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| 1 | Clinical efficacy of 0.1% pranoprofen in treatment of dry eye patients:a multicenter, randomized, controlled clinical trial显示文摘 | Chen Jingyao Dong Fei Chen Wei Sun Xuguang Deng Yingping Hong Jing Zhang Mingchang Yang Wenzhao Liu Zuguo Xie Lixin | 2014 | Chinese Medical Journal2014，，13： | 18 |
| 2 | A Novel Readout System for Wireless Passive Pressure Sensors显示文摘这份报纸基于诱导地联合的电感器和洞(LC ) 为无线被动压力传感器论述一个新奇读出系统反响的电路。建议系统由诱导地联合到传感器电路,一个读出电路,和处理联合起来的一张个人计算机(PC ) 帖子的一条阅读器天线组成。读出电路产生代表传感器电容的一个电压信号。驾驶信号的读者天线的频率是一个常数,它等于传感器在零个压力的反响的频率。基于机械、电建模,压力传感器设计基于高温度共同开火陶器(HTCC ) 技术被进行并且讨论。读出系统的功能和精确性与一个电压电容测量系统被测试并且在现实主义的压力测量环境示威了,以便全面表演和读出系统的可行性被证明。 | Huixin Zhang Yingping Hong Binger Ge Ting Liang Jijun Xiong | 2014 | Photonic Sensors2014，4，1： | 2 |
| 3 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 4 | Wireless LTCC-based capacitive pressure sensor for harsh environment显示文摘 | Jijun Xiong Ying Li Yingping Hong Binzhen Zhang Tianhong Cui Qiulin Tan Shijun Zheng Ting Liang | 2013 | Physical2013，，： | 1 |
| 5 | Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome显示文摘Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation.In an effort to unravel the basic principle underlying genome folding,here we focus on the genome itself and report a fundamental role for L1(LINE1 or LINE-1)and B1/Alu retrotransposons,the most abundant subclasses of repetitive sequences,in chromatin compartmentalization.We find that homotypic clustering of L1 and B1/Alu demarcates the genome into grossly exclusive domains,and characterizes and predicts Hi-C compartments.Spatial segregation of L1-rich sequences in the nuclear and nucleolar peripheries and B1/Alu-rich sequences in the nuclear interior is conserved in mouse and human cells and occurs dynamically during the cell cycle.In addition,de novo establishment of L1 and B1 nuclear segregation is coincident with the formation of higher-order chromatin structures during early embryogenesis and appears to be critically regulated by L1 and B1 transcripts.Importantly,depletion of L1 transcripts in embryonic stem cells drastically weakens homotypic repeat contacts and compartmental strength,and disrupts the nuclear segregation of L1-or B1-rich chromosomal sequences at genome-wide and individual sites.Mechanistically,nuclear co-localization and liquid droplet formation of L1 repeat DNA and RNA with heterochromatin protein HP1αsuggest a phase-separation mechanism by which L1 promotes heterochromatin compartmentalization.Taken together,we propose a genetically encoded model in which L1 and B1/Alu repeats blueprint chromatin macrostructure.Our model explains the robustness of genome folding into a common conserved core,on which dynamic gene regulation is overlaid across cells. | J.Yuyang Lu Lei Chang Tong Li Ting Wang Yafei Yin Ge Zhan Xue Han Ke Zhang Yibing Tao Michelle Percharde Liang Wang Qi Peng Pixi Yan Hui Zhang Xianju Bi Wen Shao Yantao Hong Zhongyang Wu Runze Ma Peizhe Wang Wenzhi Li Jing Zhang Zai Chang Yingping Hou Bing Zhu Miguel Ramalho-Santos Pilong Li Wei Xie Jie Na Yujie Sun Xiaohua Shen | 2021 | Cell Research2021，31，6： | 1 |
| 6 | Cell membrane coated-nanoparticles for cancer immunotherapy显示文摘Cancer immunotherapy can effectively inhibit cancer progression by activating the autoimmune system, with low toxicity and high effectiveness. Some of cancer immunotherapy had positive effects on clinical cancer treatment. However, cancer immunotherapy is still restricted by cancer heterogeneity, immune cell disability, tumor immunosuppressive microenvironment and systemic immune toxicity. Cell membrane-coated nanoparticles(CMCNs) inherit abundant source cell-relevant functions, including “self” markers, cross-talking with the immune system, biological targeting, and homing to specific regions. These enable them to possess preferred characteristics, including better biological compatibility, weak immunogenicity, immune escaping, a prolonged circulation, and tumor targeting.Therefore, they are applied to precisely deliver drugs and promote the effect of cancer immunotherapy.In the review, we summarize the latest researches of biomimetic CMCNs for cancer immunotherapy,outline the existing specific cancer immune therapies, explore the unique functions and molecular mechanisms of various cell membrane-coated nanoparticles, and analyze the challenges which CMCNs face in clinical translation. | Yingping Zeng Sufen Li Shufen Zhang Li Wang Hong Yuan Fuqiang Hu | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 1 |
| 7 | Keratinocytes induce tolerance to skin graft by activating IL-10-secreting T cells in the context of costimulation molecule B7-H1 显示文摘 | Yingping Cao Hong Zhou Jian Tao | 2003 | Transplantation2003，75，8： | 1 |
| 8 | Diflurobenzothiadiazole core-based noncovalently fused small molecule acceptor exhibiting over 12% efficiency and high fill factor显示文摘The versatility and flexibility of organic photoelectric materials endow organic photovoltaic cells fine function modulation and huge commercial potential. In this work, a new noncovalent fused-ring small molecule acceptor(SMA) BID-4 F has been synthesized for high-efficient organic solar cells(OSCs). BID-4 F consists of a diflurobenzothiadiazole(DFBT) core, ladder-like indacenodithiophene(IDT) spacers, and dicyanoindanone electron-withdrawing end groups, which are supposed to be conformationally interlocked by noncovalent interactions, leading to good molecular planarity. In addition, compact solid state stacking was revealed by UV–vis–NIR absorption spectrum. The optimized PM6:BID-4 F based device delivers an eminent power conversion efficiency(PCE) of 12.30% with a high open-circuit voltage(Voc) of 0.92 V and a high fill factor(FF) of 74.3%. Most importantly, the PCE and FF are among one of the highest values reported for the OSCs based on the unfused-ring SMAs. Overall, our work demonstrates that the unfused ring central framework with high molecular planarity through noncovalent interactions provides a good strategy to construct highly efficient SMAs. | Qin Chang Honggang Chen Jun Yuan Yunbin Hu Jiefeng Hai Wei Liu Fangfang Cai Juan Hong Xuxian Xiao Yingping Zou | 2020 | Journal of Energy Chemistry2020，29，12： | 0 |
| 9 | Tumor and dendritic cell dual-targeting nanocarriers maximize the therapeutic potential of IDO1 inhibitor in vivo显示文摘Researches on indoleamine-2,3-dioxygenase-1(IDO1),a neoplastic pathogenesis-related protein,have provided a new angle of view to regulate malignancy-related immunosuppression.However,the therapeutic efficacy of IDO1 inhibitors is subject to key limitations as both cancer and dendritic cells tend to be trapped in the IDO1-mediated immune dysfunction,which poses challenges to the inhibitory potency of drug regimens in multiple targets.Here,we report on the fabrication technique of a biomimetic nanocarrier that is endowed with the whole array of cancer cell membrane proteins for encapsulating the most used IDO1 probe indoximod(IND).By fully utilizing the homologous adhesion proteins and antigenic motifs on cytomembrane,these nanoparticulate particles are capable of infiltrating tumors and actively accumulating in cancer and dendritic cells,as well as hitching a ride on dendritic cells to tumor-draining lymph nodes.Ultimately,by increasing the distribution of drugs in both tumor cells and dendritic cells in tumor-draining lymph nodes,these formulations greatly enhance the efficacy of IND without the aid of chemotherapeutic drugs,achieving substantial control of tumor growth.Overall,this leverage of bionanotechnology maximizes the therapeutic potential of IND and can provide a theoretical reference for the clinical application of IDO1 inhibitors. | Tong Yu Xiangyu Jin Fangying Yu Xiqin Yang Yingping Zeng Tingting Meng Hong Yuan Fuqiang Hu | 2022 | Nano Research2022，15，10： | 0 |
| 10 | Wireless passive flexible accelerometer fabricated using micro-electro-mechanical system technology for bending structure surfaces显示文摘We propose an inductor-capacitor(LC)wireless passive flexible accelerometer,which eliminates the difficulty in measuring the acceleration on the surface of a bending structure.The accelerometer is composed of a flexible polyimide(PI)substrate and a planar spiral inductance coil(thickness 300 nm),made using micro-electro-mechanical system(MEMS)technology.It can be bent or folded at will,and can be attached firmly to the surface of objects with a bending structure.The principle of radio frequency wireless transmission is used to measure the acceleration signal by changing the distance between the accelerometer and the antenna.Compared with other accelerometers with a lead wire,the accelerometer can prevent the lead from falling off in the course of vibration,thereby prolonging its service life.Through establishment of an experimental platform,when the distance between the antenna and accelerometer was 5 mm,the characterization of the surface of bending structures demonstrated the sensing capabilities of the accelerometer at accelerations of 20-100 m/s2.The results indicate that the acceleration and peak-to-peak output voltage were nearly linear,with accelerometer sensitivity reaching 0.27 mV/(m·s-2).Moreover,the maximum error of the accelerometer was less than 0.037%. | Chen LI Mangu JIA Yingping HONG Yanan XUE Jijun XIONG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，5： | 0 |
| 11 | Design of Linear Sweep Source Based on DDS Used in Readout System for Wireless Passive Pressure Sensor显示文摘这篇论文建议高带宽上的设计和研究线性频率打扫基于目前广泛地被使用的相互的电感联合的原则在高温度涉及无线被动压力传感器的读出单位模块的信号来源。操作原则线性基于直接数字的频率合成(DDS ) 打扫频率来源技术被介绍,并且顺序的控制过程在我们的系统要求了的硬件电路和逻辑的实现方法被认识到利用这种技术。通过在步价值的不同条件下面的实验,联系的 sweep 范围和其它在联合传感器的相互的电感的读出系统期间设计指示物,对回声频率信息的抽取方法的影响,抽取精确性,和其它被分析并且学习。线性频率的设计扫信号来源在 1 MHz100 MHz 的 sweep 宽度以内为 0.116 Hz 与 6 kHz, 1 kHz 的最小的步值,和频率的精确的回声频率变化分辨率被认识到。由于综合商业芯片的使用,线性扫频率来源为更高的应用程序值模块化的读出单位在尺寸,高工作频率,高分辨率和低步值被使小。 | Yingping HONG | 2014 | Photonic Sensors2014，4，4： | 0 |
| 12 | A Phase Readout Method for Wireless Passive Sensor Used in Pressure Measurement System显示文摘A phase difference detection method used for reading the resonant frequency through mutual coupling is designed to meet the pressure measurement in harsh environments, and a testing device of integrated modular by developing the hardware circuits is proposed.Description and discussion of the novel theoretical model in the phase readout system is presented, and a pressure test platform based on the phase difference detection is also established, which is to measure the frequency of a LC resonant sensor on the basis of 96% alumina ceramic substrate. The experimental results show that the proposed phase difference readout system presents sweep-frequency detection in the range of 1–100MHz bandwidth, and a high frequency resolution of 0.006 MHz. Sensitivity of the sensor is approximately 0.225 MHz/bar from 1 bar to 2 bar. The accuracy and functionality of the phase readout system have emphasized a wider engineering application range, so that we can make it possible that the wireless passive LC resonant sensor revolves well in practical engineering occasions outside the laboratory environment. | HONG Yingping LIANG Ting ZHENG Tingli ZHANG Hairui LIU Wenyi XIONG Jijun | 2015 | Chinese Journal of Electronics2015，24，4： | 0 |
| 13 | Optimizing side chains on different nitrogen aromatic rings achieving 17% efficiency for organic photovoltaics显示文摘Balancing charge generation and low energy loss(E_(loss)), especially in the wide spectral absorption region is critical to obtain high-performance organic photovoltaics(OPVs). Therefore, Y11-M and Y11-EB are designed and synthesized through modifying alkyl chains on different nitrogen aromatic rings of the reported non-fullerene acceptor Y11. Although all the molecules have almost similar low band-gap(around 1.30 e V), Y11-M and Y11-EB exhibit wider absorption in 410–870 nm region. Eventually, the conventional devices based on Y11-M and Y11-EB possess more efficient charge generation with low Eloss(around 0.44 e V). In addition, outstanding efficiencies of 16.64% and 17.15% with the fill factor of 76.15% and 74.73% are obtained in PM6:Y11-M and PM6:Y11-EB-based devices, both higher than Y11:PM6. The results highlight the importance of rational alkyl chains optimization, and a good structureproperty relationship is established as well. | Zhe Li Can Zhu Jun Yuan Liuyang Zhou Wei Liu Xinxin Xia c Juan Hong Honggang Chen Qingya Wei Xinhui Lu Yongfang Li Yingping Zou | 2022 | Journal of Energy Chemistry2022，31，2： | 0 |
| 14 | Identification of anti-inflammatory components in Panax ginseng of Sijunzi Decoction based on spectrum-effect relationship显示文摘Objective: This study aimed to identify the main medicinal active components of Panax ginseng(P. ginseng) in the compatibility environment of clinical application. For this purpose, the anti-inflammatory ingredients of P. ginseng were investigated based on its therapeutic effect in Sijunzi Decoction(SJD) which is a widely used traditional Chinese formula.Methods: The fingerprints of 10 batches of SJD consisting of different sources of P. ginseng were established by UPLC technique to investigate the chemical components. At the same time, the antiinflammatory effects of these components were evaluated by dextran sulfate sodium-induced ulcerative colitis mouse model. Grey relational analysis was applied to explore the correlation degree between fingerprints and anti-inflammatory effects in SJD. Lipopolysaccharide-stimulated RAW264.7 murine macrophages were established to evaluate the anti-inflammatory action of the screened effective substances of P. ginseng.Results: According to grey relational analysis, notoginsenoside R1, ginsenoside Rg2 and ginsenoside Rb3of P. ginseng were the major anti-inflammatory contributions in SJD. They had been proven to be closely associated with the anti-inflammatory process of SJD and displayed a close effect compared with SJD by LPS-stimulated RAW264.7 murine macrophages.Conclusion: Our work provides a general strategy for exploring the pharmacological ingredients of P. ginseng in traditional Chinese formulas which is beneficial for establishing the quality standards of traditional herbs in traditional Chinese medicine prescription based on their clinical therapeutic effect. | Hong Kan Dongxue Zhang Weijia Chen Shihan Wang Zhongmei He Shifeng Pang Shuai Qu Yingping Wang | 2023 | Chinese Herbal Medicines2023，15，1： | 0 |
| 15 | Rationally optimized generation of integrated Escherichia coli with stable and high yield lycopene biosynthesis from heterologous mevalonate(MVA)and lycopene expression pathways显示文摘The stability and high productivity of heterogeneous terpenoid production in Escherichia coli expression system is one of the most key issues for its large scale industrialization.In the current study on taking lycopene biosynthesis as an example,an integrated Escherichia coli system has been generated successfully,which resulted into stable and high lycopene production.In this process,two modules of mevalonate(MVA)pathway and one module of lycopene expression pathway were completely integrated in the chromosome.Firstly,the copy number and integrated position of three modules of heterologous pathways were rationally optimized.Later,a strain DH416 equipped with heterogeneous expression pathways through chromosomal integration was efficiently derived from parental strain DH411.The evolving DH416 strain efficiently produced the lycopene level of 1.22 g/L(49.9 mg/g DCW)in a 5 L fermenter with mean productivity of 61.0 mg/L/h.Additionally,the integrated strain showed more genetic stability than the plasmid systems after successive 21st passage. | Muhammad Hammad Hussain Qi Hong Waqas Qamar Zaman Ali Mohsin Yanlong Wei Ning Zhang Hongqing Fang Zejian Wang Haifeng Hang Yingping Zhuang Meijin Guo | 2021 | Synthetic and Systems Biotechnology2021，6，2： | 0 |
| 16 | An Arc Tangent Function Demodulation Method of Fiber-Optic Fabry-Perot High-Temperature Pressure Sensor显示文摘光纤的 Fabry-Perot 洞长度的一个新解调算法基于阶段,产生搬运人(PGC ) 在这份报纸被建议,它能在高温度的压力传感器中被使用。这个新算法由利用一个光系统基于弧正切功能输出二个直角的信号,它基于地可编程的门数组(FPGA ) 被设计克服原来的 PGC 弧正切函数解调算法的范围限制。模拟和分析也被继续。根据解调的分析,速度和精确,采样点的不同数字的模拟,和测量压力传感器结果,弧正切功能解调方法有好解调结果:单个数据和在 Fabry-Perot 高温度的压力传感器的光纤的 Fabry-Perot 洞长度解调显示出实际可行性的不到 1% 错误的 1 MHz 处理速度。 | Qianyu REN Junhong LI Yingping HONG Pinggang JIA Jijun XIONG | 2017 | Photonic Sensors2017，7，3： | 0 |
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