|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Spatial structure of valley economic development in the mountainous areas in Beijing显示文摘山谷经济是在被山谷开发的各种各样的人物定义的多山的区域开发的一个新模式,并且是区分为多山的区域开发的节俭的地理模式。在在山谷的不同多山的元素的分发的特殊空间联合关系是为山发展研究的新题目,并且如此的研究为研究和惯例两个都是有意义的。把简短探索基于关于多山的区域开发和追随者的长期的研究进涵义和山谷经济的空间组织进程,作者在北京多山的区域分析了山谷经济的开发的现在的状况,在北京多山的区域学习了特征和山谷经济的空间结构的变化的影响,并且最后建议了山谷经济的空间结构的合理安排山谷经济在新时代在北京多山的区域在发展和功能的转变起一个重要作用,这在这研究被考虑。第一,山谷经济没被行政边界构画出,并且它沿着主要交通线粗略地在多山的区域连接大多数村庄。因此,山谷经济能在多山的区域对发展施加积极影响,至少在象在多山的区域和农村、城市的区域的协调发展的工业结构的重新整理那样的方面。另外,在北京多山的区域的山谷经济在第二等的集中的一个空间组织阶段被发展,这被发现,它被节省资源的、生态的保护和工业优化描绘。因此,山谷经济的发展将在多山的区域对在生态的保护和经济开发之间的协作有用,并且将支持多山的区域的综合发展。在北京多山的区域的山谷经济的发展中的模式将在北京多山的区域的功能的角色的转变为决策提供基础,并且在另一方面,将在北京外面在多山的区域为研究介绍经验。 | ZHANG Yifeng JIA Dameng ZHANG Hongye TAN Jie SONG Siyu SUN Ruifeng | 2011 | Journal of Geographical Sciences2011，21，2： | 9 |
| 2 | The influence of intimacy on the ’iterative reactions’ during OX-ZEO process for aromatic production显示文摘The oxide-zeolite process provides a promising way for one-step production of aromatics from syngas,whereas the reasons for the dramatic effect of intimacy between oxide and zeolite in the composite catalyst on the product selectivity are still unclear. In order to explore the optimal intimacy and the essential influence factors, ZnCrOxcombined with ZSM-5 are employed to prepare the composite catalysts with different distances between the two components by changing the mixing methods. An aromatic selectivity of 74%(with CO conversion to be 16%) is achieved by the composite catalyst when the intimacy is in the range of nanometer. A so-called ‘iterative reactions’ mechanism of intermediates over oxides is then proposed and studied: the intermediate chemical can undergo a hydrogenation reaction on oxide.So the shorter the intermediates stay on oxide, the more of chance for C-C coupling takes place on zeolite to form aromatics. Moreover, the aero-environments of reaction is found to impact on the extent of iterative reaction as well. Therefore, when the intimacy between the two components changes, the extent of iterative reactions vary, resulting in alteration of product distribution. This work provides new insight in understanding the mechanisms during the complex process of OX-ZEO composite catalysis and sheds light to the design of a high-yield catalyst for synthetization of aromatics from syngas. | Xiaoli Yang Ting Sun Junguo Ma Xiong Su Ruifeng Wang Yaru Zhang Hongmin Duan Yanqiang Huang Tao Zhang | 2019 | Journal of Energy Chemistry2019，28，8： | 4 |
| 3 | Association of single nucleotide polymorphisms of brain-derived neurotrophic factor gene and multidrug resistance 1 gene to refractory epilepsy in Chinese Han children显示文摘BACKGROUND:There are two hypotheses for the underlying cause of refractory epilepsy:'target'and'transport'.Studies have shown that brain-derived neurotrophic factor(BDNF) is over-expressed in refractory epilepsy.Multidrug resistance 1(MDR1) gene encodes for P-glycoprotein,the primary ATP-binding cassette transporter in the human body.Some single nucleotide polymorphisms of the MDR1 gene have been associated with refractory epilepsy. OBJECTIVE:To investigate the association between BDNF gene C270T polymorphism and MDR1 T-129C polymorphism with refractory epilepsy in Chinese Han children through the use of polymerase chain reaction(PCR)-restriction fragment length polymorphism analysis. DESIGN,TIME AND SETTING:A case-control,genetic association study was performed at the Central Laboratory,Third Xiangya Hospital of Central South University from June 2005 to November 2007. PARTICIPANTS:A total of 84 cases of unrelated children with epilepsy,including 41 cases of refractory epilepsy and 43 cases of drug-responsive epilepsy,were enrolled.An additional 30 healthy,Chinese Han children,whose ages and gender matched the refractory epilepsy patients, were selected as normal controls. METHODS:Venous blood was collected and genomic DNA was extracted from the blood specimens.C270T polymorphism in BDNF gene and T-129C polymorphism in MDR1 gene were genotyped using PCR-restriction fragment length polymorphism analysis.Association analysis using the Ftest and Chi-square test was statistically performed between C270T polymorphism in BDNF gene and T-129C polymorphism in MDR1 gene and refractory epilepsy. MAIN OUTCOME MEASURES:The distribution of genotypes and allele frequencies of C270T polymorphism in BDNF gene and T-129C polymorphism in MDR1 gene. RESULTS:The distribution of CC,CT,and TT genotypes,as well as C and T allele frequencies,in the BDNF gene was not significantly different between the refractory epilepsy group, drug-responsive epilepsy group,or the normal control group(P>0.05).The distribution of TT genotype and T allele frequencies of the MDR1 gene was significantly different in the refractory epilepsy group compared with the drug-responsive epilepsy and normal control groups(P<0.05). Comparison of haplotype combinations demonstrated that there were no significant differences in combinations of TT+CC,TT+CT,TC+CC,and TC+CT among the three groups(P>0.05). CONCLUSION:C270T polymorphism of the BDNF gene was not associated with refractory epilepsy in Chinese Han children,but T-129C polymorphism in the MDR1 gene was associated with refractory epilepsy in Chinese Han children.The TT genotype and T allele frequencies could serve as susceptibility loci for refractory epilepsy.Interactions between C270T in BDNF gene and T-129C in MDR1 gene were not observed in refractory epilepsy in Chinese Han children. | Guangxin Wang Zuocheng Yang Ruifeng Jin Ruopeng Sun | 2009 | Neural Regeneration Research2009，4，11： | 2 |
| 4 | Cloning and Expression Analysis of p26 Gene in Artemia sinica显示文摘蛋白质 p26 是作为分子的女伴工作由在胚胎的 development.A 期间阻止不可逆的蛋白质损坏保护胚胎的小热吃惊蛋白质 p26 基因的 542 bp 碎片被克隆并且定序。碎片编码了 174 氨基酸残余,氨基酸顺序包含了 alpha-crystallin 领域。种系发生的分析证明八张 Artemia 人口被划分成四个主要的组。Artemia 中国一(YC ) 属于东亚两性的组。在 A 的不同发展阶段的 p26 基因的表示。中国一用克隆并且定序跟随的即时量的聚合酶链反应被确定。在 p26 基因表达和胚胎的开发的数量之间的关系被分析。结果显示 p26 的巨大的数量在 A 的发展期间被表示。中国一。在 0 h 的发展阶段,一。中国一表示了 p26 的高水平。当开发继续了, p26 基因的表达式层次显著地减少了。有在 16 手的发展阶段的 p26 基因表达的小数量 24 h。我们断定 p26 可能涉及在胚胎的开发期间保护胚胎免受生理的应力的伤害。 | Lijuan JIANG Lin HOU Xiangyang ZOU Ruifeng ZHANG Jiaqing WANG Wenjing SUN Xintao ZHAO Jialu AN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，5： | 1 |
| 5 | The weeping characteristic of submerged multi-orifice plate显示文摘Weeping is an adverse phenomenon which results in higher pressure drop and poorer aeration performance.Visual experiments have been conducted to study the mechanism by which weeping impairs the work performance of multi-orifice plate.A theoretical model is improved to analyze the weeping phenomenon of multiorifice plate based on potential flow theory.The relations of different bubbling conditions and weeping rate are analyzed.Weeping condition and average weeping rate have relation with the driven pressure differential and dynamic variation of gas chamber pressure.In addition,a set of experiments are designed to study the influence of various factors on weeping rate.The bubble coalescence during bubble formation is a fatal factor determining weeping rate,so the relation between weeping rate and gas flow rate is concerned with the pitch of orifices and orifice diameter.There is a critical plate thickness which is in favor of weeping. | Jiming Wen Ruifeng Tian Sichao Tan Qiunan Sun Haifeng Gu | 2020 | Chinese Journal of Chemical Engineering2020，28，4： | 1 |
| 6 | Disposition and fate of polyoxyethylene glycerol ricinoleate as determined by LC-Q-TOF MS coupled with MS^(ALL),SWATH and HR MS/MS techniques显示文摘Polyoxyethylene glycerol ricinoleate(PGR) serves as a solubilizer/emulsifier that is commonly used in pharmaceutical formulations despite being associated with severe anaphylactoid hypersensitivity reactions.Cremophor EL?(CrEL) is the most representative PGR produced from reacting ethylene oxide with castor oil.To help clarify the cause of side effects and potentially improve the safety of PGR-based drug delivery vehicle,we have developed separate but related analytical methods for the quantitation of CrEL and its main metabolites,glycerol ethoxylate(GE) and ricinoleic acid(RA).Since CrEL and GE are highly disperse mixtures of polymers that are not amenable to analysis by conventional liquid chromatographytandem mass spectrometry(LC-MS/MS),we used liquid chromatography-triple-quadrupole-time-of-flight mass spectrometry(LC-Q-TOF MS) combined with product ion data acquisition by MSALLand sequential window acquisition of all theoretical fragments mass spectrometry(SWATH MS),respectively to perform the analysis.In contrast,RA is a single molecular entity that could be readily analyzed using conventional LC-HR MS/MS.Selection of specific fragment ions for CrEL,GE,RA and their internal standards enabled a precise quantitation of such a complex analytes system in rat plasma after a single and simple sample preparation method.Assay validation indicated linearity for CrEL,GE and RA over the concentration ranges 0.2~20.0 μg/mL,0.1~10.0 μg/mL and 0.1~20.0 μg/m L,respectively with satisfactory results for other validation parameters.A subsequent pharmacokinetic study involving single intravenous 200 mg/kg injections of CrEL to rats showed the methods enable comprehensive and high throughput quantitation of CrEL and its metabolites in a biological matrix.Our combination of assays provides effective application in investigating the cause of the hypersensitivity reaction of PGR and potentially to improve its safety for using as a vehicle in drug formulations. | Ruifeng Bai Dong Sun Yuqin Shan Zhiqiong Guo Dafeng Chu John Paul Fawcett Jingkai Gu | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 7 | Highly Ordered Mesoporous MoS2 with Expanded Spacing of the (002) Crystal Plane for Ultrafast Lithium Ion Storage显示文摘 | Hao Liu Dawei Su Ruifeng Zhou Bing Sun Guoxiu Wang Shi Zhang Qiao | 2012 | Adv. Energy Mater2012，，8： | 1 |
| 8 | A novel double-function porous material: zeolite-activated carbon extrudates from elutrilithe显示文摘 | Jinghong Ma Hong Sun Shen Su Wenping Cheng Ruifeng Li | 2008 | Journal of Porous Materials2008，，3： | 1 |
| 9 | Structural features of binary microporous zeolite composite Y-Beta and its hydrocracking performance显示文摘 | Xiwen Zhang Qun Guo Bo Qin Zhizhi Zhang Fengxiang Ling Wanfu Sun Ruifeng Li | 2009 | Catalysis Today2009，，1： | 1 |
| 10 | A novel double-function porous material: zeolite-activated carbon extrudates from elutrilithe显示文摘 | Jinghong Ma Hong Sun Shen Su Wenping Cheng Ruifeng Li | 2008 | Journal of Porous Materials2008，，3： | 1 |
| 11 | Production and Application of Common Type C-Mn Hot Rolled Dual-Phase Steel in CSP Line 显示文摘 | Dong Ruifeng Li Degang Sun Ligang | 2009 | J of Iron and Steel Research International2009，16，： | 1 |
| 12 | Construction and application of a stoichiometric displacement model for retention in chiral recognition of molecular inprinting显示文摘 | Sun Ruifeng Yu Huimin Luo Hui Shen Zhongyao | 2004 | J Chromatogr A2004，1055，12： | 1 |
| 13 | Biodegradable porous Zn-1Mg-3βTCP scaffold for bone defect repair:In vitro and in vivo evaluation显示文摘Zn-based materials are promising as bone repair materials,but their poor mechanical property and bioactivity as well as low degradation rate render the potential application.Rational structural and material design can address the concerns.In this study,porous Zn-1 wt.%Mg-3 vol.%β-TCP scaffolds with 40%and 60%preset porosities were fabricated via heating-press sintering using NaCl particles as space holders,and their mechanical properties,in vitro degradation behavior,cytotoxicity and in vivo osteogenic activities were evaluated.The results showed that the actual porosities of the scaffolds were 22%and 50%.Mg exists in the form of Zn 2 Mg and Zn 11 Mg 2,whileβ-TCP evenly distributed in the matrix.The compressive yield strength of scaffolds ranges from approximately 58.46 to 71.04 MPa,which is close to that of cancellous bone.The in vitro degradation tests showed that the corrosion rate of the scaffolds was in the range of about 2.73-4.28 mm y^(-1).Moreover,the scaffolds not only provided great space for osteoblasts adhesion and proliferation in vitro but also possessed favorable degradability and osteogenic activity in vivo.The porous Zn-1 wt.%Mg-3 vol.%β-TCP scaffolds manifest reliable mechanical properties,desirable degradability,and osteogenic activity,which are promising as next-generation bone repair materials. | Runhua Yao Hui Wang Ruifeng Shan Lin Liu Yuyu Zhao Yonghua Sun Xiaohong Yao Di Huang Ruiqiang Hang | 2023 | Journal of Materials Science & Technology2023，，31： | 0 |
| 14 | Crustal Thickness and Velocity Ratio beneath National Seismic Stations in the Sichuan-Yunnan Area Based on Receiver Function Analysis显示文摘By using the teleseismic receiver function method, this paper analyzes the crustal thickness and v_P/v_S ratios beneath the 4 National seismic stations (KMI, TNC, CD2 and PZH) in the Sichuan-Yunnan area. This study gives the variance of Moho depths and velocity ratios of the 4 stations in different directions. The results show that the Moho depth beneath the Kunming station is around 50km, and the velocity ratio varies between 1.62 and 1.69. The thickness of crust and the velocity ratio do not change much with the direction. The crust beneath Tengchong station shows clear directivity, being 40.7km thick in the northeast and 49.7km thick in the southeast. The difference of the v_P/v_S values is remarkable between the two directions, reaching 0.2. The Chengdu station also has shallow Moho, about 40km, but is 8km deeper in the northeast and southwest and the velocity ratio has a change of 0.13 between the two directions. The crust beneath the Panzhihua station is stable. In all directions, the Moho depth is around 60km and the v_P/v_S ratio doesn't change significantly. | Sun Li Liu Ruifeng Huang Zhibin Chen Yotdin | 2009 | Earthquake Research in China2009，23，3： | 0 |
| 15 | Preliminary study of lateral variation in crustal structure of Northeast China from teleseismic receiver functions显示文摘We conducted comprehensive receiver function analyses for a large amount of high-quality broadband teleseismic waveforms data recorded at 19 China National Digital Seismic Network (CNDSN) stations deployed in Northeast China.An advanced H-κ domain search method was adopted to accurately estimate the crustal thickness and vP/vS ratio.The crust has an average thickness of about 34.4 km.The thinnest crust occurs in the central region of Northeast China,while the thickest crust is beneath the Yanshan belt.The v P /v S ratio is relatively uniform with an average of about 1.733.The highest vP/vS ratio is found beneath the Changbaishan,likely associated with its volcanic activities.We found significant lateral heterogeneity beneath three stations CN2,MDJ,and MIH located along the Suolon suture from the back-zimuthal dependence of Moho depth.The velocity modeling from receiver functions indicated complicated Earth structure beneath these stations with large crust-mantle transition zone,noticeable velocity jump in upper mantle,and low velocity zone in middle crust.Dipping velocity interface in the crust with strike approximately parallel to the Suolon suture and down-dip to the south or southeast might explain the observed lateral heterogeneity. | Youlin Chen Ruifeng Liu Zhibin Huang Li Sun | 2011 | Earthquake Science2011，24，1： | 0 |
| 16 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
| 17 | Radio Communication Scenarios in 5G-Railways显示文摘With the rapid development of railways,especially high-speed railways,there is an increasingly urgent demand for new wireless communication system for railways.Taking the mature 5G technology as an opportunity,5G-railways(5G-R)have been widely regarded as a solution to meet the diversified demands of railway wireless communications.For the design,deployment and improvement of 5GR networks,radio communication scenario classification plays an important role,affecting channel modeling and system performance evaluation.In this paper,a standardized radio communication scenario classification,including 18 scenarios,is proposed for 5GR.This paper analyzes the differences of 5G-R scenarios compared with the traditional cellular networks and GSM-railways,according to 5G-R requirements and the unique physical environment and propagation characteristics.The proposed standardized scenario classification helps deepen the research of 5G-R and promote the development and application of the existing advanced technologies in railways. | Ruisi He Bo Ai Zhangdui Zhong Mi Yang Chen Huang Ruifeng Chen Jianwen Ding Hang Mi Zhangfeng Ma Guiqi Sun Changzhu Liu | 2023 | China Communications2023，20，9： | 0 |
| 18 | Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells显示文摘The eukaryotic genome is folded into higher-order conformation accompanied with constrained dynamics for coordinated genome functions.However,the molecular machinery underlying these hierarchically organized three-dimensional(3D)chromatin architecture and dynamics remains poorly understood.Here by combining imaging and sequencing,we studied the role of lamin B1 in chromatin architecture and dynamics.We found that lamin B1 depletion leads to detachment of lamina-associated domains(LADs)from the nuclear periphery accompanied with global chromatin redistribution and decompaction.Consequently,the interchromosomal as well as inter-compartment interactions are increased,but the structure of topologically associating domains(TADs)is not affected.Using live-cell genomic loci tracking,we further proved that depletion of lamin B1 leads to increased chromatin dynamics,owing to chromatin decompaction and redistribution toward nucleoplasm.Taken together,our data suggest that lamin B1 and chromatin interactions at the nuclear periphery promote LAD maintenance,chromatin compaction,genomic compartmentalization into chromosome territories and A/B compartments and confine chromatin dynamics,supporting their crucial roles in chromatin higher-order structure and chromatin dynamics. | Lei Chang Mengfan Li Shipeng Shao Chen Li Shanshan Ai Boxin Xue Yingping Hou Yiwen Zhang Ruifeng Li Xiaoying Fan Aibin He Cheng Li Yujie Sun | 2022 | Protein & Cell2022，13，4： | 0 |
| 19 | First Beam Commissioning of SSC-Linac as an Injector of SSC显示文摘The construction of the SSC-Linac has made significant progress in 2019.The first beam commissioning of SSC-Linac as an injector of the Separated Sector Cyclotron(SSC)was performed succssfully with ^(40)Ar^(7+) beam and the particle energy of 5.98 MeV/u was obtained at the exit of SSC on December 17,2019. | Du Heng Yin Xuejun Yang Weiqing Li Zhongshan Kong Qiyu Li Xiaoni Yang Shengli Qian Cheng WangHaoning Cong Yan Jin Peng Zhang Ruifeng Han Xiaodong Fu Xin Wang Kai Jing Long Zhang Yong Li Lili Xie Wenjun Xu Xiaowei Wang Shaoming Chen Wenjun Liu Xiaojun Yue Min An Jingrui Zhang Xiang Yan Huaihai Feng Anhui Zhang Shuai Zhang Yongbo Sun Peng Zhu Tieming Sha Xiaoping Xu Jianye Sun Xiaolong Su Xuemin Li Anping Yan Tailai Meng Jun Zhang Wei Wu Junxia Yao Qinggao Yang Yaqing Xu Zhe Sun Liangting Gao Daqing Yuan Youjin Yang Jiancheng Xia Jiawen | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 20 | Qizhi Jiangtang capsule(芪蛭降糖胶囊)activates podocyte autophagy in diabetic kidney disease by inhibiting phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathways显示文摘OBJECTIVE:To investigate the therapeutic action and mechanism of the Qizhi Jiangtang capsule(芪蛭降糖胶囊,QZJT)on diabetic kidney disease(DKD)treatment.METHODS:This experiment used db/db mice and podocytes(MPC5)to develop DKD model.Evaluation of the effect of the QZJT on db/db mice by testing urine and blood biochemical parameters(24-h urinary albumin,serum creatinine,blood urine nitrogen),pathological kidney injury,and podocyte integrity.Moreover,autophagosomes in podocytes of DKD mice and cultured podocytes were detected using electron microscopy.Additionally,Western blotting was applied to detect the expression of podocyte marker protein(podocin),autophagy-associated proteins,and phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR)signaling pathway changes in vivo and in vitro.RESULTS:QZJT significantly reduced urine protein,blood nitrogen urea,and serum creatinine and showed histological restoration of renal tissues.QZJT also significantly improved the down-regulation of podocin and foot fusion and effacement in db/db mice.QZJT increased autophagic vesicles in mice and cultured podocytes.QZJT also upregulated microtubuleassociated protein 1 light chain 3-II(LC3-II)/(LC3-I)and Beclin-1 and downregulated phosphorylated-PI3K(pPI3K),p-AKT,and p-mTOR in db/db mice and MPC5 cells.However,autophagy inhibitor 3-methyladenine partially alleviated the above effects in MPC5 cells.CONCLUSIONS:These results showed that the QZJT can enhance podocyte autophagy and ameliorate podocyte injury in DKD by inhibiting the PI3K/AKT/mTOR signaling pathway. | GUO Zhaoan SUN Lina LIU Yingying LI Ruifeng LIU Chong DIAO Ke SHI Jing SUN Jun | 2023 | Journal of Traditional Chinese Medicine2023，43，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员