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| 1 | BMP2 and VEGF promote angiogenesis but retard terminal differentiation of osteoblasts in bone regeneration by up-regulating Idl显示文摘不适当的 vascularization 限制骨头缺点的修理。以便改进 angiogenesis 并且加速成骨,有在骨头新生的基因修正的 co 有教养的房间的协同在这研究被调查。Endothelial 祖先房间(EPC ) 和骨头髓干细胞(BMSC ) 是有脉管的 endothelial 生长因素(VEGF ) 和骨头的基因的 transfected 形态基因的蛋白质 2 (BMP2 ) 由侵入人体气管粘膜的病菌分别地。co 有教养的房间,包括 BMSC + EPC, Ad-BMP2BMSC + EPC, BMSC + Ad-VEGFEPC,和 Ad-BMP2BMSC + 指定 Ad-VEGFEPC 组织为四个组,在 alginate 胶化上被播种然后肌内地植入进老鼠在 angiogenesis 和成骨上评估效果。VEGF 和 BMP2 能导致禁止者的 overexpression DNA 有约束力 1 (Id1 ) 显著地在 vitro 和增加支持了试管形成的基因在在培植以后的 Ad-BMP2BMSC + Ad-VEGFEPC 组的血容器的数量。不过, Id1 的 overexpression 延迟了造骨细胞和骨头形成的终端区别。后来,在 transcriptional 水平,钙小瘤,和碱的磷酸酶(高山) 活动的 osteogenic 基因表示证明渐渐的减少和最新形成的成骨区域的数量在 Ad-BMP2BMSC + Ad-VEGFEPC 组展出了小增加。这发现建议在 VEGFEPC 和 BMP2BMSCs 的 Id1 表示的一条平衡规定可能对为骨头新生的基于房间、基于基因的途径批评。 | Xiaobin Song Shaohua Liu Xun Qu Yingwei Hu Xiaoying Zhang Tao Wang Fengcai Wei | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 13 |
| 2 | Influence of yttrium element on the corrosion behaviors of Mg-Y binary magnesium alloy显示文摘The influence of yttrium on the corrosion behavior of Mg–Y alloys has been investigated by electrochemical measurements,scanning electron microscope(SEM)observation,X-ray diffraction(XRD),and X-ray photoelectron spectroscopy(XPS)analysis in NaCl solution.The corrosion resistance decreased with increasing Y content due to increasing Y-rich zone.The solid-dissolved Y improved the chemical activity of the substrate which promoted the corrosion reaction by forming Y2O3.The corrosion resistance was improved by increasing the Y concentration of matrix and proper net Y-rich structure.The sample has the best corrosion resistance when all the Y element was dissolved into the matrix of Mg–5Y in 0.1 M NaCl. | Xianbin Liu Dayong Shan Yingwei Song En-hou Han | 2017 | Journal of Magnesium and Alloys2017，5，1： | 7 |
| 3 | Hemorrhagic Fever with Renal Syndrome — Liaoning Province, China, 1999−2018显示文摘Summary What is already known on this topic?Hemorrhagic fever with renal syndrome(HFRS)is endemic in Liaoning Province.Both Seoul and Hantaan virus are circulating in rodents,and epidemic outbreaks and sporadic cases have been recorded every year since the disease was recognized. | Cui Shang Yingwei Sun Qiangling Yin Xiaoxia Huang Xuesheng Liu Quanfu Zhang Lingling Mao Chuan Li Aqian Li Qin Wang Lina Sun Mifang Liang Shiwen Wang Dexin Li Jiandong Li | 2020 | China CDC weekly2020，2，20： | 6 |
| 4 | IL-17-triggered downregulation of miR-497 results in high HIF-1α expression and consequent IL-1β and IL-6 production by astrocytes in EAE mice显示文摘Interleukin 17(IL-17)is increasingly recognized as a key factor that contributes to the pathogenesis of multiple sclerosis(MS)and its experimental mouse autoimmune encephalomyelitis(EAE)model.However,the roles and regulatory mechanisms of IL-17-induced pro-inflammatory cytokine production in EAE mice remain largely unclear.In this study,the expression of IL-17,hypoxia inducible factor-1α(HIF-1α),IL-1β,IL-6 and microRNA-497(miR-497),as well as their intrinsic associations,was investigated using EAE model mice and cultured astrocytes exposed to IL-17 in vitro.We observed markedly increased production of IL-17,HIF-1α,IL-1βand IL-6 in the brain tissues of EAE mice,while the expression and secretion of HIF-1α,IL-1βand IL-6 were also significantly increased when cultured primary astrocytes from mice were stimulated with IL-17.Meanwhile,the expression of miR-497 was downregulated both in vivo and in vitro.Subsequent in vitro experiments revealed that IL-17 induced the production of IL-1βand IL-6 in astrocytes through the upregulation of HIF-1αas a transcriptional factor,indicating that IL-17-mediated downregulation of miR-497 enhanced HIF-1αexpression.Furthermore,astrocytespecific knockdown of IL-17RA and HIF-1αor astrocyte-specific overexpression of miR-497 by infection with different lentiviral vectors containing an astrocyte-specific promotor markedly decreased IL-1βand IL-6 production in brain tissues and alleviated the pathological changes and score of EAE mice.Collectively,these findings indicate that decreased miR-497 expression is responsible for IL-17-triggered high HIF-1αexpression and consequent IL-1βand IL-6 production by astrocytes in EAE mice. | Kai Shan Rongrong Pang Chenhui Zhao Xiaomei Liu Wenxing Gao Jing Zhang Dan Zhao Yingwei Wang Wen Qiu | 2017 | Cellular & Molecular Immunology2017，14，11： | 5 |
| 5 | Comparison of the corrosion behavior of AM60 Mg alloy with and without self-healing coating in atmospheric environment显示文摘Coatings on the surface of Mg alloys are inevitably damaged during their practical applications,and corrosion can easily initiate from the damaged areas to accelerate the failure of Mg parts.A dual self-healing coating has already been developed to solve this problem in our previous work.Considering the practical application of this coating,it is necessary to investigate its service behavior in atmospheric environment.Thus,the corrosion behavior of AM60 Mg substrate with and without the self-healing coating was compared in Shenyang industrial atmospheric environment.The results show that the enrichment of sediments and rainwater on the scratch areas can accelerate the corrosion of the exposed Mg substrate.The inhibitors can be released from the damaged coating to inhibit corrosion.The dual self-healing coating shows better inhibition ability to narrow scratches due to the higher inhibitor concentration and less resumption.Also,the coating with wide scratches displays enough inhibition ability as well.The dual self-healing coating is a good alternative for Mg alloy parts in the practical applications. | Yingwei Song Dan Liu Weineng Tang Kaihui Dong Dayong Shan En-Hou Han | 2021 | Journal of Magnesium and Alloys2021，9，4： | 4 |
| 6 | Two-dimensional noble transition-metal dichalcogenides for nanophotonics and optoelectronics:Status and prospects显示文摘An emerging subclass of transition-metal dichalcogenides(TMDs),noble-transition-metal dichalcogenides(NMDs),has led to an increase in nanoscientific research in two-dimensional(2D)materials.NMDs feature a unique structure and several useful properties.2D NMDs are promising candidates for a broad range of applications in areas such as photodetectors,phototransistors,saturable absorbers,and meta optics.In this review,the state of the art of 2D NMDs research,their structures,properties,synthesis,and potential applications are discussed,and a perspective of expected future developments is provided. | Yingwei Wang Li Zhou Mianzeng Zhong Yanping Liu Si Xiao Jun He | 2022 | Nano Research2022，15，4： | 3 |
| 7 | The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling显示文摘The E3 ubiquitin ligase(E3)-mediated ubiquitination and deubiquitinase(DUB)-mediated deubiquitination processes are closely associated with the occurrence and development of colonic inflammation.Ovarian tumor deubiquitinase 1(OTUD1)is involved in immunoregulatory functions linked to infectious diseases.However,the effect of OTUD1 on intestinal immune responses during colonic inflammatory disorders such as inflammatory bowel disease(IBD)remains unclear.Here,we show that loss of OTUD1 in mice contributes to the pathogenesis of dextran sulfate sodium(DSS)-induced colitis via excessive release of proinflammatory cytokines.In addition,bone marrow transplantation experiments revealed that OTUD1 in hematopoietic cells plays a dominant role in protection against colitis.Mechanistically,OTUD1 physically interacts with receptor-interacting serine/threonine-protein kinase 1(RIPK1)and selectively cleaves K63-linked polyubiquitin chains from RIPK1 to inhibit the recruitment of NF-κB essential modulator(NEMO).Moreover,the expression of OTUD1 in mucosa samples from ulcerative colitis(UC)patients was lower than that in mucosa samples from healthy controls.Furthermore,we demonstrate that the UC-associated OTUD1 G430V mutation abolishes the ability of OTUD1 to inhibit RIPK1-mediated NF-κB activation and intestinal inflammation.Taken together,our study unveils a previously unexplored role of OTUD1 in moderating intestinal inflammation by inhibiting RIPK1-mediated NF-κB activation,suggesting that the OTUD1-RIPK1 axis could be a potential target for the treatment of IBD. | Bo Wu Lihua Qiang Yong Zhang Yesheng Fu Mengyuan Zhao Zehui Lei Zhe Lu Yan-Ge Wei Hongmiao Dai Yingwei Ge Mingqiu Liu Xuemei Zhou Zhiqiang Peng Hongchang Li Chun-Ping Cui Jing Wang Hui Zheng Cui Hua Liu Lingqiang Zhang | 2022 | Cellular & Molecular Immunology2022，19，2： | 3 |
| 8 | 2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy显示文摘An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation,tumor progression and metastasis.This makes iron metabolism an attractive therapeutic target.Unfortunately,current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities.We report here a dual-therapeutic prodrug,DOXjade,that allows for iron chelation chemo-photothermal cancer therapy.This prodrug takes advantage of the clinically approved iron chelator deferasirox(ExJade®)and the topoisomerase 2 inhibitor,doxorubicin(DOX).Loading DOXjade onto ultrathin 2D Ti_(3)C_(2) MXene nanosheets produces a construct,Ti_(3)C_(2)-PVP@DOXjade,that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites,while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%.Antitumor mechanistic investigations reveal that upon activation,Ti_(3)C_(2)-PVP@DOXjade serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor(TfR).A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in vivo.The results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy. | Yunjie Xu Yingwei Wang Jusung An Adam C.Sedgwick Mingle Li Jianlei Xie Weibin Hu Jianlong Kang Sajal Sen Axel Steinbrueck Bin Zhang Lijun Qiao Swelm Wageh Jonathan F.Arambula Liping Liu Han Zhang Jonathan L.Sessler Jong Seung Kim | 2022 | Bioactive Materials2022，7，8： | 2 |
| 9 | Effect of preparation methods of aluminum emulsions on catalytic performance of copper-based catalysts for methanol synthesis from syngas显示文摘Various Cu/ZnO/Al2O3 catalysts have been synthesized by different aluminum emulsions as aluminum sources and their performances for methanol synthesis from syngas have been investigated. The influences of preparation methods of aluminum emulsions on physicochemical and catalytic properties of catalysts were studied by XRD, SEM, XPS,N2 adsorption-desorption techniques and methanol synthesis from syngas. The preparation methods of aluminum emulsions were found to influence the catalytic activity, CuO crystallite size, surface area and Cu0 surface area and reduction process. The results show that the catalyst CN using the aluminum source prepared by addition the ammonia into the aluminum nitrate (NP) exhibited the best catalytic performance for methanol synthesis from syngas. | Lili Wang Wen Ding Yingwei Liu Weiping Fang Yiquan Yang | 2010 | Journal of Natural Gas Chemistry2010，19，5： | 2 |
| 10 | Local Participation and Cultural Inclusion: A Case Study on Lunang's Tourism Development in the Context of Policy of Partner Assistance to Tibet显示文摘The term Lang is a place name,it means'Dragon Valley','fairy place to live'in the Tibetan language.In 1911,the Qing dynasty officer Chen Quzhen was posted here,stationed in Lunang Dongjiu.He later described the Lunang area as a place' | Yang Minghong Liu Jianxia Zhang Yingwei | 2016 | China Tibetology2016，，2： | 2 |
| 11 | A novel reputation computation model based on subjective logic for mobile ad hoe networks 显示文摘 | Liu Yining Li Keqiu Jin Yingwei | 2011 | Future Generation Computer Systems2011，27，： | 1 |
| 12 | Backward UBET simulation of the forging of a blade 显示文摘 | Wang Zhen Xue Kemin Liu Yingwei | 1997 | Journal of Materials Processing Technology1997，65，13： | 1 |
| 13 | Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation显示文摘The apoptosis of glomerular mesangial cells(GMCs)is considered to be an important contributor to the initiation and development of rat Thy-1 nephritis(Thy-1N)and is accompanied by sublytic C5b-9 deposition.However,the mechanism by which sublytic C5b-9 triggers GMC apoptosis has not been elucidated.In this study,functional and histological examinations were performed on GMCs treated with sublytic C5b-9(in vitro)and renal tissues of Thy-1N rats(in vivo).The in vitro studies found that sublytic C5b-9 could trigger GMC apoptosis through upregulating Egr-1,ATF3,and Gadd45 expression.Egr-1-mediated post-transcriptional modulation of ATF3,Egr-1/ATF3-enhanced Gadd45 promoter activity,and p300-mediated ATF3 acetylation were all involved in GMC apoptosis.More importantly,the effective binding elements for Egr-1 and ATF3 to Gadd45β/γpromoters and the ATF3 acetylation site were identified.In vivo,silencing renal p300,Egr-1,ATF3,and Gadd45β/γsignificantly decreased GMC apoptosis,secondary GMC proliferation,and urinary protein secretion in Thy-1N rats.Together,these findings implicate that sublytic C5b-9-induced activation of Egr-1/p300–ATF3/Gadd45 axis plays a critical role in GMC apoptosis in Thy-1N rats. | Fengxia He Mengya Zhou Tianyi Yu Dan Zhao Jing Zhang Wen Qiu Yanlai Lu Yu Liu Lulu Wang Yingwei Wang | 2016 | Journal of Molecular Cell Biology2016，8，6： | 1 |
| 14 | Heavy metal contamination in soil alongside mountain railway in Sichuan,China显示文摘 | Liu Hao Chen Liping Ai Yingwei | 2009 | Environmental Monitoring and Assessment2009，152，1234： | 1 |
| 15 | Effect of additives on the properties of plasma electrolytic oxidation coatings formed on AM50 magnesium alloy in electrolytes containing K 2 ZrF 6显示文摘 | Feng Liu Dayong Shan Yingwei Song En-Hou Han | 2011 | Surface & Coatings Technology2011，，2： | 1 |
| 16 | A sequential response surface method and its application in the reliability analysis of aircraft structural systems显示文摘 | Liu Yingwei Moses F | 1994 | Structural Safety1994，16，12： | 1 |
| 17 | Influ-ences of the quantity of Mg2 Sn phase on the corrosionbehavior of Mg-7Sn magnesium alloy显示文摘 | Liu Xianbin Shan Da yong Song Yingwei | 2011 | ElectrochimicaActa2011，56，： | 1 |
| 18 | Verification for Particle Size Distribution of Ultrafine Powders by the SAXS Method显示文摘 | Yingwei Xiang JinYuan Zhang ChunLan Liu | 2000 | Materials Characterization2000，44，： | 1 |
| 19 | A sequential response surface method and its application in the reliability analysis of aircraft structural systems显示文摘 | Liu Yingwei Fred Moses | 1994 | Structural Safety1994，16，： | 1 |
| 20 | A sequential response surface method and its application in the rdiability analysis of aircraft structural systems显示文摘 | Liu Yingwei Moses F | 1994 | Structural Safety1994，16，： | 1 |
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