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| 1 | Clinical efficacy of 0.1% pranoprofen in treatment of dry eye patients:a multicenter, randomized, controlled clinical trial显示文摘 | Chen Jingyao Dong Fei Chen Wei Sun Xuguang Deng Yingping Hong Jing Zhang Mingchang Yang Wenzhao Liu Zuguo Xie Lixin | 2014 | Chinese Medical Journal2014，，13： | 18 |
| 2 | Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome显示文摘Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation.In an effort to unravel the basic principle underlying genome folding,here we focus on the genome itself and report a fundamental role for L1(LINE1 or LINE-1)and B1/Alu retrotransposons,the most abundant subclasses of repetitive sequences,in chromatin compartmentalization.We find that homotypic clustering of L1 and B1/Alu demarcates the genome into grossly exclusive domains,and characterizes and predicts Hi-C compartments.Spatial segregation of L1-rich sequences in the nuclear and nucleolar peripheries and B1/Alu-rich sequences in the nuclear interior is conserved in mouse and human cells and occurs dynamically during the cell cycle.In addition,de novo establishment of L1 and B1 nuclear segregation is coincident with the formation of higher-order chromatin structures during early embryogenesis and appears to be critically regulated by L1 and B1 transcripts.Importantly,depletion of L1 transcripts in embryonic stem cells drastically weakens homotypic repeat contacts and compartmental strength,and disrupts the nuclear segregation of L1-or B1-rich chromosomal sequences at genome-wide and individual sites.Mechanistically,nuclear co-localization and liquid droplet formation of L1 repeat DNA and RNA with heterochromatin protein HP1αsuggest a phase-separation mechanism by which L1 promotes heterochromatin compartmentalization.Taken together,we propose a genetically encoded model in which L1 and B1/Alu repeats blueprint chromatin macrostructure.Our model explains the robustness of genome folding into a common conserved core,on which dynamic gene regulation is overlaid across cells. | J.Yuyang Lu Lei Chang Tong Li Ting Wang Yafei Yin Ge Zhan Xue Han Ke Zhang Yibing Tao Michelle Percharde Liang Wang Qi Peng Pixi Yan Hui Zhang Xianju Bi Wen Shao Yantao Hong Zhongyang Wu Runze Ma Peizhe Wang Wenzhi Li Jing Zhang Zai Chang Yingping Hou Bing Zhu Miguel Ramalho-Santos Pilong Li Wei Xie Jie Na Yujie Sun Xiaohua Shen | 2021 | Cell Research2021，31，6： | 1 |
| 3 | The structure of integument and wax glands of Phenacoccus fraxinus(Hemiptera:Coccoidea:Pseudococcidae)显示文摘Using scanning electron microscopy and optical microscopy,we studied the structure of the integument and wax glands of the mealybug,Phenacoccus fraxinus Tang(Hemiptera:Coccoidea:Pseudococcidae).We observed the ultrastructure of four wax pores including trilocular,quinquelocular,and multilocular pores as well as tubular ducts,recording characteristics of their structure,size and distribution.We found that that the integument of the mealybug consists of three main layers-the procuticle,epidermis and basement membrane-and four sub-layers of the procuticle-the epicuticle,exocuticle,endocuticle and formation zone.The waxsecreting gland cells were closely arranged in epidermis.All of them were complex and composed of one central cell and two or more lateral cells.These complex cells possess a large common reservoir for collection and storage.Synthesized by the glandular cells,the wax is excreted outside integument through canals. | Yanfeng ZHANG Yingping XIE Jiaoliang XUE Xiaohong FU Weimin LIU | 2012 | Zoological Research2012，33，3： | 1 |
| 4 | Mechanical compression upregulates MMP9 through SMAD3 but not SMAD2 modulation in hypertrophic scar fibroblasts显示文摘 | Dong Huang Yingping Liu Yongjun Huang Youfu Xie Kuanhong Shen Dawei Zhang Yong Mou | 2014 | Connective Tissue Research . 2014 (5-6)2014，，： | 1 |
| 5 | Large-scale roll-to-roll printed,flexible and stable organic bulk heterojunction photodetector显示文摘A flexible and stable photodetector shows great potential applications in intelligent wearable devices,health monitoring,and biological sensing.The high-output fabrication of flexible and stable photodetector via the large-scale printing process would accelerate its commercialization.Herein,a high performance,flexible organic bulk heterojunction(BHJ)photodetector with good stability is designed and fabricated via a large-scale roll-to-roll(R2R)micro-gravure printing technique on polyethylene terephthalate(PET)or paper substrate,in which the organic BHJ active layer is structured with[6,6]-phenyl C_(61)butyric acid methyl ester(PCBM)and a donor-acceptor copolymer,i.e.,employing 4,8-bis(2-ethylhexylthiophene)benzo[1,2-b;3,4-b′]dithiophene(BDTT)as the donor unit and 5,8-bis(5-thiophen-2-yl)-6,7-difluoro-2,3-bis(4-ethylhexyloxy-1-mata-luorophenyl)quinoxaline(ffQx)as the acceptor unit(PBDTT-ffQx).The PBDTT-ffQx/PCBM BHJ photodetector shows a broad photoresponse in ultraviolet and visible light,a high detectivity(D^(*))value up to 6.19×10^(11)Jones,and an excellent Iphoto/Idark as high as 5.6×10^(2).It exhibits excellent flexibility and stability.Its performance parameters could maintain over 80%of original values after bending 10,000 cycles or exposing in ambient condition(humidity~50%,temperature~30℃)for 50 days without any encapsulation.More importantly,the R2R micro-gravure printed PBDTT-ffQx/PCBM BHJ active layer is great homogeneous,and the responsivity(R)values of photodetector arrays show a very narrow distribution.The research results show that a high-performance PBDTT-ffQx/PCBM BHJ photodetector with well reliability and reproducibility can be fabricated via the R2R micro-gravure printing technique,which provides an available strategy for fabricating large-area and flexible electronic and optoelectronic devices. | Sichao Tong Jun Yuan Chujun Zhang Chunhua Wang Baoxing Liu Jianqiang Shen Huayan Xia Yingping Zou Haipeng Xie Jia Sun Si Xiao Jun He Yongli Gao Junliang Yang | 2018 | npj Flexible Electronics2018，2，1： | 0 |
| 6 | The structure of integument and wax glands of Phenacoccus fraxinus(Hemiptera:Coccoidea:Pseudococcidae)显示文摘Using scanning electron microscopy and optical microscopy,we studied the structure of the integument and wax glands of the mealybug,Phenacoccus fraxinus Tang(Hemiptera:Coccoidea:Pseudococcidae).We observed the ultrastructure of four wax pores including trilocular,quinquelocular,and multilocular pores as well as tubular ducts,recording characteristics of their structure,size and distribution.We found that that the integument of the mealybug consists of three main layers-the procuticle,epidermis and basement membrane-and four sub-layers of the procuticle-the epicuticle,exocuticle,endocuticle and formation zone.The wax-secreting gland cells were closely arranged in epidermis.All of them were complex and composed of one central cell and two or more lateral cells.These complex cells possess a large common reservoir for collection and storage.Synthesized by the glandular cells,the wax is excreted outside integument through canals. | Yanfeng ZHANG Yingping XIE Jiaoliang XUE Xiaohong FU Weimin LIU | 2012 | Zoological Research2012，33，S01： | 0 |
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