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| 1 | CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells显示文摘 | Xiaojuan Liu Yongping Zhang Chen Cheng Albert W Cheng Xingying Zhang Na Li Changqing Xia Xiaofei Wei Xiang Liu Haoyi Wang | 2017 | Cell Research2017，27，1： | 40 |
| 2 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 3 | CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells显示文摘 | Yongping Zhang Xingying Zhang Chen Cheng Wei Mu Xiaojuan Liu Na Li Xiaofei Wei Xiang Liu Changqing Xia Haoyi Wang | 2017 | Frontiers of Medicine2017，11，4： | 9 |
| 4 | Structure and properties of an ultra-high strength 7xxx aluminum alloy contained Sc and Zr显示文摘An ultra-high strength aluminum alloy was produced by casting and then extruded to rods.The effect of heat treatment on the microstructure and mechanical properties of the alloy was investigated.After single ageing(120℃,24 h),the tensile strength was 812.4 MPa and the elongation was 6.2%.After retrogression reaging(RRA),the tensile strength was 751.2 MPa and the elongation was 6.4%.The strengthening mechanism is considered as fine grain strengthening,substructure strengthening and dispersion strengthening by Al_3(Sc,Zr). | Xiaoyuan Dai Changqing Xia Xiaomin Peng Ke Ma | 2008 | Journal of University of Science and Technology Beijing2008，15，3： | 7 |
| 5 | Comparison of molybdenizing and NiCrAlY coating on Ti and Ti-6Al-4V显示文摘Two surface treatments, molybdenizing and depositing NiCrAlY coating, were applied to improve the microhardness and the oxidation re-sistance of titanium and Ti-6Al-4V. Coupons were analyzed using optical microscopy (OM), scanning electron microscopy (SEM) with X-ray energy dispersive spectrometer (EDS), and X-ray diffraction (XRD). Vickers hardness and isothermal oxidation tests were carried out to evaluate the effects of these two surface treatments on the microhardness and oxidation resistance of the substrates. The post vacuum heat treatment of the NiCrAlY coating and the molybdenizing parameters were also discussed. It is found that molybdenizing can obviously in-crease the surface hardness of titanium due to the formation of β, α″, and α′ phases in the diffusion layer. As γ′ phase is formed after vacuum heat treatment, the NiCrAlY coating is effective in improving the surface hardness of Ti-6Al-4V. The NiCrAlY coating can obviously de-crease the oxidation rate of Ti-6Al-4V at 700-900°C, which can be attributed to the formation of Al2O3 and Cr2O3 mixed scale during the oxidation. | PENG Xiaomin XIA Changqing LIU Yingying ZHANG Zhigao | 2009 | Rare Metals2009，28，1： | 5 |
| 6 | Distribution,evolution and the effects of rare earths Ce and Y on the mechanical properties of ZK60 alloys显示文摘Eight kinds of Mg-RE alloys were prepared. The distribution,evolution,and effects of RE Ce and Y in the investigated alloys were studied by examining the mechanical properties of Mg alloys using X-ray diffraction and scan electron analysis,and by TEM observation. The results show that among the investigated alloys,ZK60-1.5%Ce and ZK60-1.0%Y possessed the optimal mechanical properties. Ce and Y were distributed on the grain boundary during casting. After extrusion and T5 (150°C/0-24 h) heat-treatment,Ce and Y were distributed along the extrusion direction and they existed in compound form for both as-casting and as-extrusion specimens. The mechanical properties of the investigated alloys were better than those of ZK60 because of the solid solution strengthening of RE and the dispersion strengthening of Mg-RE or Mg-Zn-RE compounds. | Anru Wu Changqing Xia Jiewen Wang | 2006 | Journal of University of Science and Technology Beijing2006，13，5： | 5 |
| 7 | Ectopic expression of fungal EcGDH improves nitrogen assimilation and grain yield in rice显示文摘NADP(H)-dependent glutamate dehydrogenases(GDH) in lower organisms have stronger ammonium affinity than those in higher plants. Here we report that transgenic rice overexpressing the EcGDH from Eurotium cheralieri exhibited significantly enhanced aminating activities. Hydroponic and field tests showed that nitrogen assimilation efficiency and grain yields were markedly increased in these transgenic plants, especially at the low nitrogen conditions.These results suggest that EcGDH may have potential to be used to improve nitrogen assimilation and grain yield in rice. | Dongying Tang Yuchong Peng Jianzhong Lin Changqing Du Yuanzhu Yang Dan Wang Cong Liu Lu Yan Xiaoying Zhao Xia Li Liangbi Chen Xuanming Liu | 2018 | Journal of Integrative Plant Biology2018，60，2： | 4 |
| 8 | Cost Minimization of Wireless Sensor Networks with Unlimited-lifetime Energy for Monitoring Oil Pipelines显示文摘Cyber-physical-system(CPS) has been widely used in both civil and military applications.Wireless sensor network(WSN) as the part and parcel of CPS faces energy problem because sensors are battery powered,which results in limited lifetime of the network.To address this energy problem,we take advantage of energy harvesting device(EHD) and study how to indefinitely prolong oil pipeline monitoring network lifetime by reasonable selecting EHD.Firstly,we propose a general strategy worst case-energy balance strategy(WC-EBS),which defines worst case energy consumption(WCEC) as the maximum energy sensor node could expend for oil pipeline monitoring WSN.When the energy collected by EHD is equal or greater than WCEC,network can have an unlimited lifetime.However,energy harvesting rate is proportional to the price of EHD,WC-EBS will cause high network cost.To reduce network cost,we present two optimization strategies,optimization workloadenergy balance strategy(OW-EBS) and optimization first nodeenergy balance strategy(OF-EBS).The main idea of OW-EBS is to cut down WCEC by reducing critical node transmission workload;OF-EBS confirms critical node by optimizing each sensor node transmission range,then we get the optimal energy harvesting rate in OF-EBS.The experimental results demonstrate that OF-EBS can indefinitely extend network lifetime with lower cost than WC-EBS and OW-EBS,and energy harvesting rate P in each strategy satisfies Pof-EBS≤P(OW-EBS)≤PWC-EBS. | Changqing Xia Wei Liu Qingxu Deng | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，3： | 3 |
| 9 | Indoor imitation experimental study on driving factors of rainfall-runoff process显示文摘The driving actions of rainfall-runoff process can be attributed to two aspects. The first is the influence of precipitation process, and the second is that of the ground pad. The re- search results of 179 indoor experiments conducted to imitate rainfall-runoff process indicate that both precipitation duration and intensity play important roles in affecting confluence lag time, which is obviously inconsistent with the traditional hypotheses. The nonlinear relationship is of great significance to the confluence curve especially when the precipitation duration is less than the total confluence time or the precipitation intensity is small. Therefore it can be concluded that the unit hydrograph (UH) can be applied to rainfall-runoff process imitation in the humid areas in the south China region. However, the UH application should be strictly modified in accordance with precipitation conditions in the arid and semiarid region of north China where the precipitation duration is short and the intensity is unstable. It will be hard to get ideal imitation results if the UH is applied blindly without considering specific conditions in the north China region. This also explains the unsatisfactory imitation results caused by using various hydrological models in the north China region. When the precipitation duration is short, and the watershed has not reached total watershed concentration, the characteristics of confluence change greatly, which reflects the actual situation in the north China region. Therefore necessary nonlinear corrections should be made when UH is applied. If the duration is longer than the total confluence time and the balance between pondage and discharge is stricken, the imitation research results will be applicable to both rainfall-runoff relation with longer duration in the south China region and the basic theoreti- cal research on runoff generation and concentration. On conditions of adequate rainfall, peak discharge is in linear relationship with intensity, but has nothing to do with the ground pad. There is a negative linear relationship between intensity and time to peak . The amount of pondage capacity in a catchment is in linear relationship with intensity and peak discharge, with obvious influence by the ground pad status and interception, and it has nothing to do with the position of interceptions. | ZHANG Shifeng1, LIU Changming 1, XIA Jun1, TAN Ge 1, LI Lin1, LIU Caitang1, ZHOU Changqing 1 & GUO Lei2 1. Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China 2. College of Water Resources and Hydropower Engineering, Wuhan University, Wuhan 430072, China | 2005 | Science China Earth Sciences2005，48，3： | 3 |
| 10 | Effects of cerium on the microstructure and mechanical properties of AZ31 alloy显示文摘AZ31 alloy with Ce addition was studied. The influence of Ce contents on the microstructure and tensile proper-ties of the alloy was analyzed. Ce addition results in the formation of Al4Ce and the annealed microstructure is improved by the addition. There was no recrystallization of the alloy after rolling, however, it did occur after annealing. The alloy can be strengthened by adding Ce and the alloy with 1.05 wt.% Ce possessed the best synthetical properties of all the tested alloys. As rolled, σ b and δ of this alloy are 321 MPa and 6.9%, and as annealed, they are 259 MPa and 21.8%. | WU Anru XIA Changqing WANG Shaowu | 2006 | Rare Metals2006，25，4： | 3 |
| 11 | Microstructures and Properties of Al-Zn-Mg-Cu-Zr Alloys with Minor Scandium显示文摘The microstructures of Al-Zn-Mg-Cu-Zr alloys with minor Sc were studied by using optical microscope(OM), scanning electron microscope (SEM) and transmission electron microscope(TEM). The tensile mechanical properties and electric conductivity of the studied alloys under different treatment conditions were tested. The results show that adding minor Sc can greatly fines the grain size of the Al-Zn-Mg-Cu-Zr alloy ingots and obviously improves the tensile properties and electric conductivity of the alloys. The strengthening mechanism is considered as fine grain strengthening, sub-structure strengthening and dispersion strengthening by Al3(Sc, Zr). After strengthening solution and T6, the tensile strength of Al-9.0Zn-2.5Mg-1.2Cu-0.15Zr-0.12Sc and Al-9.5Zn-2.5Mg-1.2Cu-0.15Zr-0.12Sc are 829.4, 818.6 MPa respectively. | Dai Xiaoyuan Xia Changqing Li Yangyong Sun Zhenqi | 2006 | Journal of Rare Earths2006，24，5： | 3 |
| 12 | Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils显示文摘Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully elucidated.In this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and mice.FGF2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling pathway.FGF2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and activation.More importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected mice.Based on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting neutrophils.Thus,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection. | Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li Xing Lingna Zhao Shanshan Zhou Min Xia Chengyu Jiang Xiliang Wang Penghui Yang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 13 | Joint Algorithm of Message Fragmentation and No-Wait Scheduling for Time-Sensitive Networks显示文摘Time-sensitive networks(TSNs)support not only traditional best-effort communications but also deterministic communications,which send each packet at a deterministic time so that the data transmissions of networked control systems can be precisely scheduled to guarantee hard real-time constraints.No-wait scheduling is suitable for such TSNs and generates the schedules of deterministic communications with the minimal network resources so that all of the remaining resources can be used to improve the throughput of best-effort communications.However,due to inappropriate message fragmentation,the realtime performance of no-wait scheduling algorithms is reduced.Therefore,in this paper,joint algorithms of message fragmentation and no-wait scheduling are proposed.First,a specification for the joint problem based on optimization modulo theories is proposed so that off-the-shelf solvers can be used to find optimal solutions.Second,to improve the scalability of our algorithm,the worst-case delay of messages is analyzed,and then,based on the analysis,a heuristic algorithm is proposed to construct low-delay schedules.Finally,we conduct extensive test cases to evaluate our proposed algorithms.The evaluation results indicate that,compared to existing algorithms,the proposed joint algorithm improves schedulability by up to 50%. | Xi Jin Changqing Xia Nan Guan Peng Zeng | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，2： | 3 |
| 14 | Geochemical characteristics and source rock of Ordovician gas reservoir, Changqing Gasfield显示文摘Carbon isotopic composition of methane in Ordovician gas reservoir in the Changqing Gasfield can reflect the dominance of Upper Paleozoic coal-type gas despite its high mature degree. The 12C-rich ethane in the Ordovician reservoir (δ13C2 < - 29‰), known as a marker as oil-type gas, does not indicate the Ordovician marine carbonate as main source rock, it is be- | XIA Xinyu, ZHAO Lin, ZHANG Wenzheng and LI JianfengResearch Institute of Petroleum Exploration and Development, Beijing 100083, China Changqing Petroleum Exploration Bureau, XL an 710021 , China | 1999 | Chinese Science Bulletin1999，44，20： | 2 |
| 15 | Immune-mediated neuromuscular complications after haploidendtical hematopoietic stem cell transplantation显示文摘Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is associated with neuromuscluar complications in fewer than 5% of patients.1 The most common causes are associated with the toxicity of the conditioning regimen,infections,bleeding,and malignant disease relapse.Allo-HSCT related neuromuscular complications can also be caused by immune-mediated mechanisms,which are usually present in the form of myositis/polymyositis or demyelinating polyneuropathy. | Su li Ji Bingxin Hu Ronghua Lan Xiaoxi Xia Changqing | 2014 | Chinese Medical Journal2014，，15： | 2 |
| 16 | Developing polydopamine modified molybdenum disulfide/epoxy resin powder coatings with enhanced anticorrosion performance and wear resistance on magnesium lithium alloys显示文摘Epoxy resin powder coating has been successfully applied on the corrosion protection of magnesium lithium alloys.However,poor wear resistance and microcracks formed during the solidification have limited it extensive application.There are limited approaches to exploit such anti-corrosion and mechanical properties of magnesium lithium alloys.Herein,the epoxy resin powder coating with polydopamine modified molybdenum disulfide(MoS_(2)@PDA-EP powder coating with 0,0.1,0.2,0.5,1.0 wt.%loading)was well prepared by melt extrusion to investigate its anticorrosion performance and wear resistance.The results revealed that the addition of MoS_(2)@PDA enhanced the adhesion strength between coatings and alloys,wear resistance and corrosion protection of the powder coatings.Among them,the optimum was obtained by 0.2 wt.%MoS_(2)@PDA-EP powder coating which could be attributed to well dispersion and efficient adhesion with coating matrix.To conclude,MoS_(2)@PDA-EP powder coating is meaningfully beneficial for the anticorrosive and wear performance improvement of magnesium lithium alloys. | Shibo Chen Changqing Yin Yi Wang Shuang Yi Xiang Gao Xujuan Zhang Qiyu Liao Yuxin Zhang Xia Zhao Jinsong Rao Baorong Hou | 2022 | Journal of Magnesium and Alloys2022，10，9： | 2 |
| 17 | New insights into the immunopathogenesis of systemic lupus erythematosus: the role of T follicular helper cells显示文摘 | Ma Huijuan Xia Changqing Wan Suigui | 2014 | Chinese Medical Journal2014，，19： | 2 |
| 18 | Aqueous synthesis of luminescent magic sized CdSe nanoelusters显示文摘 | Xia Yunsheng Zhu Changqing | 2008 | Materials Letters2008，62，14： | 1 |
| 19 | Tensile creep behavior of heat-treated TC11 titanium alloy at 450–550<ce:hsp sp='0.25'/>°C显示文摘 | Yi Gu Fanhao Zeng Yanling Qi Changqing Xia Xiang Xiong | 2013 | Materials Science & Engineering A2013，，： | 1 |
| 20 | Turn-on and near-infrared fluorescent sensing for 2,4,6-trinitrotolu- ene based on hybrid (gold nanorod)-(quantum dots) as sembly显示文摘 | Xia Yunsheng Song Lei Zhu Changqing | 2011 | Anal Chem2011，83，4： | 1 |
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