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| 1 | High porosity and low thermal conductivity high entropy(Zr0.2Hf0.2Ti0.2Nb0.2Ta0.2C显示文摘Porous ultra-high temperature ceramics(UHTCs)are promising for ultrahigh-temperature thermal insulation applications.However,the main limitations for their applications are the high thermal conductivity and densification of porous structure at high temperatures.In order to overcome these obstacles,herein,porous high entropy(Zr(0.2)Hf(0.2)Ti(0.2)Nb(0.2)Ta(0.2))C was prepared by a simple method combing in-situ reaction and partial sintering.Porous high entropy(Zr(0.2)Hf(0.2)Ti(0.2)Nb(0.2)Ta(0.2))C possesses homogeneous microstructure with grain size in the range of 100–500 nm and pore size in the range of 0.2–1μm,which exhibits high porosity of 80.99%,high compressive strength of 3.45 MPa,low room temperature thermal conductivity of 0.39 W·m^-1K^-1,low thermal diffusivity of 0.74 mm^2·s^-1and good high temperature stability.The combination of these properties renders porous high entropy(Zr(0.2)Hf(0.2)Ti(0.2)Nb(0.2)Ta(0.2))Cpromising as light-weight ultrahigh temperature thermal insulation materials. | Heng Chen Huimin Xiang Fu-Zhi Dai Jiachen Liu Yiming Lei Jie Zhang Yanchun Zhou | 2019 | Journal of Materials Science & Technology2019，35，8： | 16 |
| 2 | Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma显示文摘Glioblastoma(GBM)is an incurable and highly heterogeneous brain tumor,originating from human neural stem/progenitor cells(hNSCs/hNPCs)years ahead of diagnosis.Despite extensive efforts to characterize hNSCs and end-stage GBM at bulk and single-cell levels,the de novo gliomagenic path from hNSCs is largely unknown due to technical difficulties in early-stage sampling and preclinical modeling.Here,we established two highly penetrant hNSC-derived malignant glioma models,which resemble the histopathology and transcriptional heterogeneity of human GBM.Integrating time-series analyses of whole-exome sequencing,bulk and single-cell RNA-seq,we reconstructed gliomagenic trajectories,and identified a persistent NSC-like population at all stages of tumorigenesis.Through trajectory analyses and lineage tracing,we showed that tumor progression is primarily driven by multi-step transcriptional reprogramming and fate-switches in the NSC-like cells,which sequentially generate malignant heterogeneity and induce tumor phenotype transitions.We further uncovered stage-specific oncogenic cascades,and among the candidate genes we functionally validated C1QL1 as a new glioma-promoting factor.Importantly,the neurogenic-to-gliogenic switch in NSC-like cells marks an early stage characterized by a burst of oncogenic alterations,during which transient AP-1 inhibition is sufficient to inhibit gliomagenesis.Together,our results reveal previously undercharacterized molecular dynamics and fate choices driving de novo gliomagenesis from hNSCs,and provide a blueprint for potential early-stage treatment/diagnosis for GBM. | Xiaofei Wang Ran Zhou Yanzhen Xiong Lingling Zhou Xiang Yan Manli Wang Fan Li Chuanxing Xie Yiming Zhang Zongyao Huang Chaoqiong Ding Kaidou Shi Weida Li Yu Liu Zhongwei Cao Zhen-Ning Zhang Shengtao Zhou Chong Chen Yan Zhang Lu Chen Yuan Wang | 2021 | Cell Research2021，31，6： | 8 |
| 3 | High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis显示文摘Rupture of atherosclerotic plaques causing thrombosis is the main cause of acute coronary syndrome and ischemic strokes.Inhibition of thrombosis is one of the important tasks developing biomedical materials such as intravascular stents and vascular grafts.Shear stress(SS)influences the formation and development of atherosclerosis.The current review focuses on the vulnerable plaques observed in the high shear stress(HSS)regions,which localizes at the proximal region of the plaque intruding into the lumen.The vascular outward remodelling occurs in the HSS region for vascular compensation and that angiogenesis is a critical factor for HSS which induces atherosclerotic vulnerable plaque formation.These results greatly challenge the established belief that low shear stress is important for expansive remodelling,which provides a new perspective for preventing the transition of stable plaques to high-risk atherosclerotic lesions. | Yi Wang Juhui Qiu Shisui Luo Xiang Xie Yiming Zheng Kang Zhang Zhiyi Ye Wanqian Liu Hans Gregersen GuixueWang | 2016 | Regenerative Biomaterials2016，3，4： | 8 |
| 4 | Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease显示文摘Accumulating evidence suggests that C-type lectin-like receptor-2(CLEC-2)plays an important role in atherothrombosis.In this case-control study,we investigated the association between CLEC-2 and incidence of coronary artery disease(CAD).A total of 216 patients,including 14 cases of stable angina pectoris(SAP,non-ACS)and 202 cases of acute coronary syndrome(ACS),and 89 non-CAD control subjects were enrolled.Plasma levels of soluble CLEC-2(sCLEC-2)were measured using the enzyme-linked immunosorbent assay(ELISA).Compared with the control group(65.69(55.36–143.22)pg/mL),the plasma levels of sCLEC-2 were significantly increased in patients with CAD(133.67(88.76–220.09)pg/mL)and ACS(134.16(88.88–225.81)pg/mL).The multivariate adjusted odds ratios(95%confidence interval)of CAD reached 2.01(1.52–2.66)(Ptrend<0.001)for each 1-quartile increase in sCLEC-2.Restricted cubic splines showed a positive dose-response association between sCLEC2 and CAD incidence(Plinearity<0.001).The addition of sCLEC-2 to conventional risk factors improved the C statistic(0.821 vs.0.761,P=0.004)and reclassification ability(net reclassification improvement:57.45%,P<0.001;integrated discrimination improvement:8.27%,P<0.001)for CAD.In conclusion,high plasma sCLEC-2 is independently associated with CAD risk,and the prognostic value of sCLEC-2 may be evaluated in future prospective studies. | Min Fei Li Xiang Xichen Chai Jingchun Jin Tao You Yiming Zhao Changgeng Ruan Yiwen Hao Li Zhu | 2020 | Frontiers of Medicine2020，14，1： | 5 |
| 5 | Circ-Smad5 retards the G1/S transition of cell cycle via inhibiting the activity of wnt/lef/cyclind1 signaling in JB6 cells显示文摘Circular RNAs are a large class of noncoding RNAs.Smad5 functions in cell differentiation,cell proliferation and metastasis.It has been reported that lnc-Smad5 can inhibit the proliferation of diffuse large B cell lymphoma.However,the function of circ-Smad5 has not yet been reported.Lentivirus vectors were constructed to establish circ-Smad5 upregulated and circ-Smad5 downregulated cell models.A CCK-8 assay was used to detect the proliferation of JB6 cells.FACS was used to analyze the cell cycle in the cell models.Western blot,immunofluorescence staining and TOP/FOP flash dual luciferase activity assays were used to determine the activity of the Wnt signaling pathway.The results revealed that the expression level of circ-Smad5 in JB6 cells was significantly lower than the expression level of linearizedSmad5.Compared with the control group,the percentage of S phase cells and the expression level of cyclin D1 protein were significantly higher in the sh-circ-Smad5 group.In the sh-circSmad5 group,b-catenin and LEF-1 were significantly increased,p-b-catenin was significantly decreased,and the relative activity of the TOP/FOP reporter gene was higher compared to the control group levels.These phenomena could be reversed by treating with Wnt signaling inhibitor PNU-74654.We conclude that the circ-Smad5 retards the proliferation and the cell cycle progression of JB6 cells.Thus,circ-Smad5 may function by inhibiting the activation of Wnt/b-catenin/Lef 1 signaling,which inhibits the expression of cyclin D1.To the best of our knowledge,we are the first to report the function of circ-Smad5. | Xiaogen Ma Fei Xiang Zhuo Pei Jiafeng Miao Pan Wu Xiaofeng Song Yuhong Li Yiming Zhang | 2021 | Genes & Diseases2021，8，3： | 3 |
| 6 | A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity显示文摘Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T-cell activation.A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance,such as program death-1(PD-1/PD-L1)pathway in the tumor environment.However,the determinants of response to anti-PD-1 monoclonal antibodies(mAbs)treatment remain incompletely understood.In murine models,PD-1 blockade alone fails to induce effective immune responses to poorly immunogenic tumors,but is successful when combined with additional interventions,such as cancer vaccines.Novel cancer vaccines combined with antibody may offer promising control of cancer development and progression.In this investigation,we generated a novel tumor cell vaccine simultaneously expressing anti-PD-1 mAbs and granulocyte-macrophage colony stimulating factor(GM-CSF)in CT26 colon cancer and B16-F10 melanoma.The antitumor effect of the vaccine was verified by therapeutic and adoptive animal experiments in vivo.The antitumor mechanism was analyzed using Flow cytometry,Elispot and in vivo intervention approaches.The results showed that tumor cell vaccine secreting PD-1 neutralizing antibodies and GM-CSF induced remarkable antitumor immune effects and prolonged the survival of tumor-bearing animals compared with animals treated with either PD-1 mAbs or GM-CSF alone.Antitumor effects and prolonged survival correlated with strong antigen-specific T-cell responses by analyzing CD11c^(+)CD86^(+)DC,CD11b^(+)F4/80^(+)MΦcells,increased ratio of Teff/Treg in the tumor microenvironment,and higher secretion levels of Th1 proinflammatory cytokines in serum.Furthermore,the results of ELISPOT and in vivo blocking strategies further confirmed that the antitumor immune response is acquired by CD4 and CD8 T immune responses,primarily dependent on CD4 Th1 immune response,not NK innate immune response.The combination of PD-1 blockade with GM-CSF secretion potency creates a novel tumor cell vaccine immunotherapy,affording significantly improved antitumor responses by releasing the state of immunosuppressive microenvironment and augmenting the tumor-reactive T-cell responses. | Hongwei Tian Gang Shi Qin Wang Yiming Li Qianmei Yang Chunlei Li Guoyou Yang Min Wu Qian Xie Shuang Zhang Yang Yang Rong Xiang Dechao Yu Yuquan Wei Hongxin Deng | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 7 | Comments on National guidelines for diagnosis and treatment of thyroid cancer 2022 in China (English version)显示文摘Thyroid cancer (TC) is the most common endocrine system cancer, of note, the overall survival of TC in China is suboptimal when comparing with the developed countries such as US (84.3%vs.98.3%), posing a great challenge among professionals involved in this field.Standardization of its diagnosis and treatment not only provides the basis for all the care givers to promote the entire level of TC management, but also is helpful in shortening the distance between China and other developed countries. A multidisciplinary team (MDT)should be involved in the comprehensive clinical management of TC, particularly for those advanced or refractory TC, which needs cooperation among members from ultrasonography, radiology, pathology, surgery. | Hao Wang Jian Wang Xiang Wang Yiming Zhu Yuqing Sun Xin Zhang Xiaorong Hou Kun Zheng Shaoyan Liu Yansong Lin | 2022 | Chinese Journal of Cancer Research2022，34，5： | 2 |
| 8 | Review of 4Pi Fluorescence Nanoscopy显示文摘Since the 1990s,continuous technical and scientific advances have defied the diffraction limit in microscopy and enabled three-dimensional(3D)super-resolution imaging.An important milestone in this pursuit is the coherent utilization of two opposing objectives(4Pi geometry)and its combination with superresolution microscopy.Herein,we review the recent progress in 4Pi nanoscopy,which provides a 3D,non-invasive,diffraction-unlimited,and isotropic resolution in transparent samples.This review includes both the targeted and stochastic switching modalities of 4Pi nanoscopy.The schematics,principles,applications,and future potential of 4Pi nanoscopy are discussed in detail. | Xiang Hao Yiming Li Shuang Fu Yanghui Li Yingke Xu Cuifang Kuang Xu Liu | 2022 | Engineering2022，8，4： | 2 |
| 9 | A Z-scheme heterojunction of ZnO/CDots/C_(3)N^(4) for strengthened photoresponsive bacteria-killing and acceleration of wound healing显示文摘The abuse of antibiotics is leading to the emergence of resistant bacteria.In this work,a drug-free composite of ZnO/CDots/g-C3N4 with Z-scheme heterojunction was developed,which was employed to kill bacteria effectively within a very short time under the irradiation of visible light due to the enhanced photocatalytic and photothermal effects.In this system,the CDots acted as a bridge between g-C3N4 and ZnO,effectively inhibiting the recombination of photo-generated electrons with holes and consequently enhancing the photocatalytic properties.In addition,CDots endowed the system with excellent photothermal effects.As a result,the antibacterial efficacy of ZnO/CDots/g-C3N4 composite against S.aureus and E.coli reached up to 99.97%and 99.99%respectively,after 15 min of visible light irradiation,due to the synergistic action of photo-inspired radical oxygen species and hyperthermia.The Zn ions released from the composite promoted the growth of fibroblasts,which accelerated the wound healing process. | Yiming Xiang Qilin Zhou Zhaoyang Li Zhenduo Cui Xiangmei Liu Yanqin Liang Shengli Zhu Yufeng Zheng Kelvin Wai Kwok Yeung Shuilin Wu | 2020 | Journal of Materials Science & Technology2020，54，22： | 2 |
| 10 | Mechanical model for double side self-propelled rolling machine based on rigid and flexible contact dynamics显示文摘The objective of the present research was to establish a mechanical model to study the performance of double side self-propelled rolling machine.There are two key models in the modeling process.The first model is the soft cover dynamics model,which is an important innovation in this study.And the insulation quilt was established based on the Macro-modeling technology.The second model is the double side self-propelled rolling machine virtual prototype model.By specifying multiple contact constraints and loadings between the soft cover dynamics model and the rigid component,the virtual prototype model was built successfully and the double side self-propelled rolling process was completely simulated.Moreover,the interaction mechanisms of the rigid and flexible coupling mechanics were investigated.The virtual rolling processes of different insulation quilt lengths were analyzed under different thickness treatments.The simulated results showed a good agreement with the experimental measurements,which suggested that the established model is an effective approach to evaluating and optimizing the rolling machine.The successful establishment of the mechanical model can facilitate the study of the performance of the product and further optimization,and also is of great significance to shorten the development cycle and reduce costs. | Yiming Li Yu Liu Xiang Yue Zhongqiu Li Xing'an Liu Tianlai Li | 2022 | International Journal of Agricultural and Biological Engineering2022，15，6： | 1 |
| 11 | A novel method to detect Listeria monocytogenes via superparamagnetic lateral flow immunoassay显示文摘 | Lei Shi Feng Wu Yiming Wen Fang Zhao Junjian Xiang Lan Ma | 2015 | Analytical and Bioanalytical Chemistry2015，，2： | 1 |
| 12 | Pitting corrosion behaviour of stainless steel in ultrasonic cell 显示文摘 | SUN Daoming JIANG Yiming TANG Yu XIANG Qiuwei ZHONG Cheng LIAO Jiaxing LI Jin | 2009 | Electrochimica Acta2009，54，： | 1 |
| 13 | A new pattern-based method for identifying recent HIV-1 infections from the viral env sequence显示文摘The long asymptomatic stage of HIV infection poses a great challenge in identifying recent HIV infections. This is a bottleneck for monitoring HIV epidemic trends and evaluating the effectiveness of national AIDS control programs. Several serological methods were used to address this issue with some success. Because of high false-positive rates in patients with advanced infection or in ART treatment, UNAIDS still hesitates to recommend their use in routine surveillance. We developed a new pattern-based method for measuring intra-patient viral genetic diversity for determination of recent infections and estimation of population incidence. This method is verified by using several datasets (424 subtype B and 77 CRF07_BC samples) with clearly identified HIV-1 infection times. Pattern-based diversities of recent infections are significantly lower than that of chronic ones. With larger window periods varying from 200 to 350 days, a higher accuracy (90% 95%) not affected by advanced disease nor ART treatment could be obtained. The pattern-based genetic method is supplementary to the existing serology-based assays, both of which could be suitable for use in low and high epidemic regions, respectively. | YANG Jing XIA XiaYu HE Xiang YANG SenLin RUAN YuHua ZHAO QuanBi WANG ZhiXin SHAO YiMing PAN XianMing | 2012 | Science China(Life Sciences)2012，55，4： | 1 |
| 14 | Measurement of Optical Fiber Geometry Parameters with Bessel Function Fitting Method显示文摘Geometry parameters of optical fiber are crucial in evaluating the quality of the optical fiber.Near⁃field light distribution method is recommended in GB15972.20-2008 for the measurement of geometry parameters.To distinguish the boundary between fiber core and cladding,it is necessary to illuminate the fiber.The end face of the core is a bright spot with unclear edge,so the true edge of the core and the cladding cannot be accurately judged.A method is proposed in this paper to measure the geometry parameters of optical fiber by Bessel function fitting.Theoretically,the solution to the electromagnetic vector of mode field satisfies Bessel function,and the boundary between the core and the cladding can be precisely extracted by Bessel function fitting.Edges of the fiber were fitted by elliptical curves,and the geometry parameters of the fibers could be calculated.Results show that the maximum deviations of the diameters and the average differences of the fibers were decreased under normal and abnormal conditions respectively.The proposed method is an efficient way to obtain edge data and can improve the accuracy and stability of geometry parameters of optical fibers. | Yiming Li Huazhong Xiang Jiankun Tu Gang Zheng Minghui Chen Bin Jiang | 2021 | Journal of Harbin Institute of Technology(New Series)2021，28，2： | 1 |
| 15 | Biomass-derived nitrogen self-doped porous activation carbon as an effective bifunctional electrocatalysts显示文摘The strategy of adopting cheap precursors or abundant resources,which can be obtained directly from nature,is a simple and excellent method of introducing accessible research into environmentally friendly development.Moreover,this is also an urgent requirement for the sustainable development of green technology.Herein,we introduce a simplistic and expandable method to prepare metal-free biomassderived nitrogen self-doped porous activation carbon(N-PAC) with large specific surface area(S_(BET)=1300.58 m^(2)/g).Moreover,the manufactural electrocatalysts exhibit prominent oxygen reduction reaction(ORR) performance in all PH values.As compared with the commercial Pt/C catalyst,the N-PAC/800 with a positive onset potential at 10 mA/cm^(2)(0.93 V),half-wave potential(0.87 V),and limiting current(6.34 mA/cm^(2)) bring to light excellent catalytic stability,selectivity,and much-enhanced methanol tolerance.Furthermore,the prepared electrocatalysts possess considerable hydrogen evolution reaction(HER) performance with a less onset potential of 0.218 V(acidic medium) and0.271 V(alkaline medium) respectively,which can show similar catalytic activity across the whole pH range.Such bifunctional electrocatalyst,with excellent electrocatalytic properties,resource-rich,low cost,and environmental-friendly,hold a promising application in energy conversion and reserve. | Yuanqing Sun Yiming Ouyang Jiaqing Luo Huihui Cao Xiang Li Jingwen Ma Jian Liu Yuanhao Wang Lin Lu | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 16 | Wind turbine manufacturing industry in China: Current situation and problems 显示文摘 | Xin Jin Yiming Rong Xiang Zhong | 2014 | Renezoable and Sustainable Energy Reviews2014，，33： | 1 |
| 17 | The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s显示文摘 | Yi Feng Xiang He Jenny H. Hsi Fan Li Xingguang Li Quan Wang Yuhua Ruan Hui Xing Tommy Tsan-Yuk Lam Oliver G. Pybus Yutaka Takebe Yiming Shao | 2013 | AIDS2013，，： | 1 |
| 18 | The MKK3–MPK7 cascade phosphorylates ERF4 and promotes its rapid degradation to release seed dormancy in Arabidopsis显示文摘Seeds establish dormancy to delay germination until the arrival of a favorable growing season.In this study,we identify a fate switch comprised of the MKK3–MPK7 kinase cascade and the ethylene response factor ERF4 that is responsible for the seed state transition from dormancy to germination.We show that dormancy-breaking factors activate the MKK3–MPK7 module,which affects the expression of some a-EXPANSIN(EXPA)genes to control seed dormancy.Furthermore,we identify a direct downstream substrate of this module,ERF4,which suppresses the expression of these EXPAs by directly binding to the GCC boxes in their exon regions.The activated MKK3–MPK7 module phosphorylates ERF4,leading to its rapid degradation and thereby releasing its inhibitory effect on the expression of these EXPAs.Collectively,our work identifies a signaling chain consisting of protein phosphorylation,degradation,and gene transcription,by which the germination promoters within the embryo sense and are activated by germination signals from ambient conditions. | Xi Chen Qiujia Li Ling Ding Shengnan Zhang Siyao Shan Xiong Xiong Wenhui Jiang Bo Zhao Liying Zhang Ying Luo Yiming Lian Xiuqin Kong Xiali Ding Jun Zhang Chunli Li Wim J.J.Soppe Yong Xiang | 2023 | Molecular Plant2023，16，11： | 0 |
| 19 | Control of large linear magnetoelectricity in Co_(3)NiNb_(2)O_(9)显示文摘Magnetoelectric(ME)materials have caught worldwide attentions owing to their potential technological applications in ME switching devices or high-density data storage.However,realizing a sufficiently strong ME effect in one single material is always the key issue.Herein,we systematically investigate the Co_(3)NiNb_(2)O_(9),including the characterization of its crystalline structure,magnetism,specific heat,and pyroelectric properties.It is revealed that Co_(3)NiNb_(2)O_(9) exhibits a remarkable ME response below the magnetic phase transition temperature of TN-32 K.On one hand,the magnetic field-induced electric polarization is observed below TN while it is non-ferroelectric at no magnetic field.The evaluated ME coefficient is as large as 21.2 ps/m.On the other hand,the magnetization is significantly modulated by the applied electric field,with the inverse ME coefficient being 14.1 ps/m.The observed ME responses suggest a stable ME mutual control by the magnetic or electric field in Co_(3)NiNb_(2)O_(9). | Xiang Li Yu Wang Meifeng Liu Yunlong Xie Jiahua Min Xiyu Chen Jingwen Gong Leiyu Li Min Zeng Yiming Xu Yiru Wang Biwen Li Xiuzhang Wang Jun-Ming Liu | 2021 | Journal of Materiomics2021，7，4： | 0 |
| 20 | Fluorinated bimetallic nanoparticles decorated carbon nanofibers as highly active and durable oxygen electrocatalyst for fuel cells显示文摘The low activity and durability are still the critical barriers for non-precious metal electrocatalyst,mainly involving M-N/C(M=Fe,Co,Mn et al),applied in fuel cell.Constructing bimetallic sites has been explored as an effective method to boost the performance of the catalyst for the synergistic effect between metal atoms.However,this synergistic effect is always suppressed in acidic conditions and results in unstable catalytic performance.Here we create novel fluorinated iron(Fe)and cobalt(Co)bimetallic nanoparticles distributed on nitrogen-doped carbon nanofibers(CNFs)for oxygen reduction reaction(ORR).The fluorination strongly increased the charge density of the bimetallic catalyst and resulted in a remarkable catalytic performance with the half-wave potential of 804 m V in 0.1 M HCl O_(4)and 1.6 times power density improvement for the proton exchange membrane fuel cell device.Importantly,the chemical and mechanical robust CNFs support improved the electric conductivity and stability of bimetallic catalysts,which leads to an ultra-stable electrocatalyst.The fuel cell voltage can keep stable even after 110 h,instead of the continuingly decrease in the traditional M-N/C. | Yiming Leng Bolong Yang Yun Zhao Zhonghua Xiang | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
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