithium-ion battery electrodes显示文摘Prelithiation has been intensively investigated in high-capacity lithiumion batteries(LIBs).However,the optimization of prelithiation degrees for long service life of LIBs still remains a challenge.The positive effect of prelithiation on suppressing degradation of LIBs,besides directly pursuing the high first Coulomb efficiency which has been widely reported in the literature,is revealed and discussed based on an analytical model focusing on the interfacial delamination in electrodes.For full charge-discharge cycling,well-designed prelithiation can effectively suppress the delamination and reduce the debonding size by approximately 25%,compared with the case without prelithiation.For the strategy combining partial charge-discharge cycling and prelithiation,the largest reversible capacity without debonding can be significantly improved by approximately100%with well-designed prelithiation.This work is expected to provide a prelithiation design principle and further improve the mechanical stability of LIB electrodes. | Yifei QIAN Bo LU Yinhua BAO Yanfei ZHAO Yicheng SONG Junqian ZHANG | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，12： | 0 |
| 15 | A Template-Based Approach for Automatic Mapping between Business Process and BPEL Process显示文摘In order to support just-in-time reconfiguration of business process execution language (BPEL) process, a tem-plate-based mapping method is proposed to map business level process to BPEL process. The method builds up mapping rela-tionships between the key points of business level process and BPEL process, which helps users to adjust the business level process with simplified operations, and automatically maps the changes to BPEL. In addition, a case of the application of the method in a clothing enterprise was illustrated. | LIANG Ying TIAN Jiuming HU Songlin SONG Yicheng ZHANG Yongdong | 2008 | Wuhan University Journal of Natural Sciences2008，13，4： | 0 |
| 16 | STRUCTURE AND FERROMAGNETIC RESONANCE OF Fe/Cu SUPERLATTICES显示文摘Metallic Fe/Cu superlattice films on glass substrates were prepared by a dc-magnetionsputtering system.The modulation behaviors and the crystal structures of the films were ex-amined by X-ray diffraction and transmission electron microscopy(TEM)respectively.Their magnetic properties were studied by means of ferromagnetic resonnance spectrometerand the vibrating sample magnetometer.The results show that there exists a strong magneticcoupling between the neighbouring Fe layers and it is the coupling that affectes the magneticproperties of these superlattice films. | BI Siyun MA Xiaoding SONG Ruitian MEI Liangmo ZHAO Jiangao GUO Yicheng Shandong University,Jinan,China | 1991 | Acta Metallurgica Sinica(English Letters)1991，4，8： | 0 |
| 17 | On stress-induced voltage hysteresis in lithium ion batteries:Impacts of surface effects and interparticle compression显示文摘Application of silicon in high capacity electrodes of lithium ion battery suffers from stress effects and, in turn, affects voltage performance of battery. This paper established a reaction-diffusion-stress coupled model and investigated the stress induced voltage hysteresis with consideration of diffusion induced stress, surface effects and interparticle compression. It was found stress and stress induced voltage hysteresis depended on particle size. In big particles, diffusion induced stress is dominant and leads to significant hysteresis in both stress and voltage, indicating energy dissipation due to stress effects. In small particles, e.g.,radius of dozens nanometers, diffusion induced stress was negligible while surface effects played dominant role, leading to nearly vanished voltage hysteresis shifting away from equilibrium potential. According to calculation, particle sizes around 100 nm are appropriate choice for electrode design as both diffusion induced stress and surface effects are insignificant. Finally,interparticle compression pushed the stress hysteresis to compressive side and led to early termination of lithiation at cut-off voltage. Denser electrode would enhance this effect. It indicated that there must be a limit of mixing ratio of silicon because higher interparticle compressive stress due to more introduced silicon would impede the battery from fully charged. | JIN ChuanJian LI HaoLiang SONG YiCheng LU Bo SOH A. K. ZHANG JunQian | 2019 | Science China(Technological Sciences)2019，62，8： | 0 |
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