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| 1 | 晚期非小细胞肺癌免疫检查点抑制剂新型生物标志物:血液PD-L1动态检测显示文摘背景免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)具有良好疗效已成为恶性肿瘤治疗领域备受瞩目的翘楚。然而,仅有小部分患者获得长期临床获益。如何选择生物标志物来筛查ICIs治疗优势人群仍是一大热点。方法收集51例晚期恶性肿瘤患者的肿瘤组织和配对血样本,进行PD-L1表达的相关性分析。40例晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受ICIs治疗,2个月时检测血液PD-L1(bloodPD-L1,bPD-L1)表达的动态变化,包括PD-L1 mRNA、外泌体PD-L1(exosomalPD-L1,exoPD-L1)蛋白和可溶性PD-L1(solublePD-L1,sPD-L1)。应用R软件计算最佳截断值,用于预测最佳客观缓解(best objective response,b OR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。结果51例不同恶性肿瘤患者中,组织PD-L1(tissuePD-L1,tPD-L1)表达阳性患者的PD-L1mRNA表达水平显著升高。40例接受ICIs治疗的晚期NSCLC患者中,bPD-L1 mRNA上调≥2.04的患者b OR、PFS和OS更佳;21例接受ICIs治疗的晚期NSCLC患者中,exoPD-L1上调≥1.86的患者临床获益更大。sPD-L1动态变化与ICIs疗效无显著相关性。PD-L1 mRNA和exoPD-L1联合检测更有利于预测ICIs治疗疗效。结论bPD-L1表达与tPD-L1表达存在正相关;晚期NSCLC患者ICIs治疗初期PD-L1 mRNA和(或)exoPD-L1表达升高,可作为评估临床获益的新型生物标志物。 | Qiao YANG Mingjing CHEN Jiaoyang GU Kai NIU Xianlan ZHAO Linpeng ZHENG Zihan XU Yongxin YU Feng LI Lingxin MENG Zhengtang CHEN Wenlei ZHUO Luping ZHANG Jianguo SUN 杨峤(译) 孙建国(译) | 2021 | 中国肺癌杂志2021，24，12： | 10 |
| 2 | Precast system and assembly connection of cement concrete slabs for road pavement: A review显示文摘Prefabricated pavement is increasingly applied worldwide due to the rapid construction on-site.This paper presents a state-of-the-art review of the precast systems and assembly connection of concrete slabs,as well as the precast pavement features.The previous research indicates that:(1)both super-slab and Michigan systems are recommended with the satisfied road performance close to the cast-in-place;(2)flexible base material is suggested for the fabricated pavement for the satisfied leveling and stress distribution;(3)to prevent the voiding phenomenon of the fabricated pavement,the sand cushion course,dry mixed mortar or self-leveling mortar,and other flowable materials could be used for the secondary leveling of the base after the pavement splicing;(4)two-direction dowel bars are recommended for slab connections of the fabricated pavement,which helps to improve the load transfer capacity of the joints and enhance the durability of the fabricated pavement structure;(5)the sealing treatment of precast slab joints needs strengthening to reduce the impact of surface runoff on the base course;(6)the further research focuses are designing with functional,composite,mechanized,intelligent,lightweight,and flexible pavement slabs.Besides,pavement mechanical properties induced by temperature overlapping traffic loads need to be revealed. | Mingjing Fang Ran Zhou Wenhui Ke Bo Tian Yubin Zhang Jianjun Liu | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，2： | 3 |
| 3 | miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis显示文摘Acidosis,regardless of hypoxia involvement,is recognized as a chronic and harsh tumor microenvironment(TME)that educates malignant cells to thrive and metastasize.Although overwhelming evidence supports an acidic environment as a driver or ubiquitous hallmark of cancer progression,the unrevealed core mechanisms underlying the direct effect of acidification on tumorigenesis have hindered the discovery of novel therapeutic targets and clinical therapy.Here,chemical-induced and transgenic mouse models for colon,liver and lung cancer were established,respectively.miR-7 and TGF-β2 expressions were examined in clinical tissues(n=184).RNA-seq,miRNA-seq,proteomics,biosynthesis analyses and functional studies were performed to validate the mechanisms involved in the acidic TME-induced lung cancer metastasis.Our data show that lung cancer is sensitive to the increased acidification of TME,and acidic TME-induced lung cancer metastasis via inhibition of miR-7-5 p.TGF-β2 is a direct target of miR-7-5 p.The reduced expression of miR-7-5 p subsequently increases the expression of TGF-β2 which enhances the metastatic potential of the lung cancer.Indeed,overexpression of miR-7-5 p reduces the acidic p H-enhanced lung cancer metastasis.Furthermore,the human lung tumor samples also show a reduced miR-7-5 p expression but an elevated level of activated TGF-β2;the expressions of both miR-7-5 p and TGF-β2 are correlated with patients’survival.We are the first to identify the role of the miR-7/TGF-β2 axis in acidic p H-enhanced lung cancer metastasis.Our study not only delineates how acidification directly affects tumorigenesis,but also suggests miR-7 is a novel reliable biomarker for acidic TME and a novel therapeutic target for non-small cell lung cancer(NSCLC)treatment.Our study opens an avenue to explore the p H-sensitive subcellular components as novel therapeutic targets for cancer treatment. | Tao Su Suchao Huang Yanmin Zhang Yajuan Guo Shuwei Zhang Jiaji Guan Mingjing Meng Linxin Liu Caiyan Wang Dihua Yu Hiu-Yee Kwan Zhiying Huang Qiuju Huang Elaine Lai-Han Leung Ming Hu Ying Wang Zhongqiu Liu Linlin Lu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 4 | The giant magnetocaloric effect in Gd_(5)Si_(2)Ge_(2)with low purity gadolinium显示文摘The giant magnetocaloric effect Gd5Si2Ge2 alloy was prepared with 99wt% low purity commercial Gd. Pow-der XRD and magnetic measurements showed that the Gd5Si2Ge2 alloy annealed at 1200℃ for 1 h had a significant magnetic- crystallographic first order phase transition at about 270 K. The maximal magnetic entropy change is 17.55 J·kg?1·K?1 under a magnetic field change of 0―5 T. The distinct increase of magnetic entropy change belongs to the first-order phase transition from the orthorhombic Gd5Si4-type to the monoclinic Gd5Si2Ge2-type after high temperature heat-treatment. | ZHANG Tiebang CHEN Yungui FU Hao TENG Baohua TANG Yongbai TU Mingjing | 2005 | Chinese Science Bulletin2005，50，16： | 2 |
| 5 | Effects of imazethapyr spraying on plant growth and leaf surface microbial communities in Arabidopsis thaliana显示文摘Imazethapyr (IM) is an acetolactate synthase (ALS)-inhibiting herbicide that has been widely used in recent years.However,IM spraying can lead to the accumulation of herbicide residues in leaves.Here,we determined the effects of IM spraying on the plant growth and leaf surface microbial communities of Arabidopsis thaliana after 7 and 14 days of exposure.The results suggested that IM spraying inhibited plant growth.Fresh weight decreased to 48% and 26% of the control value after 7 and 14 days,respectively,of 0.035 kg/ha IM exposure.In addition,anthocyanin content increased 9.2-fold and 37.2-fold relative to the control content after 7 and 14 days of treatment,respectively.Furthermore,IM spraying destroyed the cell structures of the leaves,as evidenced by increases in the number of starch granules and the stomatal closure rate.Reductions in photosynthetic efficiency and antioxidant enzyme activity were observed after IM spraying,especially after 14 days of exposure.The diversity and evenness of the leaf microbiota were not affected by IM treatment,but the composition of community structure at the genus level was altered by IM spraying.Imazethapyr application increased the abundance of Pseudomonas,a genus that includes species pathogenic to plants and humans,indicating that IM potentially increased the abundance of pathogenic bacteria on leaves.Our findings increase our understanding of the relationships between herbicide application and the microbial community structures on plant leaves,and they provide a new perspective for studying the ecological safety of herbicide usage. | Wanyue Liu Mingjing Ke Zhenyan Zhang Tao Lu Youchao Zhu Yan Li Xiangliang Pan Haifeng Qian | 2019 | Journal of Environmental Sciences2019，31，11： | 2 |
| 6 | Wood waste biochar promoted anaerobic digestion of food waste:focusing on the characteristics of biochar and microbial community analysis显示文摘Anaerobic digestion(AD)has been considered as a promising technique for food waste(FW)recycling.However,the accumulation of volatile fatty acids(VFAs)restricts the stability of anaerobic reactors.The present study investigated the use of biochar produced at different conditions(750℃-30 min,750℃-60 min,750℃-120 min,550℃-60 min,650℃-60 min,850℃-60 min,950℃-60 min)for enhancing the AD of FW.Batch experiments showed that all the biochar increased the methane production rates and biochar obtained at 750℃-60 min resulted in the highest enhance-ment by 21.5%.It was further showed surface oxygen-containing functional groups and graphitization degree of biochar were the critical factors for improving methane production.Microbial analysis showed that biochar addi-tion formed different microbial communities,and Methanosaeta,Romboutsia,and norank_f_Anaerolineaceae were enriched,which might be correlated with direct interspecies electron transfer(DIET).This research showed biochar could enhance the AD of FW and also revealed the main characteristics of biochar relating with the enhancement of AD. | Chao Zhang Rui Yang Meichen Sun Shicheng Zhang Mingjing He Daniel C.W.Tsang Gang Luo | 2022 | Biochar2022，4，1： | 2 |
| 7 | Generalized Manifold-Ranking-Based Image Retrieval显示文摘 | He Jingrui Li Mingjing Zhang Hongjiang | 2006 | IEEE Trans Image Process2006，15，10： | 1 |
| 8 | Multi-view face detection with floatboost显示文摘 | Zhang Zhenqiu Li Mingjing | 2002 | WACV2002，，： | 1 |
| 9 | A state-of-the-art review on shallow geothermal ventilation systems with thermal performance enhancement-system classifications,advanced technologies and applications显示文摘Geothermal energy with abundance and large quantity can partially cover building heating/cooling loads and promote the carbon-neutrality transitions.Shallow geothermal ventilation(SGV)system,with a little initial in-vestment cost,is one of promising technologies to partly replace the conventional air-conditioning system for air pre-cooling/pre-heating.This paper reviews applications of SGV system for improving thermal performance over latest two decades,which mainly includes the reclassification of SGV system,coupling with other advanced energy-saving technologies,application potentials for building cooling/heating under various weather conditions.Heat transfer mechanism and mathematical modelling techniques have been reviewed,together with in-depth analysis on current research trends,existing limitations,and recommendations of SGV system.Phase change materials,with considerable latent energy density,can stabilize the thermal performance with high reliability.The review identifies that optimization designs and advanced approaches need to be investigated to address the existing urgent issues of SGV system(e.g.,large land occupation,difficulty in centralized collection of condensate water timely for horizontal buried pipe,bacteria growth,polluted supply air,and high construction cost for ver-tical buried pipe).A plenty of studies show that the SGV system could greatly expand the application scope and improve system energy efficiency by combining with other energy-saving technologies.This paper will provide some guidelines for the scientific researchers and engineers to keep track on recent advancements and research trends of SGV system for the building thermal performance enhancement and pave path for future research works. | Zhengxuan Liu Mingjing Xie Yuekuan Zhou Yingdong He Lei Zhang Guoqiang Zhang Dachuan Chen | 2023 | Energy and Built Environment2023，4，2： | 1 |
| 10 | A unified framework for image retrieval using keyword and visual features显示文摘 | Jing Feng Li Mingjing Zhang Hongjiang | 2005 | IEEE Transactions on Image Processing2005，14，7： | 1 |
| 11 | Comparison of two in vitro angiogenesis assays for evaluating the effects of netrin-1 on tube formation显示文摘Netrin-1 是也调整脉管的开发的神经指导暗示。然而,争论结果在 vivo 并且在 vitro 在脉管的开发有关 netrin-1 的角色被获得了。在现在的学习,二在 vitro angiogenesis 试金与相比评估藏匿由的 netrin-1 的效果 retrovirally 试管形成上的 transduced 黑瘤房间(Mel2a-netrin1 ) 。结果证明在调节媒介(厘米) 在 matrigel 试金从控制, Mel2a-netrin1 和 Mel2a 房间导致的试管形成没有明显的差别。在哪个 endothelial 房间然而与人的成纤维细胞是 co 有教养的,在 vitro 试金的另外一个的结果证明那 Mel2a-netrin1 厘米禁止了试管形成,据说通过堵住人的脐的静脉 endothelial 房间(HUVEC ) 的延伸和结合。这些结果证实 matrigel 试金不能表明 netrin-1 的 anti-angiogenic 角色。 | Hui Guo Yin Jia Min Shang Yuan Zhang Fu'an Xie Heng Wang Mingjing Yuan Li Yuan Jura Ye | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 1 |
| 12 | Statistical Correlation Analysis in Image Retrieval显示文摘 | CHEN Zheng ZHANG Hong-jiang | 2002 | Pattern Recognition2002，35，12： | 1 |
| 13 | Chemical substitution effects of elements on photoluminescence properties of YAG:Ce phosphors using orthogonal experimental design显示文摘 | Tao Han Shixiu Cao Lingling Peng Dachuan Zhu Cong Zhao Mingjing Tu Jin Zhang | 2012 | Optical Materials2012，，9： | 1 |
| 14 | The research of influence for lucerneroot system to soil structure and fertility显示文摘 | Fan Mingjing Lu Zhaozheng Zhang Conghua | 1999 | Shandong Hydraulic Eng Inst1999，11，2： | 1 |
| 15 | Gen- eralized manifold ranking based image retrieval 显示文摘 | HE Jingrui LI Mingjing ZHANG Hongjiang | 2006 | IEEE Transactions on Image Process2006，15，10： | 1 |
| 16 | Robust multipose face detection in images显示文摘 | Xiao Rong Li Mingjing Zhang Hongjiang | 2004 | IEEE Trans on Circuits and Systems for Video Technology2004，14，1： | 1 |
| 17 | An investigation on loose cemented granular materials via DEM analyses显示文摘 | Mingjing Jiang Wangcheng Zhang Yugang Sun Stefano Utili | 2013 | Granular Matter2013，，1： | 1 |
| 18 | Influence of Patio on Indoor Environment in a Chinese Traditional Folk House in Summer 显示文摘 | Mingjing Xie Guoqiang Zhang Feng Xu Quan Zhang Ke Wang | 2010 | Journal of Southeast University2010，26，2： | 1 |
| 19 | Influence of site selection on natural ventilation in Chinese trational folk house 显示文摘 | Xu Feng Zhang Guoqiang Xie Mingjing | 2010 | Journal of Southeast University (English Edition)2010，26，2： | 1 |
| 20 | α-Glucosidase inhibitors from Chinese Yam ( Dioscorea opposita Thunb.)显示文摘 | Lin Zhang Bing Bai Xiuhua Liu Yong Wang Mingjing Li Dongbao Zhao | 2010 | Food Chemistry2010，，1： | 1 |
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