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| 1 | High reproducibility and sensitivity of bifacial copper nanowire array for detection of glucose显示文摘The ordered bifacial copper nanowire array(Cu BNWA) was synthesized by a template assisted electrochemical deposition method.The morphology and structure of the as-prepared samples were investigated by field emission scanning electron microscope(FESEM) and X-ray diffraction(XRD).The results show that the ordered Cu nanowire array with uniform geometrical dimensions covered both side of the Cu substrate.When used as the electrode for glucose detection,the minimum detectable concentration of glucose can be reached as low as 0.2 mM.Impressively,the sample still showed high sensitivity and stability for glucose detection after two months placement in ambient environment.These excellent performances of the Cu BNWA make it a promising non-enzyme glucose detection sensor for various applications. | Hanqing Zhang Yining Wang Xuesen Gao Zhuo Gao Yan Chen | 2017 | Progress in Natural Science:Materials International2017，27，3： | 2 |
| 2 | Newly self-administered two-step tool for screening cognitive function in an ageing Chinese population:an exploratory cross-sectional study显示文摘Background Early screening of cognitive function is critical to dementia treatment and care.However,traditional tests require face-to-face administration and are often limited by implementation costs and biases.Aims This study aimed to assess whether the Thoven Cognitive Self-Assessment(TCSA),a novel,innovative two-step touchscreen-based cognition assessment tool,could identify early cognitive impairment due to dementia in older adults.Methods The TCSA was administered to 61 healthy controls(HCs),46 participants with mild cognitive impairment(MCI)and 44 participants diagnosed with dementia recruited from Shanghai.Two outcome measures were generated from the TCSA test:the TCSA_(primary task)score and the TCSA_(secondary task)score.Results The total average scores in the control group for the TCSA_(primary task)and TCSA_(secondary task)were significantly higher than those in the MCI and dementia groups(TCSA_(primary task):HCs vs MCI group vs dementia group,8.58±1.76 vs 5.40±2.67 vs 2.74±2.11,F=75.40,p<0.001;TCSA_(secondary task):HCs vs MCI group vs dementia group,23.02±3.31 vs 17.95±4.93 vs 11.93±5.50,F=76.46,p<0.001).Moreover,receiver operating characteristic analysis showed that a score below 7.5 for the TCSA_(primary task)and a score below 22.5 for the TCSA_(secondary task)were indicators of MCI.Conclusions The TCSA appears to be efficacious for the detection of cognitive impairment in older adults.It demonstrates the potential for large-scale cognition screening in community service settings. | Jing Nie Yang Yang Yining Gao Wenwen Jiang Aisikeer Aidina Fei Sun Lucas R Prieto Jie Yu Kang Ju Lisheng Song Xia Li | 2023 | General Psychiatry2023，36，1： | 2 |
| 3 | Fast-convolution multicarrier based frequency division multiple access显示文摘Fast-convolution multicarrier(FCMC), the asynchronous waveform with ultra-low sidelobe, has appeared to be a promising waveform technique for future wireless communications. In this paper, we investigate the filter bank optimization as well as receiver design including low-complexity channel estimator and equalizer for FCMC based frequency division multiple access(FDMA). Starting from the conventional multi-carrier signals, we first derive a vectorized signal model as a framework to systematically design the FCMC transceiver. For nearly perfect reconstruction(NPR) filter banks design, an optimization criterion which consists of minimizing received signal segments’ mean square error(MSE) is proposed. From the fact that Toeplitz matrices can be asymptotically diagonalized by discrete Fourier transform(DFT) matrix, the channel equalizer can be simplified to one-tap frequency domain equalizer when DFT size is large enough.The minimum mean square error(MMSE) criterion is then applied to calculate the coefficients of onetap frequency domain equalizer. In practice, due to the channel fading, the channel estimation has to be performed to obtain the channel state information(CSI) which is required by the channel equalization. To this end, we propose a combined cyclic prefix(CP) and cyclic suffix(CS) pilot structure which facilitates to estimate the frequency domain CSI directly in the receiver end. The proposed FCMC based FDMA features low-complexity receiver, adjustable users’ bandwidth and low peak-to-average power ratio. Simulation results confirm the performance of the proposed scheme. | Yining LI Wenjin WANG Jiaheng WANG Xiqi GAO | 2019 | Science China(Information Sciences)2019，62，8： | 2 |
| 4 | Characterization and environmental applications of clay–biochar composites显示文摘 | Ying Yao Bin Gao June Fang Ming Zhang Hao Chen Yanmei Zhou Anne Elise Creamer Yining Sun Liuyan Yang | 2014 | Chemical Engineering Journal2014，，： | 1 |
| 5 | Use of oral anticoagulation among stroke patients with atrial fibrillation in C hina: the C hina QUEST ( Q uality evaluation of stroke care and treatment) registry study显示文摘 | Qingchun Gao Xian Fu Jade W. Wei Xiangyan Chen Yining Huang Jiguang Wang Craig S. Anderson Ka Sing Wong | 2011 | Int J Stroke2011，，3： | 1 |
| 6 | Effects of feedstock type, production method, and pyrolysis temperature on biochar and hydrochar properties显示文摘 | Yining Sun Bin Gao Ying Yao June Fang Ming Zhang Yanmei Zhou Hao Chen Liuyan Yang | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 7 | Effects of feedstock type, production method, and pyrolysis temperature on biochar and hydrochar properties显示文摘 | Sun Yining Gao Bin Yao Ying | 2014 | Chemical Engineering Journal2014，240，： | 1 |
| 8 | Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study显示文摘 | Yining Huang Yan Cheng Jiang Wu Yansheng Li En Xu Zhen Hong Zhengyi Li Weiwei Zhang Meiping Ding Xuguang Gao Dongsheng Fan Jinsheng Zeng Kasing Wong Chuanzhen Lu Jiangxi Xiao Chen Yao | 2008 | Lancet Neurology2008，，6： | 1 |
| 9 | Triple oxygen isotope constraints on the origin of ocean island basalts显示文摘Understanding the origin of ocean island basalts(OIB) has important bearings on Earth's deep mantle.Although it is widely accepted that subducted oceanic crust, as a consequence of plate tectonics, contributes material to OIB's formation, its exact fraction in OIB's mantle source remains ambiguous largely due to uncertainties associated with existing geochemical proxies. Here we show, through theoretical calculation, that unlike many known proxies, triple oxygen isotope compositions(i.e.D^(17 )O) in olivine samples are not affected by crystallization and partial melting. This unique feature, therefore, allows olivine D^(17 )O values to identify subducted oceanic crusts in OIB's mantle source. Furthermore, the fractions of subducted ocean sediments and hydrothermally altered oceanic crust in OIB's mantle source can be quantified using their characteristic D^(17 )O values. Based on published D^(17 )O data, we estimated the fraction of subducted oceanic crust to be as high as 22.3% in certain OIB, but the affected region in the respective mantle plume is likely to be limited. | Xiaobin Cao Huiming Bao Caihong Gao Yun Liu Fang Huang Yongbo Peng Yining Zhang | 2019 | Acta Geochimica2019，38，3： | 1 |
| 10 | Beliefs towards the COVID-19 pandemic among patients with emotional disorders in China显示文摘Background The novel coronavirus disease 2019(COVID-19)pandemic has given rise to fear and panic in the public.Although hospitals in China reduced outpatient visits and restricted inpatient admission to lower the risk of transmission of COVID-19,this has significantly affected patients in need of medical attention,for example,patients with emotional disorders.Aims This study aimed to compare the beliefs towards COVID-19 among outpatients with emotional disorders(ie,anxiety or depression)with those offamily caregivers and the general public and examine factors that shape the beliefs towards COVID-19 among outpatients with emotional disorders.Methods Survey data from 570 outpatients with anxiety or depression disorders,449 family caregivers and 470 general public subjects were collected.Multiple stepwise regression analyses were used to describe participants'level of concern,prevention atitude and positive expectations towards the COVID-19 outbreak.Results About 70.9%of outpatients had to postpone their mental health treatment;43.2%of patients admitted that their mental health was adversely affected by the COVID-19 outbreak--these patients tended to be older,male and less educated.After controlling for age and education level,outpatients with emotional disorders had significantly lower levels of concerns but more negative expectations towards COVID-19,compared with family caregivers and the public.Multivariate linear stepwise regression analysis showed that age,education and the perception of the impact of COVID-19 on one's existing mental ilness were significantly associated with outpatients'beliefs about the epidemic.Conclusion Outpatients with anxiety or depression disorders were relatively less focused on the COVID-19 outbreak,but the impact of the infection was found to be independently associated with their beliefs towards COVID-19.In addition,outpatients who were older and of low educational levels particularly held more negative beliefs about the epidemic,which may place them at a higher risk for poor mental health. | Yining Gao Fei Sun Wenwen Jiang Yuan Fang Ling Yue Xiang Lin Xia Li | 2020 | General Psychiatry2020，33，3： | 1 |
| 11 | Sorption of heavy metals on chitosan-modified biochars and its biological effects显示文摘 | Yanmei Zhou Bin Gao Andrew R. Zimmerman June Fang Yining Sun Xinde Cao | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 12 | Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study显示文摘 | Yining Huang Yan Cheng Jiang Wu Yansheng Li En Xu Zhen Hong Zhengyi Li Weiwei Zhang Meiping Ding Xuguang Gao Dongsheng Fan Jinsheng Zeng Kasing Wong Chuanzhen Lu Jiangxi Xiao Chen Yao | 2008 | Lancet Neurology2008，，6： | 1 |
| 13 | Maillard reaction-derived laser lithography for printing functional inorganics显示文摘Photopolymerization-based additive printing of functional inorganics has drawn great attention in recent years and one important challenge is the photoresin loading with diverse inorganics. Here, we introduce a Maillard reaction-derived laser lithography strategy for an unprecedented direct printing of diverse inorganic compounds. The sugar-assisted laser lithography(SLL) is powerful to carry choice metal ions and versatile for the generation of patterned inorganic materials comprising metal oxides,metal sulfides, and metal nitrides, characterized by ferroelectric, magnetic, semiconductivity, superconductivity, or other properties. The material architecture is flexibly manipulated by the laser intensity, power, printing speed, precursor solution, and computer-aided design to satisfy the practical requirements. This work demonstrates a new possibility for the further development of laser lithography in the directly printing of feature-rich inorganic materials and devices. | Xiao Dai Yining Jiang Xiaohan Wang Fengnan Chen Liang Gao Xiaofeng Li Guifu Zou | 2022 | Science China Chemistry2022，65，7： | 0 |
| 14 | Hydrogel-Based Stimuli-Responsive Micromotors for Biomedicine显示文摘The rapid development of medical micromotors draws a beautiful blueprint for the noninvasive or minimally invasive diagnosis and therapy.By combining stimuli-sensitive hydrogel materials,micromotors are bestowed with new characteristics such as stimuli-responsive shape transformation/morphing.excellent biocompatibility and biodegradability,and drug loading ability.Actuated by chemical fuels or external fields(eg,magnetic field,ultrasound,light,and electric field),hydrogel-based stimuli-responsive(HBSR)micromotors can be utilized to load therapeutic agents into the hydrogel networks or directly grip the target cargos(eg.,drug-loaded partides,cells,and thrombus),transport them to sites of interest(e.g.,tumor area and diseased tissues),and unload the cargos or execute a specific task(e.g.,cell capture,targeted sampling,and removal of blood dots)in response to a stimulus(eg.,change of temperature,pH,ion strength,and chemicals)in the physiological environment.The high flexibility,adaptive capacity,and shape morphing property enable the H BSR micromotors to complete specific medical tasks in complex physiological scenarios,especially in confined,hard to-reach tissues,and vessels of the body.Herein,this review summarizes the current progress in hydrogel-based medical micromotors with stimuli responsiveness.The thermo-responsive,photothermal-responsive,magnetocaloric-responsive,pH-responsive,ionic strength-responsive,and chemoresponsive micromotors are discussed in detail.Finally,curent challenges and future perspectives for the development of HBSR micromotors in the biomedical field are discussed. | Huaijuan Zhou Guozhao Dong Ge Gao Ran Du Xiaoying Tang Yining Ma Jinhua Li | 2022 | Cyborg and Bionic Systems2022，，1： | 0 |
| 15 | Heat Shock Factor A1s are required for phytochrome-interacting factor 4-mediated thermomorphogenesis in Arabidopsis显示文摘Thermomorphogenesis and the heat shock(HS)response are distinct thermal responses in plants that are regulated by PHYTOCHROME-INTERACTING FACTOR 4(PIF4)and HEAT SHOCK FACTOR A1s(HSFA1s),respectively.Little is known about whether these responses are interconnected and whether they are activated by similar mechanisms.An analysis of transcriptome dynamics in response to warm temperature(28℃)treatment revealed that 30 min of exposure activated the expression of a subset of HSFA1 target genes in Arabidopsis thaliana.Meanwhile,a loss-of-function HSFA1 quadruple mutant(hsfa1-cq)was insensitive to warm temperature-induced hypocotyl growth.In hsfa1-cq plants grown at 28℃,the protein and transcript levels of PIF4 were greatly reduced,and the circadian rhythm of many thermomorphogenesis-related genes(including PIF4)was disturbed.Additionally,the nuclear localization of HSFA1s and the binding of HSFA1d to the PIF4 promoter increased following warm temperature exposure,whereas PIF4 overexpression in hsfa1-cq partially rescued the altered warm temperature-induced hypocotyl growth of the mutant.Taken together,these results suggest that HSFA1s are required for PIF4 accumulation at a warm temperature,and they establish a central role for HSFA1s in regulating both thermomorphogenesis and HS responses in Arabidopsis. | Bingjie Li Shimeng Jiang Liang Gao Wenhui Wang Haozheng Luo Yining Dong Zhihua Gao Shuzhi Zheng Xinye Liu Wenqiang Tang | 2024 | Journal of Integrative Plant Biology2024，66，1： | 0 |
| 16 | A perspective on therapies for amyotrophic lateral sclerosis:can disease progression be curbed?显示文摘Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease involving both upper and lower motor neurons,leading to paralysis and eventually death.Symptomatic treatments such as inhibition of salivation,alleviation of muscle cramps,and relief of spasticity and pain still play an important role in enhancing the quality of life.To date,riluzole and edaravone are the only two drugs approved by the Food and Drug Administration for the treatment of ALS in a few countries.While there is adequate consensus on the modest efficacy of riluzole,there are still open questions concerning the efficacy of edaravone in slowing the disease progression.Therefore,identification of novel therapeutic strategies is urgently needed.Impaired autophagic process plays a critical role in ALS pathogenesis.In this review,we focus on therapies modulating autophagy in the context of ALS.Furthermore,stem cell therapies,gene therapies,and newly-developed biomaterials have great potentials in alleviating neurodegeneration,which might halt the disease progression.In this review,we will summarize the current and prospective therapies for ALS. | Xiaojiao Xu Dingding Shen Yining Gao Qinming Zhou You Ni Huanyu Meng Hongqin Shi Weidong Le Shengdi Chen Sheng Chen | 2021 | Translational Neurodegeneration2021，10，3： | 0 |
| 17 | Wind tunnel test of gust load alleviation for a large-scale full aircraft model显示文摘Wind tunnel test is an important way to test the performance of Gust Load Alleviation(GLA).At present,some component-level wind tunnel tests have been carried out in big aviation countries,but there is a lack of full aircraft model GLA tests.In this study,a set of large-scale GLA test system in low-speed wind tunnel is developed,which includes a gust generator,a five-degree-of-freedom suspension system,a full elastic aircraft model with control system,and gust load measuring devices.Two control schemes based on closed-loop feedback control and open-loop feed forward control are respectively designed and verified by the full-model GLA tests in the wind tunnel.The experimental results show that the designed gust generator can generate a stable wideband,wide-area gust wind field;the suspension support system can sustain static and dynamic stability during wind tunnel test,and enables the model moving in the horizontal,vertical,pitching,rolling and yawing directions.The results show that the closed-loop feedback control can obtain good control performance of reducing the peak values of elastic vibration response induced by gust excitation,but has little effect on suppressing the rigid body motion excited by low-frequency gust,while the open-loop feed forward control presents superior performance in allevi-ating the high-frequency elastic vibration as well as the low-frequency rigid body motion with more than 40%overall reduction rate. | Dongqiang ZHAO Zhichun YANG Xianang ZENG Jinge YU Yining GAO Guoning HUANG | 2023 | Chinese Journal of Aeronautics2023，36，4： | 0 |
| 18 | An in-situ polymerized interphase engineering for high-voltage allsolid- state lithium-metal batteries显示文摘All-solid-state lithium batteries(ASSLBs)have attracted great interest due to their promising energy density and strong safety.However,the interface issues,including large interfacial resistance between electrode and electrolyte and low electrochemical stability of solid-state electrolytes against high-voltage cathodes,have restricted the development of high-voltage ASSLBs.Herein,we report an ASSLB with stable cycling by adopting a conformal polymer interlayer in-situ formed at the Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)–cathode interfaces.The polymer can perfectlyfill the voids and create a stable interface contact between LLZTO and cathodes.In addition,the electric field across the polymer interlayer is reduced compared with pure solid polymer electrolyte(SPE),which facilitates the electrochemical stability with high-voltage cathode.The all-solid-state Li|LLZTO-SPE|LiFe_(0.4)Mn_(0.6)PO_(4)(LMFP)cells achieve a low interface impedance,high specific capacity,and excellent cycling performance.This work presents an effective and practical strategy to rationally design the electrode–electrolyte interface for the application of high-voltage ASSLBs. | Lu Nie Shaojie Chen Mengtian Zhang Tianyi Gao Yuyao Zhang Ran Wei Yining Zhang Wei Liu | 2024 | Nano Research2024，17，4： | 0 |
| 19 | Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target显示文摘Amyotrophic lateral sclerosis(ALS)is the most common motor neuron disease.At present,no definite ALS biomarkers are available.In this study,exosomes from the plasma of patients with ALS and healthy controls were extracted,and differentially expressed exosomal proteins were compared.Among them,the expression of exosomal coronin-1a(CORO1A)was 5.3-fold higher than that in the controls.CORO1A increased with disease progression at a certain proportion in the plasma of patients with ALS and in the spinal cord of ALS mice.CORO1A was also overexpressed in NSC-34 motor neuron-like cells,and apoptosis,oxidative stress,and autophagic protein expression were evaluated.CORO1A overexpression resulted in increased apoptosis and oxidative stress,overactivated autophagy,and hindered the formation of autolysosomes.Moreover,CORO1A activated Ca^(2+)-dependent phosphatase calcineurin,thereby blocking the fusion of autophagosomes and lysosomes.The inhibition of calcineurin activation by cyclosporin A reversed the damaged autolysosomes.In conclusion,the role of CORO1A in ALS pathogenesis was discovered,potentially affecting the disease onset and progression by blocking autophagic flux.Therefore,CORO1A might be a potential biomarker and therapeutic target for ALS. | Qinming Zhou Lu He Jin Hu Yining Gao Dingding Shen You Ni Yuening Qin Huafeng Liang Jun Liu Weidong Le Sheng Chen | 2022 | Frontiers of Medicine2022，16，5： | 0 |
| 20 | LncRNA ZFAS1 regulates cardiomyocyte differentiation of human embryonic stem cells显示文摘Background:Cardiomyocytes derived from human embryonic stem cells(hESCs)are regulated by complex and stringent gene networks during differentiation.Long non-coding RNAs(lncRNAs)exert critical epigenetic regulatory functions in multiple differentiation processes.However,the involvement of lncRNAs in the differentiation of hESCs into cardiomyocytes has not yet been fully elucidated.Here,we identified the key roles of ZFAS1(lncRNA zinc finger antisense 1)in the differentiation of cardiomyocytes from hESCs.Methods:A model of cardiomyocyte differentiation from stem cells was established using the monolayer differentiation method,and the number of beating hESCs-derived cardiomyocytes was calculated.Gene expression was analyzed by quantitative real-time PCR(qRTPCR).Immunofluorescence assays were performed to assess the expression of cardiac troponin T(cTnT)andα-actinin protein in cardiomyocytes.Results:qRT-PCR showed that ZFAS1 expression in the mesoderm was significantly higher than that in embryonic stem cells,cardiac progenitor cells,and cardiomyocytes.Knockdown of ZFAS1 inhibited cardiomyocyte differentiation from hESCs,which was characterized by reduced expression of the cardiac-specific markers cTnT,α-actinin,myosin heavy chain 6(MYH6),and myosin heavy chain 7(MYH7).In contrast,ZFAS1 overexpression remarkably increased the percentage of spontaneously beating cardiomyocytes.In terms of the mechanism,we found that ZFAS1 is an antisense lncRNA at the 5′end of the protein-coding gene ZNFX1.Knockdown of ZFAS1 could increase the mRNA expression level of ZNFX1.Furthermore,qRT-PCR demonstrated that the silencing of ZNFX1 led to an increase in cardiac-specific markers that predicted the promotion of cardiomyocyte differentiation.Conclusion:Altogether,these data suggest that lncRNA-ZFAS1 is required for cardiac differentiation by functionally inhibiting the expression of ZNFX1,which may provide a reference for the treatment of heart disease to a certain extent. | YANG CAO YINING LIU YANG YU XIAOFEI GUO XIUXIU WANG WENYA MA HANJING LI ZHONGYU REN XINLU GAO SIJIA LI HAOYU JI HONGYANG CHEN HONG YAN YANAN TIAN XIN WANG BENZHI CAI | 2023 | BIOCELL2023，47，6： | 0 |
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