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| 1 | microRNA-21a-5p/PDCD4 axis regulates mesenchymal stem cell-induced neuroprotection in acute glaucoma显示文摘间充质的干细胞(MSC ) 被表明了为许多神经病学的疾病有有希望的治疗学的好处;然而,内在的机制糟糕被理解。这里,我们显示出 MSC 的那 intravitreal 注入在尖锐绿内障的一个老鼠模型的支持的网膜的中心细胞(RGC ) 幸存与 microglial 激活的重要抑制, TNF- , IL-1,和反应的氧种类的生产,以及 caspase-8 和 caspase-3 激活。在 vitro, MSC 禁止了两 caspase-8-mediated RGC apoptosis 和 microglial 激活,部分经由 stanniocalcin 的行动 1 (STC1 ) 。而且,我们发现了那 microRNA-21a-5p (miR-21 ) 和它的目标, PDCD4,为 STC1 生产和在 vitro 并且在 vivo 的 MSC 的 neuroprotective 性质是必要的。重要地, miR-21 overexpression 或 PDCD4 尖锐绿内障上的击倒的扩充调停 MSC 的 neuroprotective 效果。miR-21/PDCD4 轴由导致 MSC 分泌施加 neuroprotective 的 STC1 和另外的因素的以前未被认出的 neuroprotective 机制完成的这些数据热点。因此, modulating miR-21/PDCD4 轴可能是为尖锐绿内障和另外的神经病学的疾病的临床的处理的有希望的策略。 | Wenru Su Zuohong Li Yu Jia Yingting Zhu Wenjia Cai Peixing Wan Yingying Zhang Song Guo Zheng Yehong Zhuo | 2017 | Journal of Molecular Cell Biology2017，9，4： | 5 |
| 2 | Hypoxia-mimicking 3D bioglass-nanoclay scaffolds promote endogenous bone regeneration显示文摘Large bone defect repair requires biomaterials that promote angiogenesis and osteogenesis.In present work,a nanoclay(Laponite,XLS)-functionalized 3D bioglass(BG)scaffold with hypoxia mimicking property was prepared by foam replication coupled with UV photopolymerization methods.Our data revealed that the incorporation of XLS can significantly promote the mechanical property of the scaffold and the osteogenic differentiation of human adipose mesenchymal stem cells(ADSCs)compared to the properties of the neat BG scaffold.Desferoxamine,a hypoxia mimicking agent,encourages bone regeneration via activating hypoxia-inducible factor-1 alpha(HIF-1α)-mediated angiogenesis.GelMA-DFO immobilization onto BG-XLS scaffold achieved sustained DFO release and inhibited DFO degradation.Furthermore,in vitro data demonstrated increased HIF-1αand vascular endothelial growth factor(VEGF)expressions on human adipose mesenchymal stem cells(ADSCs).Moreover,BG-XLS/GelMA-DFO scaffolds also significantly promoted the osteogenic differentiation of ADSCs.Most importantly,our in vivo data indicated BG-XLS/GelMA-DFO scaffolds strongly increased bone healing in a critical-sized mouse cranial bone defect model.Therefore,we developed a novel BG-XLS/GelMA-DFO scaffold which can not only induce the expression of VEGF,but also promote osteogenic differentiation of ADSCs to promote endogenous bone regeneration. | Xiao Zheng Xiaorong Zhang Yingting Wang Yangxi Liu Yining Pan Yijia Li Man Ji Xueqin Zhao Shengbin Huang Qingqing Yao | 2021 | Bioactive Materials2021，6，10： | 4 |
| 3 | Digital medical education empowered by intelligent fabric space显示文摘Medical education plays an important role in promoting the development of global medical science.Nevertheless,the intrinsic gap existing between institutional medical teaching and practical clinical tasks causes low education efficiency and students’weak initiative.Recent developments of sensing fabric and embedded computing,along with the advances in artificial intelligence(AI)and digital twin technology are paving the way for the transformation of medical research towards digitization.In this work,we present an intelligent fabric space based on novel functional fabric materials and digital twin networking enabled by 5G and internet of things(IoT)technologies.In this space,medical students can learn knowledge with collaborative mapping of the digital and real world,cyber-physical interaction and real-time tactile feedback.And the proposed service system will evaluate and feedback students’operational behaviors to improve their experimental skills.We provide four typical applications of intelligent fabric space for medical education,including medical education training,health and behavior tracking,operation playback and reproduction,as well as medical knowledge popularization.The proposed intelligent fabric space has the potential to promote innovative technologies for training cutting-edge medical students by effective and efficient ways. | Min Chen Rui Wang Rui Wang Yingting Zhou Zicheng He Xiaojuan Liu Muyao He Jiaxi Wang Chaolin Huang Huamin Zhou Ping Hong Chong Hou Ning Zhou Dingyu Zhang Guangming Tao | 2022 | National Science Open2022，1，1： | 2 |
| 4 | Loss-of-function of KMT5B leads to neurodevelopmental disorder and impairs neuronal development and neurogenesis显示文摘Autism spectrum disorder(ASD)is a group of neurodevelopmental disorders that cause severe social,communication,and behavioral problems.Recent studies show that the variants of a histone methyltransferase gene KMT5B cause neurodevelopmental disorders(NDDs),including ASD,and the knockout of Kmt5b in mice is embryonic lethal.However,the detailed genotype-phenotype correlations and functional effects of KMT5B in neurodevelopment are unclear.By targeted sequencing of a large Chinese ASD cohort,analyzing published genome-wide sequencing data,and mining literature,we curated 39 KMT5B variants identified from NDD individuals.A genotype-phenotype correlation analysis for 10 individuals with KMT5B pathogenic variants reveals common symptoms,including ASD,intellectual disability,languages problem,and macrocephaly.In vitro knockdown of the expression of Kmt5b in cultured mouse primary cortical neurons leads to a decrease in neuronal dendritic complexity and an increase in dendritic spine density,which can be rescued by expression of human KMT5B but not that of pathogenic de novo missense mutants.In vivo knockdown of the Kmt5b expression in the mouse embryonic cerebral cortex by in utero electroporation results in decreased proliferation and accelerated migration of neural progenitor cells.Our findings reveal essential roles of histone methyltransferase KMT5B in neuronal development,prenatal neurogenesis,and neuronal migration. | Guodong Chen Lin Han Senwei Tan Xiangbin Jia Huidan Wu Yingting Quan Qiumeng Zhang Bin Yu Zhengmao Hu Kun Xia Hui Guo | 2022 | Journal of Genetics and Genomics2022，49，9： | 1 |
| 5 | Single relay selection for bidirectional cooperative networks with physical-layer network coding显示文摘 | Liu Yingting Zhang Hailin Hui Leifang | 2012 | ETRI Journal2012，34，1： | 1 |
| 6 | Upregulation of H19 promotes invasion and induces epithelial-to-mesenchymaltransition in esophageal cancer显示文摘 | Cheng Huang Lihua Cao Limin Qiu Xiaoli Dai Linwei Ma Yingting Zhou Huifen Li Min Gao Weiyong Li Qing Zhang Koulan Han Hongzhen Lv | 2015 | Oncology Letters2015，，： | 1 |
| 7 | Autonomous battery-changing system for UAV's lifelong flight显示文摘Unmanned aerial vehicles(UAVs)lifelong flight is essential to accomplish various tasks,e.g.,aerial patrol,aerial rescue,etc.However,traditional UAVs have limited power to sustain their flight and need skilled operators manually control their charging process.Manufacturers and users are eagerly seeking a reliable autonomous battery-changing solution.To address this need,we propose and design an autonomous battery-changing system for UAVs using the theory of inventive problem solving(TRIZ)and user-centered design(UCD)methods.For practical application,we employ UCD to thoroughly analyze user requirements,identify multiple pairs of technical contradictions,and solve these inconsistencies using TRIZ theory.Furthermore,we design an autonomous battery-changing hardware system that meets user requirements and realizes the battery change process after the automatic landing of UAVs.Finally,we conduct experiments to validate our system’s effectiveness.The experimental results show that our battery-changing system can implement the autonomous battery-changing task,and our system has high efficiency and robustness in the real environment. | Jiyang Chen Wenxi Li Yingting Sha Yinchuan Wang Zhenqiang Zhang Shikuan Li Chaoqun Wang Sile Ma | 2023 | Biomimetic Intelligence & Robotics2023，3，2： | 0 |
| 8 | Improving IEC thermal model for oil natural air natural transformers using optimised parameters based on dynamic simulation显示文摘Accurate assessment of hot-spot temperature is essential for the safe operation of power transformers.Existing dynamic thermal models cannot estimate hot-spot temperature accurately since some input parameters are roughly determined by transformer capacity and cooling mode while ignoring the effect of winding structure,tank dimensions,and material physical properties.To improve the accuracy of temperature assessment,empirical parameters of the IEC thermal model including thermal constants,winding and oil exponents are optimised with the help of numerical simulation in this article.Based on energy conservation and heat transfer theory,a computational fluid dynamic(CFD)model of a transformer in oil natural air natural(ONAN)cooling mode is established.This CFD model simulates the entity's structure,sizes,and multi-stage heat dissipation processes realistically,so it can more precisely calculate the dynamic hot-spot temperature.According to the simulated temperature curves at different operating conditions,the thermal constants and oil exponent are estimated using non-linear regression,and the winding exponent is optimised using linear regression.A case study is conducted on an ONAN transformer.It shows the improved IEC model with optimised parameters can more accurately evaluate hot-spot temperature,and the absolute error is decreased by 2.4 K(38.7%)compared with traditional thermal models. | Lijing Zhang Yingting Luo Gehao Sheng Zizhan Ni Xiuchen Jiang | 2024 | High Voltage2024，9，1： | 0 |
| 9 | Active tunable terahertz bandwidth absorber based on single layer graphene显示文摘In this paper,an active tunable terahertz bandwidth absorber based on single-layer graphene is proposed,which consists of a graphene layer,a photo crystal plate,and a gold substrate.When the Fermi energy(Ef)of graphene is 1.5 eV,the absorber shows high absorption in the range of 3.7 THz–8 THz,and the total absorption rate is 96.8%.By exploring the absorption mechanism of the absorber,the absorber shows excellent physical regulation.The absorber also shows good adjustability by changing the Efof graphene.This means that the absorber exhibits excellent tunability by adjusting the physical parameters and Efof the absorber.Meanwhile,the absorber is polarization independent and insensitive to the incident angle.The fine characteristics of the absorber mean that the absorber has superior application value in many fields such as biotechnology and space exploration. | Wenxin Li Yingting Yi Hua Yang Shubo Cheng Wenxing Yang Huafeng Zhang Zao Yi Yougen Yi Hailiang Li | 2023 | Communications in Theoretical Physics2023，75，4： | 0 |
| 10 | Comparative Analyses and Phylogenetic Relationships between Cryptomeria fortunei and Related Species Based on Complete Chloroplast Genomes显示文摘Cryptomeria fortunei(Chinese cedar)is a highly adaptable woody species and one of the main forest plantation trees in subtropical high-altitude areas in China.However,there are few studies on its chloroplast(cp)genome.In this study,the complete cp genome of C.fortunei was sequenced and evaluated via comparative analyses with those of related species(formerly the Taxodiaceae)in Cupressaceae.The C.fortunei cp genome was 131,580 bp in length,and the GC content of the whole genome was 35.38%.It lost one relevant large inverted repeat and contained 114 unique genes,including 82 protein-coding genes,28 tRNAs and 4 rRNAs.The relative synonymous codon usage(RSCU)of codons ending with A/U was more than twice that of codons ending with G/C.Thirty long repeat structures(LRSs)and 213 simple sequence repeat(SSR)loci were detected in the C.fortunei cp genome.Comparative analyses of 10 cp genomes revealed that substantial rearrangements occurred in the gene organization.Additionally,6 cp hotspot regions(trnS-GGA,ycf1,trnP-GGG,trnC-GCA,psbZ and accD)were identified,and 4 genes(petL,psbM,rpl22 and psaM)had likely underwent positive selection.Phylogenetic analysis showed that Cupressaceae,Taxaceae and Cephalotaxaceae clustered to form a clade and that C.fortunei was most closely related to C.japonica(Japanese cedar),C.japonica cv.Wogon Hort and Taxodium distichum(baldcypress).These results provide references for future studies of population genetics,phylogenetic status and molecular markers among Cupressaceae species and for the cultivation of improved varieties. | Yingting Zhang Junjie Yang Zhenhao Guo Jiaxing Mo Jiebing Cui Hailiang Hu Jin Xu | 2020 | Phyton-International Journal of Experimental Botany2020，89，4： | 0 |
| 11 | Corrigendum to‘microRNA-21a-5p/PDCD4 axis regulates mesenchymal stem cell-induced neuroprotection in acute glaucoma’显示文摘Journal of Molecular Cell Biology(2017),9(4),289‒301,http://gffzzd3cc09b8251d45dfspwp9fqwnpvcx6q5v.ffgz.tsg.suse.edu.cn/10.1093/jmcb/mjx022 In this article,there were errors in Figures 4D(western blotting analysis),3E and F,5G and H,and 5J and K(flow cytometry analysis).Iba1 band in Figure 4D was the same as Cleaved caspase-3 band in Figure 2F.This was caused by carelessly mistaking the latter(Cleaved caspase-3,#1)for Iba1 band due to the high similarity between images(raw blot images of these bands from three experiments are provided in the Supplementary material).The corrected Figure 4D with updated Iba1 band(#1)and quantitation graph is shown below. | Wenru Su Zuohong Li Yu Jia Yingting Zhu Wenjia Cai Peixing Wan Yingying Zhang Song Guo Zheng Yehong Zhuo | 2023 | Journal of Molecular Cell Biology2023，15，4： | 0 |
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