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| 1 | First-generation EGFR tyrosine kinase inhibitor therapy in 106 patients with compound EGFR-mutated lung cancer: a single institution’s clinical practice experience显示文摘Background:The antitumour efficacy of tyrosine kinase inhibitors(TKIs)in lung cancer patients with compound epidermal growth factor receptor(EGFR)mutations has not been resolved.Our study summarizes a single institutional experience of first-generation TKI therapy for lung cancers with compound EGFR mutations.Methods:A total of 106 consecutive patients with tumours bearing compound EGFR mutations were identified between January 2012 and May 2016;all patients received first-generation TKI therapy.Deletions in exon 19 and the L858R point mutation in exon 21 were considered common mutations;T790M was considered separately because of its association with TKIs resistances.Any other mutation was defined as a rare mutation.Patients were divided as follows:double common mutations(group A);common plus T790M mutations(group B);common plus rare muta-tions(group C);double rare mutations(group D);and rare plus T790M mutations(group E).A separate group of 115 consecutive patients with a single common mutation was created for comparative analysis(group F).Results:The frequency of patients with compound EGFR was 2.9%(114/3925)and their response rate to first-genera-tion TKIs was 50.9%,which was not significantly different from group F(67.0%,P=0.088).The progression-free survival(PFS)of the 106 patients receiving TKI therapy was worse than that of group F(median,9.1 vs.13.0 months,respec-tively;P<0.001).The PFS of the compound mutation group was shorter than that of the single common mutation group(median,10.1 months in group A,P=0.240;9.1 months in group B,P<0.001;9.6 months in group C,P=0.010;6.5 months in group D,P=0.048;5.4 months in group E,P=0.017).Patients with a co-occurring mutation in exon 20(excluding T790M)exhibited significantly worse PFS than the patients with other compound mutations or with a single common mutation(median,6.5 vs.9.1 vs.13.0 months,respectively,P=0.002).Conclusions:There was significant heterogeneity among the compound EGFR mutations and their response to first-generation TKIs.Individualized treatment in clinical practice should be considered for each case. | Xiangyang Yu Xuewen Zhang Zichen Zhang Yongbin Lin Yingsheng Wen Yongqiang Chen Weidong Wang Lanjun Zhang | 2018 | Cancer Communications2018，38，1： | 5 |
| 2 | Sodium hydroxide-induced esophageal stricture via an endoscopic injection needle: a novel rabbit model of corrosive injury显示文摘Purpose: Benign strictures of the esophagus are commonly encountered in clinical practice and are difficult to manage conservatively. This study aimed to establish a novel animal model of benign esophageal stricture by using corrosive-induced injury in rabbits with an injection of sodium hydroxide(NaOH) via a self-made endoscopic injection needle. Materials and Methods: Corrosive injury of the esophagus was induced in 10 rabbits by administration of 1 mL of 1.5% NaOH using a laryngoscope with a self-made endoscopic injection needle. The self-made injection needle was fabricated by modification of the core of an endoscopic injection needle. The laryngoscope examination was performed at 2 weeks and 4 weeks after induction of corrosive injury; esophagography was also performed at 4 weeks to assesse sophageals tricture.A lla nimalsw eree uthanizedat th een dof the fourth week; the esophagus was removed, and stained sectionsw eree xaminedm icroscopically. Results: Laryngoscope examination at 2 weeks showed ulceration. At the end of fo urth we e k,laryngosco py,r a diolo gical, and gross exa m inations showed successful in ductionof e s ophagea l stric turein a llanimal s,without any c omp licatio n.The m eanst r ic t ure inde x at the en dof fourth week wa s49.54±3. 61%; the mean le ngth of stricture w as18.0± 2.5mm.Micros copicexa mina tionrevea ledf ocalulceratio nand subm ucosalth i cke ning secondary to fibrosis. Conclusion:Rab bit esop hageal stri ctu re induced us ing lary ngosc opy with endosco pic injec tion of a sm all am ount of lowcon centration s odium hyd roxid e is a t echn ica lly simp le,safe,and re produ cible meth od for cre atio n of an animal m odel of esophageal stricture.This model can be useful for developing new treatment methods for esop hageal s tricture. | Kai Yang Xiaofeng Li Bi Zhou Yueqi Zhu Jun cao Bin chen Yingsheng Cheng | 2018 | Journal of Interventional Medicine2018，1，1： | 2 |
| 3 | Controllable magnetic properties of cobalt ferrite particles derived from layered double hydroxide precursors显示文摘Cobalt ferrite Co x Ni 1-x Fe 2 O 4 (x = 0, 0.5, 1) particles with controllable magnetic properties have been pre- pared by calcination of co-substituted NiFe 2+ Fe 3+ -layered double hydroxide (NiFe 2+ Fe 3+ -LDH) precursors prepared via a scalable method involving separate nucleation and aging steps (SNAS). Their structural and magnetic characteristics were investigated by powder X-ray diffraction (XRD), scanning electron microscopy (SEM) and vibrating sample magnetometry (VSM). Measurements of magnetic properties show that the saturation magnetization (M s ) and coercivity (H c ) of the calcined products increased with increasing cobalt content. The LDH precursor-based product obtained by calcination of a mixture of CoFe 2+ Fe 3+ -LDH and NiFe 2+ Fe 3+ -LDH powders with a Co/Ni molar ratio of 1:1, exhibits a moderate value of M s and an increased value of H c compared to the corresponding values for an Ni 0.5 Co 0.5 Fe 2 O 4 material prepared by calcination of a Co 0.5 Ni 0.5 Fe 2+ Fe 3+ -LDH precursor, and a physical mixture of CoFe 2 O 4 and NiFe 2 O 4 with a Co/Ni molar ratio of 1:1. These results may provide a way to regulate magnetic anisotropy of ferrite spinels by varying the composition of the LDH precursors. | Yonglian Qi Yingsheng Yang Xiaofei Zhao Xilan Liu Peng Wu Fazhi Zhang Sailong Xu | 2010 | Particuology2010，8，3： | 1 |
| 4 | Microarray Scanner for Fluorescence Detection显示文摘A novel pseudo confocal microarray scanner is introduced, in which one dimension scanning is performed by a galvanometer optical scanner and a telecentric objective, another dimension scanning is performed by a stepping motor. | Wang Liqiang, Lu zukang, Li Yingsheng .Zheng Xufeng Optical Engineering Department of Zhejiang University, Hangzhou, P.R.China | 2003 | 光学学报2003，23，S1： | 1 |
| 5 | Marcinkiewicz integrals on weighted Campanato spaces 显示文摘 | Si Zengyan Jiang Yingsheng | 2008 | J of Zhejiang University: Natural Science2008，1135，6： | 1 |
| 6 | Production practices of Shougang blast furnace by using Australia Lump Ores显示文摘 | MA Zejun WANG Yingsheng ZHANG Weidong | 2003 | Ironmaking2003，22，5： | 1 |
| 7 | Effect of Palrnatine on lipopolysaccharide-induced acute lung injury by inhibiting activation of the Akt/NF-κB pathway显示文摘Inflammation plays an important role in the development of acute lung injury(ALI).Severe pulmonary inflammation can cause acute respiratory distress syndrome(ARDS)or even death.Expression of proinflammatory interleukin-1β(IL-1β)and inducible nitric oxide synthase(iNOS)in the process of pulmonary inflammation will further exacerbate the severity of ALI.The purpose of this study was to explore the effect of Palrnatine(Pa)on lipopolysaccharide(LPS)-induced mouse ALI and its underlying mechanism.Pa,a natural product,has a wide range of pharmacological activities with the potential to protect against lung injury.Western blotting and quantitative real-time polymerase chain reaction(qRT-PCR)assays were performed to detect the expression and translation of inflammatory genes and proteins in vitro and in vivo.Immunoprecipitation was used to detect the degree of P65 translocation into the nucleus.We also used molecular modeling to further clarify the mechanism of action.The results showed that Pa pretreatment could significantly inhibit the expression and secretion of the inflammatory cytokine IL-1β,and significantly reduce the protein level of the proinflammatory protease iNOS,in both in vivo and in vitro models induced by LPS.Further mechanism studies showed that Pa could significantly inhibit the activation of the protein kinase B(Akt)/nuclear factor-κB(NF-κB)signaling pathway in the LPS-induced ALI mode and in LPS-induced RAW264.7 cells.Through molecular dynamics simulation,we observed that Pa was bound to the catalytic pocket of Akt and effectively inhibited the biological activity of Akt.These results indicated that Pa significantly relieves LPS-induced ALI by activating the Akt/NF-κB signaling pathway. | Xingchi KAN Yingsheng CHEN Bingxu HUANG Shoupeng FU Wenjin GUO Xin RAN Yu CAO Dianwen XU Ji CHENG Zhanqing YANG Yanling XU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 1 |
| 8 | Analysing corrucated steel web beam bridges using spati',d grid modeling 显示文摘 | DongXu YingSheng Ni and Yu Zhao | 2015 | Steel and Composite Structures2015，，18： | 1 |
| 9 | Systematic control of size,shape and internal structure of mono-disperse α-Fe2O3 particles显示文摘 | SUGIMOTO Tadao WANG Yingsheng ITOH Hiroyuki | 1998 | Colloids and Surfaces A:Physicochemical and Engineering Aspects1998，，134： | 1 |
| 10 | Study on the develop- ment of 020 e-commerce platform of China from the per- spective of offline service quality显示文摘 | DU Yingsheng TANG Youchun | 2014 | International Journal of Business and Social Science2014，5，4： | 1 |
| 11 | Lattices generated by transitive sets of subspaces under finite classical groups I显示文摘 | HUO YUANJI LIU YINGSHENG WAN ZHEXIAN | 1992 | Communications in Algebra1992，20，： | 1 |
| 12 | WO3 nanomaterials synthesized via a sol-gel method and calcination for use as a CO gas sensor显示文摘 | Diah SUSANTI A.A. Gede Pradnyana DIPUTRA Lucky TANANTA Hariyati PURWANINGSIH George Endri KUSUMA Chenhao WANG Shaoju SHIH Yingsheng HUANG | 2014 | Frontiers of Chemical Science and Engineering2014，8，2： | 1 |
| 13 | NOX3-derived reactive oxygen species promote TNF-α-induced reductions in hepatocyte glycogen levels via a JNK pathway显示文摘 | Lanfang Li Qinghua He Xiuqing Huang Yong Man Yingsheng Zhou Shu Wang Jianye Wang Jian Li | 2010 | FEBS Letters2010，，5： | 1 |
| 14 | RETRACTED ARTICLE: ShRNA-mediated gene silencing of Heat shock protein 70 inhibits human colon cancer cell growth in vitro and in vivo显示文摘 | Haidong Cai Shaojun Yin Fang Ma Fei Yu Dan Li Mingli Lv Yingsheng Chen Zhongwei Lv | 2012 | Molecular and Cellular Biochemistry2012，，1： | 1 |
| 15 | Needle electromyography of rectus abdominis muscle in patients with ALS显示文摘 | Xu Yingsheng Zheng Juyang Zhang Shuo | 2007 | Muscle Nerve2007，35，3： | 1 |
| 16 | Contact heat evoked potentials in patients with ALS显示文摘 | Xu Yingsheng Zhang Jun Zheng Juyang | 2009 | Muscle Nerve2009，39，6： | 1 |
| 17 | 第一代EGFR酪氨酸激酶抑制剂治疗106例复合EGFR突变肺癌患者:一项单中心临床研究显示文摘背景与目的酪氨酸激酶抑制剂(tyrosine kinase inhibitors,TKIs)对具有复合表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的肺癌患者的疗效尚不确切。我们对第一代TKI治疗存在复合EGFR突变肺癌患者的疗效进行了单中心研究。方法2012年1月至2016年5月共确诊106例存在复合EGFR突变的连续肿瘤患者,所有患者均接受第一代TKI治疗。外显子19缺失和外显子21的L858R点突变为常见突变;由于T790M与TKIs耐药性相关,因此单独考虑T790M;其他突变均被定义为罕见突变。患者分组如下:双重常见突变(A组),常见加T790M突变(B组),常见加罕见突变(C组),双重罕见突变(D组)和罕见加T790M突变(E组)。我们建立了一个单独的组(F组),由115例存在单一常见突变的连续患者组成,以进行比较分析。结果EGFR复合突变患者的发生率为2.9%(114/3925),对第一代TKI的反应率为50.9%,与F组相比无显著性差异(67.0%,P=0.088)。接受TKI治疗的106例患者的无进展生存期(progression-free survival,PFS)比F组短(中位数,9.1个月vs.13.0个月,P<0.001)。复合突变组的PFS短于单一常见突变组(中位数,A组10.1个月,P=0.240;B组9.1个月,P<0.001;C组9.6个月,P=0.010;D组6.5个月,P=0.048;E组5.4个月,P=0.017)。外显子20中(不包括T790M)发生共同突变的患者显示出比其他复合突变或单一常见突变患者更短的PFS,差异具有统计学意义(中位数,6.5个月vs.9.1个月vs.13.0个月,P=0.002)。结论复合EGFR突变及其对第一代TKIs的反应存在显著的异质性。在临床中对每位患者都应考虑进行个体化治疗。 | Xiangyang Yu Xuewen Zhang Zichen Zhang Yongbin Lin Yingsheng Wen Yongqiang Chen Weidong Wang Lanjun Zhang | 2019 | 癌症2019，38，10： | 1 |
| 18 | Effects of ginsenosides Rg1 on osteoblasts cultured with Ti particles显示文摘 | Yu L Yingsheng W Jiacheng H | 2012 | Biomolecules & Therapeutics2012，1，20： | 1 |
| 19 | Acute intravenous glucose load impairs early insulin secretion and insulin content in islet β cells in mice显示文摘 | DiEn Yan YiNan Zhao XiuYing Gao YingSheng Zhou | 2016 | Life Sciences2016，，： | 1 |
| 20 | Erratum to: Mineralized manganese dioxide channel as the stent coating for in situ precise tumor navigation显示文摘 | Junyuan Xiao Yiran Zhang Tonglei Fang Tianwen Yuan Qinghua Tian Jingjing Liu Yingsheng Cheng Yueqi Zhu Liang Cheng Wenguo Cui | 2021 | Nano Research2021，14，7： | 0 |
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