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| 1 | The variation of the estimated GPS instrumental bias and its possible connection with ionospheric variability显示文摘Based on the analysis of the satellite DCB data estimated by our method and the Center for Orbit Determination in Europe(CODE)from 1999 to 2011,the features of the temporal variation of differential code biases(DCB)are studied.Summarily,there are three types of variations in DCB on different time scales.The first one is the day-to-day variation that exhibits more obviously in solar maximum years.The second one is the variation with about one year periodic variation that behaves more obviously from 1999 to 2004.The last one is the monotonously descending tendency from 1999 to 2010.Considering the basic ionospheric approximation in DCB estimation method,the features of the variability of the ionospheric morphology from 1999to 2010 are also displayed based on the ionospheric characteristic parameters.It can be concluded that the day-to-day and annual variation of the estimated global positioning system(GPS).DCB is related to the ionospheric variability.The variation of DCBs on solar cycle time scale includes the real hardware DCBs and pseudo-DCBs induced by ionospheric variation.No doubt,these kinds of'pseudo'variations of DCB will affect the precision of ionospheric total electron content(TEC)derived from the GPS data.In addition,this study is helpful for evaluating the influence of ionospheric weather on TEC derivation and is also useful for developing one estimation method of DCB with more stability and precision through introducing a more practical ionospheric model. | ZHANG DongHe SHI Hao JIN YaQi ZHANG Wei HAO YongQiang XIAO Zuo | 2014 | Science China(Technological Sciences)2014，57，1： | 14 |
| 2 | The seasonal dependence of cycle slip occurrence of GPS data over China low latitude region显示文摘The relationship of daily accumulated cycle slip occurrence with the season is analyzed using the GPS data observed in six GPS stations located in China low latitude region in 2001. It is found that the seasonal dependence of cycle slip oc-currence is evident. The cycle slip mainly occurs during the periods of two equinox months (March to May and September to October), and some correlative changes of the cycle slip occurrences over all six stations are exhibited in some special days. Considering the diurnal dependence of cycle slip, it can be inferred that the cycle slip occurrence with certain elevation limitation is related with the iono-spheric irregularities over this region. | ZHANG DongHe FENG Man XIAO Zuo HAO YongQiang SHI LiQin YANG GuangLin SUO YuCheng | 2007 | Science China(Technological Sciences)2007，50，4： | 10 |
| 3 | Case study of ionospheric fluctuation over mid-latitude region during one large magnetic storm显示文摘From Nov. 6 to 10, 2004, a large number of solar events occurred, which triggered many solar flares and coronal mass ejections (CMEs). These CMEs caused two large geomagnetic storms and continuous energy proton events. During this period, one large positive ionospheric storm happened over the East-Asian region on Nov. 8, 2004. On Nov. 10, 2004, a strong spread-F was observed by the ionosonde located in the mid-latitude region of East China and Japan, and the ionospheric fluctuation over the ionosonde stations derived from GPS observation was also obvious. In this report, the characteristics of the spatial distribution of the ionosphere fluctuation and its temporal evolution are studied using the parameter of the rate of total electron content (ROT) derived from dual-frequency GPS measurement. Strong fluctuating activity of the ionosphere was found over the mid-latitude region in the southern and northern hemispheres between longitudes of 100°E and 180°E during the magnetic storm period on Nov. 10, 2004, and a regular movement of the disturbing region was observed. In the end, the reason of the ionospheric fluctuation during this magnetic storm is analyzed. | ZHANG DongHe MO XiaoHua A Ercha HAO YongQiang | 2012 | Science China(Technological Sciences)2012，55，5： | 10 |
| 4 | Additively manufactured biodegradable porous magnesium implants for elimination of implant-related infections:An in vitro and in vivo study显示文摘Magnesium(Mg)alloys that have both antibacterial and osteogenic properties are suitable candidates for orthopedic implants.However,the fabrication of ideal Mg implants suitable for bone repair remains challenging because it requires implants with interconnected pore structures and personalized geometric shapes.In this study,we fabricated a porous 3D-printed Mg-Nd-Zn-Zr(denoted as JDBM)implant with suitable mechanical properties using selective laser melting technology.The 3D-printed JDBM implant exhibited cytocompatibility in MC3T3-E1 and RAW267.4 cells and excellent osteoinductivity in vitro.Furthermore,the implant demonstrated excellent antibacterial ratios of 90.0% and 92.1% for methicillin-resistant S.aureus(MRSA)and Escherichia coli,respectively.The 3D-printed JDBM implant prevented MRSA-induced implant-related infection in a rabbit model and showed good in vivo biocompatibility based on the results of histological evaluation,blood tests,and Mg2+deposition detection.In addition,enhanced inflammatory response and TNF-α secretion were observed at the bone-implant interface of the 3D-printed JDBM implants during the early implantation stage.The high Mg^(2+)environment produced by the degradation of 3D-printed JDBM implants could promote M1 phenotype of macrophages(Tnf,iNOS,Ccl3,Ccl4,Ccl5,Cxcl10,and Cxcl2),and enhance the phagocytic ability of macrophages.The enhanced immunoregulatory effect generated by relatively fast Mg^(2+)release and implant degradation during the early implantation stage is a potential antibacterial mechanism of Mg-based implant.Our findings indicate that 3D-printed porous JDBM implants,having both antibacterial property and osteoinductivity,hold potential for future orthopedic applications. | Kai Xie Nanqing Wang Yu Guo Shuang Zhao Jia Tan Lei Wang Guoyuan Li Junxiang Wu Yangzi Yang Wenyu Xu Juan Chen Wenbo Jiang Penghuai Fu Yongqiang Hao | 2022 | Bioactive Materials2022，7，2： | 8 |
| 5 | Ultra low frequency waves impact on radiation belt energetic particles显示文摘One of the most fundamental important issues in the space physics is to understand how solar wind energy transports into the inner magnetosphere.Ultra low frequency(ULF)wave in the magnetosphere and its impact on energetic particles,such as the wave-particle resonance,modulation,and particle acceleration,are extremely important topics in the Earth’s radiation belt dynamics and solar wind― magnetospheric coupling.In this review,we briefly introduce the recent advances on ULF waves study. Further,we will explore the density structures and ion compositions around the plasmaspheric boundary layer(PBL)and discuss its possible relation to the ULF waves. | ZONG QiuGang HAO YongQiang WANG YongFu | 2009 | Science China(Technological Sciences)2009，52，12： | 7 |
| 6 | Investigation of electrons inside the satellite by the Geant4 simulation显示文摘The measurement of the electron radiation inside the satellite is important for engineering and space environment researches.The particle radiation detectors (PRD) on board CBERS-1 and CBERS-2 made great contribution to understanding of the space environment.Then,what is the radiation relationship between inside and outside the satellite? The Monte Carlo simula-tion with Geant4 was implemented to study the problem.The boundaries of the energy bins of 0.5 and 2 MeV were precisely corresponding to outside energies of 0.99 and 2.52 MeV,respectively.Besides the changes of the energy bins,the fluxes inside were smaller than those of the corresponding bins outside.The spectrum inside the satellite was harder than that outside.An indicator was that the flux ratio of the high energy bin to the low energy bin increased more than 20% from outside to inside.The geometric factor (GF) relates to the incident energy of electrons.By using the AE-8 model to derive the incident spec-trum,the GFs of the low and high energy bins were 1.15 and 0.70 cm2 sr,respectively.GF of the low energy bin was larger than that of the high energy bin.But they were both smaller than the previous results.It was due to the scattering,straggle and shielding effects. | LI XiaoCan CHEN HongFei HAO YongQiang ZOU Hong SHI WeiHong | 2011 | Science China(Technological Sciences)2011，54，9： | 6 |
| 7 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 8 | Energetic particle radiations measured by particle detector on board CBERS-1 satellite显示文摘Using the data measured by energetic particle detector on board CBERS-01 and -02 for the past five years, statistics was made to show the general features of MeV electrons and protons along a solar synchronous orbit at an altitude of 780 km. This height is in the bottom region of the Earth's radiation belts. Detectors are inside the satellite cabinet and such continuous monitoring of particle radiation environment inside a satellite has seldom conducted so far. After a proper and careful treatment, it is indicated that the data inside satellite are well correlated with the radiation environment outside. Be-sides the agreement of the general distribution characteristics of energetic electrons and protons with similar observations from other satellites, attention is particularly paid to the disturbed conditions. Variations of particle fluxes are closely related with solar proton events, in general, electron fluxes of outer belt are well correlated with Dst index after three days' delay while the electron injection occurred almost at the same day during great magnetic storms. It is confirmed that both energetic electrons and protons appear in the Polar Cap region only after the solar proton events. | HAO YongQiang XIAO Zuo ZOU Hong ZHANG DongHe | 2007 | Chinese Science Bulletin2007，52，5： | 6 |
| 9 | Observational study of daytime ionospheric irregularities associated with typhoon显示文摘Spread-F is a manifestation of ionospheric irregularities and generally takes place at nighttime. However, it can also be observed seldom at daytime. It is recognized that acoustic gravity waves (AGWs) play an important role in triggering plasma instability which results in spread-F in the ionosphere. The typhoon is a main source of the AGWs. In this paper, two cases of ionospheric daytime spread-F in the period of typhoon were analyzed. One case was on July 29, 1988 and the other was on August 01, 1989. The results showed the following: 1) There were some wave-like disturbances appearing in the HF Doppler records firstly, consequently the Doppler echo traces became scattered, which indicated that the ionospheric spread-F was triggered; 2) the blurred echo traces in the both two cases appeared in the morning (08:30-11:30 Beijing time) and lasted for more than two hours; 3) with the blurred echoes gradually weakening, the traveling ionospheric disturbances (TIDs) still existed and became clearer; 4) the frequency shifts in the two cases were both positive, implying the effective reflecting surface of the radio wave in the ionosphere moved downwards. These results provide good observational evidence for daytime spread-F during the typhoon period in Asian region. | XIAO SalGuan SHI JianKui ZHANG DongHe HAO YongQiang HUANG WeiQuan | 2012 | Science China(Technological Sciences)2012，55，5： | 6 |
| 10 | Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice显示文摘The novel coronavirus SARS-CoV-2 has infected more than 104 million individuals and resulted in more than 2.2 million deaths worldwide as of February 7,2021(http://gffzze7c39cdc9e894ca6sxufwvbnp0b6n6pn9.ffgz.tsg.suse.edu.cn).The COVID-19 pandemic highlights the need for safe and effective vaccines against SARS-CoV-2 infection. | Shihui Sun Lei He Zhongpeng Zhao Hongjing Gu Xin Fang Tiecheng Wang Xiaolan Yang Shaolong Chen Yongqiang Deng Jiangfan Li Jian Zhao Liang Li Xinwang Li Peng He Ge Li Hao Li Yuee Zhao Chunrun Gao Xiaoling Lang Xin Wang Guoqiang Fei Yan Li Shusheng Geng Yuwei Gao Wenjin Wei Zhongyu Hu Gencheng Han Yansong Sun | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 11 | Ionospheric absorption and planetary wave activity in East Asia sector显示文摘In this paper, we focus on ionospheric absorption in the East Asia sector, and look for manifestations of atmospheric influences in this area. First, a 4-year historical record of absorption measurement at Beijing is presented. This record was obtained by a sweep frequency technique, in which 27-days periodic variation of the absorption level was found to be dominant, appearing in most seasons except winters. Instead, unusual enhancements of the absorption level appeared in winters (winter anomaly), at the meantime the level varied with periods mainly in the range of 8-12 days. Comparing to 27-days period from the Sun, the shorter period oscillations should be related to planetary wave activities in lower atmosphere. Second, fmin data from 5 mid-latitude ionosondes in Japan were used as an indirect but long-term measurement. With the fmin data covering two solar cycles, disturbances with various periods were found to be active around solar maximum years, but the 8-12 days oscillations always existed in winter, showing seasonal dependence instead of connection to solar activity. These results given in this paper demonstrate seasonal and solar cycle-dependent features of the ionospheric absorption in East Asia sector, and confirm the existence of influence from atmosphere-ionosphere coupling in this area, as well as the relationship between ionospheric winter anomaly and planetary wave activity. | HAO YongQiang ZHANG DongHe | 2012 | Science China(Technological Sciences)2012，55，5： | 4 |
| 12 | 3D Printing Hip Prostheses Offer Accurate Reconstruction,Stable Fixation,and Functional Recovery for Revision Total Hip Arthroplasty with Complex Acetabular Bone Defect显示文摘Complicated and large acetabular bone defects present the main challenges and difficulty in the revision of total hip arthroplasty(THA).This study aimed to explore the advantages of three-dimensional(3D)printing technology in the reconstruction of such acetabular bone defects.We retrospectively analyzed the prognosis of four severe bone defects around the acetabulum in three patients who were treated using 3D printing technology.Reconstruction of bone defect by conventional methods was difficult in these patients.In this endeavor,we used radiographic methods,related computer software such as Materialise's interactive medical image control system and Siemens NX software,and actual surgical experience to estimate defect volume,prosthesis stability,and installation accuracy,respectively.Moreover,a Harris hip score was obtained to evaluate limb function.It was found that bone defects could be adequately reconstructed using a 3D printing prosthesis,and its stability was reliable.The Harris hip score indicated a very good functional recovery in all three patients.In conclusion,3D printing technology had a good therapeutic effect on both complex and large bone defects in the revision of THA.It was able to achieve good curative effects in patients with large bone defects. | Yongqiang Hao Lei Wang Wenbo Jiang Wen Wu Songtao Ai Lu Shen Shuang Zhao Kerong Dai | 2020 | Engineering2020，6，11： | 4 |
| 13 | Two-Stage Transformerless Dual-Buck PV Grid-Connected Inverters with High Efficiency显示文摘A semi-two-stage common-ground-type transformerless dual-buck-based grid-connected inverter is proposed in this paper.The common-ground-type topology can eliminate common mode(CM)leakage current by connecting the negative terminal of the photovoltaic(PV)directly to the neutral point of the grid,which bypasses the PV array’s stray capacitance.The dual-buck-based topology guarantees increased robustness since the dc-link cannot be short-circuited by a shoot-through event.The semi-two-stage topology features multi-level characteristic,which has a lower forward-voltage drop and smaller dv/dt.Compared with the conventional two-stage inverter,the proposed topology achieves higher efficiency and higher reliability.Experimental results of a 1.5kW prototype show that the proposed inverter is able to achieve high efficiency and low leakage currents. | Li Zhang Fengkai Jiang Dewei(David)Xu Kai Sun Yongqiang Hao Tao Zhang | 2018 | Chinese Journal of Electrical Engineering2018，4，2： | 4 |
| 14 | Design and optimization of DBR in 980 nm bottom-emitting VCSEL显示文摘According to the theory of DBR,with the P-type DBR as an example,the electrical characteristics and optical reflection of the DBR are analyzed by studying the energy band structure with various graded region widths and doping densities. The width and doping density of graded region are decided through a comparative study. The P-type DBR of 980 nm VCSELs is designed with Al0.9Ga0.1As and Al0.1Ga0.9As selected as the high and low refractive index material for the DBR. The 980 nm bottom VCSELs,which consists of 30 pairs P-type DBR and 28 pairs N-type DBR,are then fabricated. In P-type DBR,the width of graded region is 0.02 μm and the uniformity doping concentration is 2.5×1018cm-3. Its reflectivity is 99.9%. In N-type DBR,the width of graded region is also 0.02 μm and the uniformity doping concen-tration is 2×1018cm-3. Its reflectivity is 99.3%. The I-V curve shows that the series resistance of the device is about 0.05 Ω. According to the theory of DBR,with the P-type DBR as an example,the electri-cal characteristics and optical reflection of the DBR are analyzed by studying the energy band structure with various graded region widths and doping densities. The width and doping density of graded re-gion are decided through a comparative study. The P-type DBR of 980 nm VCSELs is designed,with Al0.9Ga0.1As and Al0.1Ga0.9As selected as the high and low refractive index material for the DBR. The 980 nm bottom VCSELs,which consist of 30 pairs P-type DBR and 28 pairs N-type DBR,are then fabri-cated. In P-type DBR,the width of graded region is 0.02 μm and the uniformity doping concentration is 2.5×1018cm-3. Its reflectivity is 99.9%. In N-type DBR,the width of graded region is also 0.02 μm and the uniformity doping concentration is 2×1018cm-3. Its reflectivity is 99.3%. The I-V curve shows that the series resistance of the device is about 0.05 Ω. | LI Te NING YongQiang HAO ErJuan CUI JinJiang ZHANG Yan LIU GuangYu QIN Li LIU Yun WANG LiJun CUI DaFu XU ZuYan | 2009 | Science in China(Series F)2009，52，7： | 4 |
| 15 | Multifunctional HDPE/CNTs/PW composite phase change materials with excellent thermal and electrical conductivities显示文摘The risk of leakage and low thermal conductivity severely hinder the wide application of phase change materials(PCMs).In this work,the high-density polyethylene/carbon nanotubes(HDPE/CNTs)porous scaffolds were successfully fabricated via a sacrificial template method followed by the general melt blending and water solvent etching.Subsequently,a series of paraffin wax HDPE/CNTs/PW composite PCMs were obtained combined with the simple vacuum impregnation method.The obtained HDPE/CNTs porous scaffolds can effectively avoid the leakage of PW,meanwhile,the thermal conductivity and electrical conductivity of HDPE/CNTs/PW-3:7 are increased by 2.94 times and 13 orders of magnitude compared with the HDPE/PW-3:7 respectively,also,it exhibits high phase change enthalpy(153.95 J/g for melting enthalpy and 152.82 J/g for crystallization enthalpy).From the above perspectives,the HDPE/CNTs/PW-3:7 has promising potential value in the application of light-to-thermal conversion,electro-to-thermal conversion and thermal energy storage. | Xiaolong Li Xinxin Sheng Yongqiang Guo Xiang Lu Hao Wu Ying Chen Li Zhang Junwei Gu | 2021 | Journal of Materials Science & Technology2021，，27： | 4 |
| 16 | Meridional movement of northern and southern equatorial ionization anomaly crests in the East-Asian sector during 2002-2003SSW显示文摘The present paper investigates the asymmetrical variability of the location of the north and the south equatorial ionization anomaly(EIA) crests in the East-Asian sector,along with their association with simultaneous observations of equatorial electrojet(EEJ) strength,geomagnetic activity index,and solar flux index during the 2002-2003 sudden stratospheric wanning(SSW) event.Analysis of these observations indicates the existence of a large-scale quasi 16-day periodic meridional movement in both EIA crests,and also reveals a strong correlation between the quasi 16-day oscillation in geomagnetic latitudes of the EIA crest and EEJ strength.The latitude of the northern/southern EIA crest and the EEJ strength indicate that obvious synchronous periodic oscillations were in-phase in the northern and southern hemisphere when the SSW occurred.In addition,it is also found that both the EIA crest location and amplitude of the periodic movement of the EIA locations exhibit hemispheric asymmetry.The amplitude of the periodic movement of the EIA location in the southern hemisphere is larger than that of the northern hemisphere,and the southern EIA crest is further off from the equator than the north one.Understanding these asymmetries requires a combination of mechanisms that involve at least trans-equator meridional winds and the position of a sub-solar point;however,potential disturbances in neutral winds associated with the SSW may additionally complicate the equatorial ionospheric dynamics. | MO XiaoHua ZHANG DongHe Larisa GONCHARENKO ZHANG ShunRong HAO YongQiang XIAO Zuo PEI JiaZheng Akimasa YOSHIKAWA CHAU HaDuyen | 2017 | Science China Earth Sciences2017，60，4： | 3 |
| 17 | Particle bursts in the inner radiation belt related to global lightning activity显示文摘Particle bursts(PBs),the phenomena characterized by short-term increases of particle counting rates(CRs),were observed by space-borne radiation belt particle detectors.With the electron CR data obtained by National Oceanic and Atmospheric Administration(NOAA)-18 satellite,the occurrence of PBs in the inner belt(1 L 2 and B 20.5 T)were derived for years2006–2011.The monthly occurrence number of PBs exhibits a strong maximum in northern summer(May–August).In association with global lightning data,the seasonal occurrence of PBs is found to be consistent with the lightning activity,especially if only lightning flashes at latitudes>20°are taken into account.The positive correlation between PBs and mid-latitude lightning discharges indicates the role of lightning-induced whistler waves,and is consistent with the expected pitch-angle scattering by wave-particle interactions.The contribution of lightning is so significant that it forms a non-negligible seasonal background of PBs.If one connects PBs to seismoelectromagnetic emissions(SEME)in attempt to find the earthquake precursor,the lightning background needs to be considered with great care. | WU Fei HAO YongQiang ZHANG DongHe | 2013 | Science China(Technological Sciences)2013，56，11： | 3 |
| 18 | Design, Synthesis and Herbicidal Activities of Tetrahydroisoindoline-1,3-dione Derivatives Containing Alkoxycarbonyl Substituted 2-Benzoxazolinone显示文摘几不同代替 alkoxycarbonyl 的 2-benzoxazolinone 一半被合并了到 tetrahydroisoindoline-1,3-dione 脚手架提供 25 混合物(1a-1u 和 2a-2d ) 。这些混合物的结构被 1 H 和 13 C NMR, HRMS 和 X 光检查单个水晶的衍射。一些这些混合物(1g, 1h, 1j, 1k ) 对以 375 g AI·ha −1 的率的青麻 theophrasti, Amaranthus retroflexus 和 Echinochloa crus-galli 的展出优秀 herbicidal 活动。在他们之中,混合物 1h 和 1j 分别地与 1.8 和 5.3 g AI·ha −1, 的编辑 50 价值对青麻 theophrasti 显示了最好的出现以后的 herbicidal 效果,它比商业 acifluorfen 的优异(44.3 g AI·ha −1) 。地试用证明复合 1h 展出了类似的 herbicidal 活动到高集中 atrazine,并且发现了比 atrazine 为玉米更安全。这研究的结果因此证明复合 1h 能潜在地为玉米领域被用作出现以后的除草剂。 | Hao Zhang Kechang Liu Ruiquan Liu Qibo Li Yongqiang Li Qingmin Wang Shangzhong Liu | 2015 | Chinese Journal of Chemistry2015，33，7： | 2 |
| 19 | Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease显示文摘The parahippocampal gyrus-orbitofrontal cortex(PHG-OFC)circuit in humans is homologous to the postrhinal cortex(POR)-ventral lateral orbitofrontal cortex(vlOFC)circuit in rodents.Both are associated with visuospatial malfunctions in Alzheimer’s disease(AD).However,the underlying mechanisms remain to be elucidated.In this study,we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice,and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging(MRI)in patients on the AD spectrum.We demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD mice.Moreover,MRI measurements of the PHG-OFC circuit had an accuracy of 77.33%for the classification of amnestic mild cognitive impairment converters versus non-converters.Thus,the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD,thereby providing a potential predictor for AD progression and a promising interventional approach for AD. | Lin Zhu Zan Wang Zhanhong Du Xinyang Qi Hao Shu Duan Liu Fan Su Qing Ye Xuemei Liu Zheng Zhou Yongqiang Tang Ru Song Xiaobin Wang Li Lin Shijiang Li Ying Han Liping Wang Zhijun Zhang | 2020 | Neuroscience Bulletin2020，36，8： | 2 |
| 20 | A New Fault Detection Scheme for Networked Control Systems Subject to Uncertain Time-varying Delay 显示文摘 | Wang Yongqiang Ding S X Ye Hao | 2008 | IEEE Transactions on Signal Processing2008，56，10： | 1 |
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